Stephanie Thorn, MSc, PhD

• Alan Dardik
• Albert Sinusas
• Attila Feher
• Britton Keeshan
• Dana Peters
• Daniela Tirziu
• Demetrios Braddock
• Edward J Miller
• Enrique M. De La Cruz
• Fadi Gabriel Akar
• Henry C. Hsia
• Henry Yaggi
• Hitten Zaveri
• James Duncan
• Jeremy Steele
• Lawrence Young
• Madhav Menon
• Monique Hinchcliff
• Xenophon Papademetris
• Yi-Hwa Liu

Heart Failure; Myocardial Infarction; Radionuclide Imaging; Myocardial Reperfusion Injury; Myocardial Ischemia; Hypertrophy, Right Ventricular; Heart Failure, Diastolic; Diseases; Positron Emission Tomography Computed Tomography; Single Photon Emission Computed Tomography Computed Tomography; Computed Tomography Angiography

• Improvement in cardiac function and regional LV strain following intramyocardial injection of a theranostic hydrogel early postmyocardial infarction in a porcine modelAvendaño R, Midgett D, Melvinsdottir I, Thorn S, Uman S, Pickell Z, Lee S, Liu Z, Mamarian M, Duncan J, Spinale F, Burdick J, Sinusas A. Improvement in cardiac function and regional LV strain following intramyocardial injection of a theranostic hydrogel early postmyocardial infarction in a porcine model. Journal Of Applied Physiology 2023, 135: 405-420. PMID: 37318987, PMCID: PMC10538987, DOI: 10.1152/japplphysiol.00342.2022.
• 0488 The Relationship between Myocardial Blood Flow and Diastolic Function in a Clinical Population with Obstructive Sleep ApneaAneni E, Saeed G, Thorn S, Miller E, Sinusas A, Yaggi H. 0488 The Relationship between Myocardial Blood Flow and Diastolic Function in a Clinical Population with Obstructive Sleep Apnea. Sleep 2023, 46: a217-a217. DOI: 10.1093/sleep/zsad077.0488.
• Comprehensive Multimodality Imaging of Congenitally Corrected Transposition of the Great Arteries Incidentally Found to Have Coronary IschemiaSasse A, Feher A, Thorn S, Fahey J, Keeshan B, Sinusas A, Mojibian H, Steele J. Comprehensive Multimodality Imaging of Congenitally Corrected Transposition of the Great Arteries Incidentally Found to Have Coronary Ischemia. Circulation Cardiovascular Imaging 2023, 16: 597-600. PMID: 37092334, DOI: 10.1161/circimaging.122.015158.
• REST/STRESS DYNAMIC COMPUTED TOMOGRAPHY PERFUSION FOR EVALUATING PERIPHERAL ARTERIAL DISEASE: VALIDATION IN RABBIT MODEL OF HINDLIMB ISCHEMIAAlashi A, Vermillion B, Burns R, Lee S, Bingham B, Guerrera N, Papademetris X, Thorn S, Sinusas A. REST/STRESS DYNAMIC COMPUTED TOMOGRAPHY PERFUSION FOR EVALUATING PERIPHERAL ARTERIAL DISEASE: VALIDATION IN RABBIT MODEL OF HINDLIMB ISCHEMIA. Journal Of The American College Of Cardiology 2023, 81: 1372. DOI: 10.1016/s0735-1097(23)01816-8.
• The Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow ReserveAneni E, Thorn S, Feher A, Hong Chen J, Sinusas A, Yaggi H, Miller E. The Association Between Obstructive Sleep Apnea and Abnormal 82Rubidium Cardiac PET Perfusion Myocardial Flow Reserve. JACC Cardiovascular Imaging 2023, 16: 856-858. PMID: 36881426, PMCID: PMC10718199, DOI: 10.1016/j.jcmg.2022.11.024.
• Co-attention spatial transformer network for unsupervised motion tracking and cardiac strain analysis in 3D echocardiographyAhn S, Ta K, Thorn S, Onofrey J, Melvinsdottir I, Lee S, Langdon J, Sinusas A, Duncan J. Co-attention spatial transformer network for unsupervised motion tracking and cardiac strain analysis in 3D echocardiography. Medical Image Analysis 2022, 84: 102711. PMID: 36525845, PMCID: PMC9812938, DOI: 10.1016/j.media.2022.102711.
• Obstructive Sleep Apnea Severity is Associated with Abnormal Myocardial 82Rubidium PET Blood Flow ReserveAneni E, Chen J, Thorn S, Miller E, Sinusas A, Yaggi H. Obstructive Sleep Apnea Severity is Associated with Abnormal Myocardial 82Rubidium PET Blood Flow Reserve. Sleep Medicine 2022, 100: s261. DOI: 10.1016/j.sleep.2022.05.703.
• Abstract 14839: Clinical, Polysomnographic and Echocardiographic Correlates of Excessive Daytime SleepinessSaeed G, Aneni E, Otite F, Thorn S, Miller E, Sinusas A, Yaggi H. Abstract 14839: Clinical, Polysomnographic and Echocardiographic Correlates of Excessive Daytime Sleepiness. Circulation 2022, 146: a14839-a14839. DOI: 10.1161/circ.146.suppl_1.14839.
• Abstract 13798: Obstructive Sleep Apnea Severity and Abnormal Right Ventricular Flow Reserve in Adult OSA Patients Who Received Rubidium-82 Cardiac PET Perfusion ImagingAneni E, Miller E, Saeed G, deKemp R, KLEIN R, Beanlands R, Yaggi H, Sinusas A, Thorn S. Abstract 13798: Obstructive Sleep Apnea Severity and Abnormal Right Ventricular Flow Reserve in Adult OSA Patients Who Received Rubidium-82 Cardiac PET Perfusion Imaging. Circulation 2022, 146: a13798-a13798. DOI: 10.1161/circ.146.suppl_1.13798.
• Quantification of intramyocardial blood volume using 99mTc-RBC SPECT/CT: a pilot human studyYousefi H, Shi L, Soufer A, Tsatkin V, Bruni W, Avendano R, Greco K, McMahon D, Thorn S, Miller E, Sinusas A, Liu C. Quantification of intramyocardial blood volume using 99mTc-RBC SPECT/CT: a pilot human study. Journal Of Nuclear Cardiology 2022, 30: 292-297. PMID: 36319815, DOI: 10.1007/s12350-022-03123-0.
• Cellular recovery after prolonged warm ischaemia of the whole bodyAndrijevic D, Vrselja Z, Lysyy T, Zhang S, Skarica M, Spajic A, Dellal D, Thorn SL, Duckrow RB, Ma S, Duy PQ, Isiktas AU, Liang D, Li M, Kim SK, Daniele SG, Banu K, Perincheri S, Menon MC, Huttner A, Sheth KN, Gobeske KT, Tietjen GT, Zaveri HP, Latham SR, Sinusas AJ, Sestan N. Cellular recovery after prolonged warm ischaemia of the whole body. Nature 2022, 608: 405-412. PMID: 35922506, PMCID: PMC9518831, DOI: 10.1038/s41586-022-05016-1.
• 445 Three-dimensional High Resolution Lagrangian Strain Analysis In The Right Ventricle Using Cinect In A Porcine ModelSavarimuthu S, Midgett D, Thorn S, Ahn S, Avendano R, Melvinsdottir I, Duncan J, Papademetris X, Sinusas A. 445 Three-dimensional High Resolution Lagrangian Strain Analysis In The Right Ventricle Using Cinect In A Porcine Model. Journal Of Cardiovascular Computed Tomography 2022, 16: s21. DOI: 10.1016/j.jcct.2022.06.050.
• Deep-Learning-Based Few-Angle Cardiac SPECT Reconstruction Using TransformerXie H, Thorn S, Liu Y, Lee S, Liu Z, Wang G, Sinusas A, Liu C. Deep-Learning-Based Few-Angle Cardiac SPECT Reconstruction Using Transformer. IEEE Transactions On Radiation And Plasma Medical Sciences 2022, 7: 33-40. PMID: 37397179, PMCID: PMC10312390, DOI: 10.1109/trpms.2022.3187595.
• Matrix Metalloproteinase-Targeted SPECT/CT Imaging for Evaluation of Therapeutic Hydrogels for the Early Modulation of Post-Infarct Myocardial RemodelingThorn SL, Shuman JA, Stacy MR, Purcell BP, Doviak H, Burdick JA, Spinale FG, Sinusas AJ. Matrix Metalloproteinase-Targeted SPECT/CT Imaging for Evaluation of Therapeutic Hydrogels for the Early Modulation of Post-Infarct Myocardial Remodeling. Journal Of Cardiovascular Translational Research 2022, 16: 155-165. PMID: 35697979, PMCID: PMC10836411, DOI: 10.1007/s12265-022-10280-7.
• Increasing angular sampling through deep learning for stationary cardiac SPECT image reconstructionXie H, Thorn S, Chen X, Zhou B, Liu H, Liu Z, Lee S, Wang G, Liu YH, Sinusas AJ, Liu C. Increasing angular sampling through deep learning for stationary cardiac SPECT image reconstruction. Journal Of Nuclear Cardiology 2022, 30: 86-100. PMID: 35508796, DOI: 10.1007/s12350-022-02972-z.
• Atrial AMP-activated protein kinase is critical for prevention of dysregulation of electrical excitability and atrial fibrillationSu KN, Ma Y, Cacheux M, Ilkan Z, Raad N, Muller GK, Wu X, Guerrera N, Thorn SL, Sinusas AJ, Foretz M, Viollet B, Akar JG, Akar FG, Young LH. Atrial AMP-activated protein kinase is critical for prevention of dysregulation of electrical excitability and atrial fibrillation. JCI Insight 2022, 7: e141213. PMID: 35451373, PMCID: PMC9089788, DOI: 10.1172/jci.insight.141213.
• CineCT platform for in vivo and ex vivo measurement of 3D high resolution Lagrangian strains in the left ventricle following myocardial infarction and intramyocardial delivery of theranostic hydrogelMidgett D, Thorn S, Ahn S, Uman S, Avendano R, Melvinsdottir I, Lysyy T, Kim J, Duncan J, Humphrey J, Papademetris X, Burdick J, Sinusas A. CineCT platform for in vivo and ex vivo measurement of 3D high resolution Lagrangian strains in the left ventricle following myocardial infarction and intramyocardial delivery of theranostic hydrogel. Journal Of Molecular And Cellular Cardiology 2022, 166: 74-90. PMID: 35227737, PMCID: PMC9035115, DOI: 10.1016/j.yjmcc.2022.02.004.
• Regional heterogeneity in determinants of atrial matrix remodeling and association with atrial fibrillation vulnerability postmyocardial infarctionStacy MR, Lin BA, Thorn SL, Lobb DC, Maxfield MW, Novack C, Zellars KN, Freeburg L, Akar JG, Sinusas AJ, Spinale FG. Regional heterogeneity in determinants of atrial matrix remodeling and association with atrial fibrillation vulnerability postmyocardial infarction. Heart Rhythm 2022, 19: 847-855. PMID: 35066183, PMCID: PMC9064890, DOI: 10.1016/j.hrthm.2022.01.022.
• Abstract 13133: Heterogeneous Uptake of [99mTc]microspheres and 201Tl in Skeletal Muscles in Porcine Model of Hindlimb IschemiaLee S, de Rubio Cruz P, Thorn S, Liu Z, hawley C, Mamarian M, Turlejski T, Meng L, Liu C, Sinusas A. Abstract 13133: Heterogeneous Uptake of [99mTc]microspheres and 201Tl in Skeletal Muscles in Porcine Model of Hindlimb Ischemia. Circulation 2021, 144: a13133-a13133. DOI: 10.1161/circ.144.suppl_1.13133.
• Abstract 14327: Intramyocardial Delivery of an Imageable Theranostic Hydrogel Post Myocardial Infarction Alters Regional Strain and Reduces Remodeling in Chronic Porcine ModelMelvinsdottir I, Midgett D, Lee S, Uman S, Kim J, Avendano R, Thorn S, Lysyy T, Arnarsson K, Humphrey J, Duncan J, Burdick J, Sinusas A. Abstract 14327: Intramyocardial Delivery of an Imageable Theranostic Hydrogel Post Myocardial Infarction Alters Regional Strain and Reduces Remodeling in Chronic Porcine Model. Circulation 2021, 144: a14327-a14327. DOI: 10.1161/circ.144.suppl_1.14327.
• Multi-frame Attention Network for Left Ventricle Segmentation in 3D EchocardiographyAhn SS, Ta K, Thorn S, Langdon J, Sinusas AJ, Duncan JS. Multi-frame Attention Network for Left Ventricle Segmentation in 3D Echocardiography. 2021, 12901: 348-357. PMID: 34729554, PMCID: PMC8560213, DOI: 10.1007/978-3-030-87193-2_33.
• Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography/Computed Tomography in Patients With Systemic Sclerosis.Feher A, Boutagy NE, Oikonomou EK, Thorn S, Liu YH, Miller EJ, Sinusas AJ, Hinchcliff M. Impaired Myocardial Flow Reserve on 82Rubidium Positron Emission Tomography/Computed Tomography in Patients With Systemic Sclerosis. The Journal Of Rheumatology 2021, 48: 1574-1582. PMID: 34266986, PMCID: PMC10275580, DOI: 10.3899/jrheum.210040.
• In-vivo Measurement Of 3d Left Ventricular Myocardial Strain Using CineCT Imaging Post Myocardial Infarction And Following Intramyocardial Delivery Of Theranostic HydrogelMidgett D, Thorn S, Awn S, Uman S, Lysyy T, Kim J, Duncan J, Humphrey J, Papademetris X, Burdick J, Sinusas A. In-vivo Measurement Of 3d Left Ventricular Myocardial Strain Using CineCT Imaging Post Myocardial Infarction And Following Intramyocardial Delivery Of Theranostic Hydrogel. Journal Of Cardiovascular Computed Tomography 2021, 15: s26-s27. DOI: 10.1016/j.jcct.2021.06.215.
• Arteriovenous fistula-induced cardiac remodeling shows cardioprotective features in miceLee SR, Thorn S, Guerrera N, Gonzalez L, Taniguchi R, Langford J, Sinusas AJ, Dardik A. Arteriovenous fistula-induced cardiac remodeling shows cardioprotective features in mice. JVS Vascular Science 2021, 2: 110-128. PMID: 34423320, PMCID: PMC8375600, DOI: 10.1016/j.jvssci.2021.05.002.
• Sex Differences in Arteriovenous Fistula-induced Cardiac Hypertrophy Lead to Similar Cardioprotective AdaptationLee S, Thorn S, Guerrera N, Gonzalez L, Taniguchi R, Langford J, Sinusas A, Dardik A. Sex Differences in Arteriovenous Fistula-induced Cardiac Hypertrophy Lead to Similar Cardioprotective Adaptation. JVS Vascular Science 2021, 2: 276-277. DOI: 10.1016/j.jvssci.2021.09.007.
• Abstract 16617: Multimodality Imaging Approach in Delivery and Tracking of a Novel Imageable Hydrogel in a Chronic Porcine Infarct ModelMelvinsdottir I, Lee S, Avendano R, Midgett D, Liu Y, Thorn S, hawley C, Mamarian M, Uman S, Humphrey J, Duncan J, Burdick J, Sinusas A. Abstract 16617: Multimodality Imaging Approach in Delivery and Tracking of a Novel Imageable Hydrogel in a Chronic Porcine Infarct Model. Circulation 2020, 142 DOI: 10.1161/circ.142.suppl_3.16617.
• Quantification of myocardial blood flow (MBF) and reserve (MFR) incorporated with a novel segmentation approach: Assessments of quantitative precision and the lower limit of normal MBF and MFR in patientsLiu H, Thorn S, Wu J, Fazzone-Chettiar R, Sandoval V, Miller EJ, Sinusas AJ, Liu YH. Quantification of myocardial blood flow (MBF) and reserve (MFR) incorporated with a novel segmentation approach: Assessments of quantitative precision and the lower limit of normal MBF and MFR in patients. Journal Of Nuclear Cardiology 2020, 28: 1236-1248. PMID: 32715416, DOI: 10.1007/s12350-020-02278-y.
• Cardiac CT Approach To Guide Delivery And Evaluate The Impact Of A Novel Imageable Theranostic Hydrogel Post Myocardial Infarction In An Acute Porcine ModelAvendaño R, Midgett D, Melvinsdottir I, Lee S, Hawley C, Mamarian M, Uman S, Thorn S, Humphrey J, Duncan J, Burdick J, Sinusas A. Cardiac CT Approach To Guide Delivery And Evaluate The Impact Of A Novel Imageable Theranostic Hydrogel Post Myocardial Infarction In An Acute Porcine Model. Journal Of Cardiovascular Computed Tomography 2020, 14: s26. DOI: 10.1016/j.jcct.2020.06.029.
• Multimodality Imaging Approach To Evaluate The Delivery And Impact Of A Novel Imageable Theranostic Hydrogel Post Myocardial Infarction In A Chronic Porcine ModelMelvinsdottir I, Lee S, Avendano R, Midgett D, Thorn S, Liu Y, Uman S, Humphrey J, Duncan J, Burdick J, Sinusas A. Multimodality Imaging Approach To Evaluate The Delivery And Impact Of A Novel Imageable Theranostic Hydrogel Post Myocardial Infarction In A Chronic Porcine Model. Journal Of Cardiovascular Computed Tomography 2020, 14: s27. DOI: 10.1016/j.jcct.2020.06.031.
• Imaging of Injectable Hydrogels Delivered into Myocardium with SPECT/CTUman S, Wang LL, Thorn SL, Liu Z, Duncan JS, Sinusas AJ, Burdick JA. Imaging of Injectable Hydrogels Delivered into Myocardium with SPECT/CT. Advanced Healthcare Materials 2020, 9: e2000294. PMID: 32543053, PMCID: PMC7482444, DOI: 10.1002/adhm.202000294.
• Application of Hybrid Matrix Metalloproteinase-Targeted and Dynamic 201Tl Single-Photon Emission Computed Tomography/Computed Tomography Imaging for Evaluation of Early Post-Myocardial Infarction RemodelingThorn SL, Barlow SC, Feher A, Stacy MR, Doviak H, Jacobs J, Zellars K, Renaud JM, Klein R, deKemp RA, Khakoo AY, Lee T, Spinale FG, Sinusas AJ. Application of Hybrid Matrix Metalloproteinase-Targeted and Dynamic 201Tl Single-Photon Emission Computed Tomography/Computed Tomography Imaging for Evaluation of Early Post-Myocardial Infarction Remodeling. Circulation Cardiovascular Imaging 2019, 12: e009055. PMID: 31707811, PMCID: PMC7250243, DOI: 10.1161/circimaging.119.009055.
• A robust segmentation method with triple‐factor non‐negative matrix factorization for myocardial blood flow quantification from dynamic 82Rb positron emission tomographyLiu H, Wu J, Sun J, Wu T, Fazzone‐Chettiar R, Thorn S, Sinusas AJ, Liu Y. A robust segmentation method with triple‐factor non‐negative matrix factorization for myocardial blood flow quantification from dynamic 82Rb positron emission tomography. Medical Physics 2019, 46: 5002-5013. PMID: 31444909, DOI: 10.1002/mp.13783.
• Direct List Mode Parametric Reconstruction for Dynamic Cardiac SPECTShi L, Lu Y, Wu J, Gallezot JD, Boutagy N, Thorn S, Sinusas AJ, Carson RE, Liu C. Direct List Mode Parametric Reconstruction for Dynamic Cardiac SPECT. IEEE Transactions On Medical Imaging 2019, 39: 119-128. PMID: 31180845, PMCID: PMC7030971, DOI: 10.1109/tmi.2019.2921969.
• Angiotensin Receptor Neprilysin Inhibitor Attenuates Myocardial Remodeling and Improves Infarct Perfusion in Experimental Heart FailurePfau D, Thorn SL, Zhang J, Mikush N, Renaud JM, Klein R, deKemp RA, Wu X, Hu X, Sinusas AJ, Young LH, Tirziu D. Angiotensin Receptor Neprilysin Inhibitor Attenuates Myocardial Remodeling and Improves Infarct Perfusion in Experimental Heart Failure. Scientific Reports 2019, 9: 5791. PMID: 30962467, PMCID: PMC6453892, DOI: 10.1038/s41598-019-42113-0.
• Incisional Negative Pressure Wound Therapy Augments Perfusion and Improves Wound Healing in a Swine Model Pilot Study.Shah A, Sumpio BJ, Tsay C, Swallow M, Dash B, Thorn SL, Sinusas AJ, Koo A, Hsia HC, Au A. Incisional Negative Pressure Wound Therapy Augments Perfusion and Improves Wound Healing in a Swine Model Pilot Study. Annals Of Plastic Surgery 2019, 82: s222-s227. PMID: 30855392, DOI: 10.1097/sap.0000000000001842.
• ANGIOTENSIN RECEPTOR NEPRILYSIN INHIBITOR THERAPY PROMOTES EARLY ANGIOGENESIS AND IMPROVES MYOCARDIAL PERFUSION INHIBITING POST-INFARCT REMODELINGThorn S, Tirziu D, Pfau D, Mikush N, Zhang J, Renaud J, Klein R, deKemp R, Wu X, Hu X, Young L, Sinusas A. ANGIOTENSIN RECEPTOR NEPRILYSIN INHIBITOR THERAPY PROMOTES EARLY ANGIOGENESIS AND IMPROVES MYOCARDIAL PERFUSION INHIBITING POST-INFARCT REMODELING. Journal Of The American College Of Cardiology 2018, 71: a1466. DOI: 10.1016/s0735-1097(18)32007-2.
• Simplified Quantification and Acquisition Protocol for 123I-MIBG Dynamic SPECTWu J, Gallezot JD, Lu Y, Ye Q, Liu H, Esserman DA, Kyriakides TC, Thorn S, Zonouz TH, Liu YH, Lampert R, Sinusas AJ, Carson RE, Liu C. Simplified Quantification and Acquisition Protocol for 123I-MIBG Dynamic SPECT. Journal Of Nuclear Medicine 2018, 59: 1574-1580. PMID: 29476001, DOI: 10.2967/jnumed.117.202143.
• GPU-based List-mode Direct Parametric Reconstruction for Dynamic Cardiac SPECTShi L, Wu J, Lu Y, Gallezot J, Thorn S, Sinusas A, Carson R, Liu C. GPU-based List-mode Direct Parametric Reconstruction for Dynamic Cardiac SPECT. 2017, 00: 1-3. DOI: 10.1109/nssmic.2017.8532889.
• Evaluation of structural remodeling of the atria with OCT in a chronic rat model of myocardial infarction (Conference Presentation)Eberle M, Thorn S, Young L, Pfau D, Madwed J, Small K, Kilmas M, Choma M, Sinusas A. Evaluation of structural remodeling of the atria with OCT in a chronic rat model of myocardial infarction (Conference Presentation). Proceedings Of SPIE--the International Society For Optical Engineering 2017, 1004206-1004206-1. DOI: 10.1117/12.2252954.
• T1-refBlochi: high resolution 3D post-contrast T1 myocardial mapping based on a single 3D late gadolinium enhancement volume, Bloch equations, and a reference T1Hu C, Sinusas AJ, Huber S, Thorn S, Stacy MR, Mojibian H, Peters DC. T1-refBlochi: high resolution 3D post-contrast T1 myocardial mapping based on a single 3D late gadolinium enhancement volume, Bloch equations, and a reference T1. Journal Of Cardiovascular Magnetic Resonance 2016, 19: 63. PMID: 28821300, PMCID: PMC5563030, DOI: 10.1186/s12968-017-0375-1.
• Effects of an endothelin receptor antagonist, Macitentan, on right ventricular substrate utilization and function in a Sugen 5416/hypoxia rat model of severe pulmonary arterial hypertensionDrozd K, Ahmadi A, Deng Y, Jiang B, Petryk J, Thorn S, Stewart D, Beanlands R, deKemp RA, DaSilva JN, Mielniczuk LM. Effects of an endothelin receptor antagonist, Macitentan, on right ventricular substrate utilization and function in a Sugen 5416/hypoxia rat model of severe pulmonary arterial hypertension. Journal Of Nuclear Cardiology 2016, 24: 1979-1989. PMID: 27688036, DOI: 10.1007/s12350-016-0663-4.
• Quantitative Analysis of Dynamic 123I-mIBG SPECT Imaging Data in Healthy Humans with a Population-Based Metabolite Correction MethodWu J, Lin SF, Gallezot JD, Chan C, Prasad R, Thorn S, Stacy MR, Huang Y, Zonouz TH, Liu YH, Lampert RJ, Carson RE, Sinusas AJ, Liu C. Quantitative Analysis of Dynamic 123I-mIBG SPECT Imaging Data in Healthy Humans with a Population-Based Metabolite Correction Method. Journal Of Nuclear Medicine 2016, 57: 1226-1232. PMID: 27081169, DOI: 10.2967/jnumed.115.171710.
• Editorial in response to: PET/CT evaluation of 18F-FDG uptake in pericoronary adipose tissue in patients with stable coronary artery disease: Independent predictor of atherosclerotic lesion formation? Is there prognostic value in evaluation of 18F-FDG uptake in the pericoronary adipose tissue?Thorn SL, Sinusas AJ. Editorial in response to: PET/CT evaluation of 18F-FDG uptake in pericoronary adipose tissue in patients with stable coronary artery disease: Independent predictor of atherosclerotic lesion formation? Is there prognostic value in evaluation of 18F-FDG uptake in the pericoronary adipose tissue? Journal Of Nuclear Cardiology 2016, 24: 1085-1088. PMID: 26976143, DOI: 10.1007/s12350-016-0458-7.
• Scatter and crosstalk corrections for 99mTc/123I dual‐radionuclide imaging using a CZT SPECT system with pinhole collimatorsFan P, Hutton BF, Holstensson M, Ljungberg M, Pretorius P, Prasad R, Ma T, Liu Y, Wang S, Thorn SL, Stacy MR, Sinusas AJ, Liu C. Scatter and crosstalk corrections for 99mTc/123I dual‐radionuclide imaging using a CZT SPECT system with pinhole collimators. Medical Physics 2015, 42: 6895-6911. PMID: 26632046, DOI: 10.1118/1.4934830.
• ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancyAlbright RA, Stabach P, Cao W, Kavanagh D, Mullen I, Braddock AA, Covo MS, Tehan M, Yang G, Cheng Z, Bouchard K, Yu ZX, Thorn S, Wang X, Folta-Stogniew EJ, Negrete A, Sinusas AJ, Shiloach J, Zubal G, Madri JA, De La Cruz EM, Braddock DT. ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy. Nature Communications 2015, 6: 10006. PMID: 26624227, PMCID: PMC4686714, DOI: 10.1038/ncomms10006.
• Deletion of MLIP (Muscle-enriched A-type Lamin-interacting Protein) Leads to Cardiac Hyperactivation of Akt/Mammalian Target of Rapamycin (mTOR) and Impaired Cardiac Adaptation*Cattin ME, Wang J, Weldrick JJ, Roeske CL, Mak E, Thorn SL, DaSilva JN, Wang Y, Lusis AJ, Burgon PG. Deletion of MLIP (Muscle-enriched A-type Lamin-interacting Protein) Leads to Cardiac Hyperactivation of Akt/Mammalian Target of Rapamycin (mTOR) and Impaired Cardiac Adaptation*. Journal Of Biological Chemistry 2015, 290: 26699-26714. PMID: 26359501, PMCID: PMC4646324, DOI: 10.1074/jbc.m115.678433.
• Abstract 205: Mlip is a New Integrator of Physiological Stress Required For Proper Cardiac AdaptationCattin M, Wang J, Roeske C, Mak E, Thorn S, DaSilva J, Wang Y, Lusis A, Burgon P. Abstract 205: Mlip is a New Integrator of Physiological Stress Required For Proper Cardiac Adaptation. Circulation Research 2015, 117 DOI: 10.1161/res.117.suppl_1.205.
• Cardiac β-Adrenoceptor Expression Is Reduced in Zucker Diabetic Fatty Rats as Type-2 Diabetes ProgressesHaley JM, Thackeray JT, Thorn SL, DaSilva JN. Cardiac β-Adrenoceptor Expression Is Reduced in Zucker Diabetic Fatty Rats as Type-2 Diabetes Progresses. PLOS ONE 2015, 10: e0127581. PMID: 25996498, PMCID: PMC4440709, DOI: 10.1371/journal.pone.0127581.
• Insulin therapy normalizes reduced myocardial β-adrenoceptors at both the onset and after sustained hyperglycemia in diabetic ratsHaley JM, Thackeray JT, Kolajova M, Thorn SL, DaSilva JN. Insulin therapy normalizes reduced myocardial β-adrenoceptors at both the onset and after sustained hyperglycemia in diabetic rats. Life Sciences 2015, 132: 101-107. PMID: 25934520, DOI: 10.1016/j.lfs.2015.03.024.
• Creation of clinically relevant model of chronic heart failure: Application of multi-modality imaging to define physiologyThorn S, Sinusas AJ. Creation of clinically relevant model of chronic heart failure: Application of multi-modality imaging to define physiology. Journal Of Nuclear Cardiology 2015, 22: 673-676. PMID: 25698482, DOI: 10.1007/s12350-015-0081-z.
• PET imaging of a collagen matrix reveals its effective injection and targeted retention in a mouse model of myocardial infarctionAhmadi A, Thorn SL, Alarcon EI, Kordos M, Padavan DT, Hadizad T, Cron GO, Beanlands RS, DaSilva JN, Ruel M, deKemp RA, Suuronen EJ. PET imaging of a collagen matrix reveals its effective injection and targeted retention in a mouse model of myocardial infarction. Biomaterials 2015, 49: 18-26. PMID: 25725551, DOI: 10.1016/j.biomaterials.2015.01.016.
• Left atrial function after myocardial infarction in swinePeters D, Diaz E, Bregazi A, Thorn S, Stacy M, Hawley C, Sinusas A. Left atrial function after myocardial infarction in swine. Journal Of Cardiovascular Magnetic Resonance 2015, 17: p142. PMCID: PMC4328575, DOI: 10.1186/1532-429x-17-s1-p142.
• Towards high-resolution fat-suppressed T1-mapping of atrial fibrosis in the left atrium: a fit-free three-point methodPeters D, Thorn S, Bregazi A, Hawley C, Stacy M, Sinusas A. Towards high-resolution fat-suppressed T1-mapping of atrial fibrosis in the left atrium: a fit-free three-point method. Journal Of Cardiovascular Magnetic Resonance 2015, 17: w17. PMCID: PMC4328894, DOI: 10.1186/1532-429x-17-s1-w17.
• Abstract 19973: Dynamic Thallium-201 SPECT/CT Provides Quantitative Index of Myocardial Flow and Viability: Validation in Porcine Post-Myocardial Infarction ModelThorn S, Stacy M, Bregasi A, Paeng J, Tavakoli V, Winters J, Hawley C, Tang Y, Bennett J, Wells R, Liu C, Klein R, Sinusas A. Abstract 19973: Dynamic Thallium-201 SPECT/CT Provides Quantitative Index of Myocardial Flow and Viability: Validation in Porcine Post-Myocardial Infarction Model. Circulation 2014, 130 DOI: 10.1161/circ.130.suppl_2.19973.
• THE EFFECTS OF A NOVEL ENDOTHELIN RECEPTOR ANTAGONIST, MACITENTAN, ON RIGHT VENTRICULAR SUBSTRATE UTILIZATION AND FUNCTION IN A SUGEN5416/HYPOXIA RAT MODEL OF SEVERE PULMONARY ARTERY HYPERTENSIONDrozd K, Deng Y, Jiang B, Lockwood J, Thorn S, Stewart D, Beanlands R, DeKemp R, DaSilva J, Mielniczuk L. THE EFFECTS OF A NOVEL ENDOTHELIN RECEPTOR ANTAGONIST, MACITENTAN, ON RIGHT VENTRICULAR SUBSTRATE UTILIZATION AND FUNCTION IN A SUGEN5416/HYPOXIA RAT MODEL OF SEVERE PULMONARY ARTERY HYPERTENSION. Canadian Journal Of Cardiology 2014, 30: s203. DOI: 10.1016/j.cjca.2014.07.332.
• The Novel Endothelin Receptor Antagonist, Macitentan, Improved Right Ventricular Function and Normalized Glucose Uptake in a Sugen5416/hypoxia Rat Model of Severe Pulmonary Artery HypertensionDrozd K, Deng Y, Jiang B, Lockwood J, Thorn S, Stewart D, Beanlands R, deKemp R, DaSilva J, Mielniczuk L. The Novel Endothelin Receptor Antagonist, Macitentan, Improved Right Ventricular Function and Normalized Glucose Uptake in a Sugen5416/hypoxia Rat Model of Severe Pulmonary Artery Hypertension. Journal Of Cardiac Failure 2014, 20: s73-s74. DOI: 10.1016/j.cardfail.2014.06.209.
• Glutaredoxin-2 Is Required to Control Oxidative Phosphorylation in Cardiac Muscle by Mediating Deglutathionylation Reactions*Mailloux RJ, Xuan JY, McBride S, Maharsy W, Thorn S, Holterman CE, Kennedy CR, Rippstein P, deKemp R, da Silva J, Nemer M, Lou M, Harper ME. Glutaredoxin-2 Is Required to Control Oxidative Phosphorylation in Cardiac Muscle by Mediating Deglutathionylation Reactions*. Journal Of Biological Chemistry 2014, 289: 14812-14828. PMID: 24727547, PMCID: PMC4031535, DOI: 10.1074/jbc.m114.550574.
• Reply: Noninvasive Measurement of Mouse Myocardial Glucose Uptake with 18F-FDGThorn SL, deKemp R, Dumouchel T, Klein R, Renaud JN, Wells RG, Gollob M, Beanlands RS, DaSilva JN. Reply: Noninvasive Measurement of Mouse Myocardial Glucose Uptake with 18F-FDG. Journal Of Nuclear Medicine 2014, 55: 866-867. PMID: 24652829, DOI: 10.2967/jnumed.114.138214.
• The role of integrin α2 in cell and matrix therapy that improves perfusion, viability and function of infarcted myocardiumAhmadi A, McNeill B, Vulesevic B, Kordos M, Mesana L, Thorn S, Renaud JM, Manthorp E, Kuraitis D, Toeg H, Mesana TG, Davis DR, Beanlands RS, DaSilva JN, deKemp RA, Ruel M, Suuronen EJ. The role of integrin α2 in cell and matrix therapy that improves perfusion, viability and function of infarcted myocardium. Biomaterials 2014, 35: 4749-4758. PMID: 24631247, DOI: 10.1016/j.biomaterials.2014.02.028.
• Preclinical Evaluation of Biopolymer-Delivered Circulating Angiogenic Cells in a Swine Model of Hibernating MyocardiumGiordano C, Thorn SL, Renaud JM, Al-Atassi T, Boodhwani M, Klein R, Kuraitis D, Dwivedi G, Zhang P, DaSilva JN, Ascah KJ, deKemp RA, Suuronen EJ, Beanlands RS, Ruel M. Preclinical Evaluation of Biopolymer-Delivered Circulating Angiogenic Cells in a Swine Model of Hibernating Myocardium. Circulation Cardiovascular Imaging 2013, 6: 982-991. PMID: 24089461, DOI: 10.1161/circimaging.113.000185.
• Integrin α2β1 Is Required for Synergistic Effect of Cells and Matrix Therapy in Improving the Perfusion, Viability and Function of Infarcted HeartsAhmadi A, McNeill B, Vulesevic B, Kordos M, Mesana L, Thorn S, Renaud J, Manthorp E, Kuraitis D, Toeg H, Mesana T, Beanlands R, DaSilva J, deKemp R, Ruel M, Suuronen E. Integrin α2β1 Is Required for Synergistic Effect of Cells and Matrix Therapy in Improving the Perfusion, Viability and Function of Infarcted Hearts. Canadian Journal Of Cardiology 2013, 29: s377. DOI: 10.1016/j.cjca.2013.07.647.
• β-Adrenoceptor Expression is Reduced in Zucker Diabetic Fatty Rats and Increased in Euglycemic Zucker Obese Rats After 6 Weeks of Sustained HyperglycemiaHaley J, Thackeray J, Thorn S, Beanlands R, Dasilva J. β-Adrenoceptor Expression is Reduced in Zucker Diabetic Fatty Rats and Increased in Euglycemic Zucker Obese Rats After 6 Weeks of Sustained Hyperglycemia. Canadian Journal Of Diabetes 2013, 37: s64-s65. DOI: 10.1016/j.jcjd.2013.08.194.
• In Vivo and Ex Vivo Imaging Demonstrate Effective Injection and Retention of a Collagen Matrix in a Mouse Model of Myocardial InfarctionAhmadi A, Thorn S, Kordos M, Padavan D, Hadizad T, Cron G, Beanlands R, DaSilva J, Ruel M, Suuronen E, deKemp R. In Vivo and Ex Vivo Imaging Demonstrate Effective Injection and Retention of a Collagen Matrix in a Mouse Model of Myocardial Infarction. Canadian Journal Of Cardiology 2013, 29: s307-s308. DOI: 10.1016/j.cjca.2013.07.517.
• Elevated Fatty Acid and Glucose Uptake in Right Ventricle in a Sugen 5416/Hypoxia Rat Model of Severe Pulmonary Artery HypertensionDrozd K, Deng Y, Jiang B, Lockwood J, Thorn S, Klein R, Stewart D, Beanlands R, deKemp R, DaSilva J, Mielniczuk L. Elevated Fatty Acid and Glucose Uptake in Right Ventricle in a Sugen 5416/Hypoxia Rat Model of Severe Pulmonary Artery Hypertension. Canadian Journal Of Cardiology 2013, 29: s249. DOI: 10.1016/j.cjca.2013.07.404.
• Repeatable Noninvasive Measurement of Mouse Myocardial Glucose Uptake with 18F-FDG: Evaluation of Tracer Kinetics in a Type 1 Diabetes ModelThorn SL, deKemp RA, Dumouchel T, Klein R, Renaud JM, Wells RG, Gollob MH, Beanlands RS, DaSilva JN. Repeatable Noninvasive Measurement of Mouse Myocardial Glucose Uptake with 18F-FDG: Evaluation of Tracer Kinetics in a Type 1 Diabetes Model. Journal Of Nuclear Medicine 2013, 54: 1637-1644. PMID: 23940301, DOI: 10.2967/jnumed.112.110114.
• Abstract 185: Muscle Enriched A-Type Lamin Interacting Protein (MLIP) mediates growth and function of the adult heartCattin M, Thorn S, Wang J, Rau C, Mak E, DaSilva J, Lusis J, Burgon P. Abstract 185: Muscle Enriched A-Type Lamin Interacting Protein (MLIP) mediates growth and function of the adult heart. Circulation Research 2013, 113 DOI: 10.1161/res.113.suppl_1.a185.
• Chronic AMPK activity dysregulation produces myocardial insulin resistance in the human Arg302Gln-PRKAG2 glycogen storage disease mouse modelThorn SL, Gollob MH, Harper ME, Beanlands RS, deKemp RA, DaSilva JN. Chronic AMPK activity dysregulation produces myocardial insulin resistance in the human Arg302Gln-PRKAG2 glycogen storage disease mouse model. EJNMMI Research 2013, 3: 48. PMID: 23829931, PMCID: PMC3707764, DOI: 10.1186/2191-219x-3-48.
• MicroRNA-133 Controls Brown Adipose Determination in Skeletal Muscle Satellite Cells by Targeting Prdm16Yin H, Pasut A, Soleimani VD, Bentzinger CF, Antoun G, Thorn S, Seale P, Fernando P, van IJcken W, Grosveld F, Dekemp RA, Boushel R, Harper ME, Rudnicki MA. MicroRNA-133 Controls Brown Adipose Determination in Skeletal Muscle Satellite Cells by Targeting Prdm16. Cell Metabolism 2013, 17: 210-224. PMID: 23395168, PMCID: PMC3641657, DOI: 10.1016/j.cmet.2013.01.004.
• 713 [11C]Methyl-EXP3174 as a Potential Radioligand for Imaging AT1Receptor With PetIsmail B, Fabre J, Hadizad T, Thackeray J, Thorn S, DeKemp R, Beanlands R, DaSilva J. 713 [11C]Methyl-EXP3174 as a Potential Radioligand for Imaging AT1Receptor With Pet. Canadian Journal Of Cardiology 2012, 28: s373. DOI: 10.1016/j.cjca.2012.07.646.
• 236 Decreased β-Adrenoceptor Binding in High-Fat Diet Low-Dose Streptozotocin Rats is Normalized With Similar Efficacy by 2 or 7 Weeks of Insulin-Induced EuglycemiaHaley J, Thackeray J, Thorn S, Kolajova M, Beanlands R, DaSilva J. 236 Decreased β-Adrenoceptor Binding in High-Fat Diet Low-Dose Streptozotocin Rats is Normalized With Similar Efficacy by 2 or 7 Weeks of Insulin-Induced Euglycemia. Canadian Journal Of Cardiology 2012, 28: s177-s178. DOI: 10.1016/j.cjca.2012.07.223.
• Uniformity and repeatability of normal resting myocardial blood flow in rats using [13N]-ammonia and small animal PETLamoureux M, Thorn S, Dumouchel T, Renaud JM, Klein R, Mason S, Lortie M, DaSilva JN, Beanlands RS, deKemp RA. Uniformity and repeatability of normal resting myocardial blood flow in rats using [13N]-ammonia and small animal PET. Nuclear Medicine Communications 2012, 33: 917-925. PMID: 22692581, DOI: 10.1097/mnm.0b013e328355d8bc.
• 18F-FDG Cell Labeling May Underestimate Transplanted Cell Homing: More Accurate, Efficient, and Stable Cell Labeling with Hexadecyl-4-[18F]Fluorobenzoate for in Vivo Tracking of Transplanted Human Progenitor Cells by Positron Emission TomographyZhang Y, Dasilva JN, Hadizad T, Thorn S, Kuraitis D, Renaud JM, Ahmadi A, Kordos M, Dekemp RA, Beanlands RS, Suuronen EJ, Ruel M. 18F-FDG Cell Labeling May Underestimate Transplanted Cell Homing: More Accurate, Efficient, and Stable Cell Labeling with Hexadecyl-4-[18F]Fluorobenzoate for in Vivo Tracking of Transplanted Human Progenitor Cells by Positron Emission Tomography. Cell Transplantation 2012, 21: 1821-1835. PMID: 22469629, DOI: 10.3727/096368911x637416.
• A three-dimensional model-based partial volume correction strategy for gated cardiac mouse PET imagingDumouchel T, Thorn S, Kordos M, DaSilva J, Beanlands RS, deKemp RA. A three-dimensional model-based partial volume correction strategy for gated cardiac mouse PET imaging. Physics In Medicine And Biology 2012, 57: 4309-4334. PMID: 22705820, DOI: 10.1088/0031-9155/57/13/4309.
• 279 Right ventricular metabolic imaging in experimental pulmonary artery hypertensionMielniczuk L, Thorn S, Renaud J, Beanlands R, deKemp R, DaSilva J, Stewart D. 279 Right ventricular metabolic imaging in experimental pulmonary artery hypertension. Canadian Journal Of Cardiology 2011, 27: s163. DOI: 10.1016/j.cjca.2011.07.207.
• 705 Development of reporter gene PET imaging techniques for long-term assessment of transplanted human circulating progenitor cellsZhang Y, Kuraitis D, Burgon P, Crowe S, Vulesevic B, Thorn S, Wu J, DaSilva J, deKemp R, Beanlands R, Suuronen E, Ruel M. 705 Development of reporter gene PET imaging techniques for long-term assessment of transplanted human circulating progenitor cells. Canadian Journal Of Cardiology 2011, 27: s321-s322. DOI: 10.1016/j.cjca.2011.08.099.
• 671 Increased Cardiac AT1R in the post ischemic myocardium in a transient left anterior descending artery ligation/reperfusion rat modelMackasey K, Thorn S, Kordos M, Renaud J, Klein R, deKemp R, Beanlands R, DaSilva J. 671 Increased Cardiac AT1R in the post ischemic myocardium in a transient left anterior descending artery ligation/reperfusion rat model. Canadian Journal Of Cardiology 2011, 27: s307-s308. DOI: 10.1016/j.cjca.2011.07.558.
• 178 Abnormal Neonate Cardiomyocyte Metabolism is Associated with Alterations in Adult Cardiac Metabolism in a Mouse Model of the Arg302gln-prkag2 Cardiac SyndromeThorn S, DaSilva J, deKemp R, Moffat C, Renaud J, Klein R, Beanlands R, Harper M, Gollob M. 178 Abnormal Neonate Cardiomyocyte Metabolism is Associated with Alterations in Adult Cardiac Metabolism in a Mouse Model of the Arg302gln-prkag2 Cardiac Syndrome. Canadian Journal Of Cardiology 2011, 27: s123-s124. DOI: 10.1016/j.cjca.2011.07.125.
• 647 Imaging of atherosclerotic vascular lesions in ApoE-/- mice Using [18F]-PyKYNE-c(RGDyK) and PETValdivia A, Thorn S, Sleiman L, DeKemp R, Beanlands R, DaSilva J. 647 Imaging of atherosclerotic vascular lesions in ApoE-/- mice Using [18F]-PyKYNE-c(RGDyK) and PET. Canadian Journal Of Cardiology 2011, 27: s298. DOI: 10.1016/j.cjca.2011.07.537.
• 182 An Integrin-Linked Kinase Mechanism is Associated with Improved Perfusion, Viability, and Function of Infarcted Myocardium Following Cell-Matrix TherapyAhmadi A, Vulesevic B, Toeg H, DaSilva J, Kordos M, Thorn S, Renaud J, Mesana T, Beanlands R, deKemp R, Ruel M, Suuronen E. 182 An Integrin-Linked Kinase Mechanism is Associated with Improved Perfusion, Viability, and Function of Infarcted Myocardium Following Cell-Matrix Therapy. Canadian Journal Of Cardiology 2011, 27: s126. DOI: 10.1016/j.cjca.2011.07.129.
• 604 Pre-clinical evaluation of biopolymer-delivered endothelial progenitor cells in hibernating myocardiumGiordano C, Thorn S, Suuronen E, Renaud J, Al-Atassi T, Boodhwani M, Zhang P, Ascah K, deKemp R, Beanlands R, Ruel M. 604 Pre-clinical evaluation of biopolymer-delivered endothelial progenitor cells in hibernating myocardium. Canadian Journal Of Cardiology 2011, 27: s281. DOI: 10.1016/j.cjca.2011.07.500.
• 595 Evaluation of [18F]PyKYNE-losartan in rats using pet imagingArksey N, Thorn S, Mackasey K, deKemp R, Beanlands R, DaSilva J. 595 Evaluation of [18F]PyKYNE-losartan in rats using pet imaging. Canadian Journal Of Cardiology 2011, 27: s279. DOI: 10.1016/j.cjca.2011.07.495.
• Reduced CGP12177 binding to cardiac β-adrenoceptors in hyperglycemic high-fat-diet-fed, streptozotocin-induced diabetic ratsThackeray JT, Parsa-Nezhad M, Kenk M, Thorn SL, Kolajova M, Beanlands RS, DaSilva JN. Reduced CGP12177 binding to cardiac β-adrenoceptors in hyperglycemic high-fat-diet-fed, streptozotocin-induced diabetic rats. Nuclear Medicine And Biology 2011, 38: 1059-1066. PMID: 21831645, DOI: 10.1016/j.nucmedbio.2011.04.002.
• Right Ventricular Metabolic Imaging in Experimental Pulmonary Artery HypertensionMielniczuk L, Thorn S, Renaud J, Klein R, DaSilva J, deKemp R, Beanlands R, Stewart D. Right Ventricular Metabolic Imaging in Experimental Pulmonary Artery Hypertension. Journal Of Cardiac Failure 2011, 17: s34-s35. DOI: 10.1016/j.cardfail.2011.06.117.
• Analysis of (R)- and (S)-[11C]rolipram Kinetics in Canine Myocardium for the Evaluation of Phosphodiesterase-4 with PETLortie M, DaSilva JN, Kenk M, Thorn S, Davis D, Birnie D, Beanlands RS, deKemp RA. Analysis of (R)- and (S)-[11C]rolipram Kinetics in Canine Myocardium for the Evaluation of Phosphodiesterase-4 with PET. Molecular Imaging And Biology 2011, 14: 225-236. PMID: 21424298, DOI: 10.1007/s11307-011-0482-6.
• Kinetic model‐based factor analysis of dynamic sequences for 82‐rubidium cardiac positron emission tomographyKlein R, Beanlands RS, Wassenaar RW, Thorn SL, Lamoureux M, DaSilva JN, Adler A, deKemp RA. Kinetic model‐based factor analysis of dynamic sequences for 82‐rubidium cardiac positron emission tomography. Medical Physics 2010, 37: 3995-4010. PMID: 20879561, DOI: 10.1118/1.3438474.
• Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis programKlein R, Renaud JM, Ziadi MC, Thorn SL, Adler A, Beanlands RS, deKemp RA. Intra- and inter-operator repeatability of myocardial blood flow and myocardial flow reserve measurements using rubidium-82 pet and a highly automated analysis program. Journal Of Nuclear Cardiology 2010, 17: 600-616. PMID: 20387135, DOI: 10.1007/s12350-010-9225-3.
• Alterations of pre- and postsynaptic noradrenergic signaling in a rat model of adriamycin-induced cardiotoxicityKenk M, Thackeray JT, Thorn SL, Dhami K, Chow BJ, Ascah KJ, DaSilva JN, Beanlands RS. Alterations of pre- and postsynaptic noradrenergic signaling in a rat model of adriamycin-induced cardiotoxicity. Journal Of Nuclear Cardiology 2010, 17: 254-263. PMID: 20182926, DOI: 10.1007/s12350-009-9190-x.
• In Vivo Assessment of Myocardial Glucose Uptake by Positron Emission Tomography in Adults With the PRKAG2 Cardiac SyndromeHa AC, Renaud JM, deKemp RA, Thorn S, DaSilva J, Garrard L, Yoshinaga K, Abraham A, Green MS, Beanlands RS, Gollob MH. In Vivo Assessment of Myocardial Glucose Uptake by Positron Emission Tomography in Adults With the PRKAG2 Cardiac Syndrome. Circulation Cardiovascular Imaging 2009, 2: 485-491. PMID: 19920047, DOI: 10.1161/circimaging.109.853291.
• Distinct Early Signaling Events Resulting From the Expression of the PRKAG2 R302Q Mutant of AMPK Contribute to Increased Myocardial GlycogenFolmes KD, Chan AY, Koonen DP, Pulinilkunnil TC, Baczkó I, Hunter BE, Thorn S, Allard MF, Roberts R, Gollob MH, Light PE, Dyck JR. Distinct Early Signaling Events Resulting From the Expression of the PRKAG2 R302Q Mutant of AMPK Contribute to Increased Myocardial Glycogen. Circulation Genomic And Precision Medicine 2009, 2: 457-466. PMID: 20031621, DOI: 10.1161/circgenetics.108.834564.
• Reduced in vivo phosphodiesterase-4 response to acute noradrenaline challenge in diet-induced obese ratsGreene M, Thackeray JT, Kenk M, Thorn SL, Bevilacqua L, Harper ME, Beanlands RS, DaSilva JN. Reduced in vivo phosphodiesterase-4 response to acute noradrenaline challenge in diet-induced obese rats. Canadian Journal Of Physiology And Pharmacology 2009, 87: 196-202. PMID: 19295660, DOI: 10.1139/y09-001.
• Collagen-Based Matrices Improve the Delivery of Transplanted Circulating Progenitor CellsZhang Y, Thorn S, DaSilva JN, Lamoureux M, deKemp RA, Beanlands RS, Ruel M, Suuronen EJ. Collagen-Based Matrices Improve the Delivery of Transplanted Circulating Progenitor Cells. Circulation Cardiovascular Imaging 2008, 1: 197-204. PMID: 19808543, DOI: 10.1161/circimaging.108.781120.
• Abstract 2876: Early Retention and Subsequent Engraftment of Transplanted Progenitor Cells is Improved by Delivery within Collagen MatrixZhang Y, Lamoureux M, Thorn S, Chan V, Price J, Beanlands R, DaSilva J, deKemp R, Suuronen E, Ruel M. Abstract 2876: Early Retention and Subsequent Engraftment of Transplanted Progenitor Cells is Improved by Delivery within Collagen Matrix. Circulation 2008, 118 DOI: 10.1161/circ.118.suppl_18.s_790-b.
• Abstract 3305: FDG PET Imaging in the PRKAG2 Cardiac Syndrome Demonstrates Altered Myocardial Glucose UptakeHa A, Renaud J, Thorn S, deKemp R, Yoshinaga K, Garrard L, DaSilva J, Beanlands R, Gollob M. Abstract 3305: FDG PET Imaging in the PRKAG2 Cardiac Syndrome Demonstrates Altered Myocardial Glucose Uptake. Circulation 2007, 116 DOI: 10.1161/circ.116.suppl_16.ii_744-b.
• Performance Evaluation of the LabPET™ APD-based Digital PET ScannerBergeron M, Cadorette J, Beaudoin J, Rousseau J, Dumoulin M, Lepage M, Robert G, Selivanov V, Tétrault M, Viscogliosi N, Dumouchel T, Thorn S, DaSilva J, deKemp R, Norenberg J, Fontaine R, Lecomte R. Performance Evaluation of the LabPET™ APD-based Digital PET Scanner. 2007, 6: 4185-4191. DOI: 10.1109/nssmic.2007.4437041.
• The guinea-pig is a poor animal model for studies of niacin deficiency and presents challenges in any study using purified diets.Thorn SL, Young GS, Kirkland JB. The guinea-pig is a poor animal model for studies of niacin deficiency and presents challenges in any study using purified diets. The British Journal Of Nutrition 2007, 98: 78-85. PMID: 17391557, DOI: 10.1017/S0007114507707663.
• In vivo selective binding of (R)-[11C]rolipram to phosphodiesterase-4 provides the basis for studying intracellular cAMP signaling in the myocardium and other peripheral tissuesKenk M, Greene M, Thackeray J, deKemp RA, Lortie M, Thorn S, Beanlands RS, DaSilva JN. In vivo selective binding of (R)-[11C]rolipram to phosphodiesterase-4 provides the basis for studying intracellular cAMP signaling in the myocardium and other peripheral tissues. Nuclear Medicine And Biology 2006, 34: 71-77. PMID: 17210463, DOI: 10.1016/j.nucmedbio.2006.10.002.
• Kinetics of (R)-[11C]rolipram and (S)-[11C]rolipram in the Dog Heart: Investigation of Four Compartment ModelsLortie M, DaSilva J, Kenk M, Thorn S, Beanlands R, deKemp R. Kinetics of (R)-[11C]rolipram and (S)-[11C]rolipram in the Dog Heart: Investigation of Four Compartment Models. 2006, 5: 2671-2675. DOI: 10.1109/nssmic.2006.356431.
• Application of cardiac molecular imaging using positron emission tomography in evaluation of drug and therapeutics for cardiovascular disorders.Yoshinaga K, Chow BJ, dekemp RA, Thorn S, Ruddy TD, Davies RA, DaSilva JN, Beanlands R. Application of cardiac molecular imaging using positron emission tomography in evaluation of drug and therapeutics for cardiovascular disorders. Current Pharmaceutical Design 2005, 11: 903-32. PMID: 15777243, DOI: 10.2174/1381612053381800.