Dennis G Moledina

• Albert Ko
• Aldo Peixoto
• Anne Wyllie
• F. Perry Wilson
• Gilbert Moeckel
• Harriet Kluger
• Jason Greenberg
• Jeffrey Testani
• Lloyd G. Cantley
• Madhav Menon
• Mark Perazella
• Monique Evangeline Hinchcliff
• Nathan Grubaugh
• Sherry Mansour

Biopsy, Needle; Kidney; Kidney Diseases; Nephritis, Interstitial; Nephrology; Biomarkers; Translational Research, Biomedical; Acute Kidney Injury

• Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritisMoledina D, Obeid W, Smith R, Rosales I, Sise M, Moeckel G, Kashgarian M, Kuperman M, Campbell K, Lefferts S, Meliambro K, Bitzer M, Perazella M, Luciano R, Pober J, Cantley L, Colvin R, Wilson F, Parikh C. Identification and validation of urinary CXCL9 as a biomarker for diagnosis of acute interstitial nephritis. Journal Of Clinical Investigation 2023, 133: e168950. PMID: 37395276, PMCID: PMC10313360, DOI: 10.1172/jci168950.
• Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritisMoledina DG, Wilson FP, Pober JS, Perazella MA, Singh N, Luciano RL, Obeid W, Lin H, Kuperman M, Moeckel GW, Kashgarian M, Cantley LG, Parikh CR. Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis. JCI Insight 2019, 4: e127456. PMID: 31092735, PMCID: PMC6542610, DOI: 10.1172/jci.insight.127456.
• Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record dataMoledina DG, Eadon MT, Calderon F, Yamamoto Y, Shaw M, Perazella MA, Simonov M, Luciano R, Schwantes-An TH, Moeckel G, Kashgarian M, Kuperman M, Obeid W, Cantley LG, Parikh CR, Wilson FP. Development and external validation of a diagnostic model for biopsy-proven acute interstitial nephritis using electronic health record data. Nephrology Dialysis Transplantation 2021, 37: 2214-2222. PMID: 34865148, PMCID: PMC9755995, DOI: 10.1093/ndt/gfab346.
• Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapyBaker ML, Yamamoto Y, Perazella MA, Dizman N, Shirali AC, Hafez N, Weinstein J, Simonov M, Testani JM, Kluger HM, Cantley LG, Parikh CR, Wilson FP, Moledina DG. Mortality after acute kidney injury and acute interstitial nephritis in patients prescribed immune checkpoint inhibitor therapy. Journal For ImmunoTherapy Of Cancer 2022, 10: e004421. PMID: 35354588, PMCID: PMC8968986, DOI: 10.1136/jitc-2021-004421.
• Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritisMoledina DG, Wilson FP, Kukova L, Obeid W, Luciano R, Kuperman M, Moeckel GW, Kashgarian M, Perazella MA, Cantley LG, Parikh CR. Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis. Nephrology Dialysis Transplantation 2020, 36: 1851-1858. PMID: 33125471, PMCID: PMC8476079, DOI: 10.1093/ndt/gfaa169.
• The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort StudyMoledina DG, Simonov M, Yamamoto Y, Alausa J, Arora T, Biswas A, Cantley LG, Ghazi L, Greenberg JH, Hinchcliff M, Huang C, Mansour SG, Martin M, Peixoto A, Schulz W, Subair L, Testani JM, Ugwuowo U, Young P, Wilson FP. The Association of COVID-19 With Acute Kidney Injury Independent of Severity of Illness: A Multicenter Cohort Study. American Journal Of Kidney Diseases 2021, 77: 490-499.e1. PMID: 33422598, PMCID: PMC7791318, DOI: 10.1053/j.ajkd.2020.12.007.
• Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial FibrosisMelchinger H, Calderon-Gutierrez F, Obeid W, Xu L, Shaw MM, Luciano RL, Kuperman M, Moeckel GW, Kashgarian M, Wilson FP, Parikh CR, Moledina DG. Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis. Clinical Journal Of The American Society Of Nephrology 2022, 17: 1284-1292. PMID: 35948365, PMCID: PMC9625093, DOI: 10.2215/cjn.04360422.
• The development of lateral flow devices for urinary biomarkers to assess kidney healthD Souza S, Obeid W, Hernandez J, Hu D, Wen Y, Moledina D, Albert A, Gregg A, Wheeler A, Philbrook H, Parikh C. The development of lateral flow devices for urinary biomarkers to assess kidney health. Scientific Reports 2024, 14: 8516. PMID: 38609491, PMCID: PMC11014899, DOI: 10.1038/s41598-024-59104-5.
• COVID-19−Associated Acute Kidney Injury and Longitudinal Kidney OutcomesAklilu A, Kumar S, Nugent J, Yamamoto Y, Coronel-Moreno C, Kadhim B, Faulkner S, O’Connor K, Yasmin F, Greenberg J, Moledina D, Testani J, Wilson F. COVID-19−Associated Acute Kidney Injury and Longitudinal Kidney Outcomes. JAMA Internal Medicine 2024, 184: 414-423. PMID: 38407862, PMCID: PMC10897825, DOI: 10.1001/jamainternmed.2023.8225.
• Urinary Plasminogen as a Marker of Disease Progression in Human Glomerular Diseasede Cos M, Mosoyan G, Chauhan K, Troost J, Wong J, Lefferts S, Morgan P, Meliambro K, Egerman M, Ray J, Parker T, Levine D, Seshan S, Bardash Y, Horowitz B, Kent C, Shaw M, Perlman A, Moledina D, Coca S, Campbell K. Urinary Plasminogen as a Marker of Disease Progression in Human Glomerular Disease. American Journal Of Kidney Diseases 2024 PMID: 38452919, DOI: 10.1053/j.ajkd.2024.01.520.
• Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental GlomerulosclerosisBarsotti G, Luciano R, Kumar A, Meliambro K, Kakade V, Tokita J, Naik A, Fu J, Peck E, Pell J, Reghuvaran A, Tanvir E, Patel P, Zhang W, Li F, Moeckel G, Perincheri S, Cantley L, Moledina D, Wilson F, He J, Menon M. Rationale and Design of a Phase 2, Double-blind, Placebo-Controlled, Randomized Trial Evaluating AMP Kinase-Activation by Metformin in Focal Segmental Glomerulosclerosis. Kidney International Reports 2024, 9: 1354-1368. PMID: 38707807, PMCID: PMC11068976, DOI: 10.1016/j.ekir.2024.02.006.
• Toxic Nephropathies of the Tubulointerstitium: Core Curriculum 2024Krishnan N, Moledina D, Perazella M. Toxic Nephropathies of the Tubulointerstitium: Core Curriculum 2024. American Journal Of Kidney Diseases 2024, 83: 659-676. PMID: 38243994, DOI: 10.1053/j.ajkd.2023.09.017.
• APOBEC-1 deletion enhances cisplatin-induced acute kidney injuryGuo X, Blanc V, Davidson N, Velazquez H, Chen T, Moledina D, Moeckel G, Safirstein R, Desir G. APOBEC-1 deletion enhances cisplatin-induced acute kidney injury. Scientific Reports 2023, 13: 22255. PMID: 38097707, PMCID: PMC10721635, DOI: 10.1038/s41598-023-49575-3.
• Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injuryWen Y, Su E, Xu L, Menez S, Moledina D, Obeid W, Palevsky P, Mansour S, Devarajan P, Cantley L, Cahan P, Parikh C, Project K, Injury T. Analysis of the human kidney transcriptome and plasma proteome identifies markers of proximal tubule maladaptation to injury. Science Translational Medicine 2023, 15: eade7287. PMID: 38091407, DOI: 10.1126/scitranslmed.ade7287.
• Urinary Biomarkers and Kidney Injury in VA NEPHRON-D: Phenotyping Acute Kidney Injury in Clinical TrialsKiernan E, Hu D, Philbrook H, Ix J, Bonventre J, Coca S, Moledina D, Fried L, Shlipak M, Parikh C. Urinary Biomarkers and Kidney Injury in VA NEPHRON-D: Phenotyping Acute Kidney Injury in Clinical Trials. American Journal Of Kidney Diseases 2023, 83: 151-161. PMID: 37726051, PMCID: PMC10841767, DOI: 10.1053/j.ajkd.2023.07.012.
• Outcomes Associated with Sodium-Glucose Cotransporter-2 Inhibitor Use in Acute Heart Failure Hospitalizations Complicated by AKIAklilu A, Kumar S, Yamamoto Y, Moledina D, Sinha F, Testani J, Wilson F. Outcomes Associated with Sodium-Glucose Cotransporter-2 Inhibitor Use in Acute Heart Failure Hospitalizations Complicated by AKI. Kidney360 2023, 4: 1371-1381. PMID: 37644648, PMCID: PMC10615381, DOI: 10.34067/kid.0000000000000250.
• The ASSESS-AKI Study found urinary epidermal growth factor is associated with reduced risk of major adverse kidney eventsMenez S, Wen Y, Xu L, Moledina D, Thiessen-Philbrook H, Hu D, Obeid W, Bhatraju P, Ikizler T, Siew E, Chinchilli V, Garg A, Go A, Liu K, Kaufman J, Kimmel P, Himmelfarb J, Coca S, Cantley L, Parikh C. The ASSESS-AKI Study found urinary epidermal growth factor is associated with reduced risk of major adverse kidney events. Kidney International 2023, 104: 1194-1205. PMID: 37652206, PMCID: PMC10840723, DOI: 10.1016/j.kint.2023.08.007.
• Comparative evaluation of glomerular morphometric techniques reveals differential technical artifacts between focal segmental glomerulosclerosis and normal glomeruliReghuvaran A, Lin Q, Basgen J, Banu K, Shi H, Vashist A, Pell J, Perinchery S, He J, Moledina D, Wilson F, Menon M. Comparative evaluation of glomerular morphometric techniques reveals differential technical artifacts between focal segmental glomerulosclerosis and normal glomeruli. Physiological Reports 2023, 11: e15688. PMID: 37423891, PMCID: PMC10329935, DOI: 10.14814/phy2.15688.
• Evaluation of Plasma Biomarkers to Predict Major Adverse Kidney Events in Hospitalized Patients With COVID-19Menez S, Coca S, Moledina D, Wen Y, Chan L, Thiessen-Philbrook H, Obeid W, Garibaldi B, Azeloglu E, Ugwuowo U, Sperati C, Arend L, Rosenberg A, Kaushal M, Jain S, Wilson F, Parikh C, Consortium T, Deng J, Atta M, Bagnasco S, Ko A, Iwasaki A, Farhadian S, Nelson A, Casanovas-Massana A, White E, Schulz W, Coppi A, Young P, Nunez A, Shepard D, Matos I, Strong Y, Anastasio K, Brower K, Kuang M, Chiorazzi M, Bermejo S, Vijayakumar P, Geng B, Fournier J, Minasyan M, Muenker M, Moore A, Nadkarni G. Evaluation of Plasma Biomarkers to Predict Major Adverse Kidney Events in Hospitalized Patients With COVID-19. American Journal Of Kidney Diseases 2023, 82: 322-332.e1. PMID: 37263570, PMCID: PMC10229201, DOI: 10.1053/j.ajkd.2023.03.010.
• A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomesWilson F, Yamamoto Y, Martin M, Coronel-Moreno C, Li F, Cheng C, Aklilu A, Ghazi L, Greenberg J, Latham S, Melchinger H, Mansour S, Moledina D, Parikh C, Partridge C, Testani J, Ugwuowo U. A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes. Nature Communications 2023, 14: 2826. PMID: 37198160, PMCID: PMC10192367, DOI: 10.1038/s41467-023-38532-3.
• Longitudinal biomarkers and kidney disease progression after acute kidney injuryWen Y, Xu L, Melchinger I, Thiessen-Philbrook H, Moledina D, Coca S, Hsu C, Go A, Liu K, Siew E, Ikizler T, Chinchilli V, Kaufman J, Kimmel P, Himmelfarb J, Cantley L, Parikh C, Consortium T. Longitudinal biomarkers and kidney disease progression after acute kidney injury. JCI Insight 2023, 8: e167731. PMID: 36951957, PMCID: PMC10243801, DOI: 10.1172/jci.insight.167731.
• Joint Modeling of Clinical and Biomarker Data in Acute Kidney Injury Defines Unique Subphenotypes with Differing OutcomesVasquez-Rios G, Oh W, Lee S, Bhatraju P, Mansour S, Moledina D, Gulamali F, Siew E, Garg A, Sarder P, Chinchilli V, Kaufman J, Hsu C, Liu K, Kimmel P, Go A, Wurfel M, Himmelfarb J, Parikh C, Coca S, Nadkarni G. Joint Modeling of Clinical and Biomarker Data in Acute Kidney Injury Defines Unique Subphenotypes with Differing Outcomes. Clinical Journal Of The American Society Of Nephrology 2023, 18: 716-726. PMID: 36975209, PMCID: PMC10278836, DOI: 10.2215/cjn.0000000000000156.
• Pre-operative kidney biomarkers and risks for death, cardiovascular and chronic kidney disease events after cardiac surgery: the TRIBE-AKI studyVasquez-Rios G, Moledina D, Jia Y, McArthur E, Mansour S, Thiessen-Philbrook H, Shlipak M, Koyner J, Garg A, Parikh C, Coca S. Pre-operative kidney biomarkers and risks for death, cardiovascular and chronic kidney disease events after cardiac surgery: the TRIBE-AKI study. Journal Of Cardiothoracic Surgery 2022, 17: 338. PMID: 36567329, PMCID: PMC9790121, DOI: 10.1186/s13019-022-02066-4.
• Safety and Adequacy of Kidney Biopsy Procedure in Patients with ObesityQian L, Menez S, Hu D, Weinstein J, Melchinger H, Thiessen-Philbrook H, Luciano R, Turner J, Perazella M, Villalobos C, Shaw M, Wilson F, Parikh C, Moledina D. Safety and Adequacy of Kidney Biopsy Procedure in Patients with Obesity. Kidney360 2022, 4: 98-101. PMID: 36700910, PMCID: PMC10101611, DOI: 10.34067/kid.0006602022.
• Role of time from transplantation to biopsy in histologic ABMR: A single center reportChancay J, Liu C, Chauhan K, Andersen L, Harris C, Coca S, Delaney V, Tedla F, De Boccardo G, Sehgal V, Moledina D, Formica R, Reghuvaran A, Banu K, Florman S, Akalin E, Shapiro R, Salem F, Menon MC. Role of time from transplantation to biopsy in histologic ABMR: A single center report. Clinical Transplantation 2022, 36: e14802. PMID: 36069577, PMCID: PMC10211409, DOI: 10.1111/ctr.14802.
• Plasma Soluble Tumor Necrosis Factor Receptor Concentrations and Clinical Events After Hospitalization: Findings From the ASSESS-AKI and ARID StudiesCoca SG, Vasquez-Rios G, Mansour SG, Moledina DG, Thiessen-Philbrook H, Wurfel MM, Bhatraju P, Himmelfarb J, Siew E, Garg AX, Hsu CY, Liu KD, Kimmel PL, Chinchilli VM, Kaufman JS, Wilson M, Banks RE, Packington R, McCole E, Kurth MJ, Richardson C, Go AS, Selby NM, Parikh CR. Plasma Soluble Tumor Necrosis Factor Receptor Concentrations and Clinical Events After Hospitalization: Findings From the ASSESS-AKI and ARID Studies. American Journal Of Kidney Diseases 2022, 81: 190-200. PMID: 36108888, PMCID: PMC9868060, DOI: 10.1053/j.ajkd.2022.08.007.
• Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transitionXu L, Guo J, Moledina DG, Cantley LG. Immune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition. Nature Communications 2022, 13: 4892. PMID: 35986026, PMCID: PMC9391331, DOI: 10.1038/s41467-022-32634-0.
• Urine testing to differentiate glomerular from tubulointerstitial diseases on kidney biopsyTran AC, Melchinger H, Weinstein J, Shaw M, Kent C, Perazella MA, Wilson FP, Parikh CR, Moledina DG. Urine testing to differentiate glomerular from tubulointerstitial diseases on kidney biopsy. Practical Laboratory Medicine 2022, 30: e00271. PMID: 35465621, PMCID: PMC9018443, DOI: 10.1016/j.plabm.2022.e00271.
• Considerations in Controlling for Urine Concentration for Biomarkers of Kidney Disease Progression After Acute Kidney InjuryWen Y, Thiessen-Philbrook H, Moledina DG, Kaufman JS, Reeves WB, Ghahramani N, Ikizler TA, Go AS, Liu KD, Siew ED, Himmelfarb J, Kimmel PL, Hsu CY, Parikh CR. Considerations in Controlling for Urine Concentration for Biomarkers of Kidney Disease Progression After Acute Kidney Injury. Kidney International Reports 2022, 7: 1502-1513. PMID: 35812275, PMCID: PMC9263319, DOI: 10.1016/j.ekir.2022.03.026.
• Acute Interstitial Nephritis and Crystalline NephropathiesMoledina D, Herlitz L, Perazella M. Acute Interstitial Nephritis and Crystalline Nephropathies. Nephrology Self-Assessment Program 2022, 21: 50-70. DOI: 10.1681/nsap.2022.21.1.5.
• Clinical Features and Laboratory Findings in Acute Tubulointerstitial NephritisKodali R, Moledina D. Clinical Features and Laboratory Findings in Acute Tubulointerstitial Nephritis. 2022, 245-255. DOI: 10.1007/978-3-030-93438-5_19.
• Clinically adjudicated deceased donor acute kidney injury and graft outcomesMansour SG, Khoury N, Kodali R, Virmani S, Reese PP, Hall IE, Jia Y, Yamamoto Y, Thiessen-Philbrook HR, Obeid W, Doshi MD, Akalin E, Bromberg JS, Harhay MN, Mohan S, Muthukumar T, Singh P, Weng FL, Moledina DG, Greenberg JH, Wilson FP, Parikh CR. Clinically adjudicated deceased donor acute kidney injury and graft outcomes. PLOS ONE 2022, 17: e0264329. PMID: 35239694, PMCID: PMC8893682, DOI: 10.1371/journal.pone.0264329.
• Prognostic Significance of Urinary Biomarkers in Patients Hospitalized With COVID-19Menez S, Moledina DG, Thiessen-Philbrook H, Wilson FP, Obeid W, Simonov M, Yamamoto Y, Corona-Villalobos CP, Chang C, Garibaldi BT, Clarke W, Farhadian S, Dela Cruz C, Coca SG, Parikh CR, Investigators T, Ko A, Iwasaki A, Farhadian S, Nelson A, Casanovas-Massana A, White E, Schulz W, Coppi A, Young P, Nunez A, Shepard D, Matos I, Strong Y, Anastasio K, Brower K, Kuang M, Chiorazzi M, Bermejo S, Vijayakumar P, Geng B, Fournier J, Minasyan M, Muenker M, Moore A, Nadkarni G. Prognostic Significance of Urinary Biomarkers in Patients Hospitalized With COVID-19. American Journal Of Kidney Diseases 2021, 79: 257-267.e1. PMID: 34710516, PMCID: PMC8542781, DOI: 10.1053/j.ajkd.2021.09.008.
• Prognostic Significance of Urinary Biomarkers in Patients Hospitalized with COVID-19Menez S, Moledina D, Philbrook H, Wilson F, Obeid W, Simonov M, Yamamoto Y, villalobos C, Chang C, Garibaldi B, Clarke W, Farhadian S, Dela Cruz C, Coca S, Parikh C. Prognostic Significance of Urinary Biomarkers in Patients Hospitalized with COVID-19. Journal Of The American Society Of Nephrology 2021, 32: 107-107. DOI: 10.1681/asn.20213210s1107a.
• AKI and Mortality in Patients Prescribed Immune Checkpoint Inhibitor TherapyBaker M, Yamamoto Y, Perazella M, Parikh C, Wilson F, Moledina D. AKI and Mortality in Patients Prescribed Immune Checkpoint Inhibitor Therapy. Journal Of The American Society Of Nephrology 2021, 32: 132-132. DOI: 10.1681/asn.20213210s1132c.
• Preoperative Plasma TNFR1, TNFR2, and KIM-1 and Long-Term Adverse Events After Cardiac Surgery: The TRIBE-AKI StudyVasquez-Rios G, Moledina D, McArthur E, Mansour S, Menez S, Philbrook H, Shlipak M, Koyner J, Garg A, Parikh C, Coca S. Preoperative Plasma TNFR1, TNFR2, and KIM-1 and Long-Term Adverse Events After Cardiac Surgery: The TRIBE-AKI Study. Journal Of The American Society Of Nephrology 2021, 32: 128-128. DOI: 10.1681/asn.20213210s1128b.
• Considerations in Controlling for Urine Concentration in Performance of Biomarkers of AKIWen Y, Philbrook H, Moledina D, Kaufman J, Reeves W, Ghahramani N, Ikizler T, Go A, Liu K, Himmelfarb J, Siew E, Kimmel P, Hsu C, Parikh C. Considerations in Controlling for Urine Concentration in Performance of Biomarkers of AKI. Journal Of The American Society Of Nephrology 2021, 32: 128-129. DOI: 10.1681/asn.20213210s1128d.
• Preoperative Biomarkers and Mortality Risk After Cardiac SurgeryLiu C, Menez S, Moledina D, Philbrook H, McArthur E, Obeid W, Mansour S, Garg A, Parikh C, Coca S. Preoperative Biomarkers and Mortality Risk After Cardiac Surgery. Journal Of The American Society Of Nephrology 2021, 32: 128-128. DOI: 10.1681/asn.20213210s1128c.
• Plasma TNFR1 Predicts Major Adverse Kidney Events in Hospitalized Patients with COVID-19Menez S, Coca S, Moledina D, Wen Y, Chan L, Philbrook H, Obeid W, Azeloglu E, Wilson F, Parikh C. Plasma TNFR1 Predicts Major Adverse Kidney Events in Hospitalized Patients with COVID-19. Journal Of The American Society Of Nephrology 2021, 32: 59-60. DOI: 10.1681/asn.20213210s159e.
• The Challenges of Acute Interstitial Nephritis: Time to StandardizeMoledina DG, Perazella MA. The Challenges of Acute Interstitial Nephritis: Time to Standardize. Kidney360 2021, 2: 1051-1055. PMID: 35373086, PMCID: PMC8791367, DOI: 10.34067/kid.0001742021.
• Evidence for SARS-CoV-2 Spike Protein in the Urine of COVID-19 PatientsGeorge S, Pal AC, Gagnon J, Timalsina S, Singh P, Vydyam P, Munshi M, Chiu JE, Renard I, Harden CA, Ott IM, Watkins AE, Vogels CBF, Lu P, Tokuyama M, Venkataraman A, Casanovas-Massana A, Wyllie AL, Rao V, Campbell M, Farhadian SF, Grubaugh ND, Dela Cruz CS, Ko AI, Perez A, Akaho EH, Moledina DG, Testani J, John AR, Ledizet M, Mamoun CB, Team A. Evidence for SARS-CoV-2 Spike Protein in the Urine of COVID-19 Patients. Kidney360 2021, 2: 924-936. PMID: 35373072, PMCID: PMC8791366, DOI: 10.34067/kid.0002172021.
• Predicting patients with false negative SARS-CoV-2 testing at hospital admission: A retrospective multi-center studyGhazi L, Simonov M, Mansour SG, Moledina DG, Greenberg JH, Yamamoto Y, Biswas A, Wilson FP. Predicting patients with false negative SARS-CoV-2 testing at hospital admission: A retrospective multi-center study. PLOS ONE 2021, 16: e0251376. PMID: 33979353, PMCID: PMC8115794, DOI: 10.1371/journal.pone.0251376.
• Urinary EGF and MCP-1 and risk of CKD after cardiac surgeryMenez S, Ju W, Menon R, Moledina DG, Thiessen Philbrook H, McArthur E, Jia Y, Obeid W, Mansour SG, Koyner JL, Shlipak MG, Coca SG, Garg AX, Bomback AS, Kellum JA, Kretzler M, Parikh CR, . Urinary EGF and MCP-1 and risk of CKD after cardiac surgery. JCI Insight 2021, 6: e147464. PMID: 33974569, PMCID: PMC8262289, DOI: 10.1172/jci.insight.147464.
• Large-scale, three-dimensional tissue cytometry of the human kidney: a complete and accessible pipeline.Ferkowicz M, Winfree S, Sabo A, Kamocka M, Khochare S, Barwinska D, Eadon M, Cheng Y, Phillips C, Sutton T, Kelly K, Dagher P, El-Achkar T, Dunn K, Knight R, Lecker S, Stillman I, Mcmahon G, Waikar S, Weins A, Hacohen N, Hoover P, Aulisio M, Cooperman L, Herlitz L, O'toole J, Poggio E, Sedor J, Appelbaum P, Barasch J, Bomback A, D'agati V, Kiryluk K, Mehl K, Shang N, Weng C, Barisoni L, Alexandrov T, Ashkar T, Barwinska D, Dagher P, Dunn K, Eadon M, Ferkowicz M, Kelly K, Sutton T, Winfree S, Menez S, Parikh C, Rosenberg A, Villalobos P, Slack A, Rosas S, Williams M, Azeloglu E, He C, Iyengar R, Parikh S, Anderton C, Pasa-Tolic L, Velickovic D, Oliver G, Ardayfio J, Bebiak J, Brown K, Campbell T, Campbell C, Hayashi L, Jefferson N, Koewler R, Roberts G, Saul J, Shpigel A, Stutzke E, Wright L, Miegs L, Pinkeney R, Sealfon R, Troyanskaya O, Tuttle K, Goltsev Y, Lake B, Zhang K, Dobi D, Joanes M, Laszik Z, Nolan G, Schroeder A, Balis U, He O, Hodgin J, Kretzler M, Mariani L, Menon R, Otto E, Schaub J, Steck B, Elder M, Hall D, Kellum J, Kruth M, Murugan R, Palevsky P, Randhawa P, Rosengart M, Sims-Lucas S, Stefanick M, Stull S, Tublin M, Alpers C, Boer I, Fullerton M, Himmelfarb J, Mcclelland R, Mooney S, Shankland S, Williams K, Blank K, Dighe A, Carson J, Dowd F, Drager Z, Sharma K, Zhang G, Kermani A, Lee S, Lu C, Miller T, Moe O, Park H, Sambandam K, Sanchez F, Torrealba J, Robert T, Vazquez M, Wang N, Gaut J, Jain S, Vijayan A, Luciano R, Moledina D, Ugochukwu U, Wilson F. Large-scale, three-dimensional tissue cytometry of the human kidney: a complete and accessible pipeline. Laboratory Investigation 2021, 101: 661-676. PMID: 36775387, DOI: 10.1038/s41374-020-00518-w.
• A Comparison Study of Coronavirus Disease 2019 Outcomes in Hospitalized Kidney Transplant Recipients.Mansour SG, Malhotra D, Simonov M, Yamamoto Y, Arora T, Subair L, Alausa J, Moledina DG, Greenberg JH, Wilson FP, Marin EP. A Comparison Study of Coronavirus Disease 2019 Outcomes in Hospitalized Kidney Transplant Recipients. Kidney360 2021, 2: 494-506. PMID: 35369023, PMCID: PMC8786009, DOI: 10.34067/kid.0005652020.
• Assessment of Acute Kidney Injury and Longitudinal Kidney Function After Hospital Discharge Among Patients With and Without COVID-19Nugent J, Aklilu A, Yamamoto Y, Simonov M, Li F, Biswas A, Ghazi L, Greenberg J, Mansour S, Moledina D, Wilson FP. Assessment of Acute Kidney Injury and Longitudinal Kidney Function After Hospital Discharge Among Patients With and Without COVID-19. JAMA Network Open 2021, 4: e211095. PMID: 33688965, PMCID: PMC7948062, DOI: 10.1001/jamanetworkopen.2021.1095.
• Rationale and design of the Kidney Precision Medicine Projectde Boer IH, Alpers CE, Azeloglu EU, Balis UGJ, Barasch JM, Barisoni L, Blank KN, Bomback AS, Brown K, Dagher PC, Dighe AL, Eadon MT, El-Achkar TM, Gaut JP, Hacohen N, He Y, Hodgin JB, Jain S, Kellum JA, Kiryluk K, Knight R, Laszik ZG, Lienczewski C, Mariani LH, McClelland RL, Menez S, Moledina DG, Mooney SD, O’Toole J, Palevsky PM, Parikh CR, Poggio ED, Rosas SE, Rosengart MR, Sarwal MM, Schaub JA, Sedor JR, Sharma K, Steck B, Toto RD, Troyanskaya OG, Tuttle KR, Vazquez MA, Waikar SS, Williams K, Wilson FP, Zhang K, Iyengar R, Kretzler M, Himmelfarb J, Project K, Knight R, Lecker S, Stillman I, Waikar S, Mcmahon G, Weins A, Short S, Hacohen N, Hoover P, Aulisio M, Cooperman L, Herlitz L, O’Toole J, Poggio E, Sedor J, Jolly S, Appelbaum P, Balderes O, Barasch J, Bomback A, Canetta P, d’Agati V, Kiryluk K, Kudose S, Mehl K, Radhakrishnan J, Weng C, Barisoni L, Alexandrov T, Ashkar T, Barwinska D, Dagher P, Dunn K, Eadon M, Ferkowicz M, Kelly K, Sutton T, Winfree S, Menez S, Parikh C, Rosenberg A, Villalobos P, Malik R, Fine D, Atta M, Trujillo J, Slack A, Rosas S, Williams M, Azeloglu E, He C, Iyengar R, Hansen J, Parikh S, Rovin B, Anderton C, Pasa-Tolic L, Velickovic D, Lukowski J, Oliver G, Ardayfio J, Bebiak J, Brown K, Campbell T, Campbell C, Hayashi L, Jefferson N, Koewler R, Roberts G, Saul J, Shpigel A, Stutzke E, Wright L, Miegs L, Pinkeney R, Sealfon R, Troyanskaya O, Tuttle K, Dobi D, Goltsev Y, Lake B, Zhang K, Joanes M, Laszik Z, Schroeder A, Sarwal M, Sigdel T, Balis U, Blanc V, He O, Hodgin J, Kretzler M, Mariani L, Menon R, Otto E, Schaub J, Steck B, Lienczewski C, Eddy S, Elder M, Hall D, Kellum J, Kruth M, Murugan R, Palevsky P, Randhawa P, Rosengart M, Sims-Lucas S, Stefanick M, Stull S, Tublin M, Alpers C, de Boer I, Dighe A, Himmelfarb J, Mcclelland R, Mooney S, Shankland S, Williams K, Blank K, Carson J, Dowd F, Drager Z, Park C, Sharma K, Zhang G, Bansal S, Venkatachalam M, Kermani A, Lee S, Lu C, Miller T, Moe O, Park H, Sambandam K, Sanchez F, Torrealba J, Robert T, Vazquez M, Wang N, Gaut J, Jain S, Vijayan A, Luciano R, Moledina D, Ugochukwu U, Wilson F, Alfano S. Rationale and design of the Kidney Precision Medicine Project. Kidney International 2021, 99: 498-510. PMID: 33637194, PMCID: PMC8330551, DOI: 10.1016/j.kint.2020.08.039.
• Electronic health record alerts for acute kidney injury: multicenter, randomized clinical trialWilson FP, Martin M, Yamamoto Y, Partridge C, Moreira E, Arora T, Biswas A, Feldman H, Garg AX, Greenberg JH, Hinchcliff M, Latham S, Li F, Lin H, Mansour SG, Moledina DG, Palevsky PM, Parikh CR, Simonov M, Testani J, Ugwuowo U. Electronic health record alerts for acute kidney injury: multicenter, randomized clinical trial. The BMJ 2021, 372: m4786. PMID: 33461986, PMCID: PMC8034420, DOI: 10.1136/bmj.m4786.
• Acute tubulointerstitial Nephritis.Moledina DG. Acute tubulointerstitial Nephritis. Netter’s Internal Medicine 3rd Ed.
• Inhibiting calpain 1 and 2 in cyclin G associated kinase–knockout mice mitigates podocyte injuryTian X, Inoue K, Zhang Y, Wang Y, Sperati CJ, Pedigo CE, Zhao T, Yan M, Groener M, Moledina DG, Ebenezer K, Li W, Zhang Z, Liebermann D, Greene L, Greer P, Parikh CR, Ishibe S. Inhibiting calpain 1 and 2 in cyclin G associated kinase–knockout mice mitigates podocyte injury. JCI Insight 2020, 5: e142740. PMID: 33208557, PMCID: PMC7710277, DOI: 10.1172/jci.insight.142740.
• Variation in Best Practice Measures in Patients With Severe Hospital-Acquired Acute Kidney Injury: A Multicenter StudyMoledina DG, Belliveau O, Yamamoto Y, Arora T, Carey KA, Churpek M, Martin M, Partridge CM, Mansour SG, Parikh CR, Koyner JL, Wilson FP. Variation in Best Practice Measures in Patients With Severe Hospital-Acquired Acute Kidney Injury: A Multicenter Study. American Journal Of Kidney Diseases 2020, 77: 547-549. PMID: 33075389, PMCID: PMC8672301, DOI: 10.1053/j.ajkd.2020.08.013.
• Electronic Health Record Alerts for AKI: A MultiCenter Randomized Clinical TrialWilson F, Martin M, Yamamoto Y, Feldman H, Greenberg J, Mansour S, Moledina D, Palevsky P, Parikh C, Simonov M. Electronic Health Record Alerts for AKI: A MultiCenter Randomized Clinical Trial. Journal Of The American Society Of Nephrology 2020, 31: b3-b3. DOI: 10.1681/asn.20203110s1b3c.
• Urine Biomarkers and Risk of Long-Term Kidney Outcomes After Cardiac Surgery: the TRIBE-AKI StudyMenez S, Moledina D, Garg A, Philbrook H, McArthur E, Jia Y, Obeid W, Mansour S, Shlipak M, Coca S, Parikh C. Urine Biomarkers and Risk of Long-Term Kidney Outcomes After Cardiac Surgery: the TRIBE-AKI Study. Journal Of The American Society Of Nephrology 2020, 31: 99-99. DOI: 10.1681/asn.20203110s199b.
• Results from the TRIBE-AKI Study found associations between post-operative blood biomarkers and risk of chronic kidney disease after cardiac surgeryMenez S, Moledina DG, Garg AX, Thiessen-Philbrook H, McArthur E, Jia Y, Liu C, Obeid W, Mansour SG, Koyner JL, Shlipak MG, Wilson FP, Coca SG, Parikh CR. Results from the TRIBE-AKI Study found associations between post-operative blood biomarkers and risk of chronic kidney disease after cardiac surgery. Kidney International 2020, 99: 716-724. PMID: 32721447, PMCID: PMC8077034, DOI: 10.1016/j.kint.2020.06.037.
• Real-Time Prediction of Acute Kidney Injury in Hospitalized Adults: Implementation and Proof of ConceptUgwuowo U, Yamamoto Y, Arora T, Saran I, Partridge C, Biswas A, Martin M, Moledina DG, Greenberg JH, Simonov M, Mansour SG, Vela R, Testani JM, Rao V, Rentfro K, Obeid W, Parikh CR, Wilson FP. Real-Time Prediction of Acute Kidney Injury in Hospitalized Adults: Implementation and Proof of Concept. American Journal Of Kidney Diseases 2020, 76: 806-814.e1. PMID: 32505812, PMCID: PMC8667815, DOI: 10.1053/j.ajkd.2020.05.003.
• A Time-Updated, Parsimonious Model to Predict AKI in Hospitalized ChildrenSandokji I, Yamamoto Y, Biswas A, Arora T, Ugwuowo U, Simonov M, Saran I, Martin M, Testani JM, Mansour S, Moledina DG, Greenberg JH, Wilson FP. A Time-Updated, Parsimonious Model to Predict AKI in Hospitalized Children. Journal Of The American Society Of Nephrology 2020, 31: 1348-1357. PMID: 32381598, PMCID: PMC7269342, DOI: 10.1681/asn.2019070745.
• Association Between Early Recovery of Kidney Function After Acute Kidney Injury and Long-term Clinical OutcomesBhatraju PK, Zelnick LR, Chinchilli VM, Moledina DG, Coca SG, Parikh CR, Garg AX, Hsu CY, Go AS, Liu KD, Ikizler TA, Siew ED, Kaufman JS, Kimmel PL, Himmelfarb J, Wurfel MM. Association Between Early Recovery of Kidney Function After Acute Kidney Injury and Long-term Clinical Outcomes. JAMA Network Open 2020, 3: e202682. PMID: 32282046, PMCID: PMC7154800, DOI: 10.1001/jamanetworkopen.2020.2682.
• Association of plasma-soluble ST2 and galectin-3 with cardiovascular events and mortality following cardiac surgeryPatel DM, Thiessen-Philbrook H, Brown JR, McArthur E, Moledina DG, Mansour SG, Shlipak MG, Koyner JL, Kavsak P, Whitlock RP, Everett AD, Malenka DJ, Garg AX, Coca SG, Parikh CR. Association of plasma-soluble ST2 and galectin-3 with cardiovascular events and mortality following cardiac surgery. American Heart Journal 2019, 220: 253-263. PMID: 31911262, PMCID: PMC7008086, DOI: 10.1016/j.ahj.2019.11.014.
• Association of T Cell–Derived Inflammatory Cytokines With Acute Kidney Injury and Mortality After Cardiac SurgeryMoledina DG, Mansour SG, Jia Y, Obeid W, Thiessen-Philbrook H, Koyner JL, McArthur E, Garg AX, Wilson FP, Shlipak MG, Coca SG, Parikh CR, Consortium T. Association of T Cell–Derived Inflammatory Cytokines With Acute Kidney Injury and Mortality After Cardiac Surgery. Kidney International Reports 2019, 4: 1689-1697. PMID: 31844805, PMCID: PMC6895592, DOI: 10.1016/j.ekir.2019.09.003.
• Differentiating Acute Interstitial Nephritis from Acute Tubular Injury: A Challenge for CliniciansMoledina DG, Parikh CR. Differentiating Acute Interstitial Nephritis from Acute Tubular Injury: A Challenge for Clinicians. Nephron 2019, 143: 211-216. PMID: 31203275, PMCID: PMC6821567, DOI: 10.1159/000501207.
• The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac SurgeryMansour SG, Zhang WR, Moledina D, Coca SG, Jia Y, Thiessen-Philbrook H, McArthur E, Inoue K, Koyner JL, Shlipak MG, Wilson FP, Garg AX, Ishibe S, Parikh CR, Consortium T. The Association of Angiogenesis Markers With Acute Kidney Injury and Mortality After Cardiac Surgery. American Journal Of Kidney Diseases 2019, 74: 36-46. PMID: 30955944, PMCID: PMC6591032, DOI: 10.1053/j.ajkd.2019.01.028.
• Penkid: A Novel Biomarker of Reduced GFR in SepsisMoledina DG. Penkid: A Novel Biomarker of Reduced GFR in Sepsis. Kidney International Reports 2018, 4: 17-19. PMID: 30596164, PMCID: PMC6308914, DOI: 10.1016/j.ekir.2018.11.002.
• Treatment of Drug-Induced Acute Tubulointerstitial Nephritis: The Search for Better EvidenceMoledina DG, Perazella MA. Treatment of Drug-Induced Acute Tubulointerstitial Nephritis: The Search for Better Evidence. Clinical Journal Of The American Society Of Nephrology 2018, 13: 1785-1787. PMID: 30397028, PMCID: PMC6302332, DOI: 10.2215/cjn.12001018.
• Kidney Biopsy–Related Complications in Hospitalized Patients with Acute Kidney DiseaseMoledina DG, Luciano RL, Kukova L, Chan L, Saha A, Nadkarni G, Alfano S, Wilson FP, Perazella MA, Parikh CR. Kidney Biopsy–Related Complications in Hospitalized Patients with Acute Kidney Disease. Clinical Journal Of The American Society Of Nephrology 2018, 13: 1633-1640. PMID: 30348813, PMCID: PMC6237071, DOI: 10.2215/cjn.04910418.
• Phenotyping of Acute Kidney Injury: Beyond Serum CreatinineMoledina DG, Parikh CR. Phenotyping of Acute Kidney Injury: Beyond Serum Creatinine. Seminars In Nephrology 2018, 38: 3-11. PMID: 29291759, PMCID: PMC5753429, DOI: 10.1016/j.semnephrol.2017.09.002.
• A Survey of Patient Attitudes Toward Participation in Biopsy-Based Kidney ResearchMoledina DG, Cheung B, Kukova L, Luciano RL, Peixoto AJ, Wilson FP, Alfano S, Parikh CR. A Survey of Patient Attitudes Toward Participation in Biopsy-Based Kidney Research. Kidney International Reports 2017, 3: 412-416. PMID: 29725645, PMCID: PMC5932306, DOI: 10.1016/j.ekir.2017.11.008.
• Drug-Induced Acute Interstitial NephritisMoledina DG, Perazella MA. Drug-Induced Acute Interstitial Nephritis. Clinical Journal Of The American Society Of Nephrology 2017, 12: 2046-2049. PMID: 28893923, PMCID: PMC5718279, DOI: 10.2215/cjn.07630717.
• Performance of Serum Creatinine and Kidney Injury Biomarkers for Diagnosing Histologic Acute Tubular InjuryMoledina DG, Hall IE, Thiessen-Philbrook H, Reese PP, Weng FL, Schröppel B, Doshi MD, Wilson FP, Coca SG, Parikh CR. Performance of Serum Creatinine and Kidney Injury Biomarkers for Diagnosing Histologic Acute Tubular Injury. American Journal Of Kidney Diseases 2017, 70: 807-816. PMID: 28844586, PMCID: PMC5701867, DOI: 10.1053/j.ajkd.2017.06.031.
• Plasma Biomarkers and Kidney Function Decline in Early and Established Diabetic Kidney DiseaseCoca SG, Nadkarni GN, Huang Y, Moledina DG, Rao V, Zhang J, Ferket B, Crowley ST, Fried LF, Parikh CR. Plasma Biomarkers and Kidney Function Decline in Early and Established Diabetic Kidney Disease. Journal Of The American Society Of Nephrology 2017, 28: 2786-2793. PMID: 28476763, PMCID: PMC5576932, DOI: 10.1681/asn.2016101101.
• Plasma Monocyte Chemotactic Protein-1 Is Associated With Acute Kidney Injury and Death After Cardiac OperationsMoledina DG, Isguven S, McArthur E, Thiessen-Philbrook H, Garg AX, Shlipak M, Whitlock R, Kavsak PA, Coca SG, Parikh CR, Consortium T. Plasma Monocyte Chemotactic Protein-1 Is Associated With Acute Kidney Injury and Death After Cardiac Operations. The Annals Of Thoracic Surgery 2017, 104: 613-620. PMID: 28223055, PMCID: PMC5588689, DOI: 10.1016/j.athoracsur.2016.11.036.
• Acute Interstitial NephritisMoledina D, Perazella M. Acute Interstitial Nephritis. DeckerMed Nephrology Dialysis And Transplantation 2017 DOI: 10.2310/nephro.12028.
• Acute Tubulointerstitial Nephritis.Moledina D.G. (2017). Acute tubulointerstitial nephritis. Lerma E.V., & Rosner M.H., & Perazella M.A.(Eds.), CURRENT Diagnosis & Treatment: Nephrology & Hypertension, 2e. McGraw-Hill.
• Application of new acute kidney injury biomarkers in human randomized controlled trialsParikh CR, Moledina DG, Coca SG, Thiessen-Philbrook HR, Garg AX. Application of new acute kidney injury biomarkers in human randomized controlled trials. Kidney International 2016, 89: 1372-1379. PMID: 27165835, PMCID: PMC4869991, DOI: 10.1016/j.kint.2016.02.027.
• Proton Pump Inhibitors and CKDMoledina DG, Perazella MA. Proton Pump Inhibitors and CKD. Journal Of The American Society Of Nephrology 2016, 27: 2926-2928. PMID: 27080978, PMCID: PMC5042680, DOI: 10.1681/asn.2016020192.
• PPIs and kidney disease: from AIN to CKDMoledina DG, Perazella MA. PPIs and kidney disease: from AIN to CKD. Journal Of Nephrology 2016, 29: 611-616. PMID: 27072818, DOI: 10.1007/s40620-016-0309-2.
• We Use Dialysate Potassium Levels That Are Too Low in HemodialysisTucker B, Moledina DG. We Use Dialysate Potassium Levels That Are Too Low in Hemodialysis. Seminars In Dialysis 2016, 29: 300-302. PMID: 27061895, DOI: 10.1111/sdi.12495.
• Amino-Terminal Pro-B-Type Natriuretic Peptide for Diagnosis and Prognosis in Patients With Renal Dysfunction A Systematic Review and Meta-AnalysisSchaub JA, Coca SG, Moledina DG, Gentry M, Testani JM, Parikh CR. Amino-Terminal Pro-B-Type Natriuretic Peptide for Diagnosis and Prognosis in Patients With Renal Dysfunction A Systematic Review and Meta-Analysis. JACC Heart Failure 2015, 3: 977-989. PMID: 26671676, PMCID: PMC4683413, DOI: 10.1016/j.jchf.2015.07.014.
• Association of Perioperative Plasma Neutrophil Gelatinase-Associated Lipocalin Levels with 3-Year Mortality after Cardiac Surgery: A Prospective Observational Cohort StudyMoledina DG, Parikh CR, Garg AX, Thiessen-Philbrook H, Koyner JL, Patel UD, Devarajan P, Shlipak MG, Coca SG, . Association of Perioperative Plasma Neutrophil Gelatinase-Associated Lipocalin Levels with 3-Year Mortality after Cardiac Surgery: A Prospective Observational Cohort Study. PLOS ONE 2015, 10: e0129619. PMID: 26053382, PMCID: PMC4460181, DOI: 10.1371/journal.pone.0129619.
• Pharmacologic Treatment of Common Symptoms in Dialysis Patients: A Narrative ReviewMoledina DG, Perry Wilson F. Pharmacologic Treatment of Common Symptoms in Dialysis Patients: A Narrative Review. Seminars In Dialysis 2015, 28: 377-383. PMID: 25913502, DOI: 10.1111/sdi.12378.
• Acute Kidney Injury and Mortality in the Elderly: Add Atypical Antipsychotics to the ListMoledina DG, Perazella MA. Acute Kidney Injury and Mortality in the Elderly: Add Atypical Antipsychotics to the List. American Journal Of Kidney Diseases 2015, 65: 655-658. PMID: 25687262, DOI: 10.1053/j.ajkd.2015.01.005.
• Is Low Dialysate Potassium Ever Indicated in Outpatient Hemodialysis?Moledina D, Geller D. Is Low Dialysate Potassium Ever Indicated in Outpatient Hemodialysis? Seminars In Dialysis 2014, 27: 263-265. PMID: 24635442, DOI: 10.1111/sdi.12212.
• Longitudinal Predictors of Uremic PruritusShirazian S, Kline M, Sakhiya V, Schanler M, Moledina D, Patel C, Hazzan A, Fishbane S. Longitudinal Predictors of Uremic Pruritus. Journal Of Renal Nutrition 2013, 23: 428-431. PMID: 24209894, DOI: 10.1053/j.jrn.2013.08.002.
• A Pilot Trial of a Computerized Renal Template Note to Improve Resident Knowledge and Documentation of Kidney DiseaseShirazian S, Wang R, Moledina D, Liberman V, Zeidan J, Strand D, Mattana J. A Pilot Trial of a Computerized Renal Template Note to Improve Resident Knowledge and Documentation of Kidney Disease. Applied Clinical Informatics 2013, 04: 528-540. PMID: 24454580, PMCID: PMC3885913, DOI: 10.4338/aci-2013-07-ra-0048.