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Lloyd G. Cantley, MD

C. N. H. Long Professor of Medicine (Nephrology) and Professor of Cellular And Molecular Physiology
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Additional Titles

Vice Chair, Research

Co-director of Education, Yale Center for Clinical Investigation

About

Titles

C. N. H. Long Professor of Medicine (Nephrology) and Professor of Cellular And Molecular Physiology

Vice Chair, Research; Co-director of Education, Yale Center for Clinical Investigation

Biography

Dr. Cantley performed his clinical Internal Medicine training at the University of North Carolina followed by Nephrology fellowship training at the Beth Israel and Brigham and Women's Hospitals in Boston. He then entered research training at Harvard in the laboratories of Dr. Franklin Epstein and Dr. Guido Guidotti before accepting a faculty position at the Beth Israel. In 2000 Dr. Cantley moved from Harvard to Yale where he established his research focus on the reparative tubular responses to kidney injury.

Appointments

Other Departments & Organizations

Education & Training

Nephrology Fellow
Beth Israel Hospital, Harvard Medical School (1990)
Resident
University of North Carolina (1984)
MD
West Virginia University (1981)
BS
West Virginia Wesleyan College (1977)

Research

Overview

The primary focus of our laboratory is to determine the mechanisms of renal tubule development, homeostasis and repair. When the kidney is injured following ischemia or toxin exposure, the remaining epithelial cells de-differentiate, spread over the denuded basement membrane, divide, and re-arrange themselves in a specific pattern to regenerate functional tubules. This process requires a complex array of events involving rearrangement of cell shape and regulation of cell-matrix and cell-cell interactions. By examining epithelial cell adhesion, migration, and branching tubulogenesis in response to growth factors such as Hepatocyte Growth Factor and chitin's 3-like 1, we are determining the intracellular signaling events critical for tubule formation during kidney development and following injury. We have focused these efforts on the role of activation of specific MAPK isoforms as well as the PI 3-kinase in the regulation of cell morphogenesis and cell-matrix interactions.

In addition, we are examining the role of the innate immune response to kidney injury and found that macrophages home to the injured kidney and initially promote apoptosis of sublethally injured tubular cells. Subsequent macrophage accumulation includes increasing numbers of alternatively activated macrophages that promote the survival and proliferation of the remaining tubular cells to effect tubule repair. We are currently expanding this work to study human acute kidney injury and have developed the use of Imaging Mass Cytometry in the human kidney.

Medical Subject Headings (MeSH)

Epithelial Cells; Kidney; Macrophages; Morphogenesis; Nephrology; Physiology

Research at a Glance

Yale Co-Authors

Frequent collaborators of Lloyd G. Cantley's published research.

Publications

2024

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Clinical Care

Overview

Lloyd G. Cantley, MD, is a nephrologist whose clinical practice focuses on kidney disorders such as acute kidney injury, kidney dysfunction, chronic kidney disease and electrolyte imbalances. He is the C. N. H. Long Professor of Medicine in nephrology, professor of cellular and molecular physiology, and co-director of education at the Yale Center for Clinical Investigation.

Dr. Cantley's research explores acute kidney injury, polycystic kidney disease, chronic kidney disease, and the immune system's involvement in kidney disease. His interests include the causes of acute injury and how repair can be optimized, progression of kidney diseases, and the link between kidney diseases and general health.

Dr. Cantley has received awards and support from organizations such as the National Center for Advancing Translational Sciences, the American Heart Association, the National Institute of Diabetes and Digestive and Kidney Diseases, and the Department of Defense.

Clinical Specialties

Nephrology; Internal Medicine

Board Certifications

  • Nephrology

    Certification Organization
    AB of Internal Medicine
    Original Certification Date
    1988

  • Internal Medicine

    Certification Organization
    AB of Internal Medicine
    Original Certification Date
    1984

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Contacts

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Academic Office Number
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Administrative Support

Locations

  • Yale Nephrology

    Academic Office

    The Anlyan Center

    300 Cedar Street, Ste Room S261

    New Haven, CT 06519

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  • Patient Care Locations

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