Martin Schwartz, PhD
Research & Publications
Biography
News
Research Summary
Our work aims to understand how cells and tissues respond to mechanical forces. These studies span dimensional scales from single molecules to cells to tissues and animal models. They include basic science projects to understand fundamental mechanisms of mechanotransduction through cell adhesion receptors such as integrins and PECAM1, utilizing a variety of biophysical and cellular tools to understand how cells sense both externally applied stress and the mechanical features of their environment. Discoveries at the molecular scale are then exploited to understand how blood vessels sense mechanical forces from blood flow (fluid shear stress) and blood pressure (wall stress) and how cell responses to these forces determines vascular physiology and remodeling and disease. Lastly, we are applying results from these molecular/cellular studies to understand vascular remodeling and diseases that are characterized by pathological remodeling such as atherosclerosis, vascular malformations and aneurysms.
Extensive Research Description
Overview and Philosophy
Regulation of cell behavior by adhesion to extracellular matrix (ECM) and mechanical forces are fundamental facts of multicellular life. Cell adhesion to ECM critically regulates cell survival, growth, gene expression and function. Integrins are the major membrane receptors that mediate adhesion of cells to ECM; they also connect the actin cytoskeleton inside the cell to the ECM to provide mechanical integrity, and transmit signals that depend on the composition, organization and mechanical properties of the matrix. Similarly, mechanical forces are fundamental to life, serving as critical guides for morphogenesis and repair.Mechanical forces are especially critical in the cardiovascular system, whose primary function is pumping and delivery of blood to the tissues. Mechanical forces from blood flow, both fluid shear stress, the frictional force from blood flow, and wall stress from blood pressure, are critical for the development, maintenance, physiology and major diseases of the vascular system.
My lab has built an integrated, multi-disciplinary program that combines biophysical, cellular and whole animal approaches to study these problems.We aim to unravel fundamental mechanisms of mechanotransduction through integrins and shear stress receptors, to elucidate the cellular signaling networks that mediate effects on cell behavior and gene expression, and animal models to understand how these events play out during development, in normal physiology, and in vascular diseases such as atherosclerosis.
My laboratory has therefore developed an integrated program addressing interesting problems in cell adhesion, signaling and mechanotransduction.We are currently working in 4 major areas.
Mechanotransduction by integrins
Cells sense the mechanical properties of their ECM and respond accordingly [1].They also respond to external forces applied through the ECM [2].Exhaustive evidence has shown that integrins mediate these responses but the molecular mechanisms are not well understood. We are currently investigating the role of integrin conformation and the cytoskeletal adapter talin in these processes. We have developed a panel of integrin and talin mutants with specific alterations in conformation or mechanical variables, and are studying how these alter cellular responses to matrix stiffness and stretch.
Additionally, we developed a fluorescence-based method to measure forces across specific proteins in live cells [3]. Studies using this approach with the focal adhesion protein talin, which connects integrins to the actin cytoskeleton, showed that this protein bears force and that it plays a role in how cells sense matrix stiffness [4]. We are currently combining this sensor with high resolution microscopy and speckle imaging of actin dynamics to elucidate how integrin-mediated adhesions respond to force at the near-single molecule level, in order to elucidate these molecular mechanisms.
Fluid shear stress mechanotransduction in the vascular system
Flowing blood exerts a frictional force called fluid shear stress on the endothelial cells that line the vessels; this force is a major determinant of vascular development, physiology and disease [5]. Atherosclerosis arises in regions of arteries subject to disturbances in fluid flow patterns, while high fluid shear stress suppresses inflammatory and atherosclerotic pathways.We have identified complex between VE-cadherin, PECAM-1 and VEGFR2 as a critical mechanotransducer that mediates a subset of these effects [6]. Continuing studies on the junctional complex elucidated mechanisms of force transmission [7] and key architectural features [8]. Our continuing studies in mice are investigating how these molecular processes determine physiological vascular remodeling and development of atherosclerosis.
One major pathway downstream of the junctional complex involves activation of integrins, binding to the subendothelial extracellular matrix and subsequent signaling.An important consequence of this pathway is that cell responses to flow are modulated by the ECM. We have found that basement membrane proteins promote flow-dependent activation of anti-inflammatory pathways; by contrast, endothelial cells on provisional ECM proteins such as fibronectin activate multiple inflammatory pathways [9-11].Further studies identified a mechanism by which fibronectin promotes inflammatory activation of the endothelium by binding and activating the cAMP-specific phosphodiesterase 4D5 [12]. This results in decreased signaling through the anti-inflammatory cAMP/protein kinase a pathway, thus creating a cellular state that is permissive for activation by inflammatory mediators. We are continuing to investigate more deeply the molecular mechanisms that mediate these events and understand their consequences in animal models of vascular remodeling and disease.
Collateral artery formation
Blockage of a coronary artery after myocardial infarction leads to downstream ischemia and myocardial cell death. A major mechanism of resistance and recovery is that blockage of an artery triggers increased flow through parallel vessels, which then remodel to accommodate the higher flow. In human patients, this ability to form collateral arteries that perfuse the affected region is a major determinant of recovery after MI.However, the key steps by which high flow stimulates arterialization of small vessels are not well understood, nor are the reasons why some patients are unable to do so.We are currently applying our expertise in flow signaling to address this medical problem.Our first study of the basic pathway of flow-dependent vessel remodeling demonstrated that endothelial cells encode a fluid shear stress set point, such that shear stress above or below that level triggered outward or inward remodeling [13].Further, we found that the value for the set point was determined in part by signaling through the junctional complex. We are continuing to study the mechanisms that determine the set point and to then identify the steps that are inhibited in poor responders in order to devise therapies to improve outcomes.
Aneurysms
Healthy arteries remodel to resist the applied forces forces from blood pressure, to become thicker or thinner when blood pressure increases or decreases, respectively. Aneurysms represent a form of pathological remodeling where the artery wall expands thins and weakens under too-high pressure, eventually resulting in rupture or separation of the layers of the vessel wall, events that are often fatal. Aneurysms may be caused by very high blood pressure in normal people or normal blood pressure in people that carry mutations in genes that mediate mechanosensing or mechanical strength [14]. We aim to understand the fundamental mechanisms by which cells of the artery wall sense wall stress to regulate physiological remodeling, and what goes wrong in aneurysms.
References
7. Baeyens N., et al. Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia. J. Cell Biol. 2016, 214:807-16.
8. Conway D. et al VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN. Curr Biol 2017 27(14):2219-2225.
9. Kumar A. et al, Filamin A mediates isotropic distribution of applied force across the actin network. J Cell Biol. 2019 218(8):2481-2491.
10. Yun S. et al, Integrin α5β1 regulates PP2A complex assembly through PDE4D to control atherosclerosis. J Clin Invest. 2019, 130:4863-4874.
11. Driscoll TP, et al. Actin flow-dependent and -independent force transmission through integrins.Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32413-32422. doi: 10.1073/pnas.2010292117
12. Driscoll TP., et al. Integrin-based mechanosensing through conformational deformation. Biophys J. 2021 Sep 10:S0006-3495(21)00744-X. doi: 10.1016/j.bpj.2021.09.010
13. Deng H. et al, Activation of Smad2/3 signaling by low fluid shear stress mediates artery inward remodeling.Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2105339118. doi: 10.1073/pnas.2105339118.
Coauthors
Research Interests
Aneurysm; Cell Biology; Atherosclerosis; Vascular Malformations; Vascular Remodeling
Research Image
Reduced atherosclerosis in integrin mutant mice
Selected Publications
- SMAD4 maintains the fluid shear stress set point to protect against arterial-venous malformations.Banerjee K, Lin Y, Gahn J, Cordero J, Gupta P, Mohamed I, Graupera M, Dobreva G, Schwartz MA, Ola R. SMAD4 maintains the fluid shear stress set point to protect against arterial-venous malformations. J Clin Invest 2023 PMID: 37490341, DOI: 10.1172/JCI168352.
- The importance of character development in scientific research.Schwartz MA, Yap AS. The importance of character development in scientific research. J Cell Sci 2023, 136 PMID: 37403645, DOI: 10.1242/jcs.261405.
- Mechanisms of endothelial flow sensingAitken C, Mehta V, Schwartz M, Tzima E. Mechanisms of endothelial flow sensing Nature Cardiovascular Research 2023, 2: 517-529. DOI: 10.1038/s44161-023-00276-0.
- Altered Integrin Signaling in Thoracic AortopathyHumphrey J, Schwartz M. Altered Integrin Signaling in Thoracic Aortopathy Arteriosclerosis Thrombosis And Vascular Biology 2023, 43: 1154-1156. PMID: 37165879, DOI: 10.1161/atvbaha.123.319404.
- FN (Fibronectin)-Integrin α5 Signaling Promotes Thoracic Aortic Aneurysm in a Mouse Model of Marfan SyndromeChen M, Cavinato C, Hansen J, Tanaka K, Ren P, Hassab A, Li D, Youshao E, Tellides G, Iyengar R, Humphrey J, Schwartz M. FN (Fibronectin)-Integrin α5 Signaling Promotes Thoracic Aortic Aneurysm in a Mouse Model of Marfan Syndrome Arteriosclerosis Thrombosis And Vascular Biology 2023, 43: e132-e150. PMID: 36994727, PMCID: PMC10133209, DOI: 10.1161/atvbaha.123.319120.
- TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivityGallego-Paez L, Edwards W, Chanduri M, Guo Y, Koorman T, Lee C, Grexa N, Derksen P, Yan J, Schwartz M, Mauer J, Goult B. TLN1 contains a cancer-associated cassette exon that alters talin-1 mechanosensitivity Journal Of Cell Biology 2023, 222: e202209010. PMID: 36880935, PMCID: PMC9997659, DOI: 10.1083/jcb.202209010.
- Integrin αIIbβ3 intermediates: From molecular dynamics to adhesion assemblyTong D, Soley N, Kolasangiani R, Schwartz M, Bidone T. Integrin αIIbβ3 intermediates: From molecular dynamics to adhesion assembly Biophysical Journal 2022, 122: 533-543. PMID: 36566352, PMCID: PMC9941721, DOI: 10.1016/j.bpj.2022.12.032.
- Integrin Conformational Dynamics and MechanotransductionKolasangiani R, Bidone T, Schwartz M. Integrin Conformational Dynamics and Mechanotransduction Cells 2022, 11: 3584. PMID: 36429013, PMCID: PMC9688440, DOI: 10.3390/cells11223584.
- The UIP/IPF fibroblastic focus is a collagen biosynthesis factory embedded in a distinct extracellular matrixHerrera JA, Dingle L, Fernandez M, Venkateswaran RV, Blaikley JF, Lawless C, Schwartz MA. The UIP/IPF fibroblastic focus is a collagen biosynthesis factory embedded in a distinct extracellular matrix JCI Insight 2022, 7: e156115. PMID: 35852874, PMCID: PMC9462507, DOI: 10.1172/jci.insight.156115.
- High Fluid Shear Stress Inhibits Cytokine‐Driven Smad2/3 Activation in Vascular Endothelial CellsDeng H, Schwartz MA. High Fluid Shear Stress Inhibits Cytokine‐Driven Smad2/3 Activation in Vascular Endothelial Cells Journal Of The American Heart Association 2022, 11: e025337. PMID: 35861829, PMCID: PMC9707828, DOI: 10.1161/jaha.121.025337.
- Fibronectin-Integrin α5 Signaling in Vascular Complications of Type 1 Diabetes.Chen M, Hu R, Cavinato C, Zhuang ZW, Zhang J, Yun S, Fernandez Tussy P, Singh A, Murtada SI, Tanaka K, Liu M, Fernández-Hernando C, Humphrey JD, Schwartz MA. Fibronectin-Integrin α5 Signaling in Vascular Complications of Type 1 Diabetes. Diabetes 2022, 71: 2020-2033. PMID: 35771994, PMCID: PMC9450851, DOI: 10.2337/db21-0958.
- A mitochondrial contribution to anti-inflammatory shear stress signaling in vascular endothelial cellsCoon BG, Timalsina S, Astone M, Zhuang ZW, Fang J, Han J, Themen J, Chung M, Yang-Klingler YJ, Jain M, Hirschi KK, Yamamato A, Trudeau LE, Santoro M, Schwartz MA. A mitochondrial contribution to anti-inflammatory shear stress signaling in vascular endothelial cells Journal Of Cell Biology 2022, 221: e202109144. PMID: 35695893, PMCID: PMC9198948, DOI: 10.1083/jcb.202109144.
- MicroRNAs in Mechanical HomeostasisHerrera JA, Schwartz MA. MicroRNAs in Mechanical Homeostasis Cold Spring Harbor Perspectives In Medicine 2022, 12: a041220. PMID: 35379658, PMCID: PMC9380736, DOI: 10.1101/cshperspect.a041220.
- mTOR inhibition prevents angiotensin II–induced aortic rupture and pseudoaneurysm but promotes dissection in Apoe-deficient miceHe C, Jiang B, Wang M, Ren P, Murtada SI, Caulk AW, Li G, Qin L, Assi R, Lovoulos CJ, Schwartz MA, Humphrey JD, Tellides G. mTOR inhibition prevents angiotensin II–induced aortic rupture and pseudoaneurysm but promotes dissection in Apoe-deficient mice JCI Insight 2022, 7: e155815. PMID: 35132962, PMCID: PMC8855820, DOI: 10.1172/jci.insight.155815.
- α IIb β3 integrin intermediates: from molecular dynamics to adhesion assemblyThe platelet integrin αIIbβ3 undergoes long range conformational transitions associated with its functional conversion from inactive (low affinity) to active (high affinity) during hemostasis. Although new molecular conformations intermediate between the well-characterized bent and extended states have been identified, their molecular dynamic properties and function in adhesion assembly remain largely unexplored. In this study, we evaluated the molecular dynamic properties of intermediate conformations of integrin αIIbβ3 andcharacterized their effects on the assembly of adhesions by combining all-atom simulations, principal component analysis, and mesoscale modeling. Our results show that in the low affinity, bent state, the integrin headpiece tends to pivot around the legs; in intermediate states the upper headpiece is partially extended, away from the legs. In the fully open, activated state, αIIbβ3 is highly flexible and the motions between upper headpieces and lowe legs are accompanied by fluctuations of the transmembrane helices. At the mesoscale, bent integrins form only unstable adhesions, but intermediate or open conformations stabilize the adhesions. These studies reveal a mechanism by which small variations in ligand binding affinity and enhancement of the ligand-bound lifetime in the presence of actin retrograde flow stabilize nascent adhesions.
- Progressive Microstructural Deterioration Dictates Evolving Biomechanical Dysfunction in the Marfan AortaCavinato C, Chen M, Weiss D, Ruiz-Rodríguez MJ, Schwartz MA, Humphrey JD. Progressive Microstructural Deterioration Dictates Evolving Biomechanical Dysfunction in the Marfan Aorta Frontiers In Cardiovascular Medicine 2021, 8: 800730. PMID: 34977201, PMCID: PMC8716484, DOI: 10.3389/fcvm.2021.800730.
- MEKK3–TGFβ crosstalk regulates inward arterial remodelingDeng H, Xu Y, Hu X, Zhuang ZW, Chang Y, Wang Y, Ntokou A, Schwartz MA, Su B, Simons M. MEKK3–TGFβ crosstalk regulates inward arterial remodeling Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2112625118. PMID: 34911761, PMCID: PMC8713777, DOI: 10.1073/pnas.2112625118.
- Talin in mechanotransduction and mechanomemory at a glanceGoult BT, Brown NH, Schwartz MA. Talin in mechanotransduction and mechanomemory at a glance Journal Of Cell Science 2021, 134: jcs258749. PMID: 34708856, PMCID: PMC8697387, DOI: 10.1242/jcs.258749.
- Integrin-based mechanosensing through conformational deformationDriscoll TP, Bidone TC, Ahn SJ, Yu A, Groisman A, Voth GA, Schwartz MA. Integrin-based mechanosensing through conformational deformation Biophysical Journal 2021, 120: 4349-4359. PMID: 34509509, PMCID: PMC8553792, DOI: 10.1016/j.bpj.2021.09.010.
- Activation of Smad2/3 signaling by low fluid shear stress mediates artery inward remodelingDeng H, Min E, Baeyens N, Coon BG, Hu R, Zhuang ZW, Chen M, Huang B, Afolabi T, Zarkada G, Acheampong A, McEntee K, Eichmann A, Liu F, Su B, Simons M, Schwartz MA. Activation of Smad2/3 signaling by low fluid shear stress mediates artery inward remodeling Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2105339118. PMID: 34504019, PMCID: PMC8449390, DOI: 10.1073/pnas.2105339118.
- Fibronectin‐Mediated Inflammatory Signaling Through Integrin α5 in Vascular RemodelingBudatha M, Zhang J, Schwartz MA. Fibronectin‐Mediated Inflammatory Signaling Through Integrin α5 in Vascular Remodeling Journal Of The American Heart Association 2021, 10: e021160. PMID: 34472370, PMCID: PMC8649308, DOI: 10.1161/jaha.121.021160.
- B-AB13-03 NOVEL ROLE OF PDE4DIP IN FAMILIAL ATRIAL FIBRILLATION WITH SLOW VENTRICULAR RESPONSEZiki M, Bhat N, Neogi A, Abboud J, Chouairi S, Ugwu N, Driscoll T, Liu Y, Smith E, Schwartz M, Akar J, Mani A. B-AB13-03 NOVEL ROLE OF PDE4DIP IN FAMILIAL ATRIAL FIBRILLATION WITH SLOW VENTRICULAR RESPONSE Heart Rhythm 2021, 18: s26. DOI: 10.1016/j.hrthm.2021.06.078.
- Epistatic interaction of PDE4DIP and DES mutations in familial atrial fibrillation with slow conductionZiki M, Bhat N, Neogi A, Driscoll TP, Ugwu N, Liu Y, Smith E, Abboud JM, Chouairi S, Schwartz MA, Akar JG, Mani A. Epistatic interaction of PDE4DIP and DES mutations in familial atrial fibrillation with slow conduction Human Mutation 2021, 42: 1279-1293. PMID: 34289528, PMCID: PMC8434967, DOI: 10.1002/humu.24265.
- Vascular Mechanobiology: Homeostasis, Adaptation, and DiseaseHumphrey JD, Schwartz MA. Vascular Mechanobiology: Homeostasis, Adaptation, and Disease Annual Review Of Biomedical Engineering 2021, 23: 1-27. PMID: 34255994, PMCID: PMC8719655, DOI: 10.1146/annurev-bioeng-092419-060810.
- Defective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic TelangiectasiaPark H, Furtado J, Poulet M, Chung M, Yun S, Lee S, Sessa WC, Franco CA, Schwartz MA, Eichmann A. Defective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia Circulation 2021, 144: 805-822. PMID: 34182767, PMCID: PMC8429266, DOI: 10.1161/circulationaha.120.053047.
- Developmental Perspectives on Arterial Fate SpecificationChen D, Schwartz MA, Simons M. Developmental Perspectives on Arterial Fate Specification Frontiers In Cell And Developmental Biology 2021, 9: 691335. PMID: 34249941, PMCID: PMC8269928, DOI: 10.3389/fcell.2021.691335.
- Altered Endocytosis in Cellular SenescenceShin EY, Soung NK, Schwartz MA, Kim EG. Altered Endocytosis in Cellular Senescence Ageing Research Reviews 2021, 68: 101332. PMID: 33753287, PMCID: PMC8131247, DOI: 10.1016/j.arr.2021.101332.
- Early events in endothelial flow sensingTanaka K, Joshi D, Timalsina S, Schwartz MA. Early events in endothelial flow sensing Cytoskeleton 2021, 78: 217-231. PMID: 33543538, DOI: 10.1002/cm.21652.
- Developmental origins of mechanical homeostasis in the aortaMurtada S, Kawamura Y, Li G, Schwartz MA, Tellides G, Humphrey JD. Developmental origins of mechanical homeostasis in the aorta Developmental Dynamics 2021, 250: 629-639. PMID: 33341996, PMCID: PMC8089041, DOI: 10.1002/dvdy.283.
- Actin flow-dependent and -independent force transmission through integrinsDriscoll TP, Ahn SJ, Huang B, Kumar A, Schwartz MA. Actin flow-dependent and -independent force transmission through integrins Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 32413-32422. PMID: 33262280, PMCID: PMC7768777, DOI: 10.1073/pnas.2010292117.
- Laser capture microdissection coupled mass spectrometry (LCM-MS) for spatially resolved analysis of formalin-fixed and stained human lung tissuesHerrera JA, Mallikarjun V, Rosini S, Montero MA, Lawless C, Warwood S, O’Cualain R, Knight D, Schwartz MA, Swift J. Laser capture microdissection coupled mass spectrometry (LCM-MS) for spatially resolved analysis of formalin-fixed and stained human lung tissues Clinical Proteomics 2020, 17: 24. PMID: 32565759, PMCID: PMC7302139, DOI: 10.1186/s12014-020-09287-6.
- Integrin-mediated adhesions in regulation of cellular senescenceShin EY, Park JH, You ST, Lee CS, Won SY, Park JJ, Kim HB, Shim J, Soung NK, Lee OJ, Schwartz MA, Kim EG. Integrin-mediated adhesions in regulation of cellular senescence Science Advances 2020, 6: eaay3909. PMID: 32494696, PMCID: PMC7202880, DOI: 10.1126/sciadv.aay3909.
- Endothelial-to-Mesenchymal Transition, Vascular Inflammation, and AtherosclerosisChen PY, Schwartz MA, Simons M. Endothelial-to-Mesenchymal Transition, Vascular Inflammation, and Atherosclerosis Frontiers In Cardiovascular Medicine 2020, 7: 53. PMID: 32478094, PMCID: PMC7232582, DOI: 10.3389/fcvm.2020.00053.
- Mechanotransduction through Integrin‐mediated AdhesionsSchwartz M. Mechanotransduction through Integrin‐mediated Adhesions The FASEB Journal 2020, 34: 1-1. DOI: 10.1096/fasebj.2020.34.s1.00148.
- Author Correction: Mechanosensation of cyclical force by PIEZO1 is essential for innate immunitySolis AG, Bielecki P, Steach HR, Sharma L, Harman CCD, Yun S, de Zoete MR, Warnock JN, To SDF, York AG, Mack M, Schwartz MA, Cruz CSD, Palm NW, Jackson R, Flavell RA. Author Correction: Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity Nature 2019, 575: e7-e7. PMID: 31712625, DOI: 10.1038/s41586-019-1755-5.
- Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosisYun S, Hu R, Schwaemmle ME, Scherer AN, Zhuang Z, Koleske AJ, Pallas DC, Schwartz MA. Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis Journal Of Clinical Investigation 2019, 129: 4863-4874. PMID: 31408443, PMCID: PMC6819111, DOI: 10.1172/jci127692.
- Endothelial TGF-β signalling drives vascular inflammation and atherosclerosisChen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Cilfone N, Kauffman K, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson D, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz M, Pober J, Chittenden T, Tellides G, Simons M. Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis Nature Metabolism 2019, 1: 912-926. PMID: 31572976, PMCID: PMC6767930, DOI: 10.1038/s42255-019-0102-3.
- Mechanosensation of cyclical force by PIEZO1 is essential for innate immunitySolis AG, Bielecki P, Steach HR, Sharma L, Harman CCD, Yun S, de Zoete MR, Warnock JN, To SDF, York AG, Mack M, Schwartz MA, Dela Cruz CS, Palm NW, Jackson R, Flavell RA. Mechanosensation of cyclical force by PIEZO1 is essential for innate immunity Nature 2019, 573: 69-74. PMID: 31435009, PMCID: PMC6939392, DOI: 10.1038/s41586-019-1485-8.
- Filamin A mediates isotropic distribution of applied force across the actin networkKumar A, Shutova MS, Tanaka K, Iwamoto DV, Calderwood DA, Svitkina TM, Schwartz MA. Filamin A mediates isotropic distribution of applied force across the actin network Journal Of Cell Biology 2019, 218: 2481-2491. PMID: 31315944, PMCID: PMC6683746, DOI: 10.1083/jcb.201901086.
- Caveolin-1 Regulates Atherogenesis by Attenuating Low-Density Lipoprotein Transcytosis and Vascular Inflammation Independently of Endothelial Nitric Oxide Synthase ActivationRamírez CM, Zhang X, Bandyopadhyay C, Rotllan N, Sugiyama MG, Aryal B, Liu X, He S, Kraehling JR, Ulrich V, Lin CS, Velazquez H, Lasunción MA, Li G, Suárez Y, Tellides G, Swirski FK, Lee WL, Schwartz MA, Sessa WC, Fernández-Hernando C. Caveolin-1 Regulates Atherogenesis by Attenuating Low-Density Lipoprotein Transcytosis and Vascular Inflammation Independently of Endothelial Nitric Oxide Synthase Activation Circulation 2019, 140: 225-239. PMID: 31154825, PMCID: PMC6778687, DOI: 10.1161/circulationaha.118.038571.
- MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activationHu X, Liu ZZ, Chen X, Schulz VP, Kumar A, Hartman AA, Weinstein J, Johnston JF, Rodriguez EC, Eastman AE, Cheng J, Min L, Zhong M, Carroll C, Gallagher PG, Lu J, Schwartz M, King MC, Krause DS, Guo S. MKL1-actin pathway restricts chromatin accessibility and prevents mature pluripotency activation Nature Communications 2019, 10: 1695. PMID: 30979898, PMCID: PMC6461646, DOI: 10.1038/s41467-019-09636-6.
- Coarse-Grained Simulation of Full-Length Integrin ActivationBidone TC, Polley A, Jin J, Driscoll T, Iwamoto DV, Calderwood DA, Schwartz MA, Voth GA. Coarse-Grained Simulation of Full-Length Integrin Activation Biophysical Journal 2019, 116: 1000-1010. PMID: 30851876, PMCID: PMC6428961, DOI: 10.1016/j.bpj.2019.02.011.
- MicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasisMoro A, Driscoll TP, Boraas LC, Armero W, Kasper DM, Baeyens N, Jouy C, Mallikarjun V, Swift J, Ahn SJ, Lee D, Zhang J, Gu M, Gerstein M, Schwartz M, Nicoli S. MicroRNA-dependent regulation of biomechanical genes establishes tissue stiffness homeostasis Nature Cell Biology 2019, 21: 348-358. PMID: 30742093, PMCID: PMC6528464, DOI: 10.1038/s41556-019-0272-y.
- Actin Flow Dependent and Independent Force Transmission in Integrin-Mediated AdhesionsDriscoll T, Huang B, Ahn S, Kumar A, Schwartz M. Actin Flow Dependent and Independent Force Transmission in Integrin-Mediated Adhesions Biophysical Journal 2019, 116: 123a. DOI: 10.1016/j.bpj.2018.11.684.
- ARHGAP18: A Flow‐Responsive Gene That Regulates Endothelial Cell Alignment and Protects Against AtherosclerosisLay AJ, Coleman PR, Formaz‐Preston A, Ting KK, Roediger B, Weninger W, Schwartz MA, Vadas MA, Gamble JR. ARHGAP18: A Flow‐Responsive Gene That Regulates Endothelial Cell Alignment and Protects Against Atherosclerosis Journal Of The American Heart Association 2019, 8: e010057. PMID: 30630384, PMCID: PMC6497359, DOI: 10.1161/jaha.118.010057.
- Registration of the extracellular matrix components constituting the fibroblastic focus in idiopathic pulmonary fibrosisHerrera J, Forster C, Pengo T, Montero A, Swift J, Schwartz MA, Henke CA, Bitterman PB. Registration of the extracellular matrix components constituting the fibroblastic focus in idiopathic pulmonary fibrosis JCI Insight 2019, 4: e125185. PMID: 30626754, PMCID: PMC6485370, DOI: 10.1172/jci.insight.125185.
- Translocating transcription factors in fluid shear stress-mediated vascular remodeling and diseaseMin E, Schwartz MA. Translocating transcription factors in fluid shear stress-mediated vascular remodeling and disease Experimental Cell Research 2019, 376: 92-97. PMID: 30633880, PMCID: PMC8211025, DOI: 10.1016/j.yexcr.2019.01.005.
- Vinculin and the mechanical response of adherent fibroblasts to matrix deformationRosowski KA, Boltyanskiy R, Xiang Y, Van den Dries K, Schwartz MA, Dufresne ER. Vinculin and the mechanical response of adherent fibroblasts to matrix deformation Scientific Reports 2018, 8: 17967. PMID: 30568231, PMCID: PMC6299284, DOI: 10.1038/s41598-018-36272-9.
- Talin as a mechanosensitive signaling hubGoult BT, Yan J, Schwartz MA. Talin as a mechanosensitive signaling hub Journal Of Cell Biology 2018, 217: 3776-3784. PMID: 30254032, PMCID: PMC6219721, DOI: 10.1083/jcb.201808061.
- Local Tension on Talin in Focal Adhesions Correlates with F-Actin Alignment at the Nanometer ScaleKumar A, Anderson KL, Swift MF, Hanein D, Volkmann N, Schwartz MA. Local Tension on Talin in Focal Adhesions Correlates with F-Actin Alignment at the Nanometer Scale Biophysical Journal 2018, 115: 1569-1579. PMID: 30274833, PMCID: PMC6372196, DOI: 10.1016/j.bpj.2018.08.045.
- Abstract 5224: hMENA isoforms impact NSCLC patient outcome through fibronectin/β1 integrin axisModugno F, Spada S, Palermo B, Visca P, Iapicca P, Carlo A, Antoniani B, Sperduti I, Benedetto A, Terrenato I, Mottolese M, Gandolfi F, Facciolo F, Chen E, Schwartz M, Santoni A, Bissell M, Nisticò P. Abstract 5224: hMENA isoforms impact NSCLC patient outcome through fibronectin/β1 integrin axis Cancer Research 2018, 78: 5224-5224. DOI: 10.1158/1538-7445.am2018-5224.
- hMENA isoforms impact NSCLC patient outcome through fibronectin/β1 integrin axisDi Modugno F, Spada S, Palermo B, Visca P, Iapicca P, Di Carlo A, Antoniani B, Sperduti I, Di Benedetto A, Terrenato I, Mottolese M, Gandolfi F, Facciolo F, Chen EI, Schwartz MA, Santoni A, Bissell MJ, Nisticò P. hMENA isoforms impact NSCLC patient outcome through fibronectin/β1 integrin axis Oncogene 2018, 37: 5605-5617. PMID: 29907768, PMCID: PMC6193944, DOI: 10.1038/s41388-018-0364-3.
- Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathyLiao X, Shen Y, Zhang R, Sugi K, Vasudevan NT, Alaiti MA, Sweet DR, Zhou L, Qing Y, Gerson SL, Fu C, Wynshaw-Boris A, Hu R, Schwartz MA, Fujioka H, Richardson B, Cameron MJ, Hayashi H, Stamler JS, Jain MK. Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: e4661-e4669. PMID: 29712858, PMCID: PMC5960298, DOI: 10.1073/pnas.1720065115.
- A unifying concept in vascular health and diseaseSchwartz MA, Vestweber D, Simons M. A unifying concept in vascular health and disease Science 2018, 360: 270-271. PMID: 29674582, PMCID: PMC6295341, DOI: 10.1126/science.aat3470.
- Addendum: Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specificationFang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK. Addendum: Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification Nature Communications 2018, 9: 720. PMID: 29445140, PMCID: PMC5813030, DOI: 10.1038/s41467-018-03076-4.
- Integrin-Based Mechanosensing is Mediated by Conformational ActivationBidone T, Driscoll T, Schwartz M, Voth G. Integrin-Based Mechanosensing is Mediated by Conformational Activation Biophysical Journal 2018, 114: 21a. DOI: 10.1016/j.bpj.2017.11.160.
- Inhibiting Integrin α5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes ArteriogenesisBudatha M, Zhang J, Zhuang ZW, Yun S, Dahlman JE, Anderson DG, Schwartz MA. Inhibiting Integrin α5 Cytoplasmic Domain Signaling Reduces Atherosclerosis and Promotes Arteriogenesis Journal Of The American Heart Association 2018, 7: e007501. PMID: 29382667, PMCID: PMC5850249, DOI: 10.1161/jaha.117.007501.
- Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specificationFang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK. Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification Nature Communications 2017, 8: 2149. PMID: 29247167, PMCID: PMC5732288, DOI: 10.1038/s41467-017-01742-7.
- Integrins as Signal Transducing ReceptorsSchwartz M. Integrins as Signal Transducing Receptors 2017, 133-146. DOI: 10.1201/9780203711644-6.
- Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafishLagendijk AK, Gomez GA, Baek S, Hesselson D, Hughes WE, Paterson S, Conway DE, Belting HG, Affolter M, Smith KA, Schwartz MA, Yap AS, Hogan BM. Live imaging molecular changes in junctional tension upon VE-cadherin in zebrafish Nature Communications 2017, 8: 1402. PMID: 29123087, PMCID: PMC5680264, DOI: 10.1038/s41467-017-01325-6.
- VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGNConway DE, Coon BG, Budatha M, Arsenovic PT, Orsenigo F, Wessel F, Zhang J, Zhuang Z, Dejana E, Vestweber D, Schwartz MA. VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN Current Biology 2017, 27: 2727. PMID: 28898639, PMCID: PMC5752114, DOI: 10.1016/j.cub.2017.08.064.
- VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGNConway DE, Coon BG, Budatha M, Arsenovic PT, Orsenigo F, Wessel F, Zhang J, Zhuang Z, Dejana E, Vestweber D, Schwartz MA. VE-Cadherin Phosphorylation Regulates Endothelial Fluid Shear Stress Responses through the Polarity Protein LGN Current Biology 2017, 27: 2219-2225.e5. PMID: 28712573, PMCID: PMC5667920, DOI: 10.1016/j.cub.2017.06.020.
- Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic developmentWang Y, Baeyens N, Corti F, Tanaka K, Fang J, Zhang J, Jin Y, Coon B, Hirschi K, Schwartz M, Simons M. Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development Journal Of Cell Science 2016, 129: e1.1-e1.1. DOI: 10.1242/jcs.200089.
- Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasiaBaeyens N, Larrivée B, Ola R, Hayward-Piatkowskyi B, Dubrac A, Huang B, Ross TD, Coon BG, Min E, Tsarfati M, Tong H, Eichmann A, Schwartz MA. Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasia Journal Of Cell Biology 2016, 214: 807-816. PMID: 27646277, PMCID: PMC5037412, DOI: 10.1083/jcb.201603106.
- Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signallingYun S, Budatha M, Dahlman JE, Coon BG, Cameron RT, Langer R, Anderson DG, Baillie G, Schwartz MA. Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling Nature Cell Biology 2016, 18: 1043-1053. PMID: 27595237, PMCID: PMC5301150, DOI: 10.1038/ncb3405.
- An Osteopontin/CD44 Axis in RhoGDI2-Mediated Metastasis SuppressionAhmed M, Sottnik JL, Dancik GM, Sahu D, Hansel DE, Theodorescu D, Schwartz MA. An Osteopontin/CD44 Axis in RhoGDI2-Mediated Metastasis Suppression Cancer Cell 2016, 30: 432-443. PMID: 27593345, PMCID: PMC5154333, DOI: 10.1016/j.ccell.2016.08.002.
- Ion Channels in Endothelial Responses to Fluid Shear StressGerhold KA, Schwartz MA. Ion Channels in Endothelial Responses to Fluid Shear Stress Physiology 2016, 31: 359-369. PMID: 27511462, PMCID: PMC5504459, DOI: 10.1152/physiol.00007.2016.
- Correction: Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivityKumar A, Ouyang M, Van den Dries K, McGhee EJ, Tanaka K, Anderson MD, Groisman A, Goult BT, Anderson KI, Schwartz MA. Correction: Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity Journal Of Cell Biology 2016, 214: 231-231. PMID: 27432899, PMCID: PMC4949446, DOI: 10.1083/jcb.20151001207062016c.
- Force regulated conformational change of integrin αVβ3Chen Y, Lee H, Tong H, Schwartz M, Zhu C. Force regulated conformational change of integrin αVβ3 Matrix Biology 2016, 60: 70-85. PMID: 27423389, PMCID: PMC5237428, DOI: 10.1016/j.matbio.2016.07.002.
- Comparative biology of decellularized lung matrix: Implications of species mismatch in regenerative medicineBalestrini JL, Gard AL, Gerhold KA, Wilcox EC, Liu A, Schwan J, Le AV, Baevova P, Dimitrievska S, Zhao L, Sundaram S, Sun H, Rittié L, Dyal R, Broekelmann TJ, Mecham RP, Schwartz MA, Niklason LE, White ES. Comparative biology of decellularized lung matrix: Implications of species mismatch in regenerative medicine Biomaterials 2016, 102: 220-230. PMID: 27344365, PMCID: PMC4939101, DOI: 10.1016/j.biomaterials.2016.06.025.
- Ral-Arf6 crosstalk regulates Ral dependent exocyst trafficking and anchorage independent growth signallingPawar A, Meier JA, Dasgupta A, Diwanji N, Deshpande N, Saxena K, Buwa N, Inchanalkar S, Schwartz MA, Balasubramanian N. Ral-Arf6 crosstalk regulates Ral dependent exocyst trafficking and anchorage independent growth signalling Cellular Signalling 2016, 28: 1225-1236. PMID: 27269287, PMCID: PMC4973806, DOI: 10.1016/j.cellsig.2016.05.023.
- Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivityKumar A, Ouyang M, Van den Dries K, McGhee EJ, Tanaka K, Anderson MD, Groisman A, Goult BT, Anderson KI, Schwartz MA. Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity Journal Of Cell Biology 2016, 213: 371-383. PMID: 27161398, PMCID: PMC4862330, DOI: 10.1083/jcb.201510012.
- Endothelial fluid shear stress sensing in vascular health and diseaseBaeyens N, Bandyopadhyay C, Coon BG, Yun S, Schwartz MA. Endothelial fluid shear stress sensing in vascular health and disease Journal Of Clinical Investigation 2016, 126: 821-828. PMID: 26928035, PMCID: PMC4767335, DOI: 10.1172/jci83083.
- Spider Silk Peptide Is a Compact, Linear Nanospring Ideal for Intracellular Tension SensingBrenner MD, Zhou R, Conway DE, Lanzano L, Gratton E, Schwartz MA, Ha T. Spider Silk Peptide Is a Compact, Linear Nanospring Ideal for Intracellular Tension Sensing Nano Letters 2016, 16: 2096-2102. PMID: 26824190, PMCID: PMC4851340, DOI: 10.1021/acs.nanolett.6b00305.
- Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic developmentWang Y, Baeyens N, Corti F, Tanaka K, Fang JS, Zhang J, Jin Y, Coon B, Hirschi KK, Schwartz MA, Simons M. Syndecan 4 controls lymphatic vasculature remodeling during mouse embryonic development Development 2016, 143: 4441-4451. PMID: 27789626, PMCID: PMC5201046, DOI: 10.1242/dev.140129.
- Biomechanics of vascular mechanosensation and remodelingBaeyens N, Schwartz MA. Biomechanics of vascular mechanosensation and remodeling Molecular Biology Of The Cell 2016, 27: 7-11. PMID: 26715421, PMCID: PMC4694763, DOI: 10.1091/mbc.e14-11-1522.
- Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits NeovascularizationDubrac A, Genet G, Ola R, Zhang F, Pibouin-Fragner L, Han J, Zhang J, Thomas JL, Chedotal A, Schwartz MA, Eichmann A. Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization Circulation 2015, 133: 409-421. PMID: 26659946, PMCID: PMC4729599, DOI: 10.1161/circulationaha.115.017537.
- KLF4 is a key determinant in the development and progression of cerebral cavernous malformationsCuttano R, Rudini N, Bravi L, Corada M, Giampietro C, Papa E, Morini MF, Maddaluno L, Baeyens N, Adams RH, Jain MK, Owens GK, Schwartz M, Lampugnani MG, Dejana E. KLF4 is a key determinant in the development and progression of cerebral cavernous malformations EMBO Molecular Medicine 2015, 8: 6-24. PMID: 26612856, PMCID: PMC4718159, DOI: 10.15252/emmm.201505433.
- Endothelial-to-mesenchymal transition drives atherosclerosis progressionChen PY, Qin L, Baeyens N, Li G, Afolabi T, Budatha M, Tellides G, Schwartz MA, Simons M. Endothelial-to-mesenchymal transition drives atherosclerosis progression Journal Of Clinical Investigation 2015, 125: 4514-4528. PMID: 26517696, PMCID: PMC4665771, DOI: 10.1172/jci82719.
- Role of Mechanotransduction in Vascular BiologyHumphrey JD, Schwartz MA, Tellides G, Milewicz DM. Role of Mechanotransduction in Vascular Biology Circulation Research 2015, 116: 1448-1461. PMID: 25858068, PMCID: PMC4420625, DOI: 10.1161/circresaha.114.304936.
- Rac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interactionDaneshjou N, Sieracki N, van Nieuw Amerongen GP, Conway DE, Schwartz MA, Komarova YA, Malik AB. Rac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interaction Journal Of Cell Biology 2015, 209: 181-181. PMID: 25847538, PMCID: PMC4395484, DOI: 10.1083/jcb.20140910803202015c.
- Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complexCoon B, Baeyens N, Han J, Budatha M, Ross T, Fang J, Yun S, Thomas J, Schwartz M. Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex The Journal Of General Physiology 2015, 145: 1454oia13. DOI: 10.1085/jgp.1454oia13.
- Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complexCoon BG, Baeyens N, Han J, Budatha M, Ross TD, Fang JS, Yun S, Thomas JL, Schwartz MA. Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex Journal Of Cell Biology 2015, 208: 975-986. PMID: 25800053, PMCID: PMC4384728, DOI: 10.1083/jcb.201408103.
- ZO-1 controls endothelial adherens junctions, cell–cell tension, angiogenesis, and barrier formationTornavaca O, Chia M, Dufton N, Almagro LO, Conway DE, Randi AM, Schwartz MA, Matter K, Balda MS. ZO-1 controls endothelial adherens junctions, cell–cell tension, angiogenesis, and barrier formation Journal Of Cell Biology 2015, 208: 821-838. PMID: 25753039, PMCID: PMC4362456, DOI: 10.1083/jcb.201404140.
- Rac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interactionDaneshjou N, Sieracki N, van Nieuw Amerongen GP, Conway D, Schwartz M, Komarova Y, Malik A. Rac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interaction Journal Of Cell Biology 2015, 208: 23-32. PMID: 25559184, PMCID: PMC4284224, DOI: 10.1083/jcb.201409108.
- The importance of indifference in scientific researchSchwartz MA. The importance of indifference in scientific research Journal Of Cell Science 2015, 128: 2745-2746. PMID: 26136366, PMCID: PMC6518312, DOI: 10.1242/jcs.174946.
- Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set pointBaeyens N, Nicoli S, Coon BG, Ross TD, Van den Dries K, Han J, Lauridsen HM, Mejean CO, Eichmann A, Thomas JL, Humphrey JD, Schwartz MA. Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point ELife 2015, 4: e04645. PMID: 25643397, PMCID: PMC4337723, DOI: 10.7554/elife.04645.
- Syndecan 4 is required for endothelial alignment in flow and atheroprotective signalingBaeyens N, Mulligan-Kehoe MJ, Corti F, Simon DD, Ross TD, Rhodes JM, Wang TZ, Mejean CO, Simons M, Humphrey J, Schwartz MA. Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: 17308-17313. PMID: 25404299, PMCID: PMC4260558, DOI: 10.1073/pnas.1413725111.
- Up-regulation of Thrombospondin-2 in Akt1-null Mice Contributes to Compromised Tissue Repair Due to Abnormalities in Fibroblast Function*Bancroft T, Bouaouina M, Roberts S, Lee M, Calderwood DA, Schwartz M, Simons M, Sessa WC, Kyriakides TR. Up-regulation of Thrombospondin-2 in Akt1-null Mice Contributes to Compromised Tissue Repair Due to Abnormalities in Fibroblast Function* Journal Of Biological Chemistry 2014, 290: 409-422. PMID: 25389299, PMCID: PMC4281743, DOI: 10.1074/jbc.m114.618421.
- Integrin adjunct therapy for melanomaAndarawewa KL, Moissoglu K, Lee C, Ando Y, Yu M, Debnath P, Shannon JD, Sirinivasan S, Conaway MR, Weber MJ, Schwartz MA. Integrin adjunct therapy for melanoma Pigment Cell & Melanoma Research 2014, 28: 114-116. PMID: 25264294, PMCID: PMC6542633, DOI: 10.1111/pcmr.12320.
- Mechanotransduction and extracellular matrix homeostasisHumphrey JD, Dufresne ER, Schwartz MA. Mechanotransduction and extracellular matrix homeostasis Nature Reviews Molecular Cell Biology 2014, 15: 802-812. PMID: 25355505, PMCID: PMC4513363, DOI: 10.1038/nrm3896.
- Mechanotransduction of shear stress occurs through changes in VE-cadherin and PECAM-1 tension: Implications for cell migrationConway DE, Schwartz MA. Mechanotransduction of shear stress occurs through changes in VE-cadherin and PECAM-1 tension: Implications for cell migration Cell Adhesion & Migration 2014, 9: 335-339. PMID: 25482618, PMCID: PMC4955370, DOI: 10.4161/19336918.2014.968498.
- Chemokine-coupled β 2 integrin–induced macrophage Rac2–Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesisMorrison A, Yarovinsky T, Young B, Moraes F, Ross T, Ceneri N, Zhang J, Zhuang Z, Sinusas A, Pardi R, Schwartz M, Simons M, Bender J. Chemokine-coupled β 2 integrin–induced macrophage Rac2–Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis Journal Of Cell Biology 2014, 206: 2066oia157. DOI: 10.1083/jcb.2066oia157.
- Discovery and characterization of small molecules that target the GTPase RalYan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe WE, Ahmed M, Brautigan DL, Paschal BM, Schwartz MA, Jones DN, Ross D, Meroueh SO, Theodorescu D. Discovery and characterization of small molecules that target the GTPase Ral Nature 2014, 515: 443-447. PMID: 25219851, PMCID: PMC4351747, DOI: 10.1038/nature13713.
- Chemokine-coupled β2 integrin–induced macrophage Rac2–Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesisMorrison AR, Yarovinsky TO, Young BD, Moraes F, Ross TD, Ceneri N, Zhang J, Zhuang ZW, Sinusas AJ, Pardi R, Schwartz MA, Simons M, Bender JR. Chemokine-coupled β2 integrin–induced macrophage Rac2–Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis Journal Of Experimental Medicine 2014, 211: 1957-1968. PMID: 25180062, PMCID: PMC4172219, DOI: 10.1084/jem.20132130.
- Change of Direction in the Biomechanics of AtherosclerosisMohamied Y, Rowland EM, Bailey EL, Sherwin SJ, Schwartz MA, Weinberg PD. Change of Direction in the Biomechanics of Atherosclerosis Annals Of Biomedical Engineering 2014, 43: 16-25. PMID: 25138165, PMCID: PMC4286626, DOI: 10.1007/s10439-014-1095-4.
- Tension-Sensitive Actin Assembly Supports Contractility at the Epithelial Zonula AdherensLeerberg JM, Gomez GA, Verma S, Moussa EJ, Wu SK, Priya R, Hoffman BD, Grashoff C, Schwartz MA, Yap AS. Tension-Sensitive Actin Assembly Supports Contractility at the Epithelial Zonula Adherens Current Biology 2014, 24: 1689-1699. PMID: 25065757, PMCID: PMC5103636, DOI: 10.1016/j.cub.2014.06.028.
- Sticking to it: Tracking the paths of integrin signallingSchwartz M. Sticking to it: Tracking the paths of integrin signalling Nature Cell Biology 2014, 16: 487-487. PMID: 24875734, DOI: 10.1038/ncb2971.
- Spatial and temporal control of Rho GTPase functionsMoissoglu K, Schwartz MA. Spatial and temporal control of Rho GTPase functions Cellular Logistics 2014, 4: e943618. PMID: 25610718, PMCID: PMC4279778, DOI: 10.4161/21592780.2014.943618.
- Dysfunctional Mechanosensing in AneurysmsHumphrey JD, Milewicz DM, Tellides G, Schwartz MA. Dysfunctional Mechanosensing in Aneurysms Science 2014, 344: 477-479. PMID: 24786066, PMCID: PMC4360903, DOI: 10.1126/science.1253026.
- Molecular mechanism of Rac1 regulation of endothelial permeability (1095.4)Daneshjou N, Komarova Y, Sieracki N, Schwartz M, Malik A. Molecular mechanism of Rac1 regulation of endothelial permeability (1095.4) The FASEB Journal 2014, 28 DOI: 10.1096/fasebj.28.1_supplement.1095.4.
- Regulation of Rac1 translocation and activation by membrane domains and their boundariesMoissoglu K, Kiessling V, Wan C, Hoffman BD, Norambuena A, Tamm LK, Schwartz MA. Regulation of Rac1 translocation and activation by membrane domains and their boundaries Journal Of Cell Science 2014, 127: 2565-2576. PMID: 24695858, PMCID: PMC4038948, DOI: 10.1242/jcs.149088.
- Towards the voidDufresne ER, Schwartz MA. Towards the void Nature Materials 2013, 12: 783-784. PMID: 23966050, DOI: 10.1038/nmat3743.
- Endothelial Cell Sensing of Flow DirectionWang C, Baker BM, Chen CS, Schwartz MA. Endothelial Cell Sensing of Flow Direction Arteriosclerosis Thrombosis And Vascular Biology 2013, 33: 2130-2136. PMID: 23814115, PMCID: PMC3812824, DOI: 10.1161/atvbaha.113.301826.
- Integrins in mechanotransductionRoss TD, Coon BG, Yun S, Baeyens N, Tanaka K, Ouyang M, Schwartz MA. Integrins in mechanotransduction Current Opinion In Cell Biology 2013, 25: 613-618. PMID: 23797029, PMCID: PMC3757118, DOI: 10.1016/j.ceb.2013.05.006.
- Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1Conway DE, Breckenridge MT, Hinde E, Gratton E, Chen CS, Schwartz MA. Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1 Current Biology 2013, 23: 1024-1030. PMID: 23684974, PMCID: PMC3676707, DOI: 10.1016/j.cub.2013.04.049.
- N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathwaysOuyang M, Lu S, Kim T, Chen CE, Seong J, Leckband DE, Wang F, Reynolds AB, Schwartz MA, Wang Y. N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways Nature Communications 2013, 4: 1589. PMID: 23481397, PMCID: PMC3602931, DOI: 10.1038/ncomms2560.
- Deconstructing DimensionalitySchwartz MA, Chen CS. Deconstructing Dimensionality Science 2013, 339: 402-404. PMID: 23349278, DOI: 10.1126/science.1233814.
- Flow-dependent cellular mechanotransduction in atherosclerosisConway DE, Schwartz MA. Flow-dependent cellular mechanotransduction in atherosclerosis Journal Of Cell Science 2013, 126: 5101-5109. PMID: 24190880, PMCID: PMC3828588, DOI: 10.1242/jcs.138313.
- Endothelial Nuclear Factor-&kgr;B–Dependent Regulation of Arteriogenesis and BranchingTirziu D, Jaba IM, Yu P, Larrivée B, Coon BG, Cristofaro B, Zhuang ZW, Lanahan AA, Schwartz MA, Eichmann A, Simons M. Endothelial Nuclear Factor-&kgr;B–Dependent Regulation of Arteriogenesis and Branching Circulation 2012, 126: 2589-2600. PMID: 23091063, PMCID: PMC3514045, DOI: 10.1161/circulationaha.112.119321.
- Profilin phosphorylation as a VEGFR effector in angiogenesisSimons M, Schwartz MA. Profilin phosphorylation as a VEGFR effector in angiogenesis Nature Cell Biology 2012, 14: 985-987. PMID: 23033049, PMCID: PMC4047563, DOI: 10.1038/ncb2596.
- Neuropilin-1 Stimulates Tumor Growth by Increasing Fibronectin Fibril Assembly in the Tumor MicroenvironmentYaqoob U, Cao S, Shergill U, Jagavelu K, Geng Z, Yin M, de Assuncao TM, Cao Y, Szabolcs A, Thorgeirsson S, Schwartz M, Yang JD, Ehman R, Roberts L, Mukhopadhyay D, Shah VH. Neuropilin-1 Stimulates Tumor Growth by Increasing Fibronectin Fibril Assembly in the Tumor Microenvironment Cancer Research 2012, 72: 4047-4059. PMID: 22738912, PMCID: PMC3421041, DOI: 10.1158/0008-5472.can-11-3907.
- The role of p21-activated kinase in the initiation of atherosclerosisJhaveri K, Debnath P, Chernoff J, Sanders J, Schwartz M. The role of p21-activated kinase in the initiation of atherosclerosis BMC Cardiovascular Disorders 2012, 12: 55. PMID: 22824149, PMCID: PMC3489605, DOI: 10.1186/1471-2261-12-55.
- p21-Activated kinase 4 promotes prostate cancer progression through CREBPark M, Lee H, Lee C, You S, Kim D, Park B, Kang M, Heo W, Shin E, Schwartz M, Kim E. p21-Activated kinase 4 promotes prostate cancer progression through CREB Oncogene 2012, 32: 2475-2482. PMID: 22710715, DOI: 10.1038/onc.2012.255.
- A novel in vitro flow system for changing flow direction on endothelial cellsWang C, Lu H, Schwartz MA. A novel in vitro flow system for changing flow direction on endothelial cells Journal Of Biomechanics 2012, 45: 1212-1218. PMID: 22386042, PMCID: PMC3327813, DOI: 10.1016/j.jbiomech.2012.01.045.
- Lymphatics thrive on stress: mechanical force in lymphatic developmentSchwartz MA, Simons M. Lymphatics thrive on stress: mechanical force in lymphatic development The EMBO Journal 2012, 31: 781-782. PMID: 22334045, PMCID: PMC3280563, DOI: 10.1038/emboj.2011.484.
- Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannelsBatra N, Burra S, Siller-Jackson AJ, Gu S, Xia X, Weber GF, DeSimone D, Bonewald LF, Lafer EM, Sprague E, Schwartz MA, Jiang JX. Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 3359-3364. PMID: 22331870, PMCID: PMC3295295, DOI: 10.1073/pnas.1115967109.
- Lessons from the endothelial junctional mechanosensory complexConway D, Schwartz MA. Lessons from the endothelial junctional mechanosensory complex F1000 Biology Reports 2012, 4: 1. PMID: 22238515, PMCID: PMC3251317, DOI: 10.3410/b4-1.
- JNK2 Promotes Endothelial Cell Alignment under FlowHahn C, Wang C, Orr AW, Coon BG, Schwartz MA. JNK2 Promotes Endothelial Cell Alignment under Flow PLOS ONE 2011, 6: e24338. PMID: 21909388, PMCID: PMC3164210, DOI: 10.1371/journal.pone.0024338.
- Effects of integrin-mediated cell adhesion on plasma membrane lipid raft components and signalingNorambuena A, Schwartz MA. Effects of integrin-mediated cell adhesion on plasma membrane lipid raft components and signaling Molecular Biology Of The Cell 2011, 22: 3456-3464. PMID: 21795400, PMCID: PMC3172269, DOI: 10.1091/mbc.e11-04-0361.
- Dynamic molecular processes mediate cellular mechanotransductionHoffman BD, Grashoff C, Schwartz MA. Dynamic molecular processes mediate cellular mechanotransduction Nature 2011, 475: 316-323. PMID: 21776077, PMCID: PMC6449687, DOI: 10.1038/nature10316.
- Light‐Triggered Myosin Activation for Probing Dynamic Cellular ProcessesGoguen BN, Hoffman BD, Sellers JR, Schwartz MA, Imperiali B. Light‐Triggered Myosin Activation for Probing Dynamic Cellular Processes Angewandte Chemie International Edition 2011, 50: 5667-5670. PMID: 21542072, PMCID: PMC3406609, DOI: 10.1002/anie.201100674.
- Light‐Triggered Myosin Activation for Probing Dynamic Cellular ProcessesGoguen B, Hoffman B, Sellers J, Schwartz M, Imperiali B. Light‐Triggered Myosin Activation for Probing Dynamic Cellular Processes Angewandte Chemie 2011, 123: 5785-5788. DOI: 10.1002/ange.201100674.
- Myosin II directly binds and inhibits Dbl family guanine nucleotide exchange factorsLee C, Shin E, Hong J, Schwartz M, Kim E. Myosin II directly binds and inhibits Dbl family guanine nucleotide exchange factors The FASEB Journal 2011, 25: 930.9-930.9. DOI: 10.1096/fasebj.25.1_supplement.930.9.
- Super-Resolution Microscopy: A New Dimension in Focal AdhesionsSchwartz MA. Super-Resolution Microscopy: A New Dimension in Focal Adhesions Current Biology 2011, 21: r115-r116. PMID: 21300274, DOI: 10.1016/j.cub.2010.12.025.
- Src and Caveolin-1 Reciprocally Regulate Metastasis via a Common Downstream Signaling Pathway in Bladder CancerThomas S, Overdevest JB, Nitz MD, Williams PD, Owens CR, Sanchez-Carbayo M, Frierson HF, Schwartz MA, Theodorescu D. Src and Caveolin-1 Reciprocally Regulate Metastasis via a Common Downstream Signaling Pathway in Bladder Cancer Cancer Research 2011, 71: 832-841. PMID: 21148751, PMCID: PMC4306590, DOI: 10.1158/0008-5472.can-10-0730.
- THE IMPORTANCE OF STUPIDITY IN SCIENTIFIC RESEARCHSchwartz M. THE IMPORTANCE OF STUPIDITY IN SCIENTIFIC RESEARCH Seismological Research Letters 2011, 82: 3-4. DOI: 10.1785/gssrl.82.1.3.
- Integrins and Extracellular Matrix in MechanotransductionSchwartz MA. Integrins and Extracellular Matrix in Mechanotransduction Cold Spring Harbor Perspectives In Biology 2010, 2: a005066. PMID: 21084386, PMCID: PMC2982167, DOI: 10.1101/cshperspect.a005066.
- Cell adhesion: integrating cytoskeletal dynamics and cellular tensionParsons JT, Horwitz AR, Schwartz MA. Cell adhesion: integrating cytoskeletal dynamics and cellular tension Nature Reviews Molecular Cell Biology 2010, 11: 633-643. PMID: 20729930, PMCID: PMC2992881, DOI: 10.1038/nrm2957.
- Myosin II directly binds and inhibits Dbl family guanine nucleotide exchange factors: a possible link to Rho family GTPasesLee CS, Choi CK, Shin EY, Schwartz MA, Kim EG. Myosin II directly binds and inhibits Dbl family guanine nucleotide exchange factors: a possible link to Rho family GTPases Journal Of Cell Biology 2010, 190: 663-674. PMID: 20713598, PMCID: PMC2928003, DOI: 10.1083/jcb.201003057.
- Spatiotemporal organization, regulation, and functions of tractions during neutrophil chemotaxisShin ME, He Y, Li D, Na S, Chowdhury F, Poh YC, Collin O, Su P, de Lanerolle P, Schwartz MA, Wang N, Wang F. Spatiotemporal organization, regulation, and functions of tractions during neutrophil chemotaxis Blood 2010, 116: 3297-3310. PMID: 20616216, PMCID: PMC2995358, DOI: 10.1182/blood-2009-12-260851.
- Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamicsGrashoff C, Hoffman BD, Brenner MD, Zhou R, Parsons M, Yang MT, McLean MA, Sligar SG, Chen CS, Ha T, Schwartz MA. Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics Nature 2010, 466: 263-266. PMID: 20613844, PMCID: PMC2901888, DOI: 10.1038/nature09198.
- Abstract 5130: Src and Caveolin-1 reciprocally regulate metastasis via Rho KinaseThomas S, Overdevest J, Nitz M, Williams P, Schwartz M, Theodorescu D. Abstract 5130: Src and Caveolin-1 reciprocally regulate metastasis via Rho Kinase Cancer Research 2010, 70: 5130-5130. DOI: 10.1158/1538-7445.am10-5130.
- Atheroprone Hemodynamics Regulate Fibronectin Deposition to Create Positive Feedback That Sustains Endothelial InflammationFeaver RE, Gelfand BD, Wang C, Schwartz MA, Blackman BR. Atheroprone Hemodynamics Regulate Fibronectin Deposition to Create Positive Feedback That Sustains Endothelial Inflammation Circulation Research 2010, 106: 1703-1711. PMID: 20378855, PMCID: PMC2891748, DOI: 10.1161/circresaha.109.216283.
- Matrix-Specific Protein Kinase A Signaling Regulates p21-Activated Kinase Activation by Flow in Endothelial CellsFunk SD, Yurdagul A, Green JM, Jhaveri KA, Schwartz MA, Orr AW. Matrix-Specific Protein Kinase A Signaling Regulates p21-Activated Kinase Activation by Flow in Endothelial Cells Circulation Research 2010, 106: 1394-1403. PMID: 20224042, PMCID: PMC2862370, DOI: 10.1161/circresaha.109.210286.
- Remembrance of Dead Cells Past: Discovering That the Extracellular Matrix Is a Cell Survival FactorSchwartz MA. Remembrance of Dead Cells Past: Discovering That the Extracellular Matrix Is a Cell Survival Factor Molecular Biology Of The Cell 2010, 21: 499-500. PMID: 20150528, PMCID: PMC2820415, DOI: 10.1091/mbc.e09-07-0602.
- RalA-Exocyst Complex Regulates Integrin-Dependent Membrane Raft Exocytosis and Growth SignalingBalasubramanian N, Meier JA, Scott DW, Norambuena A, White MA, Schwartz MA. RalA-Exocyst Complex Regulates Integrin-Dependent Membrane Raft Exocytosis and Growth Signaling Current Biology 2009, 20: 75-79. PMID: 20005108, PMCID: PMC2822103, DOI: 10.1016/j.cub.2009.11.016.
- Erratum: Timing of cyclin D1 expression within G1 phase is controlled by RhoWelsh C, Roovers K, Villanueva J, Liu Y, Schwartz M, Assoian R. Erratum: Timing of cyclin D1 expression within G1 phase is controlled by Rho Nature Cell Biology 2009, 11: 1496-1496. DOI: 10.1038/ncb1209-1496.
- Focal adhesion kinase modulates activation of NF-κB by flow in endothelial cellsPetzold T, Orr AW, Hahn C, Jhaveri KA, Parsons JT, Schwartz MA. Focal adhesion kinase modulates activation of NF-κB by flow in endothelial cells American Journal Of Physiology - Cell Physiology 2009, 297: c814-c822. PMID: 19587216, PMCID: PMC2770750, DOI: 10.1152/ajpcell.00226.2009.
- Suppression of RhoG activity is mediated by a syndecan 4–synectin–RhoGDI1 complex and is reversed by PKCα in a Rac1 activation pathwayElfenbein A, Rhodes JM, Meller J, Schwartz MA, Matsuda M, Simons M. Suppression of RhoG activity is mediated by a syndecan 4–synectin–RhoGDI1 complex and is reversed by PKCα in a Rac1 activation pathway Journal Of Cell Biology 2009, 186: 75-83. PMID: 19581409, PMCID: PMC2712988, DOI: 10.1083/jcb.200810179.
- Src phosphorylation of RhoGDI2 regulates its metastasis suppressor functionWu Y, Moissoglu K, Wang H, Wang X, Frierson HF, Schwartz MA, Theodorescu D. Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 5807-5812. PMID: 19321744, PMCID: PMC2667073, DOI: 10.1073/pnas.0810094106.
- Rho GDP Dissociation Inhibitor 2 Suppresses Metastasis via Unconventional Regulation of RhoGTPasesMoissoglu K, McRoberts KS, Meier JA, Theodorescu D, Schwartz MA. Rho GDP Dissociation Inhibitor 2 Suppresses Metastasis via Unconventional Regulation of RhoGTPases Cancer Research 2009, 69: 2838-2844. PMID: 19276387, PMCID: PMC2701105, DOI: 10.1158/0008-5472.can-08-1397.
- The Subendothelial Extracellular Matrix Modulates JNK Activation by FlowHahn C, Orr AW, Sanders JM, Jhaveri KA, Schwartz MA. The Subendothelial Extracellular Matrix Modulates JNK Activation by Flow Circulation Research 2009, 104: 995-1003. PMID: 19286608, PMCID: PMC2702158, DOI: 10.1161/circresaha.108.186486.
- Cadherin Adhesion, Tissue Tension, and Noncanonical Wnt Signaling Regulate Fibronectin Matrix OrganizationDzamba BJ, Jakab KR, Marsden M, Schwartz MA, DeSimone DW. Cadherin Adhesion, Tissue Tension, and Noncanonical Wnt Signaling Regulate Fibronectin Matrix Organization Developmental Cell 2009, 16: 421-432. PMID: 19289087, PMCID: PMC2682918, DOI: 10.1016/j.devcel.2009.01.008.
- The Force Is with UsSchwartz MA. The Force Is with Us Science 2009, 323: 588-589. PMID: 19179515, DOI: 10.1126/science.1169414.
- Mechanotransduction in vascular physiology and atherogenesisHahn C, Schwartz MA. Mechanotransduction in vascular physiology and atherogenesis Nature Reviews Molecular Cell Biology 2009, 10: 53-62. PMID: 19197332, PMCID: PMC2719300, DOI: 10.1038/nrm2596.
- Regulation of LKB1/STRAD Localization and Function by E-CadherinSebbagh M, Santoni MJ, Hall B, Borg JP, Schwartz MA. Regulation of LKB1/STRAD Localization and Function by E-Cadherin Current Biology 2008, 19: 37-42. PMID: 19110428, PMCID: PMC2773019, DOI: 10.1016/j.cub.2008.11.033.
- Integrin Agonists as Adjuvants in Chemotherapy for MelanomaSchwartz MA, McRoberts K, Coyner M, Andarawewa KL, Frierson HF, Sanders JM, Swenson S, Markland F, Conaway MR, Theodorescu D. Integrin Agonists as Adjuvants in Chemotherapy for Melanoma Clinical Cancer Research 2008, 14: 6193-6197. PMID: 18829498, DOI: 10.1158/1078-0432.ccr-08-1285.
- The Role of Cellular Adaptation to Mechanical Forces in AtherosclerosisHahn C, Schwartz MA. The Role of Cellular Adaptation to Mechanical Forces in Atherosclerosis Arteriosclerosis Thrombosis And Vascular Biology 2008, 28: 2101-2107. PMID: 18787190, PMCID: PMC2737679, DOI: 10.1161/atvbaha.108.165951.
- Endothelial Cell PECAM-1 Promotes Atherosclerotic Lesions in Areas of Disturbed Flow in ApoE-Deficient MiceHarry BL, Sanders JM, Feaver RE, Lansey M, Deem TL, Zarbock A, Bruce AC, Pryor AW, Gelfand BD, Blackman BR, Schwartz MA, Ley K. Endothelial Cell PECAM-1 Promotes Atherosclerotic Lesions in Areas of Disturbed Flow in ApoE-Deficient Mice Arteriosclerosis Thrombosis And Vascular Biology 2008, 28: 2003-2008. PMID: 18688018, PMCID: PMC2651147, DOI: 10.1161/atvbaha.108.164707.
- p21-Activated Kinase Signaling Regulates Oxidant-Dependent NF-&kgr;B Activation by FlowOrr AW, Hahn C, Blackman BR, Schwartz MA. p21-Activated Kinase Signaling Regulates Oxidant-Dependent NF-&kgr;B Activation by Flow Circulation Research 2008, 103: 671-679. PMID: 18669917, PMCID: PMC2697905, DOI: 10.1161/circresaha.108.182097.
- Cell adhesion receptors in mechanotransductionSchwartz MA, DeSimone DW. Cell adhesion receptors in mechanotransduction Current Opinion In Cell Biology 2008, 20: 551-556. PMID: 18583124, PMCID: PMC2581799, DOI: 10.1016/j.ceb.2008.05.005.
- Endogenous RhoG is dispensable for integrin-mediated cell spreading but contributes to Rac-independent migrationMeller J, Vidali L, Schwartz MA. Endogenous RhoG is dispensable for integrin-mediated cell spreading but contributes to Rac-independent migration Journal Of Cell Science 2008, 121: 1981-1989. PMID: 18505794, PMCID: PMC2759683, DOI: 10.1242/jcs.025130.
- The importance of stupidity in scientific researchSchwartz MA. The importance of stupidity in scientific research Journal Of Cell Science 2008, 121: 1771-1771. PMID: 18492790, DOI: 10.1242/jcs.033340.
- Function of the N-terminus of zizimin1: autoinhibition and membrane targetingMeller N, Westbrook MJ, Shannon JD, Guda C, Schwartz MA. Function of the N-terminus of zizimin1: autoinhibition and membrane targeting Biochemical Journal 2007, 409: 525-533. PMID: 17935486, PMCID: PMC2740492, DOI: 10.1042/bj20071263.
- A fluorescence resonance energy transfer activation sensor for Arf6Hall B, McLean MA, Davis K, Casanova JE, Sligar SG, Schwartz MA. A fluorescence resonance energy transfer activation sensor for Arf6 Analytical Biochemistry 2007, 374: 243-249. PMID: 18162163, PMCID: PMC2277471, DOI: 10.1016/j.ab.2007.11.032.
- Arf6 and microtubules in adhesion-dependent trafficking of lipid raftsBalasubramanian N, Scott DW, Castle JD, Casanova JE, Schwartz MA. Arf6 and microtubules in adhesion-dependent trafficking of lipid rafts Nature Cell Biology 2007, 9: 1381-1391. PMID: 18026091, PMCID: PMC2715295, DOI: 10.1038/ncb1657.
- VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function. VOLUME 280 (2005) PAGES 2405-2408Tzima E, Reader J, Irani-Tehrani M, Ewalt K, Schwartz M, Schimmel P. VE-cadherin links tRNA synthetase cytokine to anti-angiogenic function. VOLUME 280 (2005) PAGES 2405-2408 Journal Of Biological Chemistry 2007, 282: 29068. DOI: 10.1016/s0021-9258(20)58643-2.
- Induction of Vascular Permeability: βPIX and GIT1 Scaffold the Activation of Extracellular Signal-regulated Kinase by PAKStockton R, Reutershan J, Scott D, Sanders J, Ley K, Schwartz MA. Induction of Vascular Permeability: βPIX and GIT1 Scaffold the Activation of Extracellular Signal-regulated Kinase by PAK Molecular Biology Of The Cell 2007, 18: 2346-2355. PMID: 17429073, PMCID: PMC1877103, DOI: 10.1091/mbc.e06-07-0584.
- Matrix‐Specific JNK Activation by FlowHahn C, Orr A, Sanders J, Sarembock I, Schwartz M. Matrix‐Specific JNK Activation by Flow The FASEB Journal 2007, 21: a269-a269. DOI: 10.1096/fasebj.21.5.a269-a.
- Matrix‐specific PAK activation regulates vascular permeability in atherosclerosisOrr A, Stockton R, Simmers M, Sanders J, Blackman B, Schwartz M. Matrix‐specific PAK activation regulates vascular permeability in atherosclerosis The FASEB Journal 2007, 21: a268-a268. DOI: 10.1096/fasebj.21.5.a268-d.
- Rac, membrane heterogeneity, caveolin and regulation of growth by integrinsDel Pozo MA, Schwartz MA. Rac, membrane heterogeneity, caveolin and regulation of growth by integrins Trends In Cell Biology 2007, 17: 246-250. PMID: 17363257, DOI: 10.1016/j.tcb.2007.03.001.
- Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesisOrr A, Stockton R, Simmers M, Sanders J, Sarembock I, Blackman B, Alexander Schwartz M. Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis Journal Of Experimental Medicine 2007, 204: i7-i7. DOI: 10.1084/jem2043oia7.
- Blocking p21-activated Kinase Reduces Lipopolysaccharide-induced Acute Lung Injury by Preventing Polymorphonuclear Leukocyte InfiltrationReutershan J, Stockton R, Zarbock A, Sullivan GW, Chang D, Scott D, Schwartz MA, Ley K. Blocking p21-activated Kinase Reduces Lipopolysaccharide-induced Acute Lung Injury by Preventing Polymorphonuclear Leukocyte Infiltration American Journal Of Respiratory And Critical Care Medicine 2007, 175: 1027-1035. PMID: 17322107, PMCID: PMC1899271, DOI: 10.1164/rccm.200612-1822oc.
- Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesisOrr AW, Stockton R, Simmers MB, Sanders JM, Sarembock IJ, Blackman BR, Schwartz MA. Matrix-specific p21-activated kinase activation regulates vascular permeability in atherogenesis Journal Of Cell Biology 2007, 176: 719-727. PMID: 17312022, PMCID: PMC2064028, DOI: 10.1083/jcb.200609008.
- High-resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometryLechene C, Hillion F, McMahon G, Benson D, Kleinfeld A, Kampf J, Distel D, Luyten Y, Bonventre J, Hentschel D, Park K, Ito S, Schwartz M, Benichou G, Slodzian G. High-resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometry BMC Biology 2006, 5: 20. PMID: 17010211, PMCID: PMC1781526, DOI: 10.1186/jbiol42.
- Cell-to-cell contact and extracellular matrixSchwartz M, Yap A. Cell-to-cell contact and extracellular matrix Current Opinion In Cell Biology 2006, 18: 461-462. DOI: 10.1016/j.ceb.2006.08.013.
- Integrin signalling in directed cell migrationMoissoglu K, Schwartz MA. Integrin signalling in directed cell migration Biology Of The Cell 2006, 98: 547-555. PMID: 16907663, DOI: 10.1042/bc20060025.
- Integrin-mediated adhesion regulates membrane orderGaus K, Le Lay S, Balasubramanian N, Schwartz MA. Integrin-mediated adhesion regulates membrane order Journal Of Cell Biology 2006, 174: 725-734. PMID: 16943184, PMCID: PMC2064315, DOI: 10.1083/jcb.200603034.
- Matrix-specific Suppression of Integrin Activation in Shear Stress SignalingOrr AW, Ginsberg MH, Shattil SJ, Deckmyn H, Schwartz MA. Matrix-specific Suppression of Integrin Activation in Shear Stress Signaling Molecular Biology Of The Cell 2006, 17: 4686-4697. PMID: 16928957, PMCID: PMC1635406, DOI: 10.1091/mbc.e06-04-0289.
- Integrating Adhesion, Protrusion, and Contraction during Cell MigrationSchwartz MA, Horwitz AR. Integrating Adhesion, Protrusion, and Contraction during Cell Migration Cell 2006, 125: 1223-1225. PMID: 16814706, DOI: 10.1016/j.cell.2006.06.015.
- In Vivo Dynamics of Rac-Membrane InteractionsMoissoglu K, Slepchenko BM, Meller N, Horwitz AF, Schwartz MA. In Vivo Dynamics of Rac-Membrane Interactions Molecular Biology Of The Cell 2006, 17: 2770-2779. PMID: 16597700, PMCID: PMC1474787, DOI: 10.1091/mbc.e06-01-0005.
- A mechanosensory complex that mediates the endothelial cell response to fluid shear stressTzima E, Irani‐Tehrani M, Kiosses W, Dejana E, Schultz D, Engelhardt B, Cao G, DeLisser H, Schwartz M. A mechanosensory complex that mediates the endothelial cell response to fluid shear stress The FASEB Journal 2006, 20: a1378-a1378. DOI: 10.1096/fasebj.20.5.a1378-c.
- Mechanisms of MechanotransductionOrr A, Helmke B, Blackman B, Schwartz M. Mechanisms of Mechanotransduction Developmental Cell 2006, 10: 407. DOI: 10.1016/j.devcel.2006.02.015.
- Mechanisms of MechanotransductionOrr AW, Helmke BP, Blackman BR, Schwartz MA. Mechanisms of Mechanotransduction Developmental Cell 2006, 10: 11-20. PMID: 16399074, DOI: 10.1016/j.devcel.2005.12.006.
- Regulation of Cell Adhesion Responses by Abl Family KinasesTanis K, Schwartz M. Regulation of Cell Adhesion Responses by Abl Family Kinases 2006, 16-25. DOI: 10.1007/978-0-387-68744-5_3.
- αvβ3 Integrin Activation and Matrix Binding Mediate Cellular Responses to Mechanical Stretch.Katsumi A, Matsushita T, Naoe T, Schwartz M. αvβ3 Integrin Activation and Matrix Binding Mediate Cellular Responses to Mechanical Stretch. Blood 2005, 106: 3689-3689. DOI: 10.1182/blood.v106.11.3689.3689.
- Integrin-dependent actomyosin contraction regulates epithelial cell scatteringde Rooij J, Kerstens A, Danuser G, Schwartz MA, Waterman-Storer CM. Integrin-dependent actomyosin contraction regulates epithelial cell scattering Journal Of Cell Biology 2005, 171: 153-164. PMID: 16216928, PMCID: PMC2171213, DOI: 10.1083/jcb.200506152.
- 12/15-Lipoxygenase Regulates Intercellular Adhesion Molecule-1 Expression and Monocyte Adhesion to Endothelium Through Activation of RhoA and Nuclear Factor-&kgr;BBolick DT, Orr AW, Whetzel A, Srinivasan S, Hatley ME, Schwartz MA, Hedrick CC. 12/15-Lipoxygenase Regulates Intercellular Adhesion Molecule-1 Expression and Monocyte Adhesion to Endothelium Through Activation of RhoA and Nuclear Factor-&kgr;B Arteriosclerosis Thrombosis And Vascular Biology 2005, 25: 2301-2307. PMID: 16166569, DOI: 10.1161/01.atv.0000186181.19909.a6.
- A mechanosensory complex that mediates the endothelial cell response to fluid shear stressTzima E, Irani-Tehrani M, Kiosses WB, Dejana E, Schultz DA, Engelhardt B, Cao G, DeLisser H, Schwartz MA. A mechanosensory complex that mediates the endothelial cell response to fluid shear stress Nature 2005, 437: 426-431. PMID: 16163360, DOI: 10.1038/nature03952.
- Phospho-caveolin-1 mediates integrin-regulated membrane domain internalizationdel Pozo MA, Balasubramanian N, Alderson NB, Kiosses WB, Grande-García A, Anderson RG, Schwartz MA. Phospho-caveolin-1 mediates integrin-regulated membrane domain internalization Nature Cell Biology 2005, 7: 901-908. PMID: 16113676, PMCID: PMC1351395, DOI: 10.1038/ncb1293.
- The subendothelial extracellular matrix modulates NF-κB activation by flowOrr AW, Sanders JM, Bevard M, Coleman E, Sarembock IJ, Schwartz MA. The subendothelial extracellular matrix modulates NF-κB activation by flow Journal Of Cell Biology 2005, 169: 191-202. PMID: 15809308, PMCID: PMC2171897, DOI: 10.1083/jcb.200410073.
- Integrin Activation and Matrix Binding Mediate Cellular Responses to Mechanical Stretch*Katsumi A, Naoe T, Matsushita T, Kaibuchi K, Schwartz MA. Integrin Activation and Matrix Binding Mediate Cellular Responses to Mechanical Stretch* Journal Of Biological Chemistry 2005, 280: 16546-16549. PMID: 15760908, DOI: 10.1074/jbc.c400455200.
- Model of coupled transient changes of Rac, Rho, adhesions and stress fibers alignment in endothelial cells responding to shear stressCivelekoglu-Scholey G, Orr A, Novak I, Meister J, Schwartz M, Mogilner A. Model of coupled transient changes of Rac, Rho, adhesions and stress fibers alignment in endothelial cells responding to shear stress Journal Of Theoretical Biology 2005, 232: 569-585. PMID: 15588637, DOI: 10.1016/j.jtbi.2004.09.004.
- Zizimin2: a novel, DOCK180‐related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytesNishikimi A, Meller N, Uekawa N, Isobe K, Schwartz MA, Maruyama M. Zizimin2: a novel, DOCK180‐related Cdc42 guanine nucleotide exchange factor expressed predominantly in lymphocytes FEBS Letters 2005, 579: 1039-1046. PMID: 15710388, DOI: 10.1016/j.febslet.2005.01.006.
- Rho proteins in cell migration and metastasis.Titus B, Schwartz MA, Theodorescu D. Rho proteins in cell migration and metastasis. Critical Reviews In Eukaryotic Gene Expression 2005, 15: 103-14. PMID: 16022631, DOI: 10.1615/critreveukargeneexpr.v15.i2.20.
- Rho Proteins in Cell Migration and MetastasisTitus B, Schwartz M, Theodorescu D. Rho Proteins in Cell Migration and Metastasis Critical Reviews In Eukaryotic Gene Expression 2005, 15: 103-114. DOI: 10.1615/critreveukaryotgeneexpr.v15.i2.20.
- VE-cadherin Links tRNA Synthetase Cytokine to Anti-angiogenic Function*Tzima E, Reader JS, Irani-Tehrani M, Ewalt KL, Schwartz MA, Schimmel P. VE-cadherin Links tRNA Synthetase Cytokine to Anti-angiogenic Function* Journal Of Biological Chemistry 2004, 280: 2405-2408. PMID: 15579907, DOI: 10.1074/jbc.c400431200.
- Rho signalling at a glanceSchwartz M. Rho signalling at a glance Journal Of Cell Science 2004, 117: 5457-5458. PMID: 15509861, DOI: 10.1242/jcs.01582.
- p21-activated Kinase Regulates Endothelial Permeability through Modulation of Contractility*Stockton RA, Schaefer E, Schwartz MA. p21-activated Kinase Regulates Endothelial Permeability through Modulation of Contractility* Journal Of Biological Chemistry 2004, 279: 46621-46630. PMID: 15333633, DOI: 10.1074/jbc.m408877200.
- The Novel Cdc42 Guanine Nucleotide Exchange Factor, Zizimin1, Dimerizes via the Cdc42-binding CZH2 Domain*Meller N, Irani-Tehrani M, Ratnikov BI, Paschal BM, Schwartz MA. The Novel Cdc42 Guanine Nucleotide Exchange Factor, Zizimin1, Dimerizes via the Cdc42-binding CZH2 Domain* Journal Of Biological Chemistry 2004, 279: 37470-37476. PMID: 15247287, DOI: 10.1074/jbc.m404535200.
- Putting the Squeeze on MechanotransductionHelmke BP, Schwartz MA. Putting the Squeeze on Mechanotransduction Developmental Cell 2004, 6: 745-746. PMID: 15177022, DOI: 10.1016/j.devcel.2004.05.013.
- ROLE OF CELL-CELL JUNCTIONS IN MEDIATING ENDOTHELIAL CELL RESPONSES TO FLUID SHEAR STRESSTzima E, Irani-Tehrani M, Dejana E, Schwartz M. ROLE OF CELL-CELL JUNCTIONS IN MEDIATING ENDOTHELIAL CELL RESPONSES TO FLUID SHEAR STRESS Cardiovascular Pathology 2004, 13: 41. DOI: 10.1016/j.carpath.2004.03.115.
- Rho Mediates the Shear-Enhancement of Endothelial Cell Migration and Traction Force GenerationShiu YT, Li S, Marganski WA, Usami S, Schwartz MA, Wang YL, Dembo M, Chien S. Rho Mediates the Shear-Enhancement of Endothelial Cell Migration and Traction Force Generation Biophysical Journal 2004, 86: 2558-2565. PMID: 15041692, PMCID: PMC1304103, DOI: 10.1016/s0006-3495(04)74311-8.
- Integrins in Mechanotransduction*Katsumi A, Orr AW, Tzima E, Schwartz MA. Integrins in Mechanotransduction* Journal Of Biological Chemistry 2004, 279: 12001-12004. PMID: 14960578, DOI: 10.1074/jbc.r300038200.
- Integrins Regulate Rac Targeting by Internalization of Membrane Domainsdel Pozo MA, Alderson NB, Kiosses WB, Chiang HH, Anderson RG, Schwartz MA. Integrins Regulate Rac Targeting by Internalization of Membrane Domains Science 2004, 303: 839-842. PMID: 14764880, DOI: 10.1126/science.1092571.
- Cell Migration: Integrating Signals from Front to BackRidley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR. Cell Migration: Integrating Signals from Front to Back Science 2003, 302: 1704-1709. PMID: 14657486, DOI: 10.1126/science.1092053.
- Biologically active fragment of a human tRNA synthetase inhibits fluid shear stress-activated responses of endothelial cellsTzima E, Reader J, Irani-Tehrani M, Ewalt K, Schwartz M, Schimmel P. Biologically active fragment of a human tRNA synthetase inhibits fluid shear stress-activated responses of endothelial cells Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 14903-14907. PMID: 14630953, PMCID: PMC299850, DOI: 10.1073/pnas.2436330100.
- Modulation of Rac Localization and Function by DynaminSchlunck G, Damke H, Kiosses WB, Rusk N, Symons MH, Waterman-Storer CM, Schmid SL, Schwartz MA. Modulation of Rac Localization and Function by Dynamin Molecular Biology Of The Cell 2003, 15: 256-267. PMID: 14617821, PMCID: PMC307545, DOI: 10.1091/mbc.e03-01-0019.
- Differential αv integrin–mediated Ras-ERK signaling during two pathways of angiogenesisHood JD, Frausto R, Kiosses WB, Schwartz MA, Cheresh DA. Differential αv integrin–mediated Ras-ERK signaling during two pathways of angiogenesis Journal Of Cell Biology 2003, 162: 933-943. PMID: 12952943, PMCID: PMC2172815, DOI: 10.1083/jcb.200304105.
- Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-AblTruong T, Sun G, Doorly M, Wang JY, Schwartz MA. Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-Abl Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 10281-10286. PMID: 12928501, PMCID: PMC193552, DOI: 10.1073/pnas.1635435100.
- Electrochemically Derived Gradients of the Extracellular Matrix Protein Fibronectin on GoldPlummer S, Wang Q, Bohn P, Stockton R, Schwartz M. Electrochemically Derived Gradients of the Extracellular Matrix Protein Fibronectin on Gold Langmuir 2003, 19: 7528-7536. DOI: 10.1021/la030075r.
- Rho-ROCK-LIMK-Cofilin Pathway Regulates Shear Stress Activation of Sterol Regulatory Element Binding ProteinsLin T, Zeng L, Liu Y, DeFea K, Schwartz MA, Chien S, Shyy J. Rho-ROCK-LIMK-Cofilin Pathway Regulates Shear Stress Activation of Sterol Regulatory Element Binding Proteins Circulation Research 2003, 92: 1296-1304. PMID: 12775580, DOI: 10.1161/01.res.0000078780.65824.8b.
- Localized Cdc42 Activation, Detected Using a Novel Assay, Mediates Microtubule Organizing Center Positioning in Endothelial Cells in Response to Fluid Shear Stress*Tzima E, Kiosses WB, del Pozo MA, Schwartz MA. Localized Cdc42 Activation, Detected Using a Novel Assay, Mediates Microtubule Organizing Center Positioning in Endothelial Cells in Response to Fluid Shear Stress* Journal Of Biological Chemistry 2003, 278: 31020-31023. PMID: 12754216, DOI: 10.1074/jbc.m301179200.
- Guanine Exchange-Dependent and -Independent Effects of Vav1 on Integrin-Induced T Cell Spreadingdel Pozo M, Schwartz M, Hu J, Kiosses W, Altman A, Villalba M. Guanine Exchange-Dependent and -Independent Effects of Vav1 on Integrin-Induced T Cell Spreading The Journal Of Immunology 2003, 170: 2242-2242. DOI: 10.4049/jimmunol.170.4.2242-a.
- Guanine Exchange-Dependent and -Independent Effects of Vav1 on Integrin-Induced T Cell Spreadingdel Pozo MA, Schwartz MA, Hu J, Kiosses WB, Altman A, Villalba M. Guanine Exchange-Dependent and -Independent Effects of Vav1 on Integrin-Induced T Cell Spreading The Journal Of Immunology 2003, 170: 41-47. PMID: 12496381, DOI: 10.4049/jimmunol.170.1.41.
- Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expressionTzima E, Del Pozo MA, Kiosses WB, Mohamed SA, Li S, Chien S, Schwartz MA. Activation of Rac1 by shear stress in endothelial cells mediates both cytoskeletal reorganization and effects on gene expression The EMBO Journal 2002, 21: 6791-6800. PMID: 12486000, PMCID: PMC139108, DOI: 10.1093/emboj/cdf688.
- Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteinsMeller N, Irani-Tehrani M, Kiosses WB, Del Pozo MA, Schwartz MA. Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins Nature Cell Biology 2002, 4: 639-647. PMID: 12172552, DOI: 10.1038/ncb835.
- Effects of cell tension on the small GTPase RacKatsumi A, Milanini J, Kiosses WB, del Pozo MA, Kaunas R, Chien S, Hahn KM, Schwartz MA. Effects of cell tension on the small GTPase Rac Journal Of Cell Biology 2002, 158: 153-164. PMID: 12105187, PMCID: PMC2173027, DOI: 10.1083/jcb.200201105.
- A Dominant-Negative p65 PAK Peptide Inhibits AngiogenesisKiosses WB, Hood J, Yang S, Gerritsen ME, Cheresh DA, Alderson N, Schwartz MA. A Dominant-Negative p65 PAK Peptide Inhibits Angiogenesis Circulation Research 2002, 90: 697-702. PMID: 11934838, DOI: 10.1161/01.res.0000014227.76102.5d.
- Networks and crosstalk: integrin signalling spreadsSchwartz MA, Ginsberg MH. Networks and crosstalk: integrin signalling spreads Nature Cell Biology 2002, 4: e65-e68. PMID: 11944032, DOI: 10.1038/ncb0402-e65.
- A Fragment of Paxillin Binds the α4Integrin Cytoplasmic Domain (Tail) and Selectively Inhibits α4-Mediated Cell Migration*Liu S, Kiosses WB, Rose DM, Slepak M, Salgia R, Griffin JD, Turner CE, Schwartz MA, Ginsberg MH. A Fragment of Paxillin Binds the α4Integrin Cytoplasmic Domain (Tail) and Selectively Inhibits α4-Mediated Cell Migration* Journal Of Biological Chemistry 2002, 277: 20887-20894. PMID: 11919182, DOI: 10.1074/jbc.m110928200.
- Integrins regulate the apoptotic response to DNA damage through modulation of p53Lewis JM, Truong TN, Schwartz MA. Integrins regulate the apoptotic response to DNA damage through modulation of p53 Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 3627-3632. PMID: 11904424, PMCID: PMC122574, DOI: 10.1073/pnas.062698499.
- Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDIDel Pozo MA, Kiosses WB, Alderson NB, Meller N, Hahn KM, Schwartz MA. Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI Nature Cell Biology 2002, 4: 232-239. PMID: 11862216, DOI: 10.1038/ncb759.
- Matrix and meaningSchwartz MA. Matrix and meaning 2002, 69: 13-16. PMID: 12070989, DOI: 10.1016/s0091-679x(02)69004-1.
- Integrin signaling revisitedSchwartz M. Integrin signaling revisited Trends In Cell Biology 2001, 11: 466-470. PMID: 11719050, DOI: 10.1016/s0962-8924(01)02152-3.
- Increased filamin binding to β-integrin cytoplasmic domains inhibits cell migrationCalderwood D, Huttenlocher A, Kiosses W, Rose D, Woodside D, Schwartz M, Ginsberg M. Increased filamin binding to β-integrin cytoplasmic domains inhibits cell migration Nature Cell Biology 2001, 3: 1060-1068. PMID: 11781567, DOI: 10.1038/ncb1201-1060.
- Timing of cyclin D1 expression within G1 phase is controlled by RhoWelsh C, Roovers K, Villanueva J, Liu Y, Schwartz M, Assoian R. Timing of cyclin D1 expression within G1 phase is controlled by Rho Nature Cell Biology 2001, 3: 950-957. PMID: 11715015, DOI: 10.1038/ncb1101-950.
- Ligation of Integrin α3β1 by Laminin 5 at the Wound Edge Activates Rho-dependent Adhesion of Leading Keratinocytes on Collagen*Nguyen B, Ren X, Schwartz M, Carter W. Ligation of Integrin α3β1 by Laminin 5 at the Wound Edge Activates Rho-dependent Adhesion of Leading Keratinocytes on Collagen* Journal Of Biological Chemistry 2001, 276: 43860-43870. PMID: 11571278, DOI: 10.1074/jbc.m103404200.
- Activation of integrins in endothelial cells by fluid shear stress mediates Rho‐dependent cytoskeletal alignmentTzima E, del Pozo M, Shattil S, Chien S, Schwartz M. Activation of integrins in endothelial cells by fluid shear stress mediates Rho‐dependent cytoskeletal alignment The EMBO Journal 2001, 20: 4639-4647. PMID: 11532928, PMCID: PMC125600, DOI: 10.1093/emboj/20.17.4639.
- Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways.Schwartz M, Assoian R. Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways. Journal Of Cell Science 2001, 114: 2553-60. PMID: 11683383, DOI: 10.1242/jcs.114.14.2553.
- c-Abl Tyrosine Kinase Binds and Phosphorylates Phospholipid Scramblase 1*Sun J, Zhao J, Schwartz M, Wang J, Wiedmer T, Sims P. c-Abl Tyrosine Kinase Binds and Phosphorylates Phospholipid Scramblase 1* Journal Of Biological Chemistry 2001, 276: 28984-28990. PMID: 11390389, DOI: 10.1074/jbc.m102505200.
- Rac recruits high-affinity integrin αvβ3 to lamellipodia in endothelial cell migrationKiosses W, Shattil S, Pampori N, Schwartz M. Rac recruits high-affinity integrin αvβ3 to lamellipodia in endothelial cell migration Nature Cell Biology 2001, 3: 316-320. PMID: 11231584, DOI: 10.1038/35060120.
- Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progressionAssoian R, Schwartz M. Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression Current Opinion In Genetics & Development 2001, 11: 48-53. PMID: 11163150, DOI: 10.1016/s0959-437x(00)00155-6.
- Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligandsJalali S, del Pozo M, Chen K, Miao H, Li Y, Schwartz M, Shyy J, Chien S. Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 1042-1046. PMID: 11158591, PMCID: PMC14705, DOI: 10.1073/pnas.98.3.1042.
- The Molecular Adapter SLP-76 Relays Signals from Platelet Integrin αIIbβ3 to the Actin Cytoskeleton*Obergfell A, Judd B, del Pozo M, Schwartz M, Koretzky G, Shattil S. The Molecular Adapter SLP-76 Relays Signals from Platelet Integrin αIIbβ3 to the Actin Cytoskeleton* Journal Of Biological Chemistry 2000, 276: 5916-5923. PMID: 11113155, DOI: 10.1074/jbc.m010639200.
- Cell Adhesion Regulates Ubiquitin-mediated Degradation of the Platelet-derived Growth Factor Receptor β*Baron V, Schwartz M. Cell Adhesion Regulates Ubiquitin-mediated Degradation of the Platelet-derived Growth Factor Receptor β* Journal Of Biological Chemistry 2000, 275: 39318-39323. PMID: 11007771, DOI: 10.1074/jbc.m003618200.
- Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnoverRen X, Kiosses W, Sieg D, Otey C, Schlaepfer D, Schwartz M. Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnover Journal Of Cell Science 2000, 113: 3673-3678. PMID: 11017882, DOI: 10.1242/jcs.113.20.3673.
- Localized Rac Activation Dynamics Visualized in Living CellsKraynov V, Chamberlain C, Bokoch G, Schwartz M, Slabaugh S, Hahn K. Localized Rac Activation Dynamics Visualized in Living Cells Science 2000, 290: 333-337. PMID: 11030651, DOI: 10.1126/science.290.5490.333.
- Death Effector Domain Protein PEA-15 Potentiates Ras Activation of Extracellular Signal Receptor-activated Kinase by an Adhesion-independent MechanismRamos J, Hughes P, Renshaw M, Schwartz M, Formstecher E, Chneiweiss H, Ginsberg M. Death Effector Domain Protein PEA-15 Potentiates Ras Activation of Extracellular Signal Receptor-activated Kinase by an Adhesion-independent Mechanism Molecular Biology Of The Cell 2000, 11: 2863-2872. PMID: 10982386, PMCID: PMC14961, DOI: 10.1091/mbc.11.9.2863.
- Stimulation of Fascin Spikes by Thrombospondin-1 Is Mediated by the Gtpases Rac and Cdc42Adams J, Schwartz M. Stimulation of Fascin Spikes by Thrombospondin-1 Is Mediated by the Gtpases Rac and Cdc42 Journal Of Cell Biology 2000, 150: 807-822. PMID: 10953005, PMCID: PMC2175285, DOI: 10.1083/jcb.150.4.807.
- Signaling networks linking integrins and Rho family GTPasesSchwartz M, Shattil S. Signaling networks linking integrins and Rho family GTPases Trends In Biochemical Sciences 2000, 25: 388-391. PMID: 10916159, DOI: 10.1016/s0968-0004(00)01605-4.
- Antibody-Induced Activation of β1 Integrin Receptors Stimulates cAMP-Dependent Migration of Breast Cells on Laminin-5Plopper G, Huff J, Rust W, Schwartz M, Quaranta V. Antibody-Induced Activation of β1 Integrin Receptors Stimulates cAMP-Dependent Migration of Breast Cells on Laminin-5 Archives Of Biochemistry And Biophysics 2000, 4: 129-135. PMID: 11170844, DOI: 10.1006/mcbr.2001.0267.
- The c-Abl tyrosine kinase contributes to the transient activation of MAP kinase in cells plated on fibronectinRenshaw M, Lewis J, Schwartz M. The c-Abl tyrosine kinase contributes to the transient activation of MAP kinase in cells plated on fibronectin Oncogene 2000, 19: 3216-3219. PMID: 10918577, DOI: 10.1038/sj.onc.1203667.
- Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAKdel Pozo M, Price L, Alderson N, Ren X, Schwartz M. Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK The EMBO Journal 2000, 19: 2008-2014. PMID: 10790367, PMCID: PMC305684, DOI: 10.1093/emboj/19.9.2008.
- Determination of GTP loading on RhoRen X, Schwartz M. Determination of GTP loading on Rho 2000, 325: 264-272. PMID: 11036609, DOI: 10.1016/s0076-6879(00)25448-7.
- A Role for P21-Activated Kinase in Endothelial Cell MigrationKiosses W, Daniels R, Otey C, Bokoch G, Schwartz M. A Role for P21-Activated Kinase in Endothelial Cell Migration Journal Of Cell Biology 1999, 147: 831-844. PMID: 10562284, PMCID: PMC2156168, DOI: 10.1083/jcb.147.4.831.
- Focal Adhesion Kinase Mediates the Integrin Signaling Requirement for Growth Factor Activation of Map KinaseRenshaw M, Price L, Schwartz M. Focal Adhesion Kinase Mediates the Integrin Signaling Requirement for Growth Factor Activation of Map Kinase Journal Of Cell Biology 1999, 147: 611-618. PMID: 10545504, PMCID: PMC2151196, DOI: 10.1083/jcb.147.3.611.
- Interactions between mitogenic stimuli, or, a thousand and one connectionsSchwartz M, Baron V. Interactions between mitogenic stimuli, or, a thousand and one connections Current Opinion In Cell Biology 1999, 11: 197-202. PMID: 10209147, DOI: 10.1016/s0955-0674(99)80026-x.
- Mutational Analysis of Cell Cycle Inhibition by Integrin β1C *Meredith J, Kiosses W, Takada Y, Schwartz M. Mutational Analysis of Cell Cycle Inhibition by Integrin β1C * Journal Of Biological Chemistry 1999, 274: 8111-8116. PMID: 10075712, DOI: 10.1074/jbc.274.12.8111.
- Regulation of the small GTP‐binding protein Rho by cell adhesion and the cytoskeletonRen X, Kiosses W, Schwartz M. Regulation of the small GTP‐binding protein Rho by cell adhesion and the cytoskeleton The EMBO Journal 1999, 18: 578-585. PMID: 9927417, PMCID: PMC1171150, DOI: 10.1093/emboj/18.3.578.
- Integrin-dependent Tyrosine Phosphorylation and Growth Regulation by VavYron I, Deckert M, Reff M, Munshi A, Schwartz M, Altman A. Integrin-dependent Tyrosine Phosphorylation and Growth Regulation by Vav Cell Communication & Adhesion 1999, 7: 1-11. PMID: 10228731, DOI: 10.3109/15419069909034388.
- An activated Rac mutant functions as a dominant negative for membrane rufflingSchwartz M, Meredith J, Kiosses W. An activated Rac mutant functions as a dominant negative for membrane ruffling Oncogene 1998, 17: 625-629. PMID: 9704928, DOI: 10.1038/sj.onc.1201977.
- Activation of Rac and Cdc42 by Integrins Mediates Cell SpreadingPrice L, Leng J, Schwartz M, Bokoch G. Activation of Rac and Cdc42 by Integrins Mediates Cell Spreading Molecular Biology Of The Cell 1998, 9: 1863-1871. PMID: 9658176, PMCID: PMC25428, DOI: 10.1091/mbc.9.7.1863.
- Integrins Regulate the Association and Phosphorylation of Paxillin by c-Abl*Lewis J, Schwartz M. Integrins Regulate the Association and Phosphorylation of Paxillin by c-Abl* Journal Of Biological Chemistry 1998, 273: 14225-14230. PMID: 9603926, DOI: 10.1074/jbc.273.23.14225.
- Regulation of inositol lipid kinases by Rho and RacRen X, Schwartz M. Regulation of inositol lipid kinases by Rho and Rac Current Opinion In Genetics & Development 1998, 8: 63-67. PMID: 9529607, DOI: 10.1016/s0959-437x(98)80063-4.
- Integrins, Oncogenes, and Anchorage IndependenceSchwartz M. Integrins, Oncogenes, and Anchorage Independence Journal Of Cell Biology 1997, 139: 575-578. PMID: 9348275, PMCID: PMC2141711, DOI: 10.1083/jcb.139.3.575.
- Growth factor activation of MAP kinase requires cell adhesionRenshaw M, Ren X, Schwartz M. Growth factor activation of MAP kinase requires cell adhesion The EMBO Journal 1997, 16: 5592-5599. PMID: 9312018, PMCID: PMC1170191, DOI: 10.1093/emboj/16.18.5592.
- Role of Rho and myosin phosphorylation in actin stress fiber assembly in mesangial cellsKreisberg J, Ghosh-Choudhury N, Radnik R, Schwartz M. Role of Rho and myosin phosphorylation in actin stress fiber assembly in mesangial cells American Journal Of Physiology 1997, 273: f283-f288. PMID: 9277589, DOI: 10.1152/ajprenal.1997.273.2.f283.
- Affinity Modulation of Platelet Integrin αIIbβ3 by β3-Endonexin, a Selective Binding Partner of the β3 Integrin Cytoplasmic TailKashiwagi H, Schwartz M, Eigenthaler M, Davis K, Ginsberg M, Shattil S. Affinity Modulation of Platelet Integrin αIIbβ3 by β3-Endonexin, a Selective Binding Partner of the β3 Integrin Cytoplasmic Tail Journal Of Cell Biology 1997, 137: 1433-1443. PMID: 9182673, PMCID: PMC2132534, DOI: 10.1083/jcb.137.6.1433.
- Integrins, adhesion and apoptosisMeredith J, Schwartz M. Integrins, adhesion and apoptosis Trends In Cell Biology 1997, 7: 146-150. PMID: 17708932, DOI: 10.1016/s0962-8924(97)01002-7.
- Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo.Brooks P, Klemke R, Schon S, Lewis J, Schwartz M, Cheresh D. Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo. Journal Of Clinical Investigation 1997, 99: 1390-1398. PMID: 9077549, PMCID: PMC507955, DOI: 10.1172/jci119298.
- Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase PathwayHughes P, Renshaw M, Pfaff M, Forsyth J, Keivens V, Schwartz M, Ginsberg M. Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway Cell 1997, 88: 521-530. PMID: 9038343, DOI: 10.1016/s0092-8674(00)81892-9.
- Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic–nuclear transportLewis J, Baskaran R, Taagepera S, Schwartz M, Wang J. Integrin regulation of c-Abl tyrosine kinase activity and cytoplasmic–nuclear transport Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 15174-15179. PMID: 8986783, PMCID: PMC26376, DOI: 10.1073/pnas.93.26.15174.
- Transformation by Rho exchange factor oncogenes is mediated by activation of an integrin‐dependent pathway.Schwartz M, Toksoz D, Khosravi‐Far R. Transformation by Rho exchange factor oncogenes is mediated by activation of an integrin‐dependent pathway. The EMBO Journal 1996, 15: 6525-6530. PMID: 8978679, PMCID: PMC452477, DOI: 10.1002/j.1460-2075.1996.tb01043.x.
- Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation.Lewis J, Cheresh D, Schwartz M. Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation. Journal Of Cell Biology 1996, 134: 1323-1332. PMID: 8794871, PMCID: PMC2120976, DOI: 10.1083/jcb.134.5.1323.
- Involvement of the Small GTPase Rho in Integrin-mediated Activation of Mitogen-activated Protein Kinase*Renshaw M, Toksoz D, Schwartz M. Involvement of the Small GTPase Rho in Integrin-mediated Activation of Mitogen-activated Protein Kinase* Journal Of Biological Chemistry 1996, 271: 21691-21694. PMID: 8702960, DOI: 10.1074/jbc.271.36.21691.
- The regulation of growth and intracellular signaling by integrins.Meredith J, Winitz S, Lewis J, Hess S, Ren X, Renshaw M, Schwartz M. The regulation of growth and intracellular signaling by integrins. Endocrine Reviews 1996, 17: 207-20. PMID: 8771356, DOI: 10.1210/edrv-17-3-207.
- Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells.Ren X, Bokoch G, Traynor-Kaplan A, Jenkins G, Anderson R, Schwartz M. Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells. Molecular Biology Of The Cell 1996, 7: 435-442. PMID: 8868471, PMCID: PMC275895, DOI: 10.1091/mbc.7.3.435.
- integrins mediate the rise in intracellular calcium in endothelial cells on fibronectin even though they play a minor role in adhesion.Schwartz M, Denninghoff K. integrins mediate the rise in intracellular calcium in endothelial cells on fibronectin even though they play a minor role in adhesion. Journal Of Biological Chemistry 1995, 270: 30235-30235. DOI: 10.1074/jbc.270.50.30235.
- Integrin signaling: roles for the cytoplasmic tails of alpha IIb beta 3 in the tyrosine phosphorylation of pp125FAK.Leong L, Hughes P, Schwartz M, Ginsberg M, Shattil S. Integrin signaling: roles for the cytoplasmic tails of alpha IIb beta 3 in the tyrosine phosphorylation of pp125FAK. Journal Of Cell Science 1995, 108 ( Pt 12): 3817-25. PMID: 8719888, DOI: 10.1242/jcs.108.12.3817.
- Integrins: Emerging Paradigms of Signal TransductionSchwartz M, Schaller M, Ginsberg M. Integrins: Emerging Paradigms of Signal Transduction Annual Review Of Cell And Developmental Biology 1995, 11: 549-599. PMID: 8689569, DOI: 10.1146/annurev.cb.11.110195.003001.
- Inhibition of Cell Cycle Progression by the Alternatively Spliced Integrin β1CMeredith J, Takada Y, Fornaro M, Languino L, Schwartz M. Inhibition of Cell Cycle Progression by the Alternatively Spliced Integrin β1C Science 1995, 269: 1570-1572. PMID: 7545312, DOI: 10.1126/science.7545312.
- Mapping in vivo associations of cytoplasmic proteins with integrin beta 1 cytoplasmic domain mutants.Lewis J, Schwartz M. Mapping in vivo associations of cytoplasmic proteins with integrin beta 1 cytoplasmic domain mutants. Molecular Biology Of The Cell 1995, 6: 151-160. PMID: 7540435, PMCID: PMC275825, DOI: 10.1091/mbc.6.2.151.
- The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cellsChong L, Traynor-Kaplan A, Bokoch G, Schwartz M. The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells Cell 1994, 79: 507-513. PMID: 7954816, DOI: 10.1016/0092-8674(94)90259-3.
- Differing structural requirements for GTPase-activating protein responsiveness and NADPH oxidase activation by Rac.Xu X, Barry D, Settleman J, Schwartz M, Bokoch G. Differing structural requirements for GTPase-activating protein responsiveness and NADPH oxidase activation by Rac. Journal Of Biological Chemistry 1994, 269: 23569-23574. PMID: 8089125, DOI: 10.1016/s0021-9258(17)31553-3.
- Integrating with integrins.Schwartz M, Ingber D. Integrating with integrins. Molecular Biology Of The Cell 1994, 5: 389-393. PMID: 8054683, PMCID: PMC301049, DOI: 10.1091/mbc.5.4.389.
- Alpha v integrins mediate the rise in intracellular calcium in endothelial cells on fibronectin even though they play a minor role in adhesionSchwartz M, Denninghoff K. Alpha v integrins mediate the rise in intracellular calcium in endothelial cells on fibronectin even though they play a minor role in adhesion Journal Of Biological Chemistry 1994, 269: 11133-11137. PMID: 7512559, DOI: 10.1016/s0021-9258(19)78101-0.
- Immunolocalization of anion exchanger AE2 and cation exchanger NHE-1 in distinct adjacent cells of gastric mucosaStuart-Tilley A, Sardet C, Pouyssegur J, Schwartz M, Brown D, Alper S. Immunolocalization of anion exchanger AE2 and cation exchanger NHE-1 in distinct adjacent cells of gastric mucosa American Journal Of Physiology 1994, 266: c559-c568. PMID: 8141271, DOI: 10.1152/ajpcell.1994.266.2.c559.
- Integrins as Signal Transducing ReceptorsSchwartz M. Integrins as Signal Transducing Receptors 1994, 33-47. DOI: 10.1016/b978-0-08-091729-0.50007-3.
- The extracellular matrix as a cell survival factor.Meredith J, Fazeli B, Schwartz M. The extracellular matrix as a cell survival factor. Molecular Biology Of The Cell 1993, 4: 953-961. PMID: 8257797, PMCID: PMC275725, DOI: 10.1091/mbc.4.9.953.
- A 50-kDa integrin-associated protein is required for integrin-regulated calcium entry in endothelial cells.Schwartz M, Brown E, Fazeli B. A 50-kDa integrin-associated protein is required for integrin-regulated calcium entry in endothelial cells. Journal Of Biological Chemistry 1993, 268: 19931-19934. PMID: 8376355, DOI: 10.1016/s0021-9258(20)80675-9.
- Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown.McNamee H, Ingber D, Schwartz M. Adhesion to fibronectin stimulates inositol lipid synthesis and enhances PDGF-induced inositol lipid breakdown. Journal Of Cell Biology 1993, 121: 673-678. PMID: 8387531, PMCID: PMC2119575, DOI: 10.1083/jcb.121.3.673.
- Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms.Leavesley D, Schwartz M, Rosenfeld M, Cheresh D. Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms. Journal Of Cell Biology 1993, 121: 163-170. PMID: 7681432, PMCID: PMC2119781, DOI: 10.1083/jcb.121.1.163.
- Signaling by integrins: implications for tumorigenesis.Schwartz M. Signaling by integrins: implications for tumorigenesis. Cancer Research 1993, 53: 1503-6. PMID: 8453614.
- Spreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular free calcium.Schwartz M. Spreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular free calcium. Journal Of Cell Biology 1993, 120: 1003-1010. PMID: 7679387, PMCID: PMC2200079, DOI: 10.1083/jcb.120.4.1003.
- Transmembrane signalling by integrinsSchwartz M. Transmembrane signalling by integrins Trends In Cell Biology 1992, 2: 304-308. PMID: 14731926, DOI: 10.1016/0962-8924(92)90120-c.
- Adhesion is required for protein kinase C-dependent activation of the Na+/H+ antiporter by platelet-derived growth factor.Schwartz M, Lechene C. Adhesion is required for protein kinase C-dependent activation of the Na+/H+ antiporter by platelet-derived growth factor. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 6138-6141. PMID: 1378621, PMCID: PMC402137, DOI: 10.1073/pnas.89.13.6138.
- Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape.Schwartz M, Lechene C, Ingber D. Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 7849-7853. PMID: 1652767, PMCID: PMC52401, DOI: 10.1073/pnas.88.17.7849.
- Multiple integrins share the ability to induce elevation of intracellular pHSchwartz M, Ingber D, Lawrence M, Springer T, Lechene C. Multiple integrins share the ability to induce elevation of intracellular pH Experimental Cell Research 1991, 195: 533-535. PMID: 1712734, DOI: 10.1016/0014-4827(91)90407-l.
- Binding of actin to liver cell membranes: the state of membrane-bound actin.Tranter M, Sugrue S, Schwartz M. Binding of actin to liver cell membranes: the state of membrane-bound actin. Journal Of Cell Biology 1991, 112: 891-901. PMID: 1705560, PMCID: PMC2288875, DOI: 10.1083/jcb.112.5.891.
- Radiolabel‐transfer cross‐linking demonstrates that protein 4.1 binds to the N‐terminal region of β spectrin and to actin in binary interactionsBECKER P, SCHWARTZ M, MORROW J, Samuel E. Radiolabel‐transfer cross‐linking demonstrates that protein 4.1 binds to the N‐terminal region of β spectrin and to actin in binary interactions The FEBS Journal 1990, 193: 827-836. PMID: 2249696, DOI: 10.1111/j.1432-1033.1990.tb19406.x.
- Control of intracellular pH and growth by fibronectin in capillary endothelial cells.Ingber D, Prusty D, Frangioni J, Cragoe E, Lechene C, Schwartz M. Control of intracellular pH and growth by fibronectin in capillary endothelial cells. Journal Of Cell Biology 1990, 110: 1803-1811. PMID: 2159481, PMCID: PMC2200182, DOI: 10.1083/jcb.110.5.1803.
- pH regulation in spread cells and round cells.Schwartz M, Cragoe E, Lechene C. pH regulation in spread cells and round cells. Journal Of Biological Chemistry 1990, 265: 1327-1332. PMID: 2153127, DOI: 10.1016/s0021-9258(19)40017-3.
- Cytoplasmic pH and anchorage-independent growth induced by v-Ki-ras, v-src or polyoma middle T.Schwartz M, Rupp E, Frangioni J, Lechene C. Cytoplasmic pH and anchorage-independent growth induced by v-Ki-ras, v-src or polyoma middle T. Oncogene 1990, 5: 55-8. PMID: 2181378.
- Evidence for a direct, nucleotide-sensitive interaction between actin and liver cell membranes.Tranter M, Sugrue S, Schwartz M. Evidence for a direct, nucleotide-sensitive interaction between actin and liver cell membranes. Journal Of Cell Biology 1989, 109: 2833-2840. PMID: 2592407, PMCID: PMC2115935, DOI: 10.1083/jcb.109.6.2833.
- Effect of cell spreading on cytoplasmic pH in normal and transformed fibroblasts.Schwartz M, Both G, Lechene C. Effect of cell spreading on cytoplasmic pH in normal and transformed fibroblasts. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 4525-4529. PMID: 2734302, PMCID: PMC287303, DOI: 10.1073/pnas.86.12.4525.
- Studying the Cytoskeleton by Label Transfer Crosslinking: Uses and LimitationsSchwartz M. Studying the Cytoskeleton by Label Transfer Crosslinking: Uses and Limitations 1989, 157-168. DOI: 10.1007/978-94-009-0925-0_11.
- How actin binds and assembles onto plasma membranes from Dictyostelium discoideum.Schwartz M, Luna E. How actin binds and assembles onto plasma membranes from Dictyostelium discoideum. Journal Of Cell Biology 1988, 107: 201-209. PMID: 3392099, PMCID: PMC2115166, DOI: 10.1083/jcb.107.1.201.
- Binding and assembly of actin filaments by plasma membranes from Dictyostelium discoideum.Schwartz M, Luna E. Binding and assembly of actin filaments by plasma membranes from Dictyostelium discoideum. Journal Of Cell Biology 1986, 102: 2067-2075. PMID: 2423531, PMCID: PMC2114255, DOI: 10.1083/jcb.102.6.2067.
- A 125I-radiolabel transfer crosslinking reagent with a novel cleavable groupSchwartz M. A 125I-radiolabel transfer crosslinking reagent with a novel cleavable group Analytical Biochemistry 1985, 149: 142-152. PMID: 4073473, DOI: 10.1016/0003-2697(85)90487-7.
- Cell-Cell Contact Proteins in Antigen-Specific and Antigen-Nonspecific Cellular CytotoxicitySitkovsky M, Schwartz M, Eisen H. Cell-Cell Contact Proteins in Antigen-Specific and Antigen-Nonspecific Cellular Cytotoxicity 1985, 184: 429-449. PMID: 3875975, DOI: 10.1007/978-1-4684-8326-0_29.
- Analysis of platelet adhesion with a radioactive chemical crosslinking reagent: Interaction of thrombospondin with fibronectin and collagenLahav J, Schwartz M, Hynes R. Analysis of platelet adhesion with a radioactive chemical crosslinking reagent: Interaction of thrombospondin with fibronectin and collagen Cell 1982, 31: 253-262. PMID: 7159924, DOI: 10.1016/0092-8674(82)90425-1.
- A new radioactive cross-linking reagent for studying the interactions of proteins.Schwartz M, Das O, Hynes R. A new radioactive cross-linking reagent for studying the interactions of proteins. Journal Of Biological Chemistry 1982, 257: 2343-2349. PMID: 7061425, DOI: 10.1016/s0021-9258(18)34928-7.
- Kinetics of antibody association with spin-label haptens on membrane surfacesParce J, Schwartz M, Owicki J, McConnell H. Kinetics of antibody association with spin-label haptens on membrane surfaces The Journal Of Physical Chemistry 1979, 83: 3414-3417. DOI: 10.1021/j100489a019.
- ChemInform Abstract: HYDROGEN ATOM EXCHANGE BETWEEN NITROXIDES AND HYDROXYLAMINESSCHWARTZ M, PARCE J, MCCONNELL H. ChemInform Abstract: HYDROGEN ATOM EXCHANGE BETWEEN NITROXIDES AND HYDROXYLAMINES ChemInform 1979, 10: no-no. DOI: 10.1002/chin.197940131.
- Hydrogen atom exchange between nitroxides and hydroxylaminesSchwartz M, Parce J, McConnell H. Hydrogen atom exchange between nitroxides and hydroxylamines Journal Of The American Chemical Society 1979, 101: 3592-3595. DOI: 10.1021/ja00507a026.
- Surface areas of lipid membranes.Schwartz M, McConnell H. Surface areas of lipid membranes. Biochemistry 1978, 17: 837-40. PMID: 629935, DOI: 10.1021/bi00598a014.
- A circular dichroism study of the effects of a hemolytic toxin from gymnodinium breve, the Florida red tide organism, on human erythrocyte membranesSchwartz M. A circular dichroism study of the effects of a hemolytic toxin from gymnodinium breve, the Florida red tide organism, on human erythrocyte membranes Journal Of Environmental Science And Health Part A 1976, 11: 573-581. DOI: 10.1080/10934527609385796.