Daniela Tirziu, PhD
Research Scientist; Associate Director of Academic Research, Yale Cardiovascular Research Group
Research & Publications
Biography
News
Research Summary
My clinical research is focused on the design, reporting and regulatory documentations for interventional cardiovascular device trials, including First-in-Human, CE Mark, IDE/IND Phase III and IV trials and post marketing studies in the US and worldwide.
Basic science research had been focused on growth regulatory mechanisms generated by the endothelium-to-cardiomyocytes communication through the endothelium-released nitric oxide, Gi /Gq protein signaling and microRNAs.
Specialized Terms: Ischemic Heart Disease; Medical Devices; Clinical Trial; Endothelium-Cardiomyocytes Communication; Myocardial Hypertrophy; Nitric Oxide; Gi/Gq Signaling; microRNAs.
Extensive Research Description
Dr. Tirziu has made substantial contributions to scientifically sound clinical research documents, regulatory documents (clinical trial protocols and study reports) and meta-analyses to guide clinical investigation on several novel cardiovascular devices and cerebral embolic protection devices during transcatheter heart procedures.
On the basic science front, findings from Dr. Tirziu's laboratory showed that stimulation of angiogenesis in the heart promotes cardiomyocyte growth and myocardial hypertrophy through a nitric oxide (NO)-dependent mechanism involving the degradation of regulator of G protein signaling type 4 (RGS4) and de-repression of the Gβγ/PI3Kγ/Akt/mTORC1 pathway with the up-regulation of miR-182 and miR-146b expression in cardiomyocytes.
Coauthors
Research Interests
Cardiovascular Diseases; Cell Communication; Endothelium, Vascular; Heart Diseases; Heart Failure; Clinical Trial; MicroRNAs; Endothelium-Dependent Relaxing Factors; Gene Regulatory Networks; Publication Characteristics
Selected Publications
- Impella Versus Intra-Aortic Balloon Pump for High-Risk PCI: A Propensity-Adjusted Large-Scale Claims Dataset AnalysisLansky AJ, Tirziu D, Moses JW, Pietras C, Ohman EM, O'Neill WW, Ekono MM, Grines CL, Parise H. Impella Versus Intra-Aortic Balloon Pump for High-Risk PCI: A Propensity-Adjusted Large-Scale Claims Dataset Analysis The American Journal Of Cardiology 2022, 185: 29-36. PMID: 36210212, DOI: 10.1016/j.amjcard.2022.08.032.
- TCT-209 Chocolate Touch Versus Lutonix Drug-Coated Balloon for Femoropopliteal Lesions in Patients With Diabetes Mellitus: Results of the Randomized Chocolate Touch StudyParikh S, Zeller T, Shishehbor M, Werner M, Brodmann M, Parise H, Holden A, Lichtenberg M, Kashyap V, Pietras C, Tirziu D, Ardakani S, Beschorner U, Krishnan P, Niazi K, Wali A, Lansky A. TCT-209 Chocolate Touch Versus Lutonix Drug-Coated Balloon for Femoropopliteal Lesions in Patients With Diabetes Mellitus: Results of the Randomized Chocolate Touch Study Journal Of The American College Of Cardiology 2022, 80: b84. DOI: 10.1016/j.jacc.2022.08.246.
- Randomized Trial of Chocolate Touch Compared With Lutonix Drug-Coated Balloon in Femoropopliteal Lesions (Chocolate Touch Study)Shishehbor MH, Zeller T, Werner M, Brodmann M, Parise H, Holden A, Lichtenberg M, Parikh SA, Kashyap VS, Pietras C, Tirziu D, Ardakani S, Beschorner U, Krishnan P, Niazi KA, Wali AU, Lansky AJ. Randomized Trial of Chocolate Touch Compared With Lutonix Drug-Coated Balloon in Femoropopliteal Lesions (Chocolate Touch Study) Circulation 2022, 145: 1645-1654. PMID: 35377157, DOI: 10.1161/circulationaha.122.059646.
- TCT-118 Propensity-Adjusted Population-Based Analysis of Impella in Patients Undergoing High-Risk PCI From a Large-Scale Claims DatasetLansky A, Tirziu D, Pietras C, Moses J, Ohman E, O'Neill W, Grines C, Needham K, Ekono M, Gregory D, Parise H. TCT-118 Propensity-Adjusted Population-Based Analysis of Impella in Patients Undergoing High-Risk PCI From a Large-Scale Claims Dataset Journal Of The American College Of Cardiology 2021, 78: b49-b50. DOI: 10.1016/j.jacc.2021.09.968.
- Long term outcomes of ultrathin versus standard thickness second‐generation drug eluting stents: Meta‐analysis of randomized trialsHussain Y, Gaston S, Kluger J, Shah T, Yang Y, Tirziu D, Lansky A. Long term outcomes of ultrathin versus standard thickness second‐generation drug eluting stents: Meta‐analysis of randomized trials Catheterization And Cardiovascular Interventions 2021, 99: 563-574. PMID: 34236755, DOI: 10.1002/ccd.29866.
- Impact of Persistent vs. Transient Conduction Abnormalities Within 7 Days Post-TAVR on Mortality: Results of a Single-Center Prospective RegistrySee C, Wang Y, Yang Y, Tirziu D, Papoutsidakis N, Kaple R, Cleman M, Lansky A, Forrest J. Impact of Persistent vs. Transient Conduction Abnormalities Within 7 Days Post-TAVR on Mortality: Results of a Single-Center Prospective Registry Cardiovascular Revascularization Medicine 2021, 28: s43. DOI: 10.1016/j.carrev.2021.06.099.
- IMPACT OF SEX ON OUTCOMES IN TAVR: RESULTS FROM A SINGLE CENTER PROSPECTIVE REGISTRYWang Y, Yang Y, See C, tirziu D, Papoutsidakis N, Kaple R, Cleman M, Lansky A, Forrest J. IMPACT OF SEX ON OUTCOMES IN TAVR: RESULTS FROM A SINGLE CENTER PROSPECTIVE REGISTRY Journal Of The American College Of Cardiology 2021, 77: 900. DOI: 10.1016/s0735-1097(21)02259-2.
- IMPACT OF PACEMAKER IMPLANT ≤ 30 DAYS POST TAVR ON MORTALITY: RESULTS OF A SINGLE CENTER PROSPECTIVE REGISTRYSee C, Wang Y, Yang Y, Tirziu D, Papoutsidakis N, Kaple R, Cleman M, Lansky A, Forrest J. IMPACT OF PACEMAKER IMPLANT ≤ 30 DAYS POST TAVR ON MORTALITY: RESULTS OF A SINGLE CENTER PROSPECTIVE REGISTRY Journal Of The American College Of Cardiology 2021, 77: 974. DOI: 10.1016/s0735-1097(21)02333-0.
- Meta-Analysis of Gender Disparities in In-hospital Care and Outcomes in Patients with ST-Segment Elevation Myocardial InfarctionShah T, Haimi I, Yang Y, Gaston S, Taoutel R, Mehta S, Lee HJ, Zambahari R, Baumbach A, Henry TD, Grines CL, Lansky A, Tirziu D. Meta-Analysis of Gender Disparities in In-hospital Care and Outcomes in Patients with ST-Segment Elevation Myocardial Infarction The American Journal Of Cardiology 2021, 147: 23-32. PMID: 33640366, DOI: 10.1016/j.amjcard.2021.02.015.
- Outcomes Among Patients with Chronic Critical Limb Ischemia with No-Revascularization Option: Systematic Review and Meta-Analysis.Ghare MI, Pietras C, Tirziu D, Parise H, White R, Altin E, Nagpal S, Lansky A. Outcomes Among Patients with Chronic Critical Limb Ischemia with No-Revascularization Option: Systematic Review and Meta-Analysis. J Crit Limb Ischem. 2021;1(3):E85-E92.
- Sex-Specific Outcomes in Cardiovascular Device EvaluationsGhare MI, Tirziu D, Abbott JD, Altin E, Yang Y, Ng V, Grines C, Lansky A. Sex-Specific Outcomes in Cardiovascular Device Evaluations Journal Of Women's Health 2020, 29: 1246-1255. PMID: 32543268, PMCID: PMC9545802, DOI: 10.1089/jwh.2019.8068.
- Chapter 41 Embolic protection devices for stroke prevention during cardiac interventionsGhare M, Zhou S, Tirziu D, Lansky A. Chapter 41 Embolic protection devices for stroke prevention during cardiac interventions 2020, 941-960. DOI: 10.1016/b978-0-12-813704-8.00041-3.
- First-in-Human Study of Paclitaxel Drug-Coated Chocolate Coronary Percutaneous Transluminal Coronary Angioplasty Balloon Catheter in De Novo Coronary Artery LesionsGarcia-Lithgow C, Tirziu D, Zhou S, Bouras G, Shah T, Grubman D, Javier JJ, Mustapha JA, Abizaid A, Lansky AJ. First-in-Human Study of Paclitaxel Drug-Coated Chocolate Coronary Percutaneous Transluminal Coronary Angioplasty Balloon Catheter in De Novo Coronary Artery Lesions JACC Cardiovascular Interventions 2019, 12: 2568-2570. PMID: 31857033, DOI: 10.1016/j.jcin.2019.08.044.
- Angiotensin Receptor Neprilysin Inhibitor Attenuates Myocardial Remodeling and Improves Infarct Perfusion in Experimental Heart FailurePfau D, Thorn SL, Zhang J, Mikush N, Renaud JM, Klein R, deKemp RA, Wu X, Hu X, Sinusas AJ, Young LH, Tirziu D. Angiotensin Receptor Neprilysin Inhibitor Attenuates Myocardial Remodeling and Improves Infarct Perfusion in Experimental Heart Failure Scientific Reports 2019, 9: 5791. PMID: 30962467, PMCID: PMC6453892, DOI: 10.1038/s41598-019-42113-0.
- Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization.Memi F, Tirziu D, Papangeli I. Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization. Journal Of Visualized Experiments 2018 PMID: 30272664, PMCID: PMC6235194, DOI: 10.3791/57920.
- TCT-365 Contemporary Outcomes in No-Option Chronic Critical Limb Ischemia: A Systematic Review and Meta-AnalysisGhare M, Pietras C, Tirziu D, Tsay C, Parise H, White R, Lansky A. TCT-365 Contemporary Outcomes in No-Option Chronic Critical Limb Ischemia: A Systematic Review and Meta-Analysis Journal Of The American College Of Cardiology 2018, 72: b148. DOI: 10.1016/j.jacc.2018.08.1517.
- TCT-85 Endovascular Repair of Penetrating Atherosclerotic Ulcers With the Cardiatis Multilayer Flow Modulator Implant as an Alternative to Covered Endografts to Preserve Branch Vessel PatencyTirziu D, White R, Gray W, Pietras C, Ghare M, Lansky A. TCT-85 Endovascular Repair of Penetrating Atherosclerotic Ulcers With the Cardiatis Multilayer Flow Modulator Implant as an Alternative to Covered Endografts to Preserve Branch Vessel Patency Journal Of The American College Of Cardiology 2018, 72: b38. DOI: 10.1016/j.jacc.2018.08.1180.
- ANGIOTENSIN RECEPTOR NEPRILYSIN INHIBITOR THERAPY PROMOTES EARLY ANGIOGENESIS AND IMPROVES MYOCARDIAL PERFUSION INHIBITING POST-INFARCT REMODELINGThorn S, Tirziu D, Pfau D, Mikush N, Zhang J, Renaud J, Klein R, deKemp R, Wu X, Hu X, Young L, Sinusas A. ANGIOTENSIN RECEPTOR NEPRILYSIN INHIBITOR THERAPY PROMOTES EARLY ANGIOGENESIS AND IMPROVES MYOCARDIAL PERFUSION INHIBITING POST-INFARCT REMODELING Journal Of The American College Of Cardiology 2018, 71: a1466. DOI: 10.1016/s0735-1097(18)32007-2.
- Cardiac Hypertrophy: Signaling and Cellular CrosstalkTirziu D. Cardiac Hypertrophy: Signaling and Cellular Crosstalk 2018 DOI: 10.1016/b978-0-12-801238-3.99834-9.
- Cardiac Hypertrophy: Signaling and Cellular CrosstalkTirziu D. Cardiac Hypertrophy: Signaling and Cellular Crosstalk 2018, 434-450. DOI: 10.1016/b978-0-12-809657-4.99834-x.
- miR-182 Modulates Myocardial Hypertrophic Response Induced by Angiogenesis in HeartLi N, Hwangbo C, Jaba IM, Zhang J, Papangeli I, Han J, Mikush N, Larrivée B, Eichmann A, Chun HJ, Young LH, Tirziu D. miR-182 Modulates Myocardial Hypertrophic Response Induced by Angiogenesis in Heart Scientific Reports 2016, 6: 21228. PMID: 26888314, PMCID: PMC4758045, DOI: 10.1038/srep21228.
- Live cell imaging of primary rat neonatal cardiomyocytes following adenoviral and lentiviral transduction using confocal spinning disk microscopy.Sakurai T, Lanahan A, Woolls MJ, Li N, Tirziu D, Murakami M. Live cell imaging of primary rat neonatal cardiomyocytes following adenoviral and lentiviral transduction using confocal spinning disk microscopy. Journal Of Visualized Experiments 2014, e51666. PMID: 24998400, PMCID: PMC4209952, DOI: 10.3791/51666.
- Live Cell Imaging of Primary Rat Neonatal Cardiomyocytes Following Adenoviral and Lentiviral Transduction Using Confocal Spinning Disk MicroscopySakurai T, Lanahan A, Woolls M, Li N, Tirziu D, Murakami M. Live Cell Imaging of Primary Rat Neonatal Cardiomyocytes Following Adenoviral and Lentiviral Transduction Using Confocal Spinning Disk Microscopy Journal Of Visualized Experiments 2014 DOI: 10.3791/51666-v.
- Multimodality Imaging Approach for Serial Assessment of Regional Changes in Lower Extremity Arteriogenesis and Tissue Perfusion in a Porcine Model of Peripheral Arterial DiseaseStacy MR, Yu da Y, Maxfield MW, Jaba IM, Jozwik BP, Zhuang ZW, Lin BA, Hawley CL, Caracciolo CM, Pal P, Tirziu D, Sampath S, Sinusas AJ. Multimodality Imaging Approach for Serial Assessment of Regional Changes in Lower Extremity Arteriogenesis and Tissue Perfusion in a Porcine Model of Peripheral Arterial Disease Circulation Cardiovascular Imaging 2013, 7: 92-99. PMID: 24170237, PMCID: PMC3929970, DOI: 10.1161/circimaging.113.000884.
- NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growthJaba IM, Zhuang ZW, Li N, Jiang Y, Martin KA, Sinusas AJ, Papademetris X, Simons M, Sessa WC, Young LH, Tirziu D. NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth Journal Of Clinical Investigation 2013, 123: 1718-1731. PMID: 23454748, PMCID: PMC3613910, DOI: 10.1172/jci65112.
- Endothelial Nuclear Factor-&kgr;B–Dependent Regulation of Arteriogenesis and BranchingTirziu D, Jaba IM, Yu P, Larrivée B, Coon BG, Cristofaro B, Zhuang ZW, Lanahan AA, Schwartz MA, Eichmann A, Simons M. Endothelial Nuclear Factor-&kgr;B–Dependent Regulation of Arteriogenesis and Branching Circulation 2012, 126: 2589-2600. PMID: 23091063, PMCID: PMC3514045, DOI: 10.1161/circulationaha.112.119321.
- Abstract 94: Nitric Oxide--Regulated RGS4 Loss of Function Coordinates Vascular Growth with Cardiomyocyte Growth in the Absence of External Hypertrophic StimuliJaba I, Li N, Zhuang Z, Jiang Y, Tirziu D. Abstract 94: Nitric Oxide--Regulated RGS4 Loss of Function Coordinates Vascular Growth with Cardiomyocyte Growth in the Absence of External Hypertrophic Stimuli Circulation Research 2012, 111 DOI: 10.1161/res.111.suppl_1.a94.
- Cell Communications in the HeartTirziu D, Giordano FJ, Simons M. Cell Communications in the Heart Circulation 2010, 122: 928-937. PMID: 20805439, PMCID: PMC2941440, DOI: 10.1161/circulationaha.108.847731.
- Endothelium-Driven Myocardial Growth or Nitric Oxide at the CrossroadsTirziu D, Simons M. Endothelium-Driven Myocardial Growth or Nitric Oxide at the Crossroads Trends In Cardiovascular Medicine 2008, 18: 299-305. PMID: 19345317, PMCID: PMC2692333, DOI: 10.1016/j.tcm.2009.01.002.
- Molecular Basis for Proline- and Arginine-Rich Peptide Inhibition of ProteasomeAnbanandam A, Albarado DC, Tirziu DC, Simons M, Veeraraghavan S. Molecular Basis for Proline- and Arginine-Rich Peptide Inhibition of Proteasome Journal Of Molecular Biology 2008, 384: 219-227. PMID: 18823992, PMCID: PMC2632303, DOI: 10.1016/j.jmb.2008.09.021.
- Endothelium as master regulator of organ development and growthTirziu D, Simons M. Endothelium as master regulator of organ development and growth Vascular Pharmacology 2008, 50: 1-7. PMID: 18804188, PMCID: PMC2630387, DOI: 10.1016/j.vph.2008.08.003.
- Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in miceTirziu D, Chorianopoulos E, Moodie KL, Palac RT, Zhuang ZW, Tjwa M, Roncal C, Eriksson U, Fu Q, Elfenbein A, Hall AE, Carmeliet P, Moons L, Simons M. Myocardial hypertrophy in the absence of external stimuli is induced by angiogenesis in mice Journal Of Clinical Investigation 2007, 117: 3188-3197. PMID: 17975666, PMCID: PMC2045601, DOI: 10.1172/jci32024.
- Protection against myocardial ischemia-reperfusion injury by the angiogenic Masterswitch protein PR 39 gene therapy: the roles of HIF1alpha stabilization and FGFR1 signaling.Muinck ED, Nagy N, Tirziu D, Murakami M, Gurusamy N, Goswami SK, Ghatpande S, Engelman RM, Simons M, Das DK. Protection against myocardial ischemia-reperfusion injury by the angiogenic Masterswitch protein PR 39 gene therapy: the roles of HIF1alpha stabilization and FGFR1 signaling. Antioxidants And Redox Signaling 2007, 9: 437-45. PMID: 17280485, DOI: 10.1089/ars.2006.1501.
- Syndecan-4 Clustering Induces Cell Migration in a PDZ-Dependent MannerTkachenko E, Elfenbein A, Tirziu D, Simons M. Syndecan-4 Clustering Induces Cell Migration in a PDZ-Dependent Manner Circulation Research 2006, 98: 1398-1404. PMID: 16675718, DOI: 10.1161/01.res.0000225283.71490.5a.
- Chondroitin sulfate-modified LDL induces increased cholesteryl ester synthesis and down-regulation of LDL receptors in smooth muscle cells and macrophagesTircol M, Tirziu D, Simionescu M. Chondroitin sulfate-modified LDL induces increased cholesteryl ester synthesis and down-regulation of LDL receptors in smooth muscle cells and macrophages Open Life Sciences 2006, 1: 150-166. DOI: 10.2478/s11535-006-0010-x.
- Angiogenesis in the human heart: Gene and cell therapyTirziu D, Simons M. Angiogenesis in the human heart: Gene and cell therapy Angiogenesis 2005, 8: 241-251. PMID: 16308736, DOI: 10.1007/s10456-005-9011-z.
- Adenoviral PR39 improves blood flow and myocardial function in a pig model of chronic myocardial ischemia by enhancing collateral formationPost MJ, Sato K, Murakami M, Bao J, Tirziu D, Pearlman JD, Simons M. Adenoviral PR39 improves blood flow and myocardial function in a pig model of chronic myocardial ischemia by enhancing collateral formation AJP Regulatory Integrative And Comparative Physiology 2005, 290: r494-r500. PMID: 16254127, DOI: 10.1152/ajpregu.00460.2005.
- Delayed Arteriogenesis in Hypercholesterolemic MiceTirziu D, Moodie KL, Zhuang ZW, Singer K, Helisch A, Dunn JF, Li W, Singh J, Simons M. Delayed Arteriogenesis in Hypercholesterolemic Mice Circulation 2005, 112: 2501-2509. PMID: 16230502, DOI: 10.1161/circulationaha.105.542829.
- Increased macrophage uptake of irreversibly glycated albumin modified-low density lipoproteins of normal and diabetic subjects is mediated by non-saturable mechanismsDobrian A, Lazar V, Tirziu D, Simionescu M. Increased macrophage uptake of irreversibly glycated albumin modified-low density lipoproteins of normal and diabetic subjects is mediated by non-saturable mechanisms Biochimica Et Biophysica Acta 1996, 1317: 5-14. PMID: 8876621, DOI: 10.1016/0925-4439(96)00017-8.
- Intimal thickenings of human aorta contain modified reassembled lipoproteinsTîrziu D, Dobrian A, Tasca C, Simionescu M, Simionescu N. Intimal thickenings of human aorta contain modified reassembled lipoproteins Atherosclerosis 1995, 112: 101-114. PMID: 7772061, DOI: 10.1016/0021-9150(94)05405-8.
- Pathobiochemical Changes of the Arterial Wall at the Inception of AtherosclerosisSimionescu N, Sima A, Dobrian A, Tirziu D, Simionescu M. Pathobiochemical Changes of the Arterial Wall at the Inception of Atherosclerosis 1993, 87: 1-45. PMID: 8125021, DOI: 10.1007/978-3-642-76849-1_1.