Sourav Ghosh, PhD
Associate Professor of Neurology and Pharmacology
Research & Publications
Biography
News
Locations
Research Summary
I co-lead our group with Carla Rothlin, Professor of Immunobiology and Pharmacology. We are interested in tissue morphogenesis, maintenance and repair with specific emphasis on the functional role of the immune system in development, tissue maintenance and repair/regeneration, as well as the role of cell polarity in these processes. One of the current interests in the lab is cell death and its clearance, and how this can function as a signal for specific effector responses during morphogenesis, homeostatic tissue renewal, or resolution and wound repair after damage. We hypothesize that the integration of cell death recognition, environmental signals (including tissue-specific signals) and the identity of the efferocyte (the cell that recognizes dead cells) determines the specificity for removal of dead/damaged cells, renewal of lost cells, or repair and regeneration. We use a variety of approaches including molecular, cell biology, immunology, imaging and genetics and mouse models of development/tissue homeostasis/injury or diseases to address fundamental biological mechanisms.
Current projects:
1. Astrocytes, oligodendrocytes and microglia during the formation, function and after injury in the nervous systems
2. Macrophage-stromal interactions during tissue homeostasis and wound repair
3. Tumorigenesis and tumor progression, including innate immune checkpoints and anti-tumor immunity
Coauthors
Research Interests
Glioblastoma; Immune System; Inflammation; Cell Death; Neurodegenerative Diseases; Neurodevelopmental Disorders
Selected Publications
- Tissue-specific modifier alleles determine Mertk loss-of-function traitsAkalu YT, Mercau ME, Ansems M, Hughes LD, Nevin J, Alberto EJ, Liu XN, He LZ, Alvarado D, Keler T, Kong Y, Philbrick WM, Bosenberg M, Finnemann SC, Iavarone A, Lasorella A, Rothlin CV, Ghosh S. Tissue-specific modifier alleles determine Mertk loss-of-function traits. ELife 2022, 11: e80530. PMID: 35969037, PMCID: PMC9433089, DOI: 10.7554/elife.80530.
- Cell death in development, maintenance, and diseases of the nervous systemMercau ME, Patwa S, Bhat KPL, Ghosh S, Rothlin CV. Cell death in development, maintenance, and diseases of the nervous system. Seminars In Immunopathology 2022, 44: 725-738. PMID: 35508671, DOI: 10.1007/s00281-022-00938-4.
- DNA methylation of the promoter region at the CREB1 binding site is a mechanism for the epigenetic regulation of brain-specific PKMζPramio D, Vieceli F, Varella-Branco E, Goes C, Kobayashi G, da Silva Pelegrina D, de Moraes B, El Allam A, De Kumar B, Jara G, Farfel J, Bennett D, Kundu S, Viapiano M, Reis E, de Oliveira P, Dos Santos E Passos-Bueno M, Rothlin C, Ghosh S, Schechtman D. DNA methylation of the promoter region at the CREB1 binding site is a mechanism for the epigenetic regulation of brain-specific PKMζ. Biochimica Et Biophysica Acta (BBA) - Gene Regulatory Mechanisms 2023, 1866: 194909. PMID: 36682583, PMCID: PMC10037092, DOI: 10.1016/j.bbagrm.2023.194909.
- When aging gets on the way of disposal: Senescent cell suppression of efferocytosisRothlin C, Ghosh S. When aging gets on the way of disposal: Senescent cell suppression of efferocytosis. Journal Of Cell Biology 2023, 222: e202212023. PMID: 36602762, PMCID: PMC9827511, DOI: 10.1083/jcb.202212023.
- Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosaMercau M, Akalu Y, Mazzoni F, Gyimesi G, Alberto E, Kong Y, Hafler B, Finnemann S, Rothlin C, Ghosh S. Inflammation of the retinal pigment epithelium drives early-onset photoreceptor degeneration in Mertk-associated retinitis pigmentosa. Science Advances 2023, 9: eade9459. PMID: 36662852, PMCID: PMC9858494, DOI: 10.1126/sciadv.ade9459.
- Age-dependent differences in efferocytosis determine the outcome of opsonophagocytic protection from invasive pathogensBee G, Lokken-Toyli K, Yeung S, Rodriguez L, Zangari T, Anderson E, Ghosh S, Rothlin C, Brodin P, Khanna K, Weiser J. Age-dependent differences in efferocytosis determine the outcome of opsonophagocytic protection from invasive pathogens. Immunity 2023, 56: 1255-1268.e5. PMID: 37059107, PMCID: PMC10330046, DOI: 10.1016/j.immuni.2023.03.018.
- Abstract 1189: MERTK is a target in the microenviroenment of osteolytic bone metastasisEngelmann J, Zarrer J, Riecken K, Waizenegger J, Vargas-Delgado M, Meier L, Bokemeyer C, Pantel K, Alberto E, Ghosh S, Rothlin C, Hesse E, Taipaleenmäki H, Ben-Batalla I, Loges S. Abstract 1189: MERTK is a target in the microenviroenment of osteolytic bone metastasis. Cancer Research 2023, 83: 1189-1189. DOI: 10.1158/1538-7445.am2023-1189.
- Regulation of bone homeostasis by MERTK and TYRO3Engelmann J, Zarrer J, Gensch V, Riecken K, Berenbrok N, Luu T, Beitzen-Heineke A, Vargas-Delgado M, Pantel K, Bokemeyer C, Bhamidipati S, Darwish I, Masuda E, Burstyn-Cohen T, Alberto E, Ghosh S, Rothlin C, Hesse E, Taipaleenmäki H, Ben-Batalla I, Loges S. Regulation of bone homeostasis by MERTK and TYRO3. Nature Communications 2022, 13: 7689. PMID: 36509738, PMCID: PMC9744875, DOI: 10.1038/s41467-022-33938-x.
- Prothrombotic Phenotype of a Protein S Mutant Lacking Anticoagulant ActivitySpringborn S, Ghosh S, Schulte M, Rothlin C, Branchford B. Prothrombotic Phenotype of a Protein S Mutant Lacking Anticoagulant Activity. Blood 2021, 138: 2098. DOI: 10.1182/blood-2021-153904.
- Highlights from the LiteratureCharest A, Ghosh S, Purow B, Soffietti R. Highlights from the Literature. Neuro-Oncology 2021, 23: 1631-1633. PMCID: PMC8485431, DOI: 10.1093/neuonc/noab201.
- Highlights from the LiteratureAbounader R, Charest A, Gerstner E, Ghosh S, Soffietti R. Highlights from the Literature. Neuro-Oncology 2021, 23: 715-717. PMCID: PMC8099462, DOI: 10.1093/neuonc/noab074.
- Highlights from the LiteratureViapiano M, Khasraw M, Huse J, Ghosh S, Niclou S, Golebiewska A. Highlights from the Literature. Neuro-Oncology 2021, 23: 877-880. PMCID: PMC8168813, DOI: 10.1093/neuonc/noab086.
- Highlights from the LiteratureViapiano M, Ghosh S, Soffietti R, Abounader R, Huse J. Highlights from the Literature. Neuro-Oncology 2021, 23: 352-355. PMCID: PMC7992891, DOI: 10.1093/neuonc/noab043.
- Highlights from the LiteraturePurow B, Wright K, Abounader R, Ghosh S, Charest A. Highlights from the Literature. Neuro-Oncology 2020, 22: 1725-1727. PMCID: PMC7746924, DOI: 10.1093/neuonc/noaa246.
- Highlights from the LiteratureSoffietti R, Viapiano M, Hegi M, Ghosh S, Purow B. Highlights from the Literature. Neuro-Oncology 2020, 22: 1564-1567. PMCID: PMC7690345, DOI: 10.1093/neuonc/noaa220.
- Highlights from the LiteratureGhosh S, Hegi M, Wright K, Khasraw M. Highlights from the Literature. Neuro-Oncology 2020, 22: 1070-1072. DOI: 10.1093/neuonc/noaa147.
- Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivoDamisah EC, Hill RA, Rai A, Chen F, Rothlin CV, Ghosh S, Grutzendler J. Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo. Science Advances 2020, 6: eaba3239. PMID: 32637606, PMCID: PMC7319765, DOI: 10.1126/sciadv.aba3239.
- Highlights from the LiteratureGhosh S, Purow B, Huse J, Wright K, Aldape K. Highlights from the Literature. Neuro-Oncology 2020, 22: 754-756. PMCID: PMC7282890, DOI: 10.1093/neuonc/noaa089.
- Author Correction: A conserved dendritic-cell regulatory program limits antitumour immunityMaier B, Leader AM, Chen ST, Tung N, Chang C, LeBerichel J, Chudnovskiy A, Maskey S, Walker L, Finnigan JP, Kirkling ME, Reizis B, Ghosh S, D’Amore N, Bhardwaj N, Rothlin CV, Wolf A, Flores R, Marron T, Rahman AH, Kenigsberg E, Brown BD, Merad M. Author Correction: A conserved dendritic-cell regulatory program limits antitumour immunity. Nature 2020, 582: e17-e17. PMID: 32499658, DOI: 10.1038/s41586-020-2326-5.
- Sex differences in the role of atypical PKC within the basolateral nucleus of the amygdala in a mouse hyperalgesic priming modelBaptista-de-Souza D, Tavares-Ferreira D, Megat S, Sankaranarayanan I, Shiers S, Flores CM, Ghosh S, Nunes-de-Souza R, Canto-de-Souza A, Price TJ. Sex differences in the role of atypical PKC within the basolateral nucleus of the amygdala in a mouse hyperalgesic priming model. Neurobiology Of Pain 2020, 8: 100049. PMID: 32548337, PMCID: PMC7284072, DOI: 10.1016/j.ynpai.2020.100049.
- Lifting the innate immune barriers to antitumor immunityRothlin CV, Ghosh S. Lifting the innate immune barriers to antitumor immunity. Journal For ImmunoTherapy Of Cancer 2020, 8: e000695. PMID: 32273348, PMCID: PMC7254113, DOI: 10.1136/jitc-2020-000695.
- Highlights from the LiteratureGhosh S, Huse J, Hegi M, Gerstner E. Highlights from the Literature. Neuro-Oncology 2020, 22: 177-179. PMCID: PMC7032631, DOI: 10.1093/neuonc/noz242.
- Highlights from the Literature22(8), 1070–1072, 2020 | doi:10.1093/neuonc/noaa147
- Highlights from the LiteratureNeuro-Oncology, Volume 22, Issue 11, November 2020, Pages 1564–1567, https://doi.org/10.1093/neuonc/noaa220
- Highlights from the LiteratureNeuro-oncology, 2020, doi.org/10.1093/neuonc/noaa246
- Funerals and Feasts: The Immunological Rites of Cell Death.Galimberti VE, Rothlin CV, Ghosh S. Funerals and Feasts: The Immunological Rites of Cell Death. The Yale Journal Of Biology And Medicine 2019, 92: 663-674. PMID: 31866781, PMCID: PMC6913811.
- Bringing on the itchWaizman DA, Ghosh S, Rothlin CV. Bringing on the itch. ELife 2019, 8: e52931. PMID: 31782733, PMCID: PMC6884404, DOI: 10.7554/elife.52931.
- aPKC in neuronal differentiation, maturation and functionHapak SM, Rothlin CV, Ghosh S. aPKC in neuronal differentiation, maturation and function. Neuronal Signaling 2019, 3: ns20190019. PMID: 32269838, PMCID: PMC7104321, DOI: 10.1042/ns20190019.
- Cracking the Cell Death CodeRothlin CV, Ghosh S. Cracking the Cell Death Code. Cold Spring Harbor Perspectives In Biology 2019, 12: a036343. PMID: 31548182, PMCID: PMC7197433, DOI: 10.1101/cshperspect.a036343.
- Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and FunctionScott J, Thakar S, Mao Y, Qin H, Hejran H, Lee SY, Yu T, Klezovitch O, Cheng H, Mu Y, Ghosh S, Vasioukhin V, Zou Y. Apical-Basal Polarity Signaling Components, Lgl1 and aPKCs, Control Glutamatergic Synapse Number and Function. IScience 2019, 20: 25-41. PMID: 31546104, PMCID: PMC6817635, DOI: 10.1016/j.isci.2019.09.005.
- Highlights from the LiteratureAbounader R, Bhat K, Soffietti R, Ghosh S, Viapiano M. Highlights from the Literature. Neuro-Oncology 2019, 21: 834-836. PMCID: PMC6620633, DOI: 10.1093/neuonc/noz101.
- Serous macrophages pack Bhlhe40 for a randonnéeRothlin CV, Ghosh S. Serous macrophages pack Bhlhe40 for a randonnée. Nature Immunology 2019, 20: 670-671. PMID: 31061527, PMCID: PMC7079578, DOI: 10.1038/s41590-019-0373-6.
- Induction of sterile type 2 inflammationde Kouchkovsky DA, Ghosh S, Rothlin CV. Induction of sterile type 2 inflammation. Nature Materials 2019, 18: 193-194. PMID: 30783225, PMCID: PMC7081377, DOI: 10.1038/s41563-019-0300-0.
- Highlights from the LiteratureNeuro-Oncology 21(7), 834–836, 2019 | doi:10.1093/neuonc/noz101
- Highlights from the LiteratureNeuro-Oncology 21(10), 1223–1225, 2019 | doi:10.1093/neuonc/noz149
- Highlights from the LiteratureNeuro-Oncology 22(2), 177–179, 2020 | doi:10.1093/neuonc/noz242
- Cenabis Bene: Treg Cells Invite Macrophages to DineHughes LD, Ghosh S, Rothlin CV. Cenabis Bene: Treg Cells Invite Macrophages to Dine. Immunity 2018, 49: 579-582. PMID: 30332622, DOI: 10.1016/j.immuni.2018.10.002.
- Coagulopathies and inflammatory diseases: ‘…glimpse of a Snark’del Carmen S, Hapak SM, Ghosh S, Rothlin CV. Coagulopathies and inflammatory diseases: ‘…glimpse of a Snark’. Current Opinion In Immunology 2018, 55: 44-53. PMID: 30268838, PMCID: PMC6366937, DOI: 10.1016/j.coi.2018.09.005.
- Axon Regeneration: Antagonistic Signaling Pairs in Neuronal PolarizationHapak SM, Ghosh S, Rothlin CV. Axon Regeneration: Antagonistic Signaling Pairs in Neuronal Polarization. Trends In Molecular Medicine 2018, 24: 615-629. PMID: 29934283, DOI: 10.1016/j.molmed.2018.05.007.
- PAR3–PAR6–atypical PKC polarity complex proteins in neuronal polarizationHapak SM, Rothlin CV, Ghosh S. PAR3–PAR6–atypical PKC polarity complex proteins in neuronal polarization. Cellular And Molecular Life Sciences 2018, 75: 2735-2761. PMID: 29696344, DOI: 10.1007/s00018-018-2828-6.
- aPKCζ-dependent Repression of Yap is Necessary for Functional Restoration of Irradiated Salivary Glands with IGF-1Chibly AM, Wong WY, Pier M, Cheng H, Mu Y, Chen J, Ghosh S, Limesand KH. aPKCζ-dependent Repression of Yap is Necessary for Functional Restoration of Irradiated Salivary Glands with IGF-1. Scientific Reports 2018, 8: 6347. PMID: 29679075, PMCID: PMC5910385, DOI: 10.1038/s41598-018-24678-4.
- Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhageChang CF, Goods BA, Askenase MH, Hammond MD, Renfroe SC, Steinschneider AF, Landreneau MJ, Ai Y, Beatty HE, da Costa LHA, Mack M, Sheth KN, Greer DM, Huttner A, Coman D, Hyder F, Ghosh S, Rothlin CV, Love JC, Sansing LH. Erythrocyte efferocytosis modulates macrophages towards recovery after intracerebral hemorrhage. Journal Of Clinical Investigation 2017, 128: 607-624. PMID: 29251628, PMCID: PMC5785262, DOI: 10.1172/jci95612.
- Chronicles of Cell Death Foretold: Specificities in the Mechanism of DisposalHughes LD, Bosurgi L, Ghosh S, Rothlin CV. Chronicles of Cell Death Foretold: Specificities in the Mechanism of Disposal. Frontiers In Immunology 2017, 8: 1743. PMID: 29312294, PMCID: PMC5732325, DOI: 10.3389/fimmu.2017.01743.
- Death begets a new beginningBosurgi L, Hughes LD, Rothlin CV, Ghosh S. Death begets a new beginning. Immunological Reviews 2017, 280: 8-25. PMID: 29027219, PMCID: PMC5658037, DOI: 10.1111/imr.12585.
- The receptor tyrosine kinase AXL promotes migration and invasion in colorectal cancerUribe DJ, Mandell EK, Watson A, Martinez JD, Leighton JA, Ghosh S, Rothlin CV. The receptor tyrosine kinase AXL promotes migration and invasion in colorectal cancer. PLOS ONE 2017, 12: e0179979. PMID: 28727830, PMCID: PMC5519024, DOI: 10.1371/journal.pone.0179979.
- Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cellsBosurgi L, Cao YG, Cabeza-Cabrerizo M, Tucci A, Hughes LD, Kong Y, Weinstein JS, Licona-Limon P, Schmid ET, Pelorosso F, Gagliani N, Craft JE, Flavell RA, Ghosh S, Rothlin CV. Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells. Science 2017, 356: 1072-1076. PMID: 28495875, PMCID: PMC5556699, DOI: 10.1126/science.aai8132.
- TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapyAkalu YT, Rothlin CV, Ghosh S. TAM receptor tyrosine kinases as emerging targets of innate immune checkpoint blockade for cancer therapy. Immunological Reviews 2017, 276: 165-177. PMID: 28258690, PMCID: PMC5381815, DOI: 10.1111/imr.12522.
- Negative Regulation of Type 2 Immunityde Kouchkovsky DA, Ghosh S, Rothlin CV. Negative Regulation of Type 2 Immunity. Trends In Immunology 2017, 38: 154-167. PMID: 28082101, PMCID: PMC5510550, DOI: 10.1016/j.it.2016.12.002.
- The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunityChan PY, Carrera Silva EA, De Kouchkovsky D, Joannas LD, Hao L, Hu D, Huntsman S, Eng C, Licona-Limón P, Weinstein JS, Herbert DR, Craft JE, Flavell RA, Repetto S, Correale J, Burchard EG, Torgerson DG, Ghosh S, Rothlin CV. The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Science 2016, 352: 99-103. PMID: 27034374, PMCID: PMC4935984, DOI: 10.1126/science.aaf1358.
- Endosomal regulation of contact inhibition through the AMOT:YAP pathwayCox CM, Mandell EK, Stewart L, Lu R, Johnson DL, McCarter SD, Tavares A, Runyan R, Ghosh S, Wilson JM. Endosomal regulation of contact inhibition through the AMOT:YAP pathway. Molecular Biology Of The Cell 2015, 26: 2673-2684. PMID: 25995376, PMCID: PMC4501364, DOI: 10.1091/mbc.e15-04-0224.
- PKCι interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levelsLu R, Dalgalan D, Mandell EK, Parker SS, Ghosh S, Wilson JM. PKCι interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels. Molecular Biology Of The Cell 2015, 26: 1523-1531. PMID: 25694446, PMCID: PMC4395131, DOI: 10.1091/mbc.e14-12-1613.
- TAM Receptor Signaling in Immune HomeostasisRothlin CV, Carrera-Silva EA, Bosurgi L, Ghosh S. TAM Receptor Signaling in Immune Homeostasis. Annual Review Of Immunology 2015, 33: 1-37. PMID: 25594431, PMCID: PMC4491918, DOI: 10.1146/annurev-immunol-032414-112103.
- Abstract 1991: Axl overexpression drives migration and invasion in colon cancerUribe D, Bosurgi L, Gagliani N, Joannas L, Watson A, Martinez J, Rothlin C, Ghosh S. Abstract 1991: Axl overexpression drives migration and invasion in colon cancer. 2014, 1991-1991. DOI: 10.1158/1538-7445.am2014-1991.
- Science Signaling Podcast: 19 August 2014Ghosh S, Rothlin C, VanHook A. Science Signaling Podcast: 19 August 2014. Science Signaling 2014, 7 DOI: 10.1126/scisignal.2005767.
- Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastomaKusne Y, Carrera-Silva EA, Perry AS, Rushing EJ, Mandell EK, Dietrich JD, Errasti AE, Gibbs D, Berens ME, Loftus JC, Hulme C, Yang W, Lu Z, Aldape K, Sanai N, Rothlin CV, Ghosh S. Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma. Science Signaling 2014, 7: ra75. PMID: 25118327, PMCID: PMC4486020, DOI: 10.1126/scisignal.2005196.
- Tyro3, Axl, and Mertk Receptor Signaling in Inflammatory Bowel Disease and Colitis-associated CancerRothlin CV, Leighton JA, Ghosh S. Tyro3, Axl, and Mertk Receptor Signaling in Inflammatory Bowel Disease and Colitis-associated Cancer. Inflammatory Bowel Diseases 2014, 20: 1472-1480. PMID: 24846720, PMCID: PMC4343000, DOI: 10.1097/mib.0000000000000050.
- Expression of oncogene PKMzeta in pancreatic adenocarcinoma.Patel H, Patel C, Watson-Hurthig A, Parker S, Mandell E, Uribe D, Singh P, Ghosh S. Expression of oncogene PKMzeta in pancreatic adenocarcinoma. Journal Of Clinical Oncology 2014, 32: e15235-e15235. DOI: 10.1200/jco.2014.32.15_suppl.e15235.
- Increased aPKC Expression Correlates with Prostatic Adenocarcinoma Gleason Score and Tumor Stage in the Japanese PopulationPerry AS, Furusato B, Nagle RB, Ghosh S. Increased aPKC Expression Correlates with Prostatic Adenocarcinoma Gleason Score and Tumor Stage in the Japanese Population. Prostate Cancer 2014, 2014: 481697. PMID: 24868468, PMCID: PMC4020167, DOI: 10.1155/2014/481697.
- Local Translation and Retrograde Axonal Transport of CREB Regulates IL-6-Induced Nociceptive PlasticityMelemedjian OK, Tillu DV, Moy JK, Asiedu MN, Mandell EK, Ghosh S, Dussor G, Price TJ. Local Translation and Retrograde Axonal Transport of CREB Regulates IL-6-Induced Nociceptive Plasticity. Molecular Pain 2014, 10: 1744-8069-10-45. PMID: 24993495, PMCID: PMC4091745, DOI: 10.1186/1744-8069-10-45.
- Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in miceKusne Y, Goldberg EL, Parker SS, Hapak SM, Maskaykina IY, Chew WM, Limesand KH, Brooks HL, Price TJ, Sanai N, Nikolich-Zugich J, Ghosh S. Contrasting effects of chronic, systemic treatment with mTOR inhibitors rapamycin and metformin on adult neural progenitors in mice. GeroScience 2013, 36: 199-212. PMID: 23949159, PMCID: PMC3889877, DOI: 10.1007/s11357-013-9572-5.
- Competing molecular interactions of aPKC isoforms regulate neuronal polarityParker SS, Mandell EK, Hapak SM, Maskaykina IY, Kusne Y, Kim JY, Moy JK, St. John PA, Wilson JM, Gothard KM, Price TJ, Ghosh S. Competing molecular interactions of aPKC isoforms regulate neuronal polarity. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 14450-14455. PMID: 23940317, PMCID: PMC3761571, DOI: 10.1073/pnas.1301588110.
- Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancerBosurgi L, Bernink JH, Cuevas V, Gagliani N, Joannas L, Schmid ET, Booth CJ, Ghosh S, Rothlin CV. Paradoxical role of the proto-oncogene Axl and Mer receptor tyrosine kinases in colon cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 13091-13096. PMID: 23878224, PMCID: PMC3740859, DOI: 10.1073/pnas.1302507110.
- T Cell-Derived Protein S Engages TAM Receptor Signaling in Dendritic Cells to Control the Magnitude of the Immune ResponseSilva E, Chan PY, Joannas L, Errasti AE, Gagliani N, Bosurgi L, Jabbour M, Perry A, Smith-Chakmakova F, Mucida D, Cheroutre H, Burstyn-Cohen T, Leighton JA, Lemke G, Ghosh S, Rothlin CV. T Cell-Derived Protein S Engages TAM Receptor Signaling in Dendritic Cells to Control the Magnitude of the Immune Response. Immunity 2013, 39: 160-170. PMID: 23850380, PMCID: PMC4017237, DOI: 10.1016/j.immuni.2013.06.010.
- mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERKMelemedjian OK, Khoutorsky A, Sorge RE, Yan J, Asiedu MN, Valdez A, Ghosh S, Dussor G, Mogil JS, Sonenberg N, Price TJ. mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK. Pain 2013, 154: 1080-1091. PMID: 23607966, PMCID: PMC3742001, DOI: 10.1016/j.pain.2013.03.021.
- BDNF Regulates Atypical PKC at Spinal Synapses to Initiate and Maintain a Centralized Chronic Pain StateMelemedjian OK, Tillu DV, Asiedu MN, Mandell EK, Moy JK, Blute VM, Taylor CJ, Ghosh S, Price TJ. BDNF Regulates Atypical PKC at Spinal Synapses to Initiate and Maintain a Centralized Chronic Pain State. Molecular Pain 2013, 9: 1744-8069-9-12. PMID: 23510079, PMCID: PMC3608966, DOI: 10.1186/1744-8069-9-12.
- ZIPping to Pain Relief: The Role (or Not) of PKMζ in Chronicc PainPrice TJ, Ghosh S. ZIPping to Pain Relief: The Role (or Not) of PKMζ in Chronicc Pain. Molecular Pain 2013, 9: 1744-8069-9-6. PMID: 23433248, PMCID: PMC3621284, DOI: 10.1186/1744-8069-9-6.
- TAMing Colitis and Colitis-Associated Colon CancerBosurgi L, Uribe D, Bernink J, Cuevas V, Silva E, Gagliani N, Leighton J, Ghosh S, Rothlin C. TAMing Colitis and Colitis-Associated Colon Cancer. Inflammatory Bowel Diseases 2012, 18: s13-s14. DOI: 10.1097/00054725-201212001-00033.
- TAMing Colitis and Colitis-Associated Colon CancerBosurgi L, Uribe D, Bernink J, Cuevas V, Silva E, Gagliani N, Leighton J, Ghosh S, Rothlin C. TAMing Colitis and Colitis-Associated Colon Cancer. Inflammatory Bowel Diseases 2012, 18: s104. DOI: 10.1097/00054725-201212001-00263.
- Contribution of PKMζ-dependent and independent amplification to components of experimental neuropathic painKing T, Qu C, Okun A, Melemedjian OK, Mandell EK, Maskaykina IY, Navratilova E, Dussor GO, Ghosh S, Price TJ, Porreca F. Contribution of PKMζ-dependent and independent amplification to components of experimental neuropathic pain. Pain 2012, 153: 1263-1273. PMID: 22482911, PMCID: PMC3358498, DOI: 10.1016/j.pain.2012.03.006.
- T cell derived Protein S inhibits the activation of Dendritic cells through the TAM receptors Axl and MerSilva E, Chan P, Joannas L, BurstynCohen T, Lemke G, Ghosh S, Rothlin C. T cell derived Protein S inhibits the activation of Dendritic cells through the TAM receptors Axl and Mer. Inflammatory Bowel Diseases 2011, 17: s10. DOI: 10.1097/00054725-201112002-00028.
- Spinal Protein Kinase M ζ Underlies the Maintenance Mechanism of Persistent Nociceptive SensitizationAsiedu MN, Tillu DV, Melemedjian OK, Shy A, Sanoja R, Bodell B, Ghosh S, Porreca F, Price TJ. Spinal Protein Kinase M ζ Underlies the Maintenance Mechanism of Persistent Nociceptive Sensitization. Journal Of Neuroscience 2011, 31: 6646-6653. PMID: 21543593, PMCID: PMC3090264, DOI: 10.1523/jneurosci.6286-10.2011.
- Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expressionTeo H, Ghosh S, Luesch H, Ghosh A, Wong ET, Malik N, Orth A, de Jesus P, Perry AS, Oliver JD, Tran NL, Speiser LJ, Wong M, Saez E, Schultz P, Chanda SK, Verma IM, Tergaonkar V. Telomere-independent Rap1 is an IKK adaptor and regulates NF-κB-dependent gene expression. Nature Cell Biology 2010, 12: 758-767. PMID: 20622870, DOI: 10.1038/ncb2080.
- Highlights from the LiteratureNeuro-Oncology 22(6), 754–756, 2020 | doi:10.1093/neuonc/noaa089
- Instructive role of aPKCζ subcellular localization in the assembly of adherens junctions in neural progenitorsGhosh S, Marquardt T, Thaler JP, Carter N, Andrews SE, Pfaff SL, Hunter T. Instructive role of aPKCζ subcellular localization in the assembly of adherens junctions in neural progenitors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 335-340. PMID: 18162555, PMCID: PMC2224213, DOI: 10.1073/pnas.0705713105.
- TAM Receptors Are Pleiotropic Inhibitors of the Innate Immune ResponseRothlin CV, Ghosh S, Zuniga EI, Oldstone MB, Lemke G. TAM Receptors Are Pleiotropic Inhibitors of the Innate Immune Response. Cell 2007, 131: 1124-1136. PMID: 18083102, DOI: 10.1016/j.cell.2007.10.034.
- Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-κB activation and cell survivalGhosh S, Tergaonkar V, Rothlin CV, Correa RG, Bottero V, Bist P, Verma IM, Hunter T. Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-κB activation and cell survival. Cancer Cell 2006, 10: 215-226. PMID: 16959613, DOI: 10.1016/j.ccr.2006.08.007.
- Coexpressed EphA Receptors and Ephrin-A Ligands Mediate Opposing Actions on Growth Cone Navigation from Distinct Membrane DomainsMarquardt T, Shirasaki R, Ghosh S, Andrews SE, Carter N, Hunter T, Pfaff SL. Coexpressed EphA Receptors and Ephrin-A Ligands Mediate Opposing Actions on Growth Cone Navigation from Distinct Membrane Domains. Cell 2005, 121: 127-139. PMID: 15820684, DOI: 10.1016/j.cell.2005.01.020.
- Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasionLu Z, Ghosh S, Wang Z, Hunter T. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion. Cancer Cell 2003, 4: 499-515. PMID: 14706341, DOI: 10.1016/s1535-6108(03)00304-0.
- Mitotic Regulation of Ribosomal S6 Kinase 1 Involves Ser/Thr, Pro Phosphorylation of Consensus and Non-consensus Sites by Cdc2*Shah OJ, Ghosh S, Hunter T. Mitotic Regulation of Ribosomal S6 Kinase 1 Involves Ser/Thr, Pro Phosphorylation of Consensus and Non-consensus Sites by Cdc2*. Journal Of Biological Chemistry 2003, 278: 16433-16442. PMID: 12586835, DOI: 10.1074/jbc.m300435200.
- CK2 constitutively associates with and phosphorylates chicken erythroid ankyrin and regulates its ability to bind to spectrinGhosh S, Dorsey FC, Cox JV. CK2 constitutively associates with and phosphorylates chicken erythroid ankyrin and regulates its ability to bind to spectrin. Journal Of Cell Science 2002, 115: 4107-4115. PMID: 12356915, DOI: 10.1242/jcs.00102.
- Dynamics of Ankyrin-containing Complexes in Chicken Embryonic Erythroid Cells: Role of PhosphorylationGhosh S, Cox J. Dynamics of Ankyrin-containing Complexes in Chicken Embryonic Erythroid Cells: Role of Phosphorylation. Molecular Biology Of The Cell 2001, 12: 3864-3874. PMID: 11739786, PMCID: PMC60761, DOI: 10.1091/mbc.12.12.3864.
- Chicken Erythroid AE1 Anion Exchangers Associate with the Cytoskeleton During Recycling to the GolgiGhosh S, Cox K, Cox J. Chicken Erythroid AE1 Anion Exchangers Associate with the Cytoskeleton During Recycling to the Golgi. Molecular Biology Of The Cell 1999, 10: 455-469. PMID: 9950688, PMCID: PMC25180, DOI: 10.1091/mbc.10.2.455.