Research & Publications
Our first axis of research aims at understanding the development of glial cells in the central nervous system. Studies are focusing onto the specification and migration of oligodendrocyte precursor cells (OPCs) in the avian and murine embryonic brain. Research programs are currently developed to investigate the role of Hox Homeoproteins in OPC development and myelin repair.
Our second axis of studies concerns neurovascular interactions, especially the neurobiology of vascular growth factors and receptors. In collaboration with A. EICHMANN (Dpt of CardioVascular Medicine, Yale School of Medicine), we are exploring the role of VEGFRs (Vascular Endothelial Growth Factor Receptors) in neural stem cells and neurovascular niches of the adult brain. As VEGF receptors are targeted by anti-angiogenic anti-tumor therapies, investigations of possible effects of these treatments in the CNS are clinically highly relevant.
Specialized Terms: stem cells; Glial cells; Neurovascular niches; Cell proliferation and differentiation; Cell migration; Vascular growth factors and receptors; Axonal guidance molecules
Extensive Research Description
Projet 1: Hox paralog group 2 genes in oligodendrocyte development and myelin repair
(funded by ARSEP, 2010)
Projet 2: Neurogenesis through VEGF-C/VEGFR-3 signaling
(funded by ANR 2010)
Cell Differentiation; Stem Cells; Cell Proliferation; Neurogenesis
Public Health Interests
Behavioral Health; Perinatal/Prenatal Health
- Study of myelination and remyelination process by live-imaging in XenopusSekizar S, Mannioui K, Desmazieres A, Thomas J, Zonta B, Brophy P, Zalc B. Study of myelination and remyelination process by live-imaging in Xenopus International Journal Of Developmental Neuroscience 2012, 30: 688. DOI: 10.1016/j.ijdevneu.2012.10.052.
- Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3Xu Y, Yuan L, Mak J, Pardanaud L, Caunt M, Kasman I, Larrivée B, del Toro R, Suchting S, Medvinsky A, Silva J, Yang J, Thomas J, Koch A, Alitalo K, Eichmann A, Bagri A. Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3 Journal Of Experimental Medicine 2010, 207: i1-i1. DOI: 10.1084/jem2071oia1.
- [P52]: Early fate restriction of embryonic neural stem cellsDelaunay D, Heydon K, Cumano A, Goebbels S, Thomas J, Suter U, Nave K, Zalc B, Spassky N. [P52]: Early fate restriction of embryonic neural stem cells International Journal Of Developmental Neuroscience 2006, 24: 518-519. DOI: 10.1016/j.ijdevneu.2006.09.115.
- [P75]: Study on the role of TAG‐1 in axono‐glial and axono‐axonal interactions in the embryonic optic nerveChatzopoulou E, Miguez A, Muriel M, Zalc B, Karagogeos D, Thomas J. [P75]: Study on the role of TAG‐1 in axono‐glial and axono‐axonal interactions in the embryonic optic nerve International Journal Of Developmental Neuroscience 2006, 24: 528-528. DOI: 10.1016/j.ijdevneu.2006.09.137.
- RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of GαoTRAVER S, BIDOT C, SPASSKY N, BALTAUSS T, DE TAND M, THOMAS J, Bernard Z, JANOUEIX-LEROSEY I, DE GUNZBURG J. RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of Gαo Biochemical Journal 2000, 350: 19-29. DOI: 10.1042/bj3500019.