Jiankan Guo
Assistant Professor Adjunct
Research & Publications
Biography
News
Research Summary
Life originates from a stem cell. Proper control of cell type, mass, and cell-cell contact and communication makes functional tissues, organs, and body. The mystery behind any biological event is a combined effort of genetic, epigenetic, and environmental factors. We take kidney as a model organ to study its formation, function, repair, and possible regeneration.
Extensive Research Description
The metanephos (the permanent kidney in mammals) develops as a result of the interplay between metanephric mesenchyme (a clump of embryonic renal stem cells that root from intermediate mesoderm) and ureter bud (epithelial structure that derives from Wolffian duct). One of our long term goals is to understand the molecular events that govern kidney formation and functional maintenance by analyzing genetic or epigenetic factors. One of our other goals is to delineate pathways or to devise new methods that can induce embryonic stem cells toward renal lineage, which may eventually pave the way for repair/regeneration of renal epithelium.
Coauthors
Research Interests
Congenital, Hereditary, and Neonatal Diseases and Abnormalities; WAGR Syndrome
Selected Publications
- Authors' Reply: Most Arginase-1 Positive Cells Are Likely Injured S3 Proximal Tubular Cells Carrying Upregulated Phagocytotic Capacity rather than M2 Macrophages—Too Many To Be TrueShin N, Marlier A, Xu L, Doilicho N, Linberg D, Guo J, Cantley L. Authors' Reply: Most Arginase-1 Positive Cells Are Likely Injured S3 Proximal Tubular Cells Carrying Upregulated Phagocytotic Capacity rather than M2 Macrophages—Too Many To Be True. Journal Of The American Society Of Nephrology 2022, 33: 2124-2125. PMID: 36316094, PMCID: PMC9678031, DOI: 10.1681/asn.2022070836.
- Increased Tubular Proliferation as an Adaptive Response to Glomerular AlbuminuriaGuo JK, Marlier A, Shi H, Shan A, Ardito TA, Du ZP, Kashgarian M, Krause DS, Biemesderfer D, Cantley LG. Increased Tubular Proliferation as an Adaptive Response to Glomerular Albuminuria. Journal Of The American Society Of Nephrology 2011, 23: 429-437. PMID: 22193389, PMCID: PMC3294312, DOI: 10.1681/asn.2011040396.
- Cellular Maintenance and Repair of the KidneyGuo JK, Cantley LG. Cellular Maintenance and Repair of the Kidney. Annual Review Of Physiology 2010, 72: 357-376. PMID: 20148680, DOI: 10.1146/annurev.physiol.010908.163245.
- Erythropoietin expands a stromal cell population that can mediate renoprotectionBi B, Guo J, Marlier A, Lin SR, Cantley LG. Erythropoietin expands a stromal cell population that can mediate renoprotection. American Journal Of Physiology. Renal Physiology 2008, 295: f1017-f1022. PMID: 18653480, PMCID: PMC2576137, DOI: 10.1152/ajprenal.90218.2008.
- Prevention of mesangial sclerosis by bone marrow transplantationGuo J, Ardito TA, Kashgarian M, Krause DS. Prevention of mesangial sclerosis by bone marrow transplantation. Kidney International 2006, 70: 910-913. PMID: 16850025, DOI: 10.1038/sj.ki.5001698.
- An Inducible Mouse Model for PAX2-Dependent Glomerular Disease: Insights into a Complex PathogenesisWagner KD, Wagner N, Guo JK, Elger M, Dallman MJ, Bugeon L, Schedl A. An Inducible Mouse Model for PAX2-Dependent Glomerular Disease: Insights into a Complex Pathogenesis. Current Biology 2006, 16: 793-800. PMID: 16631587, DOI: 10.1016/j.cub.2006.02.072.
- Bone Marrow Transplantation Can Attenuate the Progression of Mesangial SclerosisGuo J, Schedl A, Krause DS. Bone Marrow Transplantation Can Attenuate the Progression of Mesangial Sclerosis. Stem Cells 2005, 24: 406-415. PMID: 16150922, DOI: 10.1634/stemcells.2005-0139.
- Early Gonadal Development: Exploring Wt1 and Sox9 FunctionGuo J, Hammes A, Chaboissier M, Vidal V, Xing Y, Wong F, Schedl A. Early Gonadal Development: Exploring Wt1 and Sox9 Function. 2002, 244: 23-34. PMID: 11990794, DOI: 10.1002/0470868732.ch3.
- WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosisGuo JK, Menke AL, Gubler MC, Clarke AR, Harrison D, Hammes A, Hastie ND, Schedl A. WT1 is a key regulator of podocyte function: reduced expression levels cause crescentic glomerulonephritis and mesangial sclerosis. Human Molecular Genetics 2002, 11: 651-659. PMID: 11912180, DOI: 10.1093/hmg/11.6.651.
- Two Splice Variants of the Wilms' Tumor 1 Gene Have Distinct Functions during Sex Determination and Nephron FormationHammes A, Guo J, Lutsch G, Leheste J, Landrock D, Ziegler U, Gubler M, Schedl A. Two Splice Variants of the Wilms' Tumor 1 Gene Have Distinct Functions during Sex Determination and Nephron Formation. Cell 2001, 106: 319-329. PMID: 11509181, DOI: 10.1016/s0092-8674(01)00453-6.