Robert LaMotte, PhD
Research & Publications
Biography
News
Research Summary
Dr. LaMotte's laboratory investigates the peripheral neural mechanisms of itch and pain. The neural basis of itch is poorly understood despite its clinical importance. Dr. LaMotte and his lab are currently addressing the problem by means of NIH funded research to characterize peripheral neural mechanisms encoding acute and persistent itch. Their approach is to correlate psychophysical measurements of itch and pain in humans (measured in the LaMotte lab) with electrophysiological recordings from pruriceptive and nociceptive peripheral nerve fibers in the monkey (obtained in the laboratory of Matthias Ringkamp, Johns Hopkins School of Medicine) using the same types of pruritic and nociceptive stimuli. The correlations are used to identify candidate neural mechanisms that code the sensations of acute itch and pathologically persistent itch. For example, Dr. LaMotte and his lab are using novel pruritogens (pruritic chemicals) that selectively activate one or more types of cutaneous nociceptors to elicit itch. They are also identifying experimental conditions that can enhance the itch or the pain produced by these and other pruritogens, and are seeking to define conditions where pain and itch coexist as can sometimes occur in clinical neuropathic or inflammatory diseases.
In preclinical models of inflammatory itch, Dr. LaMotte's lab is comparing the enhanced and persistent itch and pain accompanying either of two types of contact dermatitis - irritant dermatitis that activates the innate immune system and allergic contact dermatitis that additionally activates the adaptive immune system. They will determine the effects of reducing or eliminating activity in one set of nociceptive nerve fibers on the remaining sensibilities mediated by other types. This approach will aid the development of anti-pruritic and analgesic therapies that selectively modify itch and pain.
Coauthors
Research Interests
Anesthesiology; Nervous System; Neurochemistry; Neurons; Neurophysiology; Pain; Nociceptive Pain
Selected Publications
- Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in miceWang T, Hurwitz O, Shimada SG, Tian D, Dai F, Zhou J, Ma C, LaMotte RH. Anti-nociceptive effects of bupivacaine-encapsulated PLGA nanoparticles applied to the compressed dorsal root ganglion in mice Neuroscience Letters 2018, 668: 154-158. PMID: 29355697, PMCID: PMC5829013, DOI: 10.1016/j.neulet.2018.01.031.
- Molecular basis of tactile specialization in the duck billSchneider ER, Anderson EO, Mastrotto M, Matson JD, Schulz VP, Gallagher PG, LaMotte RH, Gracheva EO, Bagriantsev SN. Molecular basis of tactile specialization in the duck bill Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 13036-13041. PMID: 29109250, PMCID: PMC5724259, DOI: 10.1073/pnas.1708793114.
- Cl− channel is required for CXCL10-induced neuronal activation and itch response in a murine model of allergic contact dermatitisQu L, Fu K, Shimada SG, LaMotte RH. Cl− channel is required for CXCL10-induced neuronal activation and itch response in a murine model of allergic contact dermatitis Journal Of Neurophysiology 2017, 118: 619-624. PMID: 28446581, PMCID: PMC5511864, DOI: 10.1152/jn.00187.2017.
- Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and MouseLaMotte RH. Allergic Contact Dermatitis: A Model of Inflammatory Itch and Pain in Human and Mouse 2016, 904: 23-32. PMID: 26900060, PMCID: PMC4910628, DOI: 10.1007/978-94-017-7537-3_2.
- Chronic Compression of the Dorsal Root Ganglion Enhances Mechanically Evoked Pain Behavior and the Activity of Cutaneous Nociceptors in MiceWang T, Hurwitz O, Shimada SG, Qu L, Fu K, Zhang P, Ma C, LaMotte RH. Chronic Compression of the Dorsal Root Ganglion Enhances Mechanically Evoked Pain Behavior and the Activity of Cutaneous Nociceptors in Mice PLOS ONE 2015, 10: e0137512. PMID: 26356638, PMCID: PMC4565551, DOI: 10.1371/journal.pone.0137512.
- CXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitisQu L, Fu K, Yang J, Shimada SG, LaMotte RH. CXCR3 chemokine receptor signaling mediates itch in experimental allergic contact dermatitis Pain 2015, 156: 1737-1746. PMID: 25932692, PMCID: PMC4545682, DOI: 10.1097/j.pain.0000000000000208.
- Psychophysical Measurements of Itch and Nociceptive Sensations in an Experimental Model of Allergic Contact DermatitisPall PS, Hurwitz OE, King BA, LaMotte RH. Psychophysical Measurements of Itch and Nociceptive Sensations in an Experimental Model of Allergic Contact Dermatitis Journal Of Pain 2015, 16: 741-749. PMID: 26002605, PMCID: PMC4522332, DOI: 10.1016/j.jpain.2015.04.009.
- Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and painQu L, Fan N, Ma C, Wang T, Han L, Fu K, Wang Y, Shimada SG, Dong X, LaMotte RH. Enhanced excitability of MRGPRA3- and MRGPRD-positive nociceptors in a model of inflammatory itch and pain Brain 2014, 137: 1039-1050. PMID: 24549959, PMCID: PMC3959553, DOI: 10.1093/brain/awu007.
- Ectopia, SpontaneousLaMotte R. Ectopia, Spontaneous 2013, 1099-1104. DOI: 10.1007/978-3-642-28753-4_1249.
- Allodynia and AlloknesisLaMotte R. Allodynia and Alloknesis 2013, 87-90. DOI: 10.1007/978-3-642-28753-4_154.
- A subpopulation of nociceptors specifically linked to itchHan L, Ma C, Liu Q, Weng HJ, Cui Y, Tang Z, Kim Y, Nie H, Qu L, Patel KN, Li Z, McNeil B, He S, Guan Y, Xiao B, LaMotte RH, Dong X. A subpopulation of nociceptors specifically linked to itch Nature Neuroscience 2012, 16: 174-182. PMID: 23263443, PMCID: PMC3557753, DOI: 10.1038/nn.3289.
- In vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humansMa C, Nie H, Gu Q, Sikand P, LaMotte RH. In vivo responses of cutaneous C-mechanosensitive neurons in mouse to punctate chemical stimuli that elicit itch and nociceptive sensations in humans Journal Of Neurophysiology 2011, 107: 357-363. PMID: 21994268, PMCID: PMC3349700, DOI: 10.1152/jn.00801.2011.
- Behavioral differentiation between itch and pain in mouseShimada SG, LaMotte RH. Behavioral differentiation between itch and pain in mouse Pain 2008, 139: 681-687. PMID: 18789837, PMCID: PMC2723192, DOI: 10.1016/j.pain.2008.08.002.
- Allodynia and AlloknesisLaMotte R. Allodynia and Alloknesis 2007, 52-55. DOI: 10.1007/978-3-540-29805-2_154.
- Ectopia, SpontaneousLaMotte R. Ectopia, Spontaneous 2007, 677-681. DOI: 10.1007/978-3-540-29805-2_1249.
- MCP-1 Enhances Excitability of Nociceptive Neurons in Chronically Compressed Dorsal Root GangliaSun J, Yang B, Donnelly D, Ma C, LaMotte R. MCP-1 Enhances Excitability of Nociceptive Neurons in Chronically Compressed Dorsal Root Ganglia Journal Of Neurophysiology 2006, 96: 2189-2199. PMID: 16775210, DOI: 10.1152/jn.00222.2006.
- (682) MCP-1/CCL2 and CCR2 upregulation following partial ligation of the infraorbital nerve: possible involvement in the development and maintenance of trigeminal neuralgiaWhite F, Bauer W, Jellish W, Chan D, LaMotte R, Miller R. (682) MCP-1/CCL2 and CCR2 upregulation following partial ligation of the infraorbital nerve: possible involvement in the development and maintenance of trigeminal neuralgia Journal Of Pain 2006, 7: s25. DOI: 10.1016/j.jpain.2006.01.084.
- Effects of a Chronic Compression of the Dorsal Root Ganglion on Voltage-Gated Na+ and K+ Currents in Cutaneous Afferent NeuronsTan Z, Donnelly D, LaMotte R. Effects of a Chronic Compression of the Dorsal Root Ganglion on Voltage-Gated Na+ and K+ Currents in Cutaneous Afferent Neurons Journal Of Neurophysiology 2006, 95: 1115-1123. PMID: 16424456, DOI: 10.1152/jn.00830.2005.
- 902. Modulation of Voltage-Gated Potassium Channels in Dorsal Root Ganglion Neurons by an Inducible Adenoviral Vector In VivoMa C, LaMotte R, Rosenzweig J, Gehlbach P, Johns D. 902. Modulation of Voltage-Gated Potassium Channels in Dorsal Root Ganglion Neurons by an Inducible Adenoviral Vector In Vivo Molecular Therapy 2006, 13: s347-s348. DOI: 10.1016/j.ymthe.2006.08.991.
- Comparison of responses to tensile and compressive stimuli in C-mechanosensitive nociceptors in rat hairy skinZheng Z, LaMotte R, Grigg P. Comparison of responses to tensile and compressive stimuli in C-mechanosensitive nociceptors in rat hairy skin Somatosensory & Motor Research 2002, 19: 109-113. PMID: 12088384, DOI: 10.1080/08990220120113095.
- Fine-Scale Organization of SI (Area 3b) in the Squirrel Monkey Revealed With Intrinsic Optical ImagingChen L, Friedman R, Ramsden B, LaMotte R, Roe A. Fine-Scale Organization of SI (Area 3b) in the Squirrel Monkey Revealed With Intrinsic Optical Imaging Journal Of Neurophysiology 2001, 86: 3011-3029. PMID: 11731557, DOI: 10.1152/jn.2001.86.6.3011.
- Softness Discrimination With a ToolLaMotte R. Softness Discrimination With a Tool Journal Of Neurophysiology 2000, 83: 1777-1786. PMID: 10758090, DOI: 10.1152/jn.2000.83.4.1777.
- Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic painDibHajj S, Fjell J, Cummins TR, Zheng Z, Fried K, LaMotte R, Black JA, Waxman S. Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain Pain 1999, 83: 591-600. PMID: 10568868, DOI: 10.1016/s0304-3959(99)00169-4.
- Mechanical and Thermal Hyperalgesia and Ectopic Neuronal Discharge After Chronic Compression of Dorsal Root GangliaSong X, Hu S, Greenquist K, Zhang J, LaMotte R. Mechanical and Thermal Hyperalgesia and Ectopic Neuronal Discharge After Chronic Compression of Dorsal Root Ganglia Journal Of Neurophysiology 1999, 82: 3347-3358. PMID: 10601466, DOI: 10.1152/jn.1999.82.6.3347.
- Enhanced Excitability of Sensory Neurons in Rats With Cutaneous Hyperalgesia Produced by Chronic Compression of the Dorsal Root GanglionZhang J, Song X, LaMotte R. Enhanced Excitability of Sensory Neurons in Rats With Cutaneous Hyperalgesia Produced by Chronic Compression of the Dorsal Root Ganglion Journal Of Neurophysiology 1999, 82: 3359-3366. PMID: 10601467, DOI: 10.1152/jn.1999.82.6.3359.
- Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodyniaBrull S, Atanassoff P, Silverman D, Zhang J, Lamotte R. Attenuation of experimental pruritus and mechanically evoked dysesthesiae in an area of cutaneous allodynia Somatosensory & Motor Research 1999, 16: 299-303. PMID: 10632027, DOI: 10.1080/08990229970366.
- Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesiaAtanassoff P, Brull S, Zhang J, Greenquist K, Silverman D, Lamotte R. Enhancement of experimental pruritus and mechanically evoked dysesthesiae with local anesthesia Somatosensory & Motor Research 1999, 16: 291-298. PMID: 10632026, DOI: 10.1080/08990229970357.
- Raised Object on a Planar Surface Stroked Across the Fingerpad: Responses of Cutaneous Mechanoreceptors to Shape and OrientationLamotte R, Friedman R, Lu C, Khalsa P, Srinivasan M. Raised Object on a Planar Surface Stroked Across the Fingerpad: Responses of Cutaneous Mechanoreceptors to Shape and Orientation Journal Of Neurophysiology 1998, 80: 2446-2466. PMID: 9819255, DOI: 10.1152/jn.1998.80.5.2446.
- Encoding of Shape and Orientation of Objects Indented Into the Monkey Fingerpad by Populations of Slowly and Rapidly Adapting MechanoreceptorsKhalsa P, Friedman R, Srinivasan M, Lamotte R. Encoding of Shape and Orientation of Objects Indented Into the Monkey Fingerpad by Populations of Slowly and Rapidly Adapting Mechanoreceptors Journal Of Neurophysiology 1998, 79: 3238-3251. PMID: 9636122, DOI: 10.1152/jn.1998.79.6.3238.
- Patch clamp recording from the intact dorsal root ganglionZhang J, Donnelly D, LaMotte R. Patch clamp recording from the intact dorsal root ganglion Journal Of Neuroscience Methods 1998, 79: 97-103. PMID: 9531465, DOI: 10.1016/s0165-0270(97)00164-7.
- Axotomy Increases the Excitability of Dorsal Root Ganglion Cells With Unmyelinated AxonsZhang J, Donnelly D, Song X, Lamotte R. Axotomy Increases the Excitability of Dorsal Root Ganglion Cells With Unmyelinated Axons Journal Of Neurophysiology 1997, 78: 2790-2794. PMID: 9356426, DOI: 10.1152/jn.1997.78.5.2790.
- An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglionZhang J, Song X, LaMotte R. An in vitro study of ectopic discharge generation and adrenergic sensitivity in the intact, nerve-injured rat dorsal root ganglion Pain 1997, 72: 51-57. PMID: 9272787, DOI: 10.1016/s0304-3959(97)00013-4.
- Tensile and Compressive Responses of Nociceptors in Rat Hairy SkinKhalsa P, Lamotte R, Grigg P. Tensile and Compressive Responses of Nociceptors in Rat Hairy Skin Journal Of Neurophysiology 1997, 78: 492-505. PMID: 9242296, DOI: 10.1152/jn.1997.78.1.492.
- Neural encoding of shape: responses of cutaneous mechanoreceptors to a wavy surface stroked across the monkey fingerpadLaMotte R, Srinivasan M. Neural encoding of shape: responses of cutaneous mechanoreceptors to a wavy surface stroked across the monkey fingerpad Journal Of Neurophysiology 1996, 76: 3787-3797. PMID: 8985876, DOI: 10.1152/jn.1996.76.6.3787.
- Abnormal spontaneous activity and responses to norepinephrine in dissociated dorsal root ganglion cells after chronic nerve constrictionPetersen M, Zhang J, Zhang J, LaMotte R. Abnormal spontaneous activity and responses to norepinephrine in dissociated dorsal root ganglion cells after chronic nerve constriction Pain 1996, 67: 391-397. PMID: 8951934, DOI: 10.1016/0304-3959(96)03146-6.
- Multiple capsaicin-induced currents in isolated rat sensory neuronsPetersen M, LaMotte R, Klusch A, Kniffki K. Multiple capsaicin-induced currents in isolated rat sensory neurons Neuroscience 1996, 75: 495-505. PMID: 8931013, DOI: 10.1016/0306-4522(96)00259-x.
- Reduction of Postburn Hyperalgesia after Local Injection of Ketorolac in Healthy VolunteersLundell J, Silverman D, Brull S, O'Connor T, Kitahata L, Collins J, LaMotte R. Reduction of Postburn Hyperalgesia after Local Injection of Ketorolac in Healthy Volunteers Anesthesiology 1996, 84: 502-509. PMID: 8659776, DOI: 10.1097/00000542-199603000-00003.
- Tactual discrimination of softness: abilities and mechanismsSrinivasan M, LaMotte R. Tactual discrimination of softness: abilities and mechanisms 1996, 123-135. DOI: 10.1007/978-3-0348-9016-8_11.
- Tactile neutral codes for the shapes and orientation of objectsLaMotte R, Lu C, Srivasan M. Tactile neutral codes for the shapes and orientation of objects 1996, 113-122. DOI: 10.1007/978-3-0348-9016-8_10.
- Chapter 8 Alterations in the functional properties of dorsal root ganglion cells with unmyelinated axons after a chronic nerve constriction in the ratLaMotte R, Zhang J, Petersen M. Chapter 8 Alterations in the functional properties of dorsal root ganglion cells with unmyelinated axons after a chronic nerve constriction in the rat 1996, 110: 105-111. PMID: 9000719, DOI: 10.1016/s0079-6123(08)62568-6.
- Functional changes in dorsal root ganglion cells after chronic nerve constriction in the ratXie Y, Zhang J, Petersen M, LaMotte R. Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat Journal Of Neurophysiology 1995, 73: 1811-1820. PMID: 7623082, DOI: 10.1152/jn.1995.73.5.1811.
- Tactual discrimination of softnessSrinivasan M, LaMotte R. Tactual discrimination of softness Journal Of Neurophysiology 1995, 73: 88-101. PMID: 7714593, DOI: 10.1152/jn.1995.73.1.88.
- Effect of Local Injection of Ketorolac on Post-burn HyperalgesiaLundell J, Silverman D, Brull S, LaMotte R, Collins J, O'Connor T, Kitahata L. Effect of Local Injection of Ketorolac on Post-burn Hyperalgesia Anesthesiology 1994, 81: a961. DOI: 10.1097/00000542-199409001-00960.
- Cutaneous neural codes for shapeLaMotte R, Srinivasan M, Lu C, Klusch-Petersen A. Cutaneous neural codes for shape Canadian Journal Of Physiology And Pharmacology 1994, 72: 498-505. PMID: 7954079, DOI: 10.1139/y94-073.
- Responses of cutaneous mechanoreceptors to the shape of objects applied to the primate fingerpadLaMotte R, Srinivasan M. Responses of cutaneous mechanoreceptors to the shape of objects applied to the primate fingerpad Acta Psychologica 1993, 84: 41-51. PMID: 8237455, DOI: 10.1016/0001-6918(93)90071-x.
- Effect of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cellsPetersen M, LaMotte R. Effect of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cells Pain 1993, 54: 37-42. PMID: 7690929, DOI: 10.1016/0304-3959(93)90097-9.
- Cutaneous Mechanoreceptors of the Hand: Experimental Studies and Their Implications for Clinical Testing of Tactile SensationGreenspan J, LaMotte R. Cutaneous Mechanoreceptors of the Hand: Experimental Studies and Their Implications for Clinical Testing of Tactile Sensation Journal Of Hand Therapy 1993, 6: 75-82. PMID: 8343885, DOI: 10.1016/s0894-1130(12)80287-0.
- A reply to the commentariesLaMotte R. A reply to the commentaries Journal Of Pain 1992, 1: 139-141. DOI: 10.1016/1058-9139(92)90044-d.
- Subpopulations of “nocifensor neurons” contributing to pain and allodynia, itch and alloknesisLaMotte R. Subpopulations of “nocifensor neurons” contributing to pain and allodynia, itch and alloknesis Journal Of Pain 1992, 1: 115-126. DOI: 10.1016/1058-9139(92)90040-j.
- Central changes in processing of mechanoreceptive input in capsaicin‐induced secondary hyperalgesia in humans.Torebjörk H, Lundberg L, LaMotte R. Central changes in processing of mechanoreceptive input in capsaicin‐induced secondary hyperalgesia in humans. The Journal Of Physiology 1992, 448: 765-780. PMID: 1593489, PMCID: PMC1176227, DOI: 10.1113/jphysiol.1992.sp019069.
- Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin.LaMotte R, Lundberg L, Torebjörk H. Pain, hyperalgesia and activity in nociceptive C units in humans after intradermal injection of capsaicin. The Journal Of Physiology 1992, 448: 749-764. PMID: 1593488, PMCID: PMC1176226, DOI: 10.1113/jphysiol.1992.sp019068.
- Relationships between capsaicin sensitivity of mammalian sensory neurons, cell size and type of voltage gated Ca-currentsPetersen M, LaMotte R. Relationships between capsaicin sensitivity of mammalian sensory neurons, cell size and type of voltage gated Ca-currents Brain Research 1991, 561: 20-26. PMID: 1665752, DOI: 10.1016/0006-8993(91)90744-g.
- Neurogenic hyperalgesia: psychophysical studies of underlying mechanismsLaMotte R, Shain C, Simone D, Tsai E. Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms Journal Of Neurophysiology 1991, 66: 190-211. PMID: 1919666, DOI: 10.1152/jn.1991.66.1.190.
- Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesiaBaumann T, Simone D, Shain C, LaMotte R. Neurogenic hyperalgesia: the search for the primary cutaneous afferent fibers that contribute to capsaicin-induced pain and hyperalgesia Journal Of Neurophysiology 1991, 66: 212-227. PMID: 1919668, DOI: 10.1152/jn.1991.66.1.212.
- Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neuronsSimone D, Sorkin L, Oh U, Chung J, Owens C, LaMotte R, Willis W. Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons Journal Of Neurophysiology 1991, 66: 228-246. PMID: 1919669, DOI: 10.1152/jn.1991.66.1.228.
- Psychophysical Studies of the Itch Sensation and Itchy Skin (“Alloknesis”) Produced by Intracutaneous Injection of HistamineSimone D, Alreja M, Lamotte R. Psychophysical Studies of the Itch Sensation and Itchy Skin (“Alloknesis”) Produced by Intracutaneous Injection of Histamine Somatosensory & Motor Research 1991, 8: 271-279. PMID: 1767623, DOI: 10.3109/08990229109144750.
- Encoding of Shape in the Responses of Cutaneous MechanoreceptorsSrinivasan M, LaMotte R. Encoding of Shape in the Responses of Cutaneous Mechanoreceptors 1991, 59-69. DOI: 10.1007/978-1-349-11597-6_5.
- Surface Microgeometry: Tactile Perception and Neural EncodingLaMotte R, Srinivasan M. Surface Microgeometry: Tactile Perception and Neural Encoding 1991, 49-58. DOI: 10.1007/978-1-349-11597-6_4.
- A model of peripheral mononeuropathy in the ratHirata H, Pataky A, Kajander K, LaMotte R, Collins J. A model of peripheral mononeuropathy in the rat Pain 1990, 42: 253-254. PMID: 2174143, DOI: 10.1016/0304-3959(90)91169-j.
- Tactile detection of slip: surface microgeometry and peripheral neural codesSrinivasan M, Whitehouse J, LaMotte R. Tactile detection of slip: surface microgeometry and peripheral neural codes Journal Of Neurophysiology 1990, 63: 1323-1332. PMID: 2358880, DOI: 10.1152/jn.1990.63.6.1323.
- Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicinSimone D, Baumann T, Collins J, LaMotte R. Sensitization of cat dorsal horn neurons to innocuous mechanical stimulation after intradermal injection of capsaicin Brain Research 1989, 486: 185-189. PMID: 2720428, DOI: 10.1016/0006-8993(89)91293-6.
- Chapter 39 Psychophysical and neurophysiological studies of chemically induced cutaneous pain and itch The case of the missing nociceptorLaMotte R. Chapter 39 Psychophysical and neurophysiological studies of chemically induced cutaneous pain and itch The case of the missing nociceptor 1988, 74: 331-335. PMID: 3187041, DOI: 10.1016/s0079-6123(08)63033-2.
- Hyperalgesia to heat after intradermal injection of capsaicinSimone D, Ngeow J, Putterman G, LaMotte R. Hyperalgesia to heat after intradermal injection of capsaicin Brain Research 1987, 418: 201-203. PMID: 3664271, DOI: 10.1016/0006-8993(87)90982-6.
- Hypothesis for novel classes of chemoreceptors mediating chemogenic pain and itchLaMotte R, Simone D, Baumann T, Shain C, Alreja M. Hypothesis for novel classes of chemoreceptors mediating chemogenic pain and itch Pain 1987, 30: s15. DOI: 10.1016/0304-3959(87)91109-2.
- The Magnitude and Duration of Itch Produced by Intracutaneous Injections of HistamineSimone D, Ngeow J, Whitehouse J, Becerra-Cabal L, Putterman G, Lamotte R. The Magnitude and Duration of Itch Produced by Intracutaneous Injections of Histamine Somatosensory & Motor Research 1987, 5: 81-92. PMID: 3423533, DOI: 10.3109/07367228709144620.
- James Daniel Hardy (1904–1985). Tribute to a pioneer in pain psychophysicsLaMotte R. James Daniel Hardy (1904–1985). Tribute to a pioneer in pain psychophysics Pain 1986, 27: 127-130. PMID: 3537920, DOI: 10.1016/0304-3959(86)90229-0.
- Tactile detection of a dot on a smooth surface: peripheral neural eventsLaMotte R, Whitehouse J. Tactile detection of a dot on a smooth surface: peripheral neural events Journal Of Neurophysiology 1986, 56: 1109-1128. PMID: 3097273, DOI: 10.1152/jn.1986.56.4.1109.
- Time-intensity profiles of cutaneous pain in normal and hyperalgesic skin: a comparison with C-fiber nociceptor activities in monkey and humanLaMotte R, Torebjörk H, Robinson C, Thalhammer J. Time-intensity profiles of cutaneous pain in normal and hyperalgesic skin: a comparison with C-fiber nociceptor activities in monkey and human Journal Of Neurophysiology 1984, 51: 1434-1450. PMID: 6737035, DOI: 10.1152/jn.1984.51.6.1434.
- Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: simultaneous recordings in humans of sensory judgments of pain and evoked responses in nociceptors with C-fibersTorebjörk H, LaMotte R, Robinson C. Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: simultaneous recordings in humans of sensory judgments of pain and evoked responses in nociceptors with C-fibers Journal Of Neurophysiology 1984, 51: 325-339. PMID: 6707724, DOI: 10.1152/jn.1984.51.2.325.
- The Role of C-Nociceptors in Cutaneous Heat Pain and HyperalgesiaLamotte R. The Role of C-Nociceptors in Cutaneous Heat Pain and Hyperalgesia 1984, 363-377. DOI: 10.1007/978-1-349-07292-7_26.
- The Role of C-Nociceptors in Cutaneous Heat Pain and HyperalgesiaLamotte R. The Role of C-Nociceptors in Cutaneous Heat Pain and Hyperalgesia 1984, 363-377. DOI: 10.1007/978-1-4613-2807-0_26.
- Psychophysical detection and pain ratings of incremental thermal stimuli: A comparison with nociceptor responses in humansRobinson C, Torebjörk H, LaMotte R. Psychophysical detection and pain ratings of incremental thermal stimuli: A comparison with nociceptor responses in humans Brain Research 1983, 274: 87-106. PMID: 6616259, DOI: 10.1016/0006-8993(83)90523-1.
- Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: a comparison of neural events in monkey with sensory judgments in humanLaMotte R, Thalhammer J, Robinson C. Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: a comparison of neural events in monkey with sensory judgments in human Journal Of Neurophysiology 1983, 50: 1-26. PMID: 6875640, DOI: 10.1152/jn.1983.50.1.1.
- Spatial properties of nociceptor sensitization following heat injury of the skinThalhammer J, LaMotte R. Spatial properties of nociceptor sensitization following heat injury of the skin Pain 1983, 16: 211. DOI: 10.1016/0304-3959(83)90214-2.
- Latency to detection of first painCampbell J, LaMotte R. Latency to detection of first pain Brain Research 1983, 266: 203-208. PMID: 6871657, DOI: 10.1016/0006-8993(83)90650-9.
- Tactile Detection Thresholds for a Single Asperity on an Otherwise Smooth SurfaceJohansson R, Lamotte R. Tactile Detection Thresholds for a Single Asperity on an Otherwise Smooth Surface Somatosensory & Motor Research 1983, 1: 21-31. PMID: 6679912, DOI: 10.3109/07367228309144538.
- Response properties of high-threshold cutaneous cold receptors in the primateLaMotte R, Thalhammer J. Response properties of high-threshold cutaneous cold receptors in the primate Brain Research 1982, 244: 279-287. PMID: 7116176, DOI: 10.1016/0006-8993(82)90086-5.
- Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heatLaMotte R, Thalhammer J, Torebjörk H, Robinson C. Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat Journal Of Neuroscience 1982, 2: 765-781. PMID: 7086482, PMCID: PMC6564351, DOI: 10.1523/jneurosci.02-06-00765.1982.
- Spatial properties of nociceptor sensitization following heat injury of the skinThalhammer J, LaMotte R. Spatial properties of nociceptor sensitization following heat injury of the skin Brain Research 1982, 231: 257-265. PMID: 7055680, DOI: 10.1016/0006-8993(82)90364-x.
- Heat sensitization of one‐half of a nociceptor's receptive field does not alter the sensitivity of the other halfThalhammer J, LaMotte R. Heat sensitization of one‐half of a nociceptor's receptive field does not alter the sensitivity of the other half Pain 1981, 11: s42. DOI: 10.1016/0304-3959(81)90255-4.
- Intensive and Temporal Determinants of Thermal PainLaMotte R. Intensive and Temporal Determinants of Thermal Pain 1979, 327-361. DOI: 10.1007/978-1-4613-3039-4_18.
- Defects in accuracy of reaching after removal of posterior parietal cortex in monkeysLamotte R, Acun˜a C. Defects in accuracy of reaching after removal of posterior parietal cortex in monkeys Brain Research 1978, 139: 309-326. PMID: 414819, DOI: 10.1016/0006-8993(78)90931-9.