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Anne Wyllie, PhD

Research Scientist in Epidemiology (Microbial Diseases); Affiliated Faculty, Yale Institute for Global Health; Member, Center for Infection and Immunity

Contact Information

Anne Wyllie, PhD

Office Location

  • Yale School of Public Health (LEPH)
    60 College Street
    New Haven, CT 06510

Research Summary

As compared to the gold standard nasopharyngeal swab, my research has identified saliva as a reliable sample type for the sensitive detection of Streptococcus pneumoniae (the pneumococcus) in healthy older adults and more recently, SARS-CoV-2 in persons suspected of Covid-19. Improved detection of the pneumococcus has unveiled more frequent colonization of older individuals than contemporary studies report on which holds importance when new vaccination strategies for preventing pneumococcal disease are being considered. For SARS-CoV-2, the use of saliva as an alternative sample type can alleviate many of the bottlenecks encountered in the mass testing strategies required to control continuing outbreaks. In an effort to address many of these issues, we further validated and optimized saliva for SARS-CoV-2 detection and developed SalivaDirect: a simple, scalable and importantly, cost-effective method to help alleviate SARS-CoV-2 testing demands.


Research Interests

Aged; Carrier State; Epidemiology; Microbiology; Pneumococcal Infections; Pneumonia, Pneumococcal; Public Health; Respiratory Tract Infections; Saliva; Streptococcus pneumoniae; Coronavirus Infections; Pneumococcal Vaccines; Molecular Diagnostic Techniques; Real-Time Polymerase Chain Reaction; Microbiota

Public Health Interests

Community Health; Global Health; Infectious Diseases; Maternal & Child Health; Respiratory Disease/Infections; Microbiome; COVID-19

Research Image

Selected Publications