Carla Rothlin, PhD
Dorys McConnell Duberg Professor of Immunobiology and Professor of Pharmacology; Co-Leader, Cancer Immunology, Yale Cancer Center
Research & Publications
Biography
News
Locations
Research Summary
I co-lead our group with Sourav Ghosh, Associate Professor of Neurology and Pharmacology. We have a long-term interest in how the immune response is calibrated to avoid chronic inflammation, autoimmunity and self-harm. We study mechanisms that set or limit the magnitude of the immune response. We also study mechanisms that signal the temporal shift from a pathogen-defense mode following successful immune defense to resolution and wound repair. One of the current interests in the lab is cell death and its clearance, and how this can function as a signal for specific effector responses during morphogenesis, homeostatic tissue renewal, or resolution and wound repair after damage. We hypothesize that the integration of cell death recognition, environmental signals (including tissue-specific signals) and the identity of the efferocyte (the cell that recognizes dead cells) determines the specificity for removal of dead/damaged cells, renewal of lost cells, or repair and regeneration. We use a variety of approaches including molecular, cell biology, immunology, imaging and genetics and mouse models of development/tissue homeostasis/injury or diseases to address fundamental biological mechanisms.
Current projects:
- Macrophage-stromal interactions during tissue homeostasis and wound repair
- Crosstalk between stromal and immune cells, in the context of cell turnover or injury, during the formation and function of the nervous system
- Innate immune checkpoints and anti-tumor immunity
Extensive Research Description
Immunobiology; Immune Homeostasis; TAM Receptor Tyrosine Kinases
Coauthors
Research Interests
Inflammation
Selected Publications
- Regulation of bone homeostasis by MERTK and TYRO3Engelmann J, Zarrer J, Gensch V, Riecken K, Berenbrok N, Luu T, Beitzen-Heineke A, Vargas-Delgado M, Pantel K, Bokemeyer C, Bhamidipati S, Darwish I, Masuda E, Burstyn-Cohen T, Alberto E, Ghosh S, Rothlin C, Hesse E, Taipaleenmäki H, Ben-Batalla I, Loges S. Regulation of bone homeostasis by MERTK and TYRO3. Nature Communications 2022, 13: 7689. PMID: 36509738, PMCID: PMC9744875, DOI: 10.1038/s41467-022-33938-x.
- Tissue-specific modifier alleles determine Mertk loss-of-function traitsAkalu YT, Mercau ME, Ansems M, Hughes LD, Nevin J, Alberto EJ, Liu XN, He LZ, Alvarado D, Keler T, Kong Y, Philbrick WM, Bosenberg M, Finnemann SC, Iavarone A, Lasorella A, Rothlin CV, Ghosh S. Tissue-specific modifier alleles determine Mertk loss-of-function traits. ELife 2022, 11: e80530. PMID: 35969037, PMCID: PMC9433089, DOI: 10.7554/elife.80530.
- Decoding Cell Death: From a Veritable Library of Babel to Vade Mecum?Hughes LD, Wang Y, Meli AP, Rothlin CV, Ghosh S. Decoding Cell Death: From a Veritable Library of Babel to Vade Mecum? Annual Review Of Immunology 2021, 39: 791-817. PMID: 33902311, DOI: 10.1146/annurev-immunol-102819-072601.
- Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivoDamisah EC, Hill RA, Rai A, Chen F, Rothlin CV, Ghosh S, Grutzendler J. Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo. Science Advances 2020, 6: eaba3239. PMID: 32637606, PMCID: PMC7319765, DOI: 10.1126/sciadv.aba3239.
- Universal Principled Review: A Community-Driven Method to Improve Peer ReviewKrummel M, Blish C, Kuhns M, Cadwell K, Oberst A, Goldrath A, Ansel K, Chi H, O’Connell R, Wherry E, Pepper M, Consortium T, Brodsky I, Chang J, Arron J, Haining N, Bhattacharya D, Anderson M, Rothlin C, Schwab S, Belkaid Y, Molofsky A, Savage P, Mucida D, Iwasaki A, Victora G, Ansel K, Hamerman J, Masopust D, Barton G, Kaech S, Woodruff P, Stetson D, Scharschmidt T, Kedl R, Zúñiga E, Hoffmann A, Williams M, Mayer-Barber K, Shin S, Bensinger S, Lu L, Looney M, Round J, Amigorena S, Yewdell J, Sun J, Harty J. Universal Principled Review: A Community-Driven Method to Improve Peer Review. Cell 2019, 179: 1441-1445. PMID: 31835023, DOI: 10.1016/j.cell.2019.11.029.
- Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cellsBosurgi L, Cao YG, Cabeza-Cabrerizo M, Tucci A, Hughes LD, Kong Y, Weinstein JS, Licona-Limon P, Schmid ET, Pelorosso F, Gagliani N, Craft JE, Flavell RA, Ghosh S, Rothlin CV. Macrophage function in tissue repair and remodeling requires IL-4 or IL-13 with apoptotic cells. Science 2017, 356: 1072-1076. PMID: 28495875, PMCID: PMC5556699, DOI: 10.1126/science.aai8132.
- The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunityChan PY, Carrera Silva EA, De Kouchkovsky D, Joannas LD, Hao L, Hu D, Huntsman S, Eng C, Licona-Limón P, Weinstein JS, Herbert DR, Craft JE, Flavell RA, Repetto S, Correale J, Burchard EG, Torgerson DG, Ghosh S, Rothlin CV. The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Science 2016, 352: 99-103. PMID: 27034374, PMCID: PMC4935984, DOI: 10.1126/science.aaf1358.
- TAM Receptor Signaling in Immune HomeostasisRothlin CV, Carrera-Silva EA, Bosurgi L, Ghosh S. TAM Receptor Signaling in Immune Homeostasis. Annual Review Of Immunology 2015, 33: 1-37. PMID: 25594431, PMCID: PMC4491918, DOI: 10.1146/annurev-immunol-032414-112103.
- T cell derived Protein S inhibits the activation of Dendritic cells through the TAM receptors Axl and MerSilva E, Chan P, Joannas L, BurstynCohen T, Lemke G, Ghosh S, Rothlin C. T cell derived Protein S inhibits the activation of Dendritic cells through the TAM receptors Axl and Mer. Inflammatory Bowel Diseases 2011, 17: s10. DOI: 10.1097/00054725-201112002-00028.
- α10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cellsElgoyhen A, Vetter D, Katz E, Rothlin C, Heinemann S, Boulter J. α10: A determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 3501-3506. PMID: 11248107, PMCID: PMC30682, DOI: 10.1073/pnas.051622798.
- Mixed nicotinic–muscarinic properties of the α9 nicotinic cholinergic receptorVerbitsky M, Rothlin C, Katz E, Elgoyhen A. Mixed nicotinic–muscarinic properties of the α9 nicotinic cholinergic receptor. Neuropharmacology 2000, 39: 2515-2524. PMID: 11044723, DOI: 10.1016/s0028-3908(00)00124-6.
- Block of the α9 nicotinic receptor by ototoxic aminoglycosidesRothlin C, Katz E, Verbitsky M, Vetter D, Heinemann S, Elgoyhen A. Block of the α9 nicotinic receptor by ototoxic aminoglycosides. Neuropharmacology 2000, 39: 2525-2532. PMID: 11044724, DOI: 10.1016/s0028-3908(00)00056-3.
- High calcium permeability and calcium block of the α9 nicotinic acetylcholine receptorKatz E, Verbitsky M, Rothlin C, Vetter D, Heinemann S, Elgoyhen A. High calcium permeability and calcium block of the α9 nicotinic acetylcholine receptor. Hearing Research 2000, 141: 117-128. PMID: 10713500, DOI: 10.1016/s0378-5955(99)00214-2.
- The α9 Nicotinic Acetylcholine Receptor Shares Pharmacological Properties with Type A γ-Aminobutyric Acid, Glycine, and Type 3 Serotonin ReceptorsRothlin C, Katz E, Verbitsky M, Elgoyhen A. The α9 Nicotinic Acetylcholine Receptor Shares Pharmacological Properties with Type A γ-Aminobutyric Acid, Glycine, and Type 3 Serotonin Receptors. Molecular Pharmacology 1999, 55: 248-254. PMID: 9927615, DOI: 10.1124/mol.55.2.248.