Slav Bagriantsev, PhD

• Elena Gracheva
• Patrick Gallagher
• Robert LaMotte

Biochemistry; Biophysics; Ducks; Electrophysiology; Ion Channels; Mechanoreceptors; Neurosciences; Pacinian Corpuscles; Sensory Receptor Cells; Trigeminal Ganglion; Thermoreceptors; Potassium Channels; Anseriformes; Transient Receptor Potential Channels; Voltage-Gated Sodium Channels

• Mechanotransduction events at the physiological site of touch detectionZiolkowski L, Gracheva E, Bagriantsev S. Mechanotransduction events at the physiological site of touch detection ELife 2023, 12: e84179. PMID: 36607222, PMCID: PMC9833821, DOI: 10.7554/elife.84179.
• Sensational channelsGracheva EO, Bagriantsev SN. Sensational channels Cell 2021, 184: 6213-6216. PMID: 34942094, DOI: 10.1016/j.cell.2021.11.034.
• Lamellar cells in Pacinian and Meissner corpuscles are touch sensorsNikolaev YA, Feketa VV, Anderson EO, Schneider ER, Gracheva EO, Bagriantsev SN. Lamellar cells in Pacinian and Meissner corpuscles are touch sensors Science Advances 2020, 6: eabe6393. PMID: 33328243, PMCID: PMC7744075, DOI: 10.1126/sciadv.abe6393.
• Piezo2 Integrates Mechanical and Thermal Cues in Vertebrate MechanoreceptorsNikolaev Y, Zheng W, Gracheva E, Bagriantsev S. Piezo2 Integrates Mechanical and Thermal Cues in Vertebrate Mechanoreceptors Biophysical Journal 2020, 118: 396a. DOI: 10.1016/j.bpj.2019.11.2254.
• Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptorsZheng W, Nikolaev YA, Gracheva EO, Bagriantsev SN. Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 17547-17555. PMID: 31413193, PMCID: PMC6717272, DOI: 10.1073/pnas.1910213116.
• A Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist BirdsSchneider ER, Anderson EO, Feketa VV, Mastrotto M, Nikolaev YA, Gracheva EO, Bagriantsev SN. A Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds Cell Reports 2019, 26: 1979-1987.e3. PMID: 30784581, PMCID: PMC6420409, DOI: 10.1016/j.celrep.2019.01.100.
• Ground squirrels – experts in thermoregulatory adaptationFeketa V, Bagriantsev S, Gracheva E. Ground squirrels – experts in thermoregulatory adaptation Trends In Neurosciences 2023, 46: 505-507. PMID: 37188617, DOI: 10.1016/j.tins.2023.04.008.
• Human TRPV1 structure and inhibition by the analgesic SB-366791Neuberger A, Oda M, Nikolaev Y, Nadezhdin K, Gracheva E, Bagriantsev S, Sobolevsky A. Human TRPV1 structure and inhibition by the analgesic SB-366791 Nature Communications 2023, 14: 2451. PMID: 37117175, PMCID: PMC10147690, DOI: 10.1038/s41467-023-38162-9.
• CNGA3 acts as a cold sensor in hypothalamic neuronsFeketa VV, Nikolaev YA, Merriman DK, Bagriantsev SN, Gracheva EO. CNGA3 acts as a cold sensor in hypothalamic neurons ELife 2020, 9: e55370. PMID: 32270761, PMCID: PMC7182431, DOI: 10.7554/elife.55370.
• Osmolyte Depletion and Thirst Suppression Allow Hibernators to Survive for Months without WaterFeng NY, Junkins MS, Merriman DK, Bagriantsev SN, Gracheva EO. Osmolyte Depletion and Thirst Suppression Allow Hibernators to Survive for Months without Water Current Biology 2019, 29: 3053-3058.e3. PMID: 31495581, PMCID: PMC6759396, DOI: 10.1016/j.cub.2019.07.038.
• Piezo2 Underlies Slowly-Inactivating Mechano-Current in Sensory Neurons from Tactile Specialist BirdsBagriantsev S, Schneider E, Anderson E. Piezo2 Underlies Slowly-Inactivating Mechano-Current in Sensory Neurons from Tactile Specialist Birds Biophysical Journal 2019, 116: 305a. DOI: 10.1016/j.bpj.2018.11.1654.
• A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channelsZheng W, Gracheva EO, Bagriantsev SN. A hydrophobic gate in the inner pore helix is the major determinant of inactivation in mechanosensitive Piezo channels ELife 2019, 8: e44003. PMID: 30628892, PMCID: PMC6349400, DOI: 10.7554/elife.44003.
• Somatosensory Neurons Enter a State of Altered Excitability during HibernationHoffstaetter LJ, Mastrotto M, Merriman DK, Dib-Hajj SD, Waxman SG, Bagriantsev SN, Gracheva EO. Somatosensory Neurons Enter a State of Altered Excitability during Hibernation Current Biology 2018, 28: 2998-3004.e3. PMID: 30174191, PMCID: PMC6173314, DOI: 10.1016/j.cub.2018.07.020.
• TMEM150C/Tentonin3 Is a Regulator of Mechano-gated Ion ChannelsAnderson EO, Schneider ER, Matson JD, Gracheva EO, Bagriantsev SN. TMEM150C/Tentonin3 Is a Regulator of Mechano-gated Ion Channels Cell Reports 2018, 23: 701-708. PMID: 29669276, PMCID: PMC5929159, DOI: 10.1016/j.celrep.2018.03.094.
• Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and HamstersMatos-Cruz V, Schneider ER, Mastrotto M, Merriman DK, Bagriantsev SN, Gracheva EO. Molecular Prerequisites for Diminished Cold Sensitivity in Ground Squirrels and Hamsters Cell Reports 2017, 21: 3329-3337. PMID: 29262313, PMCID: PMC5741102, DOI: 10.1016/j.celrep.2017.11.083.
• Molecular basis of tactile specialization in the duck billSchneider ER, Anderson EO, Mastrotto M, Matson JD, Schulz VP, Gallagher PG, LaMotte RH, Gracheva EO, Bagriantsev SN. Molecular basis of tactile specialization in the duck bill Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: 13036-13041. PMID: 29109250, PMCID: PMC5724259, DOI: 10.1073/pnas.1708793114.
• Chapter Seven Piezo2 in Cutaneous and Proprioceptive Mechanotransduction in VertebratesaaThis work was supported by grants from National Science Foundation (1453167), National Institutes of Health (1R01NS097547-01A1) and American Heart Association (14SDG17880015) to S.N.B. E.R.S. was partially supported by a training grant from National Institutes of Health T32HD007094 and a postdoctoral fellowship from the Arnold and Mabel Beckman Foundation. E.O.A. is a fellow of The Gruber Foundation and an Edward L. Tatum Fellow. Correspondence should be addressed to S.N.B (slav.bagriantsev@yale.edu).Anderson E, Schneider E, Bagriantsev S. Chapter Seven Piezo2 in Cutaneous and Proprioceptive Mechanotransduction in VertebratesaaThis work was supported by grants from National Science Foundation (1453167), National Institutes of Health (1R01NS097547-01A1) and American Heart Association (14SDG17880015) to S.N.B. E.R.S. was partially supported by a training grant from National Institutes of Health T32HD007094 and a postdoctoral fellowship from the Arnold and Mabel Beckman Foundation. E.O.A. is a fellow of The Gruber Foundation and an Edward L. Tatum Fellow. Correspondence should be addressed to S.N.B (slav.bagriantsev@yale.edu). 2017, 79: 197-217. PMID: 28728817, PMCID: PMC5630267, DOI: 10.1016/bs.ctm.2016.11.002.
• Low-cost functional plasticity of TRPV1 supports heat tolerance in squirrels and camelsLaursen WJ, Schneider ER, Merriman DK, Bagriantsev SN, Gracheva EO. Low-cost functional plasticity of TRPV1 supports heat tolerance in squirrels and camels Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 11342-11347. PMID: 27638213, PMCID: PMC5056056, DOI: 10.1073/pnas.1604269113.
• Stretch-Gated Ion Channels in Neuronal MechanoreceptorsBagriantsev S, Schneider E, Anderson E, Matson J, Gracheva E. Stretch-Gated Ion Channels in Neuronal Mechanoreceptors Biophysical Journal 2016, 110: 349a. DOI: 10.1016/j.bpj.2015.11.1876.
• Probing the Contribution of Nav1.7 and Nav1.8 to Cold Tolerance in HibernatorsHoffstaetter L, Tonsfeldt K, Matos-Cruz V, Bagriantsev S, Gracheva E. Probing the Contribution of Nav1.7 and Nav1.8 to Cold Tolerance in Hibernators Biophysical Journal 2016, 110: 318a. DOI: 10.1016/j.bpj.2015.11.1710.
• Investigating the Role of Nav1.5 in Somatosensory MechanosensationAnderson E, Schneider E, Matson J, Gracheva E, Bagriantsev S. Investigating the Role of Nav1.5 in Somatosensory Mechanosensation Biophysical Journal 2016, 110: 91a. DOI: 10.1016/j.bpj.2015.11.552.
• Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernationLaursen WJ, Mastrotto M, Pesta D, Funk OH, Goodman JB, Merriman DK, Ingolia N, Shulman GI, Bagriantsev SN, Gracheva EO. Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation Proceedings Of The National Academy Of Sciences Of The United States Of America 2015, 112: 1607-1612. PMID: 25605929, PMCID: PMC4321293, DOI: 10.1073/pnas.1421419112.
• Sensing Force by Trigeminal Neurons of Acutely Mechanosensitive BirdsSchneider E, Mastrotto M, Laursen W, Schulz V, Goodman J, Funk O, Gallagher P, Gracheva E, Bagriantsev S. Sensing Force by Trigeminal Neurons of Acutely Mechanosensitive Birds Biophysical Journal 2015, 108: 562a. DOI: 10.1016/j.bpj.2014.11.3080.
• Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowlSchneider ER, Mastrotto M, Laursen WJ, Schulz VP, Goodman JB, Funk OH, Gallagher PG, Gracheva EO, Bagriantsev SN. Neuronal mechanism for acute mechanosensitivity in tactile-foraging waterfowl Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 14941-14946. PMID: 25246547, PMCID: PMC4205607, DOI: 10.1073/pnas.1413656111.
• Molecular Adaptations to Extreme Thermogenesis in Mammalian HibernatorsLaursen W, Funk O, Goodman J, Merriman D, Ingolia N, Bagriantsev S, Gracheva E. Molecular Adaptations to Extreme Thermogenesis in Mammalian Hibernators Biophysical Journal 2014, 106: 337a. DOI: 10.1016/j.bpj.2013.11.1931.
• A Modular Heat-Sensing Domain Activates K2P2.1 through a Heat-Insensitive GateBagriantsev S, Clark K, Minor D. A Modular Heat-Sensing Domain Activates K2P2.1 through a Heat-Insensitive Gate Biophysical Journal 2012, 102: 412a. DOI: 10.1016/j.bpj.2011.11.2251.
• Protons, Heat, and Mechanical Force Act Through a Common Gate to Control K2P Channel FunctionBagriantsev S, Peyronnet R, Clark K, Honoré E, Minor D. Protons, Heat, and Mechanical Force Act Through a Common Gate to Control K2P Channel Function Biophysical Journal 2011, 100: 348a. DOI: 10.1016/j.bpj.2010.12.2097.
• P2‐350: Yeast cell‐based genetic and chemical screens for inhibitors of Aβ42 oligomerizationPark S, Bagriantsev S, Callan L, Pegan S, Mesecar A, Liebman S. P2‐350: Yeast cell‐based genetic and chemical screens for inhibitors of Aβ42 oligomerization Alzheimer's & Dementia 2008, 4: t475-t475. DOI: 10.1016/j.jalz.2008.05.1427.
• Guanidine reduces stop codon read‐through caused by missense mutations in SUP35 or SUP45Bradley M, Bagriantsev S, Vishveshwara N, Liebman S. Guanidine reduces stop codon read‐through caused by missense mutations in SUP35 or SUP45 Yeast 2003, 20: 625-632. PMID: 12734800, DOI: 10.1002/yea.985.