Kristen Brennand, PhD

• Flora Vaccarino
• Pasko Rakic

Biological Psychiatry; Neurodegenerative Diseases

Genetics, Genomics, Epigenetics

• Synergistic effects of common schizophrenia risk variantsSchrode N, Ho SM, Yamamuro K, Dobbyn A, Huckins L, Matos MR, Cheng E, Deans PJM, Flaherty E, Barretto N, Topol A, Alganem K, Abadali S, Gregory J, Hoelzli E, Phatnani H, Singh V, Girish D, Aronow B, Mccullumsmith R, Hoffman GE, Stahl EA, Morishita H, Sklar P, Brennand KJ. Synergistic effects of common schizophrenia risk variants. Nature Genetics 2019, 51: 1475-1485. PMID: 31548722, PMCID: PMC6778520, DOI: 10.1038/s41588-019-0497-5.
• Neuron-specific signatures in the chromosomal connectome associated with schizophrenia riskRajarajan P, Borrman T, Liao W, Schrode N, Flaherty E, Casiño C, Powell S, Yashaswini C, LaMarca EA, Kassim B, Javidfar B, Espeso-Gil S, Li A, Won H, Geschwind DH, Ho SM, MacDonald M, Hoffman GE, Roussos P, Zhang B, Hahn CG, Weng Z, Brennand KJ, Akbarian S. Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk. Science 2018, 362 PMID: 30545851, PMCID: PMC6408958, DOI: 10.1126/science.aat4311.
• Neuronal impact of patient-specific aberrant NRXN1α splicingFlaherty E, Zhu S, Barretto N, Cheng E, Deans PJM, Fernando MB, Schrode N, Francoeur N, Antoine A, Alganem K, Halpern M, Deikus G, Shah H, Fitzgerald M, Ladran I, Gochman P, Rapoport J, Tsankova NM, McCullumsmith R, Hoffman GE, Sebra R, Fang G, Brennand KJ. Neuronal impact of patient-specific aberrant NRXN1α splicing. Nature Genetics 2019, 51: 1679-1690. PMID: 31784728, PMCID: PMC7451045, DOI: 10.1038/s41588-019-0539-z.
• Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expressionSeah C, Breen M, Rusielewicz T, Bader H, Xu C, Hunter C, McCarthy B, Deans P, Chattopadhyay M, Goldberg J, Desarnaud F, Makotkine I, Flory J, Bierer L, Staniskyte M, Noggle S, Huckins L, Paull D, Brennand K, Yehuda R. Modeling gene × environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression. Nature Neuroscience 2022, 25: 1434-1445. PMID: 36266471, PMCID: PMC9630117, DOI: 10.1038/s41593-022-01161-y.
• Modelling schizophrenia using human induced pluripotent stem cellsBrennand K, Simone A, Jou J, Gelboin-Burkhart C, Tran N, Sangar S, Li Y, Mu Y, Chen G, Yu D, McCarthy S, Sebat J, Gage F. Modelling schizophrenia using human induced pluripotent stem cells. Nature 2011, 473: 221-225. PMID: 21490598, PMCID: PMC3392969, DOI: 10.1038/nature09915.
• Modeling Gene by Environment Interactions in Post-Traumatic Stress Disorder Across the Post-Mortem Brain and in hiPSC-Derived NeuronsSeah C, Signer R, Young H, Rusielewicz T, Bader H, Xu C, dePins A, Breen M, Paull D, Girgenti M, Yehuda R, Brennand K, Huckins L. Modeling Gene by Environment Interactions in Post-Traumatic Stress Disorder Across the Post-Mortem Brain and in hiPSC-Derived Neurons. Biological Psychiatry 2023, 93: s11. DOI: 10.1016/j.biopsych.2023.02.048.
• Contributions of circadian clock genes to cell survival in fibroblast models of lithium-responsive bipolar disorderMishra H, Wei H, Rohr K, Ko I, Nievergelt C, Maihofer A, Shilling P, Alda M, Berrettini W, Brennand K, Calabrese J, Coryell W, Frye M, Gage F, Gershon E, McInnis M, Nurnberger J, Oedegaard K, Zandi P, Kelsoe J, McCarthy M. Contributions of circadian clock genes to cell survival in fibroblast models of lithium-responsive bipolar disorder. European Neuropsychopharmacology 2023, 74: 1-14. PMID: 37126998, DOI: 10.1016/j.euroneuro.2023.04.009.
• The functional and evolutionary impacts of human-specific deletions in conserved elementsXue J, Mackay-Smith A, Mouri K, Garcia M, Dong M, Akers J, Noble M, Li X, Lindblad-Toh K, Karlsson E, Noonan J, Capellini T, Brennand K, Tewhey R, Sabeti P, Reilly S, Andrews G, Armstrong J, Bianchi M, Birren B, Bredemeyer K, Breit A, Christmas M, Clawson H, Damas J, Di Palma F, Diekhans M, Dong M, Eizirik E, Fan K, Fanter C, Foley N, Forsberg-Nilsson K, Garcia C, Gatesy J, Gazal S, Genereux D, Goodman L, Grimshaw J, Halsey M, Harris A, Hickey G, Hiller M, Hindle A, Hubley R, Hughes G, Johnson J, Juan D, Kaplow I, Karlsson E, Keough K, Kirilenko B, Koepfli K, Korstian J, Kowalczyk A, Kozyrev S, Lawler A, Lawless C, Lehmann T, Levesque D, Lewin H, Li X, Lind A, Lindblad-Toh K, Mackay-Smith A, Marinescu V, Marques-Bonet T, Mason V, Meadows J, Meyer W, Moore J, Moreira L, Moreno-Santillan D, Morrill K, Muntané G, Murphy W, Navarro A, Nweeia M, Ortmann S, Osmanski A, Paten B, Paulat N, Pfenning A, Phan B, Pollard K, Pratt H, Ray D, Reilly S, Rosen J, Ruf I, Ryan L, Ryder O, Sabeti P, Schäffer D, Serres A, Shapiro B, Smit A, Springer M, Srinivasan C, Steiner C, Storer J, Sullivan K, Sullivan P, Sundström E, Supple M, Swofford R, Talbot J, Teeling E, Turner-Maier J, Valenzuela A, Wagner F, Wallerman O, Wang C, Wang J, Weng Z, Wilder A, Wirthlin M, Xue J, Zhang X. The functional and evolutionary impacts of human-specific deletions in conserved elements. Science 2023, 380: eabn2253. PMID: 37104592, PMCID: PMC10202372, DOI: 10.1126/science.abn2253.
• Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findingsHicks E, Seah C, Cote A, Marchese S, Brennand K, Nestler E, Girgenti M, Huckins L. Integrating genetics and transcriptomics to study major depressive disorder: a conceptual framework, bioinformatic approaches, and recent findings. Translational Psychiatry 2023, 13: 129. PMID: 37076454, PMCID: PMC10115809, DOI: 10.1038/s41398-023-02412-7.
• Convergent coexpression of autism-associated genes suggests some novel risk genes may not be detectable in large-scale genetic studiesLiao C, Moyses-Oliveira M, De Esch C, Bhavsar R, Nuttle X, Li A, Yu A, Burt N, Erdin S, Fu J, Wang M, Morley T, Han L, Consortium C, Dion P, Rouleau G, Zhang B, Brennand K, Talkowski M, Ruderfer D. Convergent coexpression of autism-associated genes suggests some novel risk genes may not be detectable in large-scale genetic studies. Cell Genomics 2023, 3: 100277. PMID: 37082147, PMCID: PMC10112287, DOI: 10.1016/j.xgen.2023.100277.
• Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brainSeah C, Brennand K. Pandemic city: Village-in-a-dish unlocks dynamic genetic effects in the brain. Cell Stem Cell 2023, 30: 239-241. PMID: 36868190, DOI: 10.1016/j.stem.2023.02.002.
• Reduced LYNX1 expression in transcriptome of human iPSC-derived neural progenitors modeling fragile X syndromeTalvio K, Minkeviciene R, Townsley K, Achuta V, Huckins L, Corcoran P, Brennand K, Castrén M. Reduced LYNX1 expression in transcriptome of human iPSC-derived neural progenitors modeling fragile X syndrome. Frontiers In Cell And Developmental Biology 2022, 10: 1034679. PMID: 36506088, PMCID: PMC9731341, DOI: 10.3389/fcell.2022.1034679.
• Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndromeFulton S, Wenderski W, Lepack A, Eagle A, Fanutza T, Bastle R, Ramakrishnan A, Hays E, Neal A, Bendl J, Farrelly L, Al-Kachak A, Lyu Y, Cetin B, Chan J, Tran T, Neve R, Roper R, Brennand K, Roussos P, Schimenti J, Friedman A, Shen L, Blitzer R, Robison A, Crabtree G, Maze I. Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome. Nature Communications 2022, 13: 6384. PMID: 36289231, PMCID: PMC9606253, DOI: 10.1038/s41467-022-34200-0.
• Stem Cell Models for Context-Specific Modeling in Psychiatric DisordersSeah C, Huckins L, Brennand K. Stem Cell Models for Context-Specific Modeling in Psychiatric Disorders. Biological Psychiatry 2022, 93: 642-650. PMID: 36658083, DOI: 10.1016/j.biopsych.2022.09.033.
• MODELLING GENE X ENVIRONMENT INTERACTIONS: PTSD-SPECIFIC GLUCOCORTICOID-INDUCED TRANSCRIPTOMICS IN HUMAN NEURONSSeah C, Breen M, Rusielewicz T, Bader H, Xu C, Hunter C, Noggle S, Huckins L, Paull D, Brennand K, Yehuda R. MODELLING GENE X ENVIRONMENT INTERACTIONS: PTSD-SPECIFIC GLUCOCORTICOID-INDUCED TRANSCRIPTOMICS IN HUMAN NEURONS. European Neuropsychopharmacology 2022, 63: e34. DOI: 10.1016/j.euroneuro.2022.07.074.
• T73. MODELING GENE BY ENVIRONMENT INTERACTIONS IN POST-TRAUMATIC STRESS DISORDER USING HIPSC-DERIVED NEURONSSeah C, Rusielewicz T, Bader H, Xu C, Young H, Signer R, dePins A, Hunter C, Deans P, Breen M, Paull D, Brennand K, Huckins L, Yehuda R. T73. MODELING GENE BY ENVIRONMENT INTERACTIONS IN POST-TRAUMATIC STRESS DISORDER USING HIPSC-DERIVED NEURONS. European Neuropsychopharmacology 2022, 63: e207-e208. DOI: 10.1016/j.euroneuro.2022.07.372.
• USING STEM CELLS TO EXPLORE THE GENETICS UNDERLYING BRAIN DISEASEBrennand K. USING STEM CELLS TO EXPLORE THE GENETICS UNDERLYING BRAIN DISEASE. European Neuropsychopharmacology 2022, 63: e313. DOI: 10.1016/j.euroneuro.2022.07.559.
• 37. CONVERGENT IMPACT OF SCHIZOPHRENIA RISK GENESTownsley K, Li A, Deans P, Fullard J, Yu A, Cartwright S, Wang M, Voloudakis G, Girdhar K, Akbarian S, Stahl E, Roussos P, Zhang B, Huckins L, Brennand K. 37. CONVERGENT IMPACT OF SCHIZOPHRENIA RISK GENES. European Neuropsychopharmacology 2022, 63: e65-e66. DOI: 10.1016/j.euroneuro.2022.07.126.
• The three-dimensional landscape of cortical chromatin accessibility in Alzheimer’s diseaseBendl J, Hauberg M, Girdhar K, Im E, Vicari J, Rahman S, Fernando M, Townsley K, Dong P, Misir R, Kleopoulos S, Reach S, Apontes P, Zeng B, Zhang W, Voloudakis G, Brennand K, Nixon R, Haroutunian V, Hoffman G, Fullard J, Roussos P. The three-dimensional landscape of cortical chromatin accessibility in Alzheimer’s disease. Nature Neuroscience 2022, 25: 1366-1378. PMID: 36171428, PMCID: PMC9581463, DOI: 10.1038/s41593-022-01166-7.
• Population-level variation in enhancer expression identifies disease mechanisms in the human brainDong P, Hoffman G, Apontes P, Bendl J, Rahman S, Fernando M, Zeng B, Vicari J, Zhang W, Girdhar K, Townsley K, Misir R, Brennand K, Haroutunian V, Voloudakis G, Fullard J, Roussos P. Population-level variation in enhancer expression identifies disease mechanisms in the human brain. Nature Genetics 2022, 54: 1493-1503. PMID: 36163279, PMCID: PMC9547946, DOI: 10.1038/s41588-022-01170-4.
• A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibilityVoloudakis G, Vicari J, Venkatesh S, Hoffman G, Dobrindt K, Zhang W, Beckmann N, Higgins C, Argyriou S, Jiang S, Hoagland D, Gao L, Corvelo A, Cho K, Lee K, Bian J, Lee J, Iyengar S, Luoh S, Akbarian S, Striker R, Assimes T, Schadt E, Lynch J, Merad M, tenOever B, Charney A, Brennand K, Fullard J, Roussos P. A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility. Npj Genomic Medicine 2022, 7: 52. PMID: 36064543, PMCID: PMC9441828, DOI: 10.1038/s41525-022-00324-x.
• Transcriptional and Translational Dynamics of Zika and Dengue Virus InfectionSingh K, Martinez M, Lin J, Gregory J, Nguyen T, Abdelaal R, Kang K, Brennand K, Grünweller A, Ouyang Z, Phatnani H, Kielian M, Wendel H. Transcriptional and Translational Dynamics of Zika and Dengue Virus Infection. Viruses 2022, 14: 1418. PMID: 35891396, PMCID: PMC9316442, DOI: 10.3390/v14071418.
• Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophreniaFarrelly L, Zheng S, Schrode N, Topol A, Bhanu N, Bastle R, Ramakrishnan A, Chan J, Cetin B, Flaherty E, Shen L, Gleason K, Tamminga C, Garcia B, Li H, Brennand K, Maze I. Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia. Nature Communications 2022, 13: 2195. PMID: 35459277, PMCID: PMC9033776, DOI: 10.1038/s41467-022-29922-0.
• Using Stem Cell Models to Explore the Genetics Underlying Psychiatric Disorders: Linking Risk Variants, Genes, and Biology in Brain DiseaseBrennand K. Using Stem Cell Models to Explore the Genetics Underlying Psychiatric Disorders: Linking Risk Variants, Genes, and Biology in Brain Disease. American Journal Of Psychiatry 2022, 179: 322-328. PMID: 35491564, DOI: 10.1176/appi.ajp.20220235.
• Quickly moving too slowly: Interneuron migration in Timothy SyndromeFernando M, Brennand K. Quickly moving too slowly: Interneuron migration in Timothy Syndrome. Cell Stem Cell 2022, 29: 181-183. PMID: 35120616, DOI: 10.1016/j.stem.2022.01.004.
• A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learningHafez A, Zimmerman A, Papageorgiou G, Chandrasekaran J, Amoah S, Lin R, Lozano E, Pierotti C, Dell'Orco M, Hartley B, Alural B, Lalonde J, Esposito J, Berretta S, Squassina A, Chillotti C, Voloudakis G, Shao Z, Fullard J, Brennand K, Turecki G, Roussos P, Perlis R, Haggarty S, Perrone-Bizzozero N, Brigman J, Mellios N. A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning. Cell Reports 2022, 38: 110282. PMID: 35045295, PMCID: PMC8809079, DOI: 10.1016/j.celrep.2021.110282.
• 19. GENETIC RISK ARCHITECTURE OF SCHIZOPHRENIA AND THREE-DIMENSIONAL CHROMATIN DYNAMICS ACROSS NEUROTRANSMITTER SYSTEMSPowell S, O'Shea C, Townsley K, Dobrindt K, Elahi R, Prytkova I, Slesinger P, Huckins L, Akbarian S, Brennand K. 19. GENETIC RISK ARCHITECTURE OF SCHIZOPHRENIA AND THREE-DIMENSIONAL CHROMATIN DYNAMICS ACROSS NEUROTRANSMITTER SYSTEMS. European Neuropsychopharmacology 2021, 51: e50. DOI: 10.1016/j.euroneuro.2021.07.111.
• MODELING GENE X ENVIRONMENT INTERACTIONS IN PTSD USING GLUCOCORTICOID-INDUCED TRANSCRIPTOMICS IN HUMAN NEURONSBreen M, Rusielewicz T, Bader H, Seah C, Xu C, Hunter C, McCarthy B, Chattopadhyay M, Flory J, Bierer L, Staniskyte M, Noggle S, Paull D, Brennand K, Yehua R. MODELING GENE X ENVIRONMENT INTERACTIONS IN PTSD USING GLUCOCORTICOID-INDUCED TRANSCRIPTOMICS IN HUMAN NEURONS. European Neuropsychopharmacology 2021, 51: e30. DOI: 10.1016/j.euroneuro.2021.07.072.
• SYSTEMS GENOMIC AND FUNCTIONAL APPROACHES TO PSYCHIATRIC DISORDERSBrennand K, Huckins L, Koenen K. SYSTEMS GENOMIC AND FUNCTIONAL APPROACHES TO PSYCHIATRIC DISORDERS. European Neuropsychopharmacology 2021, 51: e28. DOI: 10.1016/j.euroneuro.2021.07.068.
• Prenatal Δ9-Tetrahydrocannabinol Exposure in Males Leads to Motivational Disturbances Related to Striatal Epigenetic DysregulationEllis R, Bara A, Vargas C, Frick A, Loh E, Landry J, Uzamere T, Callens J, Martin Q, Rajarajan P, Brennand K, Ramakrishnan A, Shen L, Szutorisz H, Hurd Y. Prenatal Δ9-Tetrahydrocannabinol Exposure in Males Leads to Motivational Disturbances Related to Striatal Epigenetic Dysregulation. Biological Psychiatry 2021, 92: 127-138. PMID: 34895699, PMCID: PMC8957623, DOI: 10.1016/j.biopsych.2021.09.017.
• Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease riskPowell SK, O’Shea C, Townsley K, Prytkova I, Dobrindt K, Elahi R, Iskhakova M, Lambert T, Valada A, Liao W, Ho SM, Slesinger PA, Huckins LM, Akbarian S, Brennand KJ. Induction of dopaminergic neurons for neuronal subtype-specific modeling of psychiatric disease risk. Molecular Psychiatry 2021, 28: 1970-1982. PMID: 34493831, PMCID: PMC8898985, DOI: 10.1038/s41380-021-01273-0.
• Using the dCas9-KRAB system to repress gene expression in hiPSC-derived NGN2 neuronsLi A, Cartwright S, Yu A, Ho SM, Schrode N, Deans PJM, Matos MR, Garcia MF, Townsley KG, Zhang B, Brennand KJ. Using the dCas9-KRAB system to repress gene expression in hiPSC-derived NGN2 neurons. STAR Protocols 2021, 2: 100580. PMID: 34151300, PMCID: PMC8188621, DOI: 10.1016/j.xpro.2021.100580.
• Applying stem cells and CRISPR engineering to uncover the etiology of schizophreniaMichael Deans P, Brennand K. Applying stem cells and CRISPR engineering to uncover the etiology of schizophrenia. Current Opinion In Neurobiology 2021, 69: 193-201. PMID: 34010781, PMCID: PMC8387340, DOI: 10.1016/j.conb.2021.04.003.
• Transcriptional Perturbations to Glucocorticoids Across Blood and Brain Cells Derived From Individuals With Post-Traumatic Stress DisorderBreen M, Bierer L, Bader H, Xu C, Flory J, Rusielewicz T, Brennand K, Yehuda R. Transcriptional Perturbations to Glucocorticoids Across Blood and Brain Cells Derived From Individuals With Post-Traumatic Stress Disorder. Biological Psychiatry 2021, 89: s18-s19. DOI: 10.1016/j.biopsych.2021.02.066.
• Fitness selection of hyperfusogenic measles virus F proteins associated with neuropathogenic phenotypesIkegame S, Hashiguchi T, Hung C, Dobrindt K, Brennand K, Takeda M, Lee B. Fitness selection of hyperfusogenic measles virus F proteins associated with neuropathogenic phenotypes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2026027118. PMID: 33903248, PMCID: PMC8106313, DOI: 10.1073/pnas.2026027118.
• Induced Pluripotent Stem Cells in Psychiatry: An Overview and Critical PerspectiveDe Los Angeles A, Fernando M, Hall N, Brennand K, Harrison P, Maher B, Weinberger D, Tunbridge E. Induced Pluripotent Stem Cells in Psychiatry: An Overview and Critical Perspective. Biological Psychiatry 2021, 90: 362-372. PMID: 34176589, PMCID: PMC8375580, DOI: 10.1016/j.biopsych.2021.04.008.
• Haploinsufficiency of POU4F1 causes an ataxia syndrome with hypotonia and intention tremorWebb BD, Evans A, Naidich TP, Bird L, Parikh S, Garcia M, Henderson LB, Millan F, Si Y, Brennand KJ, Hung P, Rucker JC, Wheeler PG, Schadt EE. Haploinsufficiency of POU4F1 causes an ataxia syndrome with hypotonia and intention tremor. Human Mutation 2021, 42: 685-693. PMID: 33783914, PMCID: PMC8162891, DOI: 10.1002/humu.24201.
• Circadian rhythms in bipolar disorder patient-derived neurons predict lithium response: preliminary studiesMishra H, Ying N, Luis A, Wei H, Nguyen M, Nakhla T, Vandenburgh S, Alda M, Berrettini W, Brennand K, Calabrese J, Coryell W, Frye M, Gage F, Gershon E, McInnis M, Nievergelt C, Nurnberger J, Shilling P, Oedegaard K, Zandi P, Kelsoe J, Welsh D, McCarthy M. Circadian rhythms in bipolar disorder patient-derived neurons predict lithium response: preliminary studies. Molecular Psychiatry 2021, 26: 3383-3394. PMID: 33674753, PMCID: PMC8418615, DOI: 10.1038/s41380-021-01048-7.
• Xenopus models suggest convergence of gene signatures on neurogenesis in autismBrennand K, Talkowski M. Xenopus models suggest convergence of gene signatures on neurogenesis in autism. Neuron 2021, 109: 743-745. PMID: 33662268, DOI: 10.1016/j.neuron.2021.02.017.
• Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 InfectionDobrindt K, Hoagland DA, Seah C, Kassim B, O'Shea CP, Murphy A, Iskhakova M, Fernando MB, Powell SK, Deans PJM, Javidfar B, Peter C, Møller R, Uhl SA, Garcia MF, Kimura M, Iwasawa K, Crary JF, Kotton DN, Takebe T, Huckins LM, tenOever BR, Akbarian S, Brennand KJ. Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection. Stem Cell Reports 2021, 16: 505-518. PMID: 33636110, PMCID: PMC7881728, DOI: 10.1016/j.stemcr.2021.02.010.
• Analysis framework and experimental design for evaluating synergy-driving gene expressionSchrode N, Seah C, Deans P, Hoffman G, Brennand K. Analysis framework and experimental design for evaluating synergy-driving gene expression. Nature Protocols 2021, 16: 812-840. PMID: 33432232, PMCID: PMC8609447, DOI: 10.1038/s41596-020-00436-7.
• Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targetsNeff R, Wang M, Vatansever S, Guo L, Ming C, Wang Q, Wang E, Horgusluoglu-Moloch E, Song W, Li A, Castranio E, Julia T, Ho L, Goate A, Fossati V, Noggle S, Gandy S, Ehrlich M, Katsel P, Schadt E, Cai D, Brennand K, Haroutunian V, Zhang B. Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets. Science Advances 2021, 7: eabb5398. PMID: 33523961, PMCID: PMC7787497, DOI: 10.1126/sciadv.abb5398.
• Chapter 30 Functional genomics of psychiatric disease risk using genome engineeringGarcia M, Powell S, LaMarca E, Fernando M, Cohen S, Fang G, Akbarian S, Brennand K. Chapter 30 Functional genomics of psychiatric disease risk using genome engineering. 2021, 711-734. DOI: 10.1016/b978-0-12-823577-5.00021-0.
• Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s DiseaseWang M, Li A, Sekiya M, Beckmann ND, Quan X, Schrode N, Fernando MB, Yu A, Zhu L, Cao J, Lyu L, Horgusluoglu E, Wang Q, Guo L, Wang YS, Neff R, Song WM, Wang E, Shen Q, Zhou X, Ming C, Ho SM, Vatansever S, Kaniskan HÜ, Jin J, Zhou MM, Ando K, Ho L, Slesinger PA, Yue Z, Zhu J, Katsel P, Gandy S, Ehrlich ME, Fossati V, Noggle S, Cai D, Haroutunian V, Iijima KM, Schadt E, Brennand KJ, Zhang B. Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease. Neuron 2020, 109: 257-272.e14. PMID: 33238137, PMCID: PMC7855384, DOI: 10.1016/j.neuron.2020.11.002.
• Massively parallel techniques for cataloguing the regulome of the human brainTownsley KG, Brennand KJ, Huckins LM. Massively parallel techniques for cataloguing the regulome of the human brain. Nature Neuroscience 2020, 23: 1509-1521. PMID: 33199899, PMCID: PMC8018778, DOI: 10.1038/s41593-020-00740-1.
• Publicly Available hiPSC Lines with Extreme Polygenic Risk Scores for Modeling SchizophreniaDobrindt K, Zhang H, Das D, Abdollahi S, Prorok T, Ghosh S, Weintraub S, Genovese G, Powell S, Lund A, Akbarian S, Eggan K, McCarroll S, Duan J, Avramopoulos D, Brennand K. Publicly Available hiPSC Lines with Extreme Polygenic Risk Scores for Modeling Schizophrenia. Complex Psychiatry 2020, 6: 68-82. PMID: 34883504, PMCID: PMC7923934, DOI: 10.1159/000512716.
• Parsing the Functional Impact of Noncoding Genetic Variants in the Brain EpigenomePowell SK, O'Shea C, Brennand KJ, Akbarian S. Parsing the Functional Impact of Noncoding Genetic Variants in the Brain Epigenome. Biological Psychiatry 2020, 89: 65-75. PMID: 33131715, PMCID: PMC7718420, DOI: 10.1016/j.biopsych.2020.06.033.
• Pluripotent Stem Cells May Unlock How Genetic Variants Result in Mental DisordersPowell S, Yu A, Katz C, Brennand K. Pluripotent Stem Cells May Unlock How Genetic Variants Result in Mental Disorders. Psychiatric News 2020, 55 DOI: 10.1176/appi.pn.2020.7b14.
• Integration of CRISPR-engineering and hiPSC-based models of psychiatric genomicsMatos MR, Ho SM, Schrode N, Brennand KJ. Integration of CRISPR-engineering and hiPSC-based models of psychiatric genomics. Molecular And Cellular Neuroscience 2020, 107: 103532. PMID: 32712198, PMCID: PMC7484226, DOI: 10.1016/j.mcn.2020.103532.
• Investigation of Schizophrenia with Human Induced Pluripotent Stem CellsPowell SK, O’Shea C, Shannon SR, Akbarian S, Brennand KJ. Investigation of Schizophrenia with Human Induced Pluripotent Stem Cells. 2020, 25: 155-206. PMID: 32578147, PMCID: PMC8033573, DOI: 10.1007/978-3-030-45493-7_6.
• Transcriptional signatures of participant-derived neural progenitor cells and neurons implicate altered Wnt signaling in Phelan-McDermid syndrome and autismBreen MS, Browne A, Hoffman GE, Stathopoulos S, Brennand K, Buxbaum JD, Drapeau E. Transcriptional signatures of participant-derived neural progenitor cells and neurons implicate altered Wnt signaling in Phelan-McDermid syndrome and autism. Molecular Autism 2020, 11: 53. PMID: 32560742, PMCID: PMC7304190, DOI: 10.1186/s13229-020-00355-0.
• Functional annotation of rare structural variation in the human brainHan L, Zhao X, Benton ML, Perumal T, Collins RL, Hoffman GE, Johnson JS, Sloofman L, Wang HZ, Stone MR, Brennand K, Brand H, Sieberts S, Marenco S, Peters M, Lipska B, Roussos P, Capra J, Talkowski M, Ruderfer D. Functional annotation of rare structural variation in the human brain. Nature Communications 2020, 11: 2990. PMID: 32533064, PMCID: PMC7293301, DOI: 10.1038/s41467-020-16736-1.
• Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural ModelsGregory JA, Hoelzli E, Abdelaal R, Braine C, Cuevas M, Halpern M, Barretto N, Schrode N, Akbalik G, Kang K, Cheng E, Bowles K, Lotz S, Goderie S, Karch CM, Temple S, Goate A, Brennand KJ, Phatnani H. Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models. Cells 2020, 9: 1406. PMID: 32516938, PMCID: PMC7349756, DOI: 10.3390/cells9061406.
• T9. EPIGENETIC PROFILING IN SCHIZOPHRENIA DERIVED HUMAN INDUCED PLURIPOTENT STEM CELLS (HIPSCS) AND NEURONSFarrelly L, Zhang S, Flaherty E, Topol A, Schrode N, Bastle R, Bhanu N, Garcia B, Li H, Brennand K, Maze I. T9. EPIGENETIC PROFILING IN SCHIZOPHRENIA DERIVED HUMAN INDUCED PLURIPOTENT STEM CELLS (HIPSCS) AND NEURONS. Schizophrenia Bulletin 2020, 46: s234-s234. PMCID: PMC7233850, DOI: 10.1093/schbul/sbaa029.569.
• Transcriptional Signatures of Participant-Derived Neural Progenitor Cells and Neurons Implicate Altered WNT Signaling in Phelan-McDermid Syndrome and AutismBreen M, Browne A, Hoffman G, Stathopoulous S, Brennand K, Buxbaum J, Drapeau E. Transcriptional Signatures of Participant-Derived Neural Progenitor Cells and Neurons Implicate Altered WNT Signaling in Phelan-McDermid Syndrome and Autism. Biological Psychiatry 2020, 87: s456-s457. DOI: 10.1016/j.biopsych.2020.02.1162.
• Differential Transcriptional Responses to Glucocorticoid Activation in Cultured Blood Immune Cells and Neurons: A Novel Approach to PTSD Biomarker DevelopmentBreen M, Bierer L, Bader H, Makotkine I, Flory J, Meaney M, Brennand K, Yehuda R. Differential Transcriptional Responses to Glucocorticoid Activation in Cultured Blood Immune Cells and Neurons: A Novel Approach to PTSD Biomarker Development. Biological Psychiatry 2020, 87: s49-s50. DOI: 10.1016/j.biopsych.2020.02.151.
• A Psychiatric Disease-Related Circular RNA Controls Synaptic Gene Expression and CognitionZimmerman A, Hafez A, Amoah S, DellOrco M, Haggarty S, Brennand K, Webster M, Perrone-Bizzozero N, Brigman J, Mellios N. A Psychiatric Disease-Related Circular RNA Controls Synaptic Gene Expression and Cognition. Biological Psychiatry 2020, 87: s356-s357. DOI: 10.1016/j.biopsych.2020.02.914.
• Partial Pharmacological “Rescue” and MRS spectroscopy in Two Carriers of a Rare Marker Chromosome Containing Extra Copies of the GLDC Gene Encoding a Glycine-Degrading Enzyme Implicate NMDA Receptor Hypofunction in PsychosisLevy D, Morgan C, Bodkin J, Coleman M, Godfrey L, Carvalho C, Grochowski C, Kaufman M, Jensen J, Julia T, Brennand K, McCarthy S, Malhotra D, Sebat J, Goff D, Lupski J, Coyle J, Rudolph U. Partial Pharmacological “Rescue” and MRS spectroscopy in Two Carriers of a Rare Marker Chromosome Containing Extra Copies of the GLDC Gene Encoding a Glycine-Degrading Enzyme Implicate NMDA Receptor Hypofunction in Psychosis. Biological Psychiatry 2020, 87: s98-s99. DOI: 10.1016/j.biopsych.2020.02.272.
• If there is not one cure for schizophrenia, there may be manySeah C, Brennand KJ. If there is not one cure for schizophrenia, there may be many. Schizophrenia 2020, 6: 11. PMID: 32313122, PMCID: PMC7170875, DOI: 10.1038/s41537-020-0101-0.
• Sex-Specific Role for the Long Non-coding RNA LINC00473 in DepressionIssler O, van der Zee YY, Ramakrishnan A, Wang J, Tan C, Loh YE, Purushothaman I, Walker DM, Lorsch ZS, Hamilton PJ, Peña CJ, Flaherty E, Hartley BJ, Torres-Berrío A, Parise EM, Kronman H, Duffy JE, Estill MS, Calipari ES, Labonté B, Neve RL, Tamminga CA, Brennand KJ, Dong Y, Shen L, Nestler EJ. Sex-Specific Role for the Long Non-coding RNA LINC00473 in Depression. Neuron 2020, 106: 912-926.e5. PMID: 32304628, PMCID: PMC7305959, DOI: 10.1016/j.neuron.2020.03.023.
• Modeling the complex genetic architectures of brain diseaseFernando MB, Ahfeldt T, Brennand KJ. Modeling the complex genetic architectures of brain disease. Nature Genetics 2020, 52: 363-369. PMID: 32203467, PMCID: PMC7909729, DOI: 10.1038/s41588-020-0596-3.
• A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profilesSey NYA, Hu B, Mah W, Fauni H, McAfee JC, Rajarajan P, Brennand KJ, Akbarian S, Won H. A computational tool (H-MAGMA) for improved prediction of brain-disorder risk genes by incorporating brain chromatin interaction profiles. Nature Neuroscience 2020, 23: 583-593. PMID: 32152537, PMCID: PMC7131892, DOI: 10.1038/s41593-020-0603-0.
• ASCL1- and DLX2-induced GABAergic neurons from hiPSC-derived NPCsBarretto N, Zhang H, Powell SK, Fernando MB, Zhang S, Flaherty EK, Ho SM, Slesinger PA, Duan J, Brennand KJ. ASCL1- and DLX2-induced GABAergic neurons from hiPSC-derived NPCs. Journal Of Neuroscience Methods 2020, 334: 108548. PMID: 32065989, PMCID: PMC7426253, DOI: 10.1016/j.jneumeth.2019.108548.
• Integrating CRISPR Engineering and hiPSC-Derived 2D Disease Modeling SystemsRehbach K, Fernando MB, Brennand KJ. Integrating CRISPR Engineering and hiPSC-Derived 2D Disease Modeling Systems. Journal Of Neuroscience 2020, 40: 1176-1185. PMID: 32024766, PMCID: PMC7002154, DOI: 10.1523/jneurosci.0518-19.2019.
• A psychiatric disease-related circular RNA controls synaptic gene expression and cognitionZimmerman AJ, Hafez AK, Amoah SK, Rodriguez BA, Dell’Orco M, Lozano E, Hartley BJ, Alural B, Lalonde J, Chander P, Webster MJ, Perlis RH, Brennand KJ, Haggarty SJ, Weick J, Perrone-Bizzozero N, Brigman JL, Mellios N. A psychiatric disease-related circular RNA controls synaptic gene expression and cognition. Molecular Psychiatry 2020, 25: 2712-2727. PMID: 31988434, PMCID: PMC7577899, DOI: 10.1038/s41380-020-0653-4.
• Correction: Differential transcriptional response following glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker developmentBreen M, Bierer L, Daskalakis N, Bader H, Makotkine I, Chattopadhyay M, Xu C, Grice A, Tocheva A, Flory J, Buxbaum J, Meaney M, Brennand K, Yehuda R. Correction: Differential transcriptional response following glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker development. Translational Psychiatry 2020, 10: 1. PMID: 32066695, PMCID: PMC7026151, DOI: 10.1038/s41398-019-0665-5.
• 25 FUNCTIONAL ANNOTATION OF RARE STRUCTURAL VARIATION IN THE HUMAN BRAINHan L, Zhao X, Benton M, Perumal T, Collins R, Brand H, Hoffman G, Johnson J, Sloofman L, Brennand K, Consortium C, Sieberts S, Marenco S, Peters M, Lipska B, Roussos P, Capra J, Talkowski M, Ruderfer D. 25 FUNCTIONAL ANNOTATION OF RARE STRUCTURAL VARIATION IN THE HUMAN BRAIN. European Neuropsychopharmacology 2019, 29: s72-s73. DOI: 10.1016/j.euroneuro.2019.07.166.
• Differential transcriptional response following glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker developmentBreen MS, Bierer LM, Daskalakis NP, Bader HN, Makotkine I, Chattopadhyay M, Xu C, Buxbaum Grice A, Tocheva AS, Flory JD, Buxbaum JD, Meaney MJ, Brennand K, Yehuda R. Differential transcriptional response following glucocorticoid activation in cultured blood immune cells: a novel approach to PTSD biomarker development. Translational Psychiatry 2019, 9: 201. PMID: 31434874, PMCID: PMC6704073, DOI: 10.1038/s41398-019-0539-x.
• Examining the relationship between astrocyte dysfunction and neurodegeneration in ALS using hiPSCsHalpern M, Brennand KJ, Gregory J. Examining the relationship between astrocyte dysfunction and neurodegeneration in ALS using hiPSCs. Neurobiology Of Disease 2019, 132: 104562. PMID: 31381978, PMCID: PMC6834907, DOI: 10.1016/j.nbd.2019.104562.
• CRISPR-based functional evaluation of schizophrenia risk variantsRajarajan P, Flaherty E, Akbarian S, Brennand KJ. CRISPR-based functional evaluation of schizophrenia risk variants. Schizophrenia Research 2019, 217: 26-36. PMID: 31277978, PMCID: PMC6939156, DOI: 10.1016/j.schres.2019.06.017.
• Spatial genome exploration in the context of cognitive and neurological diseaseRajarajan P, Borrman T, Liao W, Espeso-Gil S, Chandrasekaran S, Jiang Y, Weng Z, Brennand KJ, Akbarian S. Spatial genome exploration in the context of cognitive and neurological disease. Current Opinion In Neurobiology 2019, 59: 112-119. PMID: 31255842, PMCID: PMC6889018, DOI: 10.1016/j.conb.2019.05.007.
• F163. A Psychiatric Disease-Related Circular RNA Controls Neuronal Function and CognitionWeick J, Zimmerman A, Amoah S, Rodriguez B, DellOrco M, Hafez A, Chander P, Alural B, Hartley B, Lalonde J, Chen J, Webster M, Perlis R, Haggarty S, Brennand K, Calhoun V, Liu J, Perrone-Bizzozero N, Brigman J, Mellios N. F163. A Psychiatric Disease-Related Circular RNA Controls Neuronal Function and Cognition. Biological Psychiatry 2019, 85: s276. DOI: 10.1016/j.biopsych.2019.03.700.
• 9. MODELLING THE IMPACT OF RARE AND COMMON VARIANTS IN SCHIZOPHRENIA USING STEM CELLSBrennand K. 9. MODELLING THE IMPACT OF RARE AND COMMON VARIANTS IN SCHIZOPHRENIA USING STEM CELLS. Schizophrenia Bulletin 2019, 45: s101-s101. PMCID: PMC6455771, DOI: 10.1093/schbul/sbz022.032.
• Entrainment of Circadian Rhythms to Temperature Reveals Amplitude Deficits in Fibroblasts from Patients with Bipolar Disorder and Possible Links to Calcium ChannelsNudell V, Wei H, Nievergelt C, Maihofer AX, Shilling P, Alda M, Berrettini WH, Brennand KJ, Calabrese JR, Coryell WH, Covault JM, Frye MA, Gage F, Gershon E, McInnis MG, Nurnberger JI, Oedegaard KJ, Shekhtman T, Zandi PP, Kelsoe JR, McCarthy MJ. Entrainment of Circadian Rhythms to Temperature Reveals Amplitude Deficits in Fibroblasts from Patients with Bipolar Disorder and Possible Links to Calcium Channels. Complex Psychiatry 2019, 5: 115-124. PMID: 31192224, PMCID: PMC6528084, DOI: 10.1159/000497354.
• CRISPR‐based functional evaluation of common SZ risk variantsSchrode N, Ho S, Brennand K. CRISPR‐based functional evaluation of common SZ risk variants. The FASEB Journal 2019, 33: 205.2-205.2. DOI: 10.1096/fasebj.2019.33.1_supplement.205.2.
• Leveraging Human Induced Pluripotent Stem Cell–Based Models Provides Biological Context to Genome-wide Association Study FindingsBrennand KJ. Leveraging Human Induced Pluripotent Stem Cell–Based Models Provides Biological Context to Genome-wide Association Study Findings. Biological Psychiatry 2019, 85: 532-533. PMID: 30871689, DOI: 10.1016/j.biopsych.2019.01.021.
• Type I interferon response impairs differentiation potential of pluripotent stem cellsEggenberger J, Blanco-Melo D, Panis M, Brennand KJ, tenOever BR. Type I interferon response impairs differentiation potential of pluripotent stem cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 1384-1393. PMID: 30606801, PMCID: PMC6347712, DOI: 10.1073/pnas.1812449116.
• MODELING THE IMPACT OF RARE AND COMMON VARIANTS ON PREDISPOSITION TO SCHIZOPHRENIA USING STEM CELLSBrennand K, Hoffman G, Schrode N, Flaherty E, Ho S. MODELING THE IMPACT OF RARE AND COMMON VARIANTS ON PREDISPOSITION TO SCHIZOPHRENIA USING STEM CELLS. European Neuropsychopharmacology 2019, 29: s1061. DOI: 10.1016/j.euroneuro.2018.07.083.
• 21ABERRANT NRXN1α SPLICING ARISING FROM 2P16.3 HETEROZYGOUS DELETIONS IMPACTS NEURONAL FUNCTIONAbsherty E, Zhu S, Cheng E, Antoine A, Halpern M, Deikus G, Gochman P, Rapoport J, Hoffman G, Tsankova N, Crary J, Sebra R, Fang G, Brennand K. 21ABERRANT NRXN1α SPLICING ARISING FROM 2P16.3 HETEROZYGOUS DELETIONS IMPACTS NEURONAL FUNCTION. European Neuropsychopharmacology 2019, 29: s1077-s1078. DOI: 10.1016/j.euroneuro.2018.08.028.
• Dysregulated In Psychiatric Disorders Circular RNAs Interact With Rna Binding Proteins To Regulate Synaptic PlasticityWeick J, Rodriguez B, Amoah S, DellOrco M, Hafez A, Hartley B, Brennand K, Haggarty S, Perrone-Bizzozero N, Mellios N. Dysregulated In Psychiatric Disorders Circular RNAs Interact With Rna Binding Proteins To Regulate Synaptic Plasticity. European Neuropsychopharmacology 2019, 29: s720-s721. DOI: 10.1016/j.euroneuro.2017.06.035.
• M97 TRANSCRIPTIONAL SIGNATURES OF CHILDHOOD ONSET SCHIZOPHRENIA IN HIPSC-DERIVED NPCS AND NEURONS ARE CONCORDANT WITH SIGNATURES FROM POST MORTEM ADULT BRAINSHoffman G, Hartley B, Flaherty E, Ladran I, Gochman P, Ruderfer D, Rapoport J, Sklar P, Brennand K. M97 TRANSCRIPTIONAL SIGNATURES OF CHILDHOOD ONSET SCHIZOPHRENIA IN HIPSC-DERIVED NPCS AND NEURONS ARE CONCORDANT WITH SIGNATURES FROM POST MORTEM ADULT BRAINS. European Neuropsychopharmacology 2019, 29: s1008. DOI: 10.1016/j.euroneuro.2017.08.404.
• Large-Scale Reprogramming and Neuronal Differentiation In Complex Psychiatric DisordersBuxbaum J, Brennand K, Browne A, Drapeau E, Brenner K, Noggle S, Yehuda R. Large-Scale Reprogramming and Neuronal Differentiation In Complex Psychiatric Disorders. European Neuropsychopharmacology 2019, 29: s765-s766. DOI: 10.1016/j.euroneuro.2017.06.124.
• GJA1 (connexin43) is a key regulator of Alzheimer’s disease pathogenesisKajiwara Y, Wang E, Wang M, Sin WC, Brennand KJ, Schadt E, Naus CC, Buxbaum J, Zhang B. GJA1 (connexin43) is a key regulator of Alzheimer’s disease pathogenesis. Acta Neuropathologica Communications 2018, 6: 144. PMID: 30577786, PMCID: PMC6303945, DOI: 10.1186/s40478-018-0642-x.
• Author Correction: Expression-based drug screening of neural progenitor cells from individuals with schizophreniaReadhead B, Hartley B, Eastwood B, Collier D, Evans D, Farias R, He C, Hoffman G, Sklar P, Dudley J, Schadt E, Savić R, Brennand K. Author Correction: Expression-based drug screening of neural progenitor cells from individuals with schizophrenia. Nature Communications 2018, 9: 4926. PMID: 30451900, PMCID: PMC6242834, DOI: 10.1038/s41467-018-07326-3.
• Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorderMcCarthy MJ, Wei H, Nievergelt CM, Stautland A, Maihofer AX, Welsh DK, Shilling P, Alda M, Alliey-Rodriguez N, Anand A, Andreasson OA, Balaraman Y, Berrettini WH, Bertram H, Brennand KJ, Calabrese JR, Calkin CV, Claasen A, Conroy C, Coryell WH, Craig DW, D’Arcangelo N, Demodena A, Djurovic S, Feeder S, Fisher C, Frazier N, Frye MA, Gage FH, Gao K, Garnham J, Gershon ES, Glazer K, Goes F, Goto T, Harrington G, Jakobsen P, Kamali M, Karberg E, Kelly M, Leckband SG, Lohoff F, McInnis MG, Mondimore F, Morken G, Nurnberger JI, Obral S, Oedegaard KJ, Ortiz A, Ritchey M, Ryan K, Schinagle M, Schoeyen H, Schwebel C, Shaw M, Shekhtman T, Slaney C, Stapp E, Szelinger S, Tarwater B, Zandi PP, Kelsoe JR. Chronotype and cellular circadian rhythms predict the clinical response to lithium maintenance treatment in patients with bipolar disorder. Neuropsychopharmacology 2018, 44: 620-628. PMID: 30487653, PMCID: PMC6333516, DOI: 10.1038/s41386-018-0273-8.
• Expression-based drug screening of neural progenitor cells from individuals with schizophreniaReadhead B, Hartley BJ, Eastwood BJ, Collier DA, Evans D, Farias R, He C, Hoffman G, Sklar P, Dudley JT, Schadt EE, Savić R, Brennand KJ. Expression-based drug screening of neural progenitor cells from individuals with schizophrenia. Nature Communications 2018, 9: 4412. PMID: 30356048, PMCID: PMC6200740, DOI: 10.1038/s41467-018-06515-4.
• Landscape of Conditional eQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWASDobbyn A, Huckins L, Boocock J, Sloofman L, Glicksberg B, Giambartolomei C, Hoffman G, Perumal T, Girdhar K, Jiang Y, Raj T, Ruderfer D, Kramer R, Pinto D, Akbarian S, Roussos P, Domenici E, Devlin B, Sklar P, Stahl E, Sieberts S, Sklar P, Buxbaum J, Devlin B, Lewis D, Gur R, Hahn C, Hirai K, Toyoshiba H, Domenici E, Essioux L, Mangravite L, Peters M, Lehner T, Lipska B, Cicek A, Lu C, Roeder K, Xie L, Talbot K, Hemby S, Essioux L, Browne A, Chess A, Topol A, Charney A, Dobbyn A, Readhead B, Zhang B, Pinto D, Bennett D, Kavanagh D, Ruderfer D, Stahl E, Schadt E, Hoffman G, Shah H, Zhu J, Johnson J, Fullard J, Dudley J, Girdhar K, Brennand K, Sloofman L, Huckins L, Fromer M, Mahajan M, Roussos P, Akbarian S, Purcell S, Hamamsy T, Raj T, Haroutunian V, Wang Y, Gümüş Z, Senthil G, Kramer R, Logsdon B, Derry J, Dang K, Sieberts S, Perumal T, Visintainer R, Shinobu L, Sullivan P, Klei L. Landscape of Conditional eQTL in Dorsolateral Prefrontal Cortex and Co-localization with Schizophrenia GWAS. American Journal Of Human Genetics 2018, 102: 1169-1184. PMID: 29805045, PMCID: PMC5993513, DOI: 10.1016/j.ajhg.2018.04.011.
• Marker chromosome genomic structure and temporal origin implicate a chromoanasynthesis event in a family with pleiotropic psychiatric phenotypesGrochowski CM, Gu S, Yuan B, Julia T, Brennand KJ, Sebat J, Malhotra D, McCarthy S, Rudolph U, Lindstrand A, Chong Z, Levy DL, Lupski JR, Carvalho CMB. Marker chromosome genomic structure and temporal origin implicate a chromoanasynthesis event in a family with pleiotropic psychiatric phenotypes. Human Mutation 2018, 39: 939-946. PMID: 29696747, PMCID: PMC5995661, DOI: 10.1002/humu.23537.
• 105. Modeling the Contribution of Common Variants to Schizophrenia RiskBrennand K. 105. Modeling the Contribution of Common Variants to Schizophrenia Risk. Biological Psychiatry 2018, 83: s43. DOI: 10.1016/j.biopsych.2018.02.123.
• THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disordersGuennewig B, Bitar M, Obiorah I, Hanks J, O’Brien E, Kaczorowski DC, Hurd YL, Roussos P, Brennand KJ, Barry G. THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Translational Psychiatry 2018, 8: 89. PMID: 29691375, PMCID: PMC5915454, DOI: 10.1038/s41398-018-0137-3.
• Modeling the Brain in the Culture Dish: Advancements and Applications of Induced Pluripotent Stem‐Cell‐Derived NeuronsChandrasekaran S, Rajarajan P, Akbarian S, Brennand K. Modeling the Brain in the Culture Dish: Advancements and Applications of Induced Pluripotent Stem‐Cell‐Derived Neurons. 2018, 119-157. DOI: 10.1002/9781119283249.ch6.
• Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem CellsLaMarca EA, Powell SK, Akbarian S, Brennand KJ. Modeling Neuropsychiatric and Neurodegenerative Diseases With Induced Pluripotent Stem Cells. Frontiers In Pediatrics 2018, 6: 82. PMID: 29666786, PMCID: PMC5891587, DOI: 10.3389/fped.2018.00082.
• 20.4 MODELING THE CONTRIBUTION OF COMMON VARIANTS TO SCHIZOPHRENIA RISKHoffman G, Hartley B, Ruderfer D, Rapoport J, Sklar P, Brennand K. 20.4 MODELING THE CONTRIBUTION OF COMMON VARIANTS TO SCHIZOPHRENIA RISK. Schizophrenia Bulletin 2018, 44: s34-s34. PMCID: PMC5887296, DOI: 10.1093/schbul/sby014.083.
• 20. THE APPLICATION OF STEM CELL MODELS TO VALIDATE RARE AND COMMON VARIANTS CONTRIBUTING TO SCHIZOPHRENIABrennand K. 20. THE APPLICATION OF STEM CELL MODELS TO VALIDATE RARE AND COMMON VARIANTS CONTRIBUTING TO SCHIZOPHRENIA. Schizophrenia Bulletin 2018, 44: s32-s33. PMCID: PMC5887971, DOI: 10.1093/schbul/sby014.079.
• New considerations for hiPSC-based models of neuropsychiatric disordersHoffman GE, Schrode N, Flaherty E, Brennand KJ. New considerations for hiPSC-based models of neuropsychiatric disorders. Molecular Psychiatry 2018, 24: 49-66. PMID: 29483625, PMCID: PMC6109625, DOI: 10.1038/s41380-018-0029-1.
• Mapping regulatory variants in hiPSC modelsHoffman GE, Brennand KJ. Mapping regulatory variants in hiPSC models. Nature Genetics 2017, 50: 1-2. PMID: 29273803, DOI: 10.1038/s41588-017-0017-4.
• Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brainsHoffman GE, Hartley BJ, Flaherty E, Ladran I, Gochman P, Ruderfer DM, Stahl EA, Rapoport J, Sklar P, Brennand KJ. Transcriptional signatures of schizophrenia in hiPSC-derived NPCs and neurons are concordant with post-mortem adult brains. Nature Communications 2017, 8: 2225. PMID: 29263384, PMCID: PMC5738408, DOI: 10.1038/s41467-017-02330-5.
• The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug ScreeningGonzalez D, Gregory J, Brennand K. The Importance of Non-neuronal Cell Types in hiPSC-Based Disease Modeling and Drug Screening. Frontiers In Cell And Developmental Biology 2017, 5: 117. PMID: 29312938, PMCID: PMC5742170, DOI: 10.3389/fcell.2017.00117.
• Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem CellsPrytkova I, Brennand K. Prospects for Modeling Abnormal Neuronal Function in Schizophrenia Using Human Induced Pluripotent Stem Cells. Frontiers In Cellular Neuroscience 2017, 11: 360. PMID: 29217999, PMCID: PMC5703699, DOI: 10.3389/fncel.2017.00360.
• Cerebral organoids reveal early cortical maldevelopment in schizophrenia—computational anatomy and genomics, role of FGFR1Stachowiak E, Benson C, Narla S, Dimitri A, Chuye L, Dhiman S, Harikrishnan K, Elahi S, Freedman D, Brennand K, Sarder P, Stachowiak M. Cerebral organoids reveal early cortical maldevelopment in schizophrenia—computational anatomy and genomics, role of FGFR1. Translational Psychiatry 2017, 7: 6. PMID: 30446636, PMCID: PMC5802550, DOI: 10.1038/s41398-017-0054-x.
• Personalized medicine in a dish: the growing possibility of neuropsychiatric disease drug discovery tailored to patient genetic variants using stem cellsBrennand K. Personalized medicine in a dish: the growing possibility of neuropsychiatric disease drug discovery tailored to patient genetic variants using stem cells. Stem Cell Investigation 2017, 4: 91-91. PMID: 29270417, PMCID: PMC5723749, DOI: 10.21037/sci.2017.10.05.
• Patient-derived hiPSC neurons with heterozygous CNTNAP2 deletions display altered neuronal gene expression and network activityFlaherty E, Deranieh R, Artimovich E, Lee I, Siegel A, Levy D, Nestor M, Brennand K. Patient-derived hiPSC neurons with heterozygous CNTNAP2 deletions display altered neuronal gene expression and network activity. Schizophrenia 2017, 3: 35. PMID: 28970473, PMCID: PMC5624885, DOI: 10.1038/s41537-017-0033-5.
• Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor CellsTopol A, Zhu S, Hartley B, English J, Hauberg M, Tran N, Rittenhouse C, Simone A, Ruderfer D, Johnson J, Readhead B, Hadas Y, Gochman P, Wang Y, Shah H, Cagney G, Rapoport J, Gage F, Dudley J, Sklar P, Mattheisen M, Cotter D, Fang G, Brennand K. Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells. Cell Reports 2017, 20: 2525. PMID: 28877483, PMCID: PMC5599129, DOI: 10.1016/j.celrep.2017.08.073.
• An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem CellsJulia T, Wang M, Pimenova A, Bowles K, Hartley B, Lacin E, Machlovi S, Abdelaal R, Karch C, Phatnani H, Slesinger P, Zhang B, Goate A, Brennand K. An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells. Stem Cell Reports 2017, 9: 600-614. PMID: 28757165, PMCID: PMC5550034, DOI: 10.1016/j.stemcr.2017.06.018.
• Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in hiPSC-Derived NPCs, Neurons, and AstrocytesHo S, Hartley B, Flaherty E, Rajarajan P, Abdelaal R, Obiorah I, Barretto N, Muhammad H, Phatnani H, Akbarian S, Brennand K. Evaluating Synthetic Activation and Repression of Neuropsychiatric-Related Genes in hiPSC-Derived NPCs, Neurons, and Astrocytes. Stem Cell Reports 2017, 9: 615-628. PMID: 28757163, PMCID: PMC5550013, DOI: 10.1016/j.stemcr.2017.06.012.
• High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult BrainZhou T, Tan L, Cederquist G, Fan Y, Hartley B, Mukherjee S, Tomishima M, Brennand K, Zhang Q, Schwartz R, Evans T, Studer L, Chen S. High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain. Cell Stem Cell 2017, 21: 274-283.e5. PMID: 28736217, PMCID: PMC5553280, DOI: 10.1016/j.stem.2017.06.017.
• THC Treatment Alters Glutamate Receptor Gene Expression in Human Stem Cell-Derived NeuronsObiorah I, Muhammad H, Stafford K, Flaherty E, Brennand K. THC Treatment Alters Glutamate Receptor Gene Expression in Human Stem Cell-Derived Neurons. Complex Psychiatry 2017, 3: 73-84. PMID: 29230395, PMCID: PMC5701275, DOI: 10.1159/000477762.
• The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domainJiang Y, Loh YE, Rajarajan P, Hirayama T, Liao W, Kassim BS, Javidfar B, Hartley BJ, Kleofas L, Park RB, Labonte B, Ho SM, Chandrasekaran S, Do C, Ramirez BR, Peter CJ, C W JT, Safaie BM, Morishita H, Roussos P, Nestler EJ, Schaefer A, Tycko B, Brennand KJ, Yagi T, Shen L, Akbarian S. The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain. Nature Genetics 2017, 49: 1239-1250. PMID: 28671686, PMCID: PMC5560095, DOI: 10.1038/ng.3906.
• Application of CRISPR/Cas9 to the study of brain development and neuropsychiatric diseasePowell S, Gregory J, Akbarian S, Brennand K. Application of CRISPR/Cas9 to the study of brain development and neuropsychiatric disease. Molecular And Cellular Neuroscience 2017, 82: 157-166. PMID: 28549865, PMCID: PMC5516945, DOI: 10.1016/j.mcn.2017.05.007.
• Variations in brain defects result from cellular mosaicism in the activation of heat shock signallingIshii S, Torii M, Son AI, Rajendraprasad M, Morozov YM, Kawasawa YI, Salzberg AC, Fujimoto M, Brennand K, Nakai A, Mezger V, Gage FH, Rakic P, Hashimoto-Torii K. Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling. Nature Communications 2017, 8: 15157. PMID: 28462912, PMCID: PMC5418582, DOI: 10.1038/ncomms15157.
• 705 Using iPS Derived Neurons and GWAS Together to Identify Genes for Lithium ResponseKelsoe J, McCarthy M, Nievergelt C, Shilling P, Nurnberger J, Gershon E, Coryell W, McInnis M, Berrettini W, Odegaard K, Calabrese J, Zandi P, Alda M, Frye M, Craig D, Mertens J, Brennand K, Yao J, Gage F. 705 Using iPS Derived Neurons and GWAS Together to Identify Genes for Lithium Response. Biological Psychiatry 2017, 81: s285-s286. DOI: 10.1016/j.biopsych.2017.02.772.
• 692 From Nucleosome to Nucleus: 3D Genome Mappings in Mouse Models of Psychiatric Disease, and in Human Postmortem BrainAkbarian S, Rajaran P, Brennand K. 692 From Nucleosome to Nucleus: 3D Genome Mappings in Mouse Models of Psychiatric Disease, and in Human Postmortem Brain. Biological Psychiatry 2017, 81: s280-s281. DOI: 10.1016/j.biopsych.2017.02.759.
• SA93. Deletion of CNTNAP2 and White Matter Changes in SchizophreniaGönenç A, Douvaras P, Siegel A, Olson D, Rudolph U, Fossati V, Brennand K, Levy D. SA93. Deletion of CNTNAP2 and White Matter Changes in Schizophrenia. Schizophrenia Bulletin 2017, 43: s146-s146. PMCID: PMC5475988, DOI: 10.1093/schbul/sbx023.091.
• Divergent Levels of Marker Chromosomes in an hiPSC-Based Model of PsychosisJulia T, Carvalho C, Yuan B, Gu S, Altheimer A, McCarthy S, Malhotra D, Sebat J, Siegel A, Rudolph U, Lupski J, Levy D, Brennand K. Divergent Levels of Marker Chromosomes in an hiPSC-Based Model of Psychosis. Stem Cell Reports 2017, 8: 519-528. PMID: 28216146, PMCID: PMC5355568, DOI: 10.1016/j.stemcr.2017.01.010.
• In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brainChatterton Z, Hartley B, Seok M, Mendelev N, Chen S, Milekic M, Rosoklija G, Stankov A, Trencevsja-Ivanovska I, Brennand K, Ge Y, Dwork A, Haghighi F. In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain. Epigenetics & Chromatin 2017, 10: 4. PMID: 28149327, PMCID: PMC5270321, DOI: 10.1186/s13072-017-0111-y.
• MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in miceMitchell A, Javidfar B, Pothula V, Ibi D, Shen E, Peter C, Bicks L, Fehr T, Jiang Y, Brennand K, Neve R, Gonzalez-Maeso J, Akbarian S. MEF2C transcription factor is associated with the genetic and epigenetic risk architecture of schizophrenia and improves cognition in mice. Molecular Psychiatry 2017, 23: 123-132. PMID: 28115742, PMCID: PMC5966823, DOI: 10.1038/mp.2016.254.
• Common developmental genome deprogramming in schizophrenia — Role of Integrative Nuclear FGFR1 Signaling (INFS)Narla S, Lee Y, Benson C, Sarder P, Brennand K, Stachowiak E, Stachowiak M. Common developmental genome deprogramming in schizophrenia — Role of Integrative Nuclear FGFR1 Signaling (INFS). Schizophrenia Research 2017, 185: 17-32. PMID: 28094170, PMCID: PMC5507209, DOI: 10.1016/j.schres.2016.12.012.
• Activity-Dependent Changes in Gene Expression in Schizophrenia Human-Induced Pluripotent Stem Cell NeuronsRoussos P, Guennewig B, Kaczorowski D, Barry G, Brennand K. Activity-Dependent Changes in Gene Expression in Schizophrenia Human-Induced Pluripotent Stem Cell Neurons. JAMA Psychiatry 2016, 73: 1180-1188. PMID: 27732689, PMCID: PMC5437975, DOI: 10.1001/jamapsychiatry.2016.2575.
• Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s diseaseWang M, Roussos P, McKenzie A, Zhou X, Kajiwara Y, Brennand K, De Luca G, Crary J, Casaccia P, Buxbaum J, Ehrlich M, Gandy S, Goate A, Katsel P, Schadt E, Haroutunian V, Zhang B. Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease. Genome Medicine 2016, 8: 104. PMID: 27799057, PMCID: PMC5088659, DOI: 10.1186/s13073-016-0355-3.
• Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia modelsXu J, Hartley BJ, Kurup P, Phillips A, Topol A, Xu M, Ononenyi C, Foscue E, Ho SM, Baguley TD, Carty N, Barros CS, Müller U, Gupta S, Gochman P, Rapoport J, Ellman JA, Pittenger C, Aronow B, Nairn AC, Nestor MW, Lombroso PJ, Brennand KJ. Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models. Molecular Psychiatry 2016, 23: 271-281. PMID: 27752082, PMCID: PMC5395367, DOI: 10.1038/mp.2016.163.
• Neural organoids for disease phenotyping, drug screening and developmental biology studiesHartley B, Brennand K. Neural organoids for disease phenotyping, drug screening and developmental biology studies. Neurochemistry International 2016, 106: 85-93. PMID: 27744003, PMCID: PMC5389930, DOI: 10.1016/j.neuint.2016.10.004.
• Spatial genome organization and cognitionRajarajan P, Gil S, Brennand K, Akbarian S. Spatial genome organization and cognition. Nature Reviews Neuroscience 2016, 17: 681-691. PMID: 27708356, PMCID: PMC5503467, DOI: 10.1038/nrn.2016.124.
• Gene expression elucidates functional impact of polygenic risk for schizophreniaFromer M, Roussos P, Sieberts S, Johnson J, Kavanagh D, Perumal T, Ruderfer D, Oh E, Topol A, Shah H, Klei L, Kramer R, Pinto D, Gümüş Z, Cicek A, Dang K, Browne A, Lu C, Xie L, Readhead B, Stahl E, Xiao J, Parvizi M, Hamamsy T, Fullard J, Wang Y, Mahajan M, Derry J, Dudley J, Hemby S, Logsdon B, Talbot K, Raj T, Bennett D, De Jager P, Zhu J, Zhang B, Sullivan P, Chess A, Purcell S, Shinobu L, Mangravite L, Toyoshiba H, Gur R, Hahn C, Lewis D, Haroutunian V, Peters M, Lipska B, Buxbaum J, Schadt E, Hirai K, Roeder K, Brennand K, Katsanis N, Domenici E, Devlin B, Sklar P. Gene expression elucidates functional impact of polygenic risk for schizophrenia. Nature Neuroscience 2016, 19: 1442-1453. PMID: 27668389, PMCID: PMC5083142, DOI: 10.1038/nn.4399.
• Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screenXu M, Lee E, Wen Z, Cheng Y, Huang W, Qian X, TCW J, Kouznetsova J, Ogden S, Hammack C, Jacob F, Nguyen H, Itkin M, Hanna C, Shinn P, Allen C, Michael S, Simeonov A, Huang W, Christian K, Goate A, Brennand K, Huang R, Xia M, Ming G, Zheng W, Song H, Tang H. Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen. Nature Medicine 2016, 22: 1101-1107. PMID: 27571349, PMCID: PMC5386783, DOI: 10.1038/nm.4184.
• Altered proliferation and networks in neural cells derived from idiopathic autistic individualsMarchetto M, Belinson H, Tian Y, Freitas B, Fu C, Vadodaria K, Beltrao-Braga P, Trujillo C, Mendes A, Padmanabhan K, Nunez Y, Ou J, Ghosh H, Wright R, Brennand K, Pierce K, Eichenfield L, Pramparo T, Eyler L, Barnes C, Courchesne E, Geschwind D, Gage F, Wynshaw-Boris A, Muotri A. Altered proliferation and networks in neural cells derived from idiopathic autistic individuals. Molecular Psychiatry 2016, 22: 820-835. PMID: 27378147, PMCID: PMC5215991, DOI: 10.1038/mp.2016.95.
• P1‐021: Exploring Cell Autonomous and Non‐Cell Autonomous Effects of APOE Genotype in IPSC‐Derived Astrocytes and NeuronsTcw J, Wang M, Bertelsen S, Zhang B, Brennand K, Goate A. P1‐021: Exploring Cell Autonomous and Non‐Cell Autonomous Effects of APOE Genotype in IPSC‐Derived Astrocytes and Neurons. Alzheimer's & Dementia 2016, 12: p407-p407. DOI: 10.1016/j.jalz.2016.06.768.
• The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sampleOedegaard K, Alda M, Anand A, Andreassen O, Balaraman Y, Berrettini W, Bhattacharjee A, Brennand K, Burdick K, Calabrese J, Calkin C, Claasen A, Coryell W, Craig D, DeModena A, Frye M, Gage F, Gao K, Garnham J, Gershon E, Jakobsen P, Leckband S, McCarthy M, McInnis M, Maihofer A, Mertens J, Morken G, Nievergelt C, Nurnberger J, Pham S, Schoeyen H, Shekhtman T, Shilling P, Szelinger S, Tarwater B, Yao J, Zandi P, Kelsoe J. The Pharmacogenomics of Bipolar Disorder study (PGBD): identification of genes for lithium response in a prospective sample. BMC Psychiatry 2016, 16: 129. PMID: 27150464, PMCID: PMC4857276, DOI: 10.1186/s12888-016-0732-x.
• Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor CellsTopol A, Zhu S, Hartley B, English J, Hauberg M, Tran N, Rittenhouse C, Simone A, Ruderfer D, Johnson J, Readhead B, Hadas Y, Gochman P, Wang Y, Shah H, Cagney G, Rapoport J, Gage F, Dudley J, Sklar P, Mattheisen M, Cotter D, Fang G, Brennand K. Dysregulation of miRNA-9 in a Subset of Schizophrenia Patient-Derived Neural Progenitor Cells. Cell Reports 2016, 15: 1024-1036. PMID: 27117414, PMCID: PMC4856588, DOI: 10.1016/j.celrep.2016.03.090.
• Can prenatal infection contribute to psychiatric disease in offspring?Brennand K. Can prenatal infection contribute to psychiatric disease in offspring? Science Translational Medicine 2016, 8 DOI: 10.1126/scitranslmed.aaf3846.
• Is Huntington’s disease a neurodevelopmental disorder?Brennand K. Is Huntington’s disease a neurodevelopmental disorder? Science Translational Medicine 2016, 8 DOI: 10.1126/scitranslmed.aad9760.
• Chapter 23 hiPSC Models Relevant to SchizophreniaHartley B, Hadas Y, Brennand K. Chapter 23 hiPSC Models Relevant to Schizophrenia. 2016, 23: 391-406. DOI: 10.1016/b978-0-12-800981-9.00023-7.
• Erratum: Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorderMertens J, Wang Q, Kim Y, Yu D, Pham S, Yang B, Zheng Y, Diffenderfer K, Zhang J, Soltani S, Eames T, Schafer S, Boyer L, Marchetto M, Nurnberger J, Calabrese J, Oedegaard K, McCarthy M, Zandi P, Alda M, Nievergelt C, Mi S, Brennand K, Kelsoe J, Gage F, Yao J. Erratum: Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature 2015, 530: 242-242. PMID: 26605530, DOI: 10.1038/nature16182.
• Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cellsHo S, Hartley B, Julia T, Beaumont M, Stafford K, Slesinger P, Brennand K. Rapid Ngn2-induction of excitatory neurons from hiPSC-derived neural progenitor cells. Methods 2015, 101: 113-124. PMID: 26626326, PMCID: PMC4860098, DOI: 10.1016/j.ymeth.2015.11.019.
• Creating Patient-Specific Neural Cells for the In Vitro Study of Brain DisordersBrennand KJ, Marchetto MC, Benvenisty N, Brüstle O, Ebert A, Belmonte J, Kaykas A, Lancaster MA, Livesey FJ, McConnell MJ, McKay RD, Morrow EM, Muotri AR, Panchision DM, Rubin LL, Sawa A, Soldner F, Song H, Studer L, Temple S, Vaccarino FM, Wu J, Vanderhaeghen P, Gage FH, Jaenisch R. Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders. Stem Cell Reports 2015, 5: 933-945. PMID: 26610635, PMCID: PMC4881284, DOI: 10.1016/j.stemcr.2015.10.011.
• A new recipe for serotonergic neuronsBrennand K. A new recipe for serotonergic neurons. Science Translational Medicine 2015, 7 DOI: 10.1126/scitranslmed.aad5908.
• Using hiPSCs to model neuropsychiatric copy number variations (CNVs) has potential to reveal underlying disease mechanismsFlaherty E, Brennand K. Using hiPSCs to model neuropsychiatric copy number variations (CNVs) has potential to reveal underlying disease mechanisms. Brain Research 2015, 1655: 283-293. PMID: 26581337, PMCID: PMC4865445, DOI: 10.1016/j.brainres.2015.11.009.
• Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorderMertens J, Wang Q, Kim Y, Yu D, Pham S, Yang B, Zheng Y, Diffenderfer K, Zhang J, Soltani S, Eames T, Schafer S, Boyer L, Marchetto M, Nurnberger J, Calabrese J, Oedegaard K, McCarthy M, Zandi P, Alda M, Nievergelt C, Mi S, Brennand K, Kelsoe J, Gage F, Yao J. Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. Nature 2015, 527: 95-99. PMID: 26524527, PMCID: PMC4742055, DOI: 10.1038/nature15526.
• Increased abundance of translation machinery in stem cell–derived neural progenitor cells from four schizophrenia patientsTopol A, English J, Flaherty E, Rajarajan P, Hartley B, Gupta S, Desland F, Zhu S, Goff T, Friedman L, Rapoport J, Felsenfeld D, Cagney G, Mackay-Sim A, Savas J, Aronow B, Fang G, Zhang B, Cotter D, Brennand K. Increased abundance of translation machinery in stem cell–derived neural progenitor cells from four schizophrenia patients. Translational Psychiatry 2015, 5: e662-e662. PMID: 26485546, PMCID: PMC4930118, DOI: 10.1038/tp.2015.118.
• Insights into the pharmacology of depressionBrennand K. Insights into the pharmacology of depression. Science Translational Medicine 2015, 7 DOI: 10.1126/scitranslmed.aad3628.
• Inheritance of fear and traumaBrennand K. Inheritance of fear and trauma. Science Translational Medicine 2015, 7 DOI: 10.1126/scitranslmed.aad1822.
• Detecting mutant huntingtin protein in HD patientsBrennand K. Detecting mutant huntingtin protein in HD patients. Science Translational Medicine 2015, 7 DOI: 10.1126/scitranslmed.aac8559.
• Characterization of molecular and cellular phenotypes associated with a heterozygous CNTNAP2 deletion using patient-derived hiPSC neural cellsLee I, Carvalho C, Douvaras P, Ho S, Hartley B, Zuccherato L, Ladran I, Siegel A, McCarthy S, Malhotra D, Sebat J, Rapoport J, Fossati V, Lupski J, Levy D, Brennand K. Characterization of molecular and cellular phenotypes associated with a heterozygous CNTNAP2 deletion using patient-derived hiPSC neural cells. Schizophrenia 2015, 1: 15019. PMID: 26985448, PMCID: PMC4789165, DOI: 10.1038/npjschz.2015.19.
• Stem cells in gelsBrennand K. Stem cells in gels. Science Translational Medicine 2015, 7 DOI: 10.1126/scitranslmed.aac5089.
• Cracking the bell jarBrennand K. Cracking the bell jar. Science Translational Medicine 2015, 7 DOI: 10.1126/scitranslmed.aab3128.
• Noncoding RNAs and neurobehavioral mechanisms in psychiatric diseaseKocerha J, Dwivedi Y, Brennand K. Noncoding RNAs and neurobehavioral mechanisms in psychiatric disease. Molecular Psychiatry 2015, 20: 677-684. PMID: 25824307, PMCID: PMC4440836, DOI: 10.1038/mp.2015.30.
• A guide to generating and using hiPSC derived NPCs for the study of neurological diseases.Topol A, Tran N, Brennand K. A guide to generating and using hiPSC derived NPCs for the study of neurological diseases. Journal Of Visualized Experiments 2015, e52495. PMID: 25742222, PMCID: PMC4354663, DOI: 10.3791/52495.
• A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological DiseasesTopol A, Tran N, Brennand K. A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases. Journal Of Visualized Experiments 2015 DOI: 10.3791/52495-v.
• Altered WNT Signaling in Human Induced Pluripotent Stem Cell Neural Progenitor Cells Derived from Four Schizophrenia PatientsTopol A, Zhu S, Tran N, Simone A, Fang G, Brennand K. Altered WNT Signaling in Human Induced Pluripotent Stem Cell Neural Progenitor Cells Derived from Four Schizophrenia Patients. Biological Psychiatry 2015, 78: e29-e34. PMID: 25708228, PMCID: PMC4520784, DOI: 10.1016/j.biopsych.2014.12.028.
• Dopaminergic differentiation of schizophrenia hiPSCsHartley B, Tran N, Ladran I, Reggio K, Brennand K. Dopaminergic differentiation of schizophrenia hiPSCs. Molecular Psychiatry 2015, 20: 549-550. PMID: 25623947, PMCID: PMC4500053, DOI: 10.1038/mp.2014.194.
• From “Directed Differentiation” to “Neuronal Induction”: Modeling Neuropsychiatric DiseaseHo S, Topol A, Brennand K. From “Directed Differentiation” to “Neuronal Induction”: Modeling Neuropsychiatric Disease. Biomarker Insights 2015, 10s1: bmi.s20066. PMID: 26045654, PMCID: PMC4444490, DOI: 10.4137/bmi.s20066.
• Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disordersSchadt E, Buchanan S, Brennand K, Merchant K. Evolving toward a human-cell based and multiscale approach to drug discovery for CNS disorders. Frontiers In Pharmacology 2014, 5: 252. PMID: 25520658, PMCID: PMC4251289, DOI: 10.3389/fphar.2014.00252.
• Modeling predisposition to schizophrenia using hiPSCsBrennand K. Modeling predisposition to schizophrenia using hiPSCs. Schizophrenia Research 2014, 160: e11-e12. DOI: 10.1016/j.schres.2014.09.077.
• A Role for Noncoding Variation in SchizophreniaRoussos P, Mitchell A, Voloudakis G, Fullard J, Pothula V, Tsang J, Stahl E, Georgakopoulos A, Ruderfer D, Charney A, Okada Y, Siminovitch K, Worthington J, Padyukov L, Klareskog L, Gregersen P, Plenge R, Raychaudhuri S, Fromer M, Purcell S, Brennand K, Robakis N, Schadt E, Akbarian S, Sklar P. A Role for Noncoding Variation in Schizophrenia. Cell Reports 2014, 9: 1417-1429. PMID: 25453756, PMCID: PMC4255904, DOI: 10.1016/j.celrep.2014.10.015.
• Human iPSC Neurons Display Activity-Dependent Neurotransmitter Secretion: Aberrant Catecholamine Levels in Schizophrenia NeuronsHook V, Brennand K, Kim Y, Toneff T, Funkelstein L, Lee K, Ziegler M, Gage F. Human iPSC Neurons Display Activity-Dependent Neurotransmitter Secretion: Aberrant Catecholamine Levels in Schizophrenia Neurons. Stem Cell Reports 2014, 3: 531-538. PMID: 25358781, PMCID: PMC4223699, DOI: 10.1016/j.stemcr.2014.08.001.
• Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem CellsYu D, Di Giorgio F, Yao J, Marchetto M, Brennand K, Wright R, Mei A, Mchenry L, Lisuk D, Grasmick J, Silberman P, Silberman G, Jappelli R, Gage F. Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells. Stem Cell Reports 2014, 3: 217. PMCID: PMC4110748, DOI: 10.1016/j.stemcr.2014.06.015.
• Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain DisordersHashimoto-Torii K, Torii M, Fujimoto M, Nakai A, Fatimy R, Mezger V, Ju MJ, Ishii S, Chao SH, Brennand KJ, Gage FH, Rakic P. Roles of Heat Shock Factor 1 in Neuronal Response to Fetal Environmental Risks and Its Relevance to Brain Disorders. Neuron 2014, 82: 560-572. PMID: 24726381, PMCID: PMC4051437, DOI: 10.1016/j.neuron.2014.03.002.
• investigating the mechanisms involved in aberrant neurosphere migration in schizophrenia (784.2)Patruno A, Tran N, Abdelrahim M, Brennand K. investigating the mechanisms involved in aberrant neurosphere migration in schizophrenia (784.2). The FASEB Journal 2014, 28 DOI: 10.1096/fasebj.28.1_supplement.784.2.
• Phenotypic differences in hiPSC NPCs derived from patients with schizophreniaBrennand K, Savas J, Kim Y, Tran N, Simone A, Hashimoto-Torii K, Beaumont K, Kim H, Topol A, Ladran I, Abdelrahim M, Matikainen-Ankney B, Chao S, Mrksich M, Rakic P, Fang G, Zhang B, Yates J, Gage F. Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia. Molecular Psychiatry 2014, 20: 361-368. PMID: 24686136, PMCID: PMC4182344, DOI: 10.1038/mp.2014.22.
• MODELING PREDISPOSITION TO SZ USING HIPSCSBrennand K. MODELING PREDISPOSITION TO SZ USING HIPSCS. Schizophrenia Research 2014, 153: s45. DOI: 10.1016/s0920-9964(14)70147-1.
• Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem CellsYu D, Di Giorgio F, Yao J, Marchetto M, Brennand K, Wright R, Mei A, Mchenry L, Lisuk D, Grasmick J, Silberman P, Silberman G, Jappelli R, Gage F. Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells. Stem Cell Reports 2014, 2: 295-310. PMID: 24672753, PMCID: PMC3964286, DOI: 10.1016/j.stemcr.2014.01.009.
• Developing inexpensive malaria vaccines from plants and algaeGregory J, Mayfield S. Developing inexpensive malaria vaccines from plants and algae. Applied Microbiology And Biotechnology 2014, 98: 1983-1990. PMID: 24413920, DOI: 10.1007/s00253-013-5477-6.
• Inducing Cellular Aging: Enabling Neurodegeneration-in-a-DishBrennand K. Inducing Cellular Aging: Enabling Neurodegeneration-in-a-Dish. Cell Stem Cell 2013, 13: 635-636. PMID: 24315433, PMCID: PMC3908665, DOI: 10.1016/j.stem.2013.11.017.
• Modeling Heterogeneous Patients With a Clinical Diagnosis of Schizophrenia With Induced Pluripotent Stem CellsBrennand K, Landek-Salgado M, Sawa A. Modeling Heterogeneous Patients With a Clinical Diagnosis of Schizophrenia With Induced Pluripotent Stem Cells. Biological Psychiatry 2013, 75: 936-944. PMID: 24331955, PMCID: PMC4022707, DOI: 10.1016/j.biopsych.2013.10.025.
• Mosaic Copy Number Variation in Human NeuronsMcConnell MJ, Lindberg MR, Brennand KJ, Piper JC, Voet T, Cowing-Zitron C, Shumilina S, Lasken RS, Vermeesch JR, Hall IM, Gage FH. Mosaic Copy Number Variation in Human Neurons. Science 2013, 342: 632-637. PMID: 24179226, PMCID: PMC3975283, DOI: 10.1126/science.1243472.
• Neural stem and progenitor cells in health and diseaseLadran I, Tran N, Topol A, Brennand K. Neural stem and progenitor cells in health and disease. WIREs Mechanisms Of Disease 2013, 5: 701-715. PMID: 24068527, PMCID: PMC4160040, DOI: 10.1002/wsbm.1239.
• Chapter 6 Neural Induction of Embryonic Stem/Induced Pluripotent Stem CellsBrennand K, Gage F. Chapter 6 Neural Induction of Embryonic Stem/Induced Pluripotent Stem Cells. 2013, 111-129. DOI: 10.1016/b978-0-12-397265-1.00046-0.
• Modeling Schizophrenia Using Induced Pluripotent Stem Cell–Derived and Fibroblast-Induced NeuronsTran N, Ladran I, Brennand K. Modeling Schizophrenia Using Induced Pluripotent Stem Cell–Derived and Fibroblast-Induced Neurons. Schizophrenia Bulletin 2012, 39: 4-10. PMID: 23172000, PMCID: PMC3523925, DOI: 10.1093/schbul/sbs127.
• Modeling psychiatric disorders at the cellular and network levelsBrennand K, Simone A, Tran N, Gage F. Modeling psychiatric disorders at the cellular and network levels. Molecular Psychiatry 2012, 17: 1239-1253. PMID: 22472874, PMCID: PMC3465628, DOI: 10.1038/mp.2012.20.
• Concise Review: The Promise of Human Induced Pluripotent Stem Cell‐Based Studies of SchizophreniaBrennand K, Gage F. Concise Review: The Promise of Human Induced Pluripotent Stem Cell‐Based Studies of Schizophrenia. Stem Cells 2011, 29: 1915-1922. PMID: 22009633, PMCID: PMC3381343, DOI: 10.1002/stem.762.
• Erratum: Modelling schizophrenia using human induced pluripotent stem cellsBrennand K, Simone A, Jou J, Gelboin-Burkhart C, Tran N, Sangar S, Li Y, Mu Y, Chen G, Yu D, McCarthy S, Sebat J, Gage F. Erratum: Modelling schizophrenia using human induced pluripotent stem cells. Nature 2011, 479: 556-556. DOI: 10.1038/nature10603.
• Modeling psychiatric disorders through reprogrammingBrennand K, Gage F. Modeling psychiatric disorders through reprogramming. Disease Models & Mechanisms 2011, 5: 26-32. PMID: 21954066, PMCID: PMC3255540, DOI: 10.1242/dmm.008268.
• Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promisesMarchetto M, Brennand K, Boyer L, Gage F. Induced pluripotent stem cells (iPSCs) and neurological disease modeling: progress and promises. Human Molecular Genetics 2011, 20: r109-r115. PMID: 21828073, PMCID: PMC4447776, DOI: 10.1093/hmg/ddr336.
• Brief Report: Efficient Generation of Hematopoietic Precursors and Progenitors from Human Pluripotent Stem Cell LinesWoods N, Parker A, Moraghebi R, Lutz M, Firth A, Brennand K, Berggren W, Raya A, Belmonte J, Gage F, Verma I. Brief Report: Efficient Generation of Hematopoietic Precursors and Progenitors from Human Pluripotent Stem Cell Lines. Stem Cells 2011, 29: 1158-1164. PMID: 21544903, PMCID: PMC3254148, DOI: 10.1002/stem.657.
• Rapid Cellular Turnover in Adipose TissueRigamonti A, Brennand K, Lau F, Cowan C. Rapid Cellular Turnover in Adipose Tissue. PLOS ONE 2011, 6: e17637. PMID: 21407813, PMCID: PMC3047582, DOI: 10.1371/journal.pone.0017637.
• Investigating synapse formation and function using human pluripotent stem cell-derived neuronsKim J, O'Sullivan M, Sanchez C, Hwang M, Israel M, Brennand K, Deerinck T, Goldstein L, Gage F, Ellisman M, Ghosh A. Investigating synapse formation and function using human pluripotent stem cell-derived neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 3005-3010. PMID: 21278334, PMCID: PMC3041068, DOI: 10.1073/pnas.1007753108.
• High-Efficient Generation of Induced Pluripotent Stem Cells from Human AstrocytesRuiz S, Brennand K, Panopoulos A, Herrerías A, Gage F, Izpisua-Belmonte J. High-Efficient Generation of Induced Pluripotent Stem Cells from Human Astrocytes. PLOS ONE 2010, 5: e15526. PMID: 21170306, PMCID: PMC3000364, DOI: 10.1371/journal.pone.0015526.
• Slow and steady is the key to β‐cell replicationBrennand K, Melton D. Slow and steady is the key to β‐cell replication. Journal Of Cellular And Molecular Medicine 2009, 13: 472-487. PMID: 19379145, PMCID: PMC2820566, DOI: 10.1111/j.1582-4934.2008.00635.x.
• Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristicsSzotek P, Chang H, Brennand K, Fujino A, Pieretti-Vanmarcke R, Celso C, Dombkowski D, Preffer F, Cohen K, Teixeira J, Donahoe P. Normal ovarian surface epithelial label-retaining cells exhibit stem/progenitor cell characteristics. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 12469-12473. PMID: 18711140, PMCID: PMC2527935, DOI: 10.1073/pnas.0805012105.
• Reprogramming of Pancreatic β Cells into Induced Pluripotent Stem CellsStadtfeld M, Brennand K, Hochedlinger K. Reprogramming of Pancreatic β Cells into Induced Pluripotent Stem Cells. Current Biology 2008, 18: 890-894. PMID: 18501604, PMCID: PMC2819222, DOI: 10.1016/j.cub.2008.05.010.
• Correction: All ß Cells Contribute Equally to Islet Growth and MaintenanceBrennand K, Huangfu D, Melton D. Correction: All ß Cells Contribute Equally to Islet Growth and Maintenance. PLOS Biology 2007, 5: e240. PMCID: PMC1994270, DOI: 10.1371/journal.pbio.0050240.
• All β Cells Contribute Equally to Islet Growth and MaintenanceBrennand K, Huangfu D, Melton D. All β Cells Contribute Equally to Islet Growth and Maintenance. PLOS Biology 2007, 5: e163. PMID: 17535113, PMCID: PMC1877817, DOI: 10.1371/journal.pbio.0050163.