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Charles Matouk, MD

Associate Professor of Neurosurgery; Vice Chair of Clinical Affairs, Neurosurgery; Chief, Neurovascular Surgery; Director, Neurovascular/Endovascular Fellowship

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Charles Matouk, MD

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Research Summary

My translational research interests can be divided along two thematic lines: (1) clinical trials implementation and design in neurological disease, and (2) advanced imaging in cerebrovascular disease.

Specialized Terms: Translational application of advanced imaging protocols in neurovascular disease; clinical trials

Extensive Research Description

1. CLINICAL TRIALS

I am currently involved in the following national and international, multi-center clinical trials that are enrolling (or about to enroll) at Yale-New Haven Hospital.

Brain Aneurysms / Subarachnoid Hemorrhage

ASTROH Trial. A multi-center, phase II randomized clinical trial of continuous low-dose IV heparin therapy in coiled low-grade aneurysmal SAH patients with significant hemorrhage burden. [My role: site-PI.]

NEWTON Trial. A multi-center, phase 3 randomized, double-blinded, placebo-controlled efficacy and safety study comparing EG-1962 to standard of care oral nimodipine in adults with aneurysmal subarachnoid hemorrhage. [My role: site-PI.]

Carotid Revascularization

CONFIDENCE Trial. A prospective, multi-center, single-arm, open-label clinical study to evaluate the safety and efficacy of Roadsaver carotid stent device used in conjunction with the Nanoparasol embolic protection system for the treatment of carotid artery stenosis in patients with elevated risk for adverse events following carotid endarterectomy. [My role: site-PI.]

CREST-2. Carotid revascularization for primary prevention of stroke (CREST-2) is two independent multicenter, randomized controlled trials of carotid revascularization and intensive medical management versus medical management alone in patients with asymptomatic high-grade carotid stenosis. [My role: sub-investigator, interventionist.]

Intracranial Hemorrhage

MISTIE-III. The purpose of this trial is to determine the safety of using a combination of minimally invasive surgery and clot lysis with rt-PA to remove intracerebral hemorrhage (ICH). [My role: site-co-PI, lead surgeon.]

2. ADVANCED IMAGING RESEARCH

My translational research is focused on advanced imaging of the critically ill neurovascular patient. Our overall aim is to improve the safety and quality of care rendered to patient's with cerebrovascular disease.

Coauthors

Research Interests

Cerebrovascular Disorders; Diagnostic Techniques, Neurological; Endothelium, Vascular; Neurosurgery; Radiology; Clinical Trial

Selected Publications

  • Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfaAmmar A, Elsamadicy A, Ammar M, Reeves B, Koo A, Falcone G, Hwang D, Petersen N, Kim J, Beekman R, Prust M, Magid-Bernstein J, Acosta J, Herbert R, Sheth K, Matouk C, Gilmore E. Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa Clinical Neurology And Neurosurgery 2023, 226: 107621. PMID: 36791588, DOI: 10.1016/j.clineuro.2023.107621.
  • Abstract WP154: Low-field Portable Mri For Routine Post-thrombectomy Assessment Of Ongoing Brain InjurySujijantarat N, Koo A, Jambor I, Malhotra A, Crawford A, Mazurek M, Parasuram N, Yadlapalli V, Chavva I, Antonios J, Elsamadicy A, Renedo D, Hebert R, Schindler J, Sansing L, De Havenon A, Olexa M, Iglesias J, Rosen M, Kimberly W, Petersen N, Sheth K, Matouk C. Abstract WP154: Low-field Portable Mri For Routine Post-thrombectomy Assessment Of Ongoing Brain Injury Stroke 2023, 54: awp154-awp154. DOI: 10.1161/str.54.suppl_1.wp154.
  • Future of Neurology & Technology: Neuroimaging Made Accessible Using Low-Field, Portable MRIParasuram N, Crawford A, Mazurek M, Chavva I, Beekman R, Gilmore E, Petersen N, Payabvash S, Sze G, Iglesias J, Omay S, Matouk C, Longbrake E, de Havenon A, Schiff S, Rosen M, Kimberly W, Sheth K. Future of Neurology & Technology: Neuroimaging Made Accessible Using Low-Field, Portable MRI Neurology 2023, 10.1212/wnl.0000000000207074. PMID: 36720639, DOI: 10.1212/wnl.0000000000207074.
  • In Reply to the Letter to Editor Regarding "Hospital Frailty Risk Score Predicts Adverse Events and Readmission Following Ventriculoperitoneal Shunt Surgery for Normal Pressure Hydrocephalus"Koo A, Elsamadicy A, Matouk C. In Reply to the Letter to Editor Regarding "Hospital Frailty Risk Score Predicts Adverse Events and Readmission Following Ventriculoperitoneal Shunt Surgery for Normal Pressure Hydrocephalus" World Neurosurgery 2023, 169: 124. PMID: 36585096, DOI: 10.1016/j.wneu.2022.11.023.
  • Response to letter to the Editor on ‘Utility of the Hospital Frailty Risk Score in patients undergoing endovascular treatment for ruptured aneurysms’Koo A, Elsamadicy A, Renedo D, Matouk C. Response to letter to the Editor on ‘Utility of the Hospital Frailty Risk Score in patients undergoing endovascular treatment for ruptured aneurysms’ Journal Of NeuroInterventional Surgery 2022, jnis-2022-019708. PMID: 36319084, DOI: 10.1136/jnis-2022-019708.
  • Unrepaired Maternal Vein of Galen Malformation in Pregnancy: A Case ReportAckerman-Banks C, Fardelmann K, Lam D, Simmons M, Elder R, Matouk C, Campbell K. Unrepaired Maternal Vein of Galen Malformation in Pregnancy: A Case Report A&A Practice 2022, 16: e01634. DOI: 10.1213/xaa.0000000000001634.
  • Unrepaired Maternal Vein of Galen Malformation in Pregnancy: A Case ReportAckerman-Banks C, Fardelmann K, Lam D, Simmons M, Elder R, Matouk C, Campbell K. Unrepaired Maternal Vein of Galen Malformation in Pregnancy: A Case Report A&A Practice 2022, 16: e01634. PMID: 36599040, DOI: 10.1213/xaa.0000000000001634.
  • P-017 Triple therapy versus dual antiplatelet therapy for dolichoectatic vertebrobasilar fusiform aneurysms treated with flow-diverters: the last frontier?Siddiqui A, Monteiro A, Hanel R, Kan P, Mohanty A, Cortez G, Rabinovich M, Matouk C, Sujijantarat N, Ebersole K, Fry L, Natarajan S, Owusu-Adjei B, Ortega-Gutierrez S, Vivanco-Suarez J, Wakhloo A, Levy E. P-017 Triple therapy versus dual antiplatelet therapy for dolichoectatic vertebrobasilar fusiform aneurysms treated with flow-diverters: the last frontier? 2022, a59.1-a59. DOI: 10.1136/neurintsurg-2022-snis.89.
  • 307 The Hospital Frailty Risk Score Independently Predicts Increased Complication Rates and Healthcare Resource Utilization After Endovascular Treatment of Ruptured AneurysmsKoo A, Elsamadicy A, Sarkozy M, Sherman J, Reeves B, Freedman I, Antonios J, Sujijantarat N, Renado D, Hebert R, Malhotra A, Matouk C. 307 The Hospital Frailty Risk Score Independently Predicts Increased Complication Rates and Healthcare Resource Utilization After Endovascular Treatment of Ruptured Aneurysms Neurosurgery 2022, 68: 67-68. DOI: 10.1227/neu.0000000000001880_307.
  • Abstract 123: Carotid Artery Stenosis In Underrepresented Populations Defined By Factors Other Than Race/ethnicity: Results From All Of UsRenedo D, Acosta J, Sheth K, Matouk C, Falcone G. Abstract 123: Carotid Artery Stenosis In Underrepresented Populations Defined By Factors Other Than Race/ethnicity: Results From All Of Us Stroke 2022, 53: a123-a123. DOI: 10.1161/str.53.suppl_1.123.
  • Abstract TP134: Association Of Neutrophil-lymphocyte Ratio With Functional Outcome In Spontaneous Intracerebral HemorrhageAtillasoy J, Leasure A, Schwartz A, Reznik M, Moody S, Bevers M, Matouk C, Falcone G, Sansing L, Kimberly W, Sheth K. Abstract TP134: Association Of Neutrophil-lymphocyte Ratio With Functional Outcome In Spontaneous Intracerebral Hemorrhage Stroke 2022, 53: atp134-atp134. DOI: 10.1161/str.53.suppl_1.tp134.
  • Abstract 105: Polygenic Burden Of Hypertension-related Alleles Leads To Non-traumatic Subarachnoid Hemorrhage At Younger AgesVanent K, Acosta J, Both C, Leasure A, Noche R, Levitt M, Matouk C, Gunel M, Sheth K, Falcone G. Abstract 105: Polygenic Burden Of Hypertension-related Alleles Leads To Non-traumatic Subarachnoid Hemorrhage At Younger Ages Stroke 2022, 53: a105-a105. DOI: 10.1161/str.53.suppl_1.105.
  • Abstract WP111: Deployment Of Portable, Bedside, Low-field Magnetic Resonance Imaging In The Emergency Department To Evaluate Patients With Acute StrokeChavva I, Mazurek M, Yuen M, Prabhat A, Crawford A, Cahn B, Schindler J, Sansing L, Matouk C, Hebert R, de Havenon A, Sharma R, Payabvash S, Sze G, Aydin A, Parwani V, Ulrich A, Brown K, Sheth K, Wira C. Abstract WP111: Deployment Of Portable, Bedside, Low-field Magnetic Resonance Imaging In The Emergency Department To Evaluate Patients With Acute Stroke Stroke 2022, 53: awp111-awp111. DOI: 10.1161/str.53.suppl_1.wp111.
  • Abstract 89: Nimodipine-induced Blood Pressure Reductions Below Personalized Limits Of Autoregulation Are Associated With Worse Outcomes After Subarachnoid HemorrhageBartolome D, Begunova Y, Prasad A, Soto A, Kobsa J, Top I, Quispe-Orozco D, Farooqui M, Zevallos C, Kim J, Gilmore E, Beekman R, de Havenon A, Matouk C, Sheth K, Ortega-Gutierrez S, Petersen N. Abstract 89: Nimodipine-induced Blood Pressure Reductions Below Personalized Limits Of Autoregulation Are Associated With Worse Outcomes After Subarachnoid Hemorrhage Stroke 2022, 53: a89-a89. DOI: 10.1161/str.53.suppl_1.89.
  • Abstract TMP55: Post-stroke Blood Pressure Variability In The Acute Phase Is Associated With Pre-stroke Blood Pressure Variability In Patients Undergoing Mechanical ThrombectomySoto A, Prasad A, Kobsa J, Bartolome D, Begunova Y, Kodali S, Quispe-Orozco D, Farooqui M, Zevallos C, Sansing L, Schindler J, Matouk C, Sheth K, de Havenon A, Ortega-Gutierrez S, Petersen N. Abstract TMP55: Post-stroke Blood Pressure Variability In The Acute Phase Is Associated With Pre-stroke Blood Pressure Variability In Patients Undergoing Mechanical Thrombectomy Stroke 2022, 53: atmp55-atmp55. DOI: 10.1161/str.53.suppl_1.tmp55.
  • Abstract 91: Large Vessel Occlusion Stroke Patients With Rapid Early Infarct Progression And Poor Collaterals Are Vulnerable To Blood Pressure ReductionsBegunova Y, Bartolome D, Kobsa J, Prasad A, Soto A, Quispe-Orozco D, Farooqui M, Zevallos C, Sansing L, Schindler J, De Havenon A, Matouk C, Sheth K, Ortega-Gutierrez S, Petersen N. Abstract 91: Large Vessel Occlusion Stroke Patients With Rapid Early Infarct Progression And Poor Collaterals Are Vulnerable To Blood Pressure Reductions Stroke 2022, 53: a91-a91. DOI: 10.1161/str.53.suppl_1.91.
  • Abstract 99: Single Cell RNA-Sequencing Reveals Array Of Immune Activation States In Intracerebral HemorrhageJohnson C, Askenase M, Beatty H, DeLong J, Zhang L, Sheth K, Cord B, Hebert R, Matouk C, Sansing L. Abstract 99: Single Cell RNA-Sequencing Reveals Array Of Immune Activation States In Intracerebral Hemorrhage Stroke 2022, 53: a99-a99. DOI: 10.1161/str.53.suppl_1.99.
  • Hybernia post-mechanical thrombectomy – Endovascular cerebral hypothermia trial in acute ischemic stroke (post-mtech trial)Choi J, Saver J, Nogueira R, Poli S, Nguyen T, Chen M, Matouk C, Pile-Spellman J. Hybernia post-mechanical thrombectomy – Endovascular cerebral hypothermia trial in acute ischemic stroke (post-mtech trial) Journal Of The Neurological Sciences 2021, 429: 119718. DOI: 10.1016/j.jns.2021.119718.
  • Drip-and-ship versus mothership for endovascular treatment of acute stroke: A comparative effectiveness analysisWu X, Wira C, Matouk C, Forman H, Gandhi D, Sanelli P, Schindler J, Malhotra A. Drip-and-ship versus mothership for endovascular treatment of acute stroke: A comparative effectiveness analysis International Journal Of Stroke 2021, 17: 315-322. PMID: 33759645, DOI: 10.1177/17474930211008701.
  • Abstract P410: Association of Serum GFAP With Hematoma Expansion and Poor Outcome After Intracerebral Hemorrhage: The Factor VII for ICH TrialLeasure A, Vanent K, Bevers M, Kimberly W, Mayer S, Steiner T, Matouk C, Sansing L, Falcone G, Sheth K. Abstract P410: Association of Serum GFAP With Hematoma Expansion and Poor Outcome After Intracerebral Hemorrhage: The Factor VII for ICH Trial Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p410.
  • Abstract P412: Klotho -vS Heterozygosity is Associated With Lower Risk of Non-Traumatic Subarachnoid HemorrhageAcosta J, Szejko N, Torres Lopez V, Both C, Sansing L, Sheth K, Matouk C, Gunel M, Falcone G. Abstract P412: Klotho -vS Heterozygosity is Associated With Lower Risk of Non-Traumatic Subarachnoid Hemorrhage Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p412.
  • Abstract P510: Ct Angiographic Radiomics Signature Predicts Functional Outcome Following Endovascular Thrombectomy in Large Vessel Occlusion StrokeAvery E, Behland J, Haider S, Zeevi T, Nguyen C, Peshwe K, Petersen N, Falcone G, Sansing L, Malhotra A, Matouk C, Sheth K, Payabvash S. Abstract P510: Ct Angiographic Radiomics Signature Predicts Functional Outcome Following Endovascular Thrombectomy in Large Vessel Occlusion Stroke Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p510.
  • Abstract MP35: Blood Pressure Reductions Before Arrival at a Thrombectomy-Capable Hospital Are Associated With Neurologic Worsening in Patients With Large-Vessel OcclusionKobsa J, Prasad A, Soto A, Kodali S, Nguyen C, Peshwe K, Quispe-Orozco D, Farooqui M, Zeballos C, Sansing L, Schindler J, Matouk C, Sheth K, Ortega-Gutierrez S, Petersen N. Abstract MP35: Blood Pressure Reductions Before Arrival at a Thrombectomy-Capable Hospital Are Associated With Neurologic Worsening in Patients With Large-Vessel Occlusion Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.mp35.
  • Abstract MP36: Blood Pressure Reductions in the Hyperacute Phase of Large Vessel Occlusion Ischemic Stroke Are Associated With Infarct Progression and Poor Functional OutcomePeshwe K, Nguyen C, Kodali S, Kobsa J, Prasad A, Soto A, Wira C, Matouk C, Sheth K, Petersen N. Abstract MP36: Blood Pressure Reductions in the Hyperacute Phase of Large Vessel Occlusion Ischemic Stroke Are Associated With Infarct Progression and Poor Functional Outcome Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.mp36.
  • Patient Risk Factors Associated with 30- and 90- Day Readmission after Ventriculoperitoneal Shunt Placement for Idiopathic Normal Pressure Hydrocephalus in Elderly PatientsKoo A, Elsamadicy A, Lin I, David W, Reeves B, Santarosa C, Cord B, Malhotra A, Kahle K, Matouk C. Patient Risk Factors Associated with 30- and 90- Day Readmission after Ventriculoperitoneal Shunt Placement for Idiopathic Normal Pressure Hydrocephalus in Elderly Patients Neurosurgery 2020, 67 DOI: 10.1093/neuros/nyaa447_202.
  • 30-Day Outcomes of Trans-Carotid Artery Revascularization with Proximal Protection Through ICA Flow Reversal in Neurosurgical PracticeCord B, Santarosa C, Sujijantarat N, Koo A, Elsamadicy A, Sheth K, Falcone G, Sansing L, Schindler J, Petersen N, Matouk C. 30-Day Outcomes of Trans-Carotid Artery Revascularization with Proximal Protection Through ICA Flow Reversal in Neurosurgical Practice Neurosurgery 2020, 67 DOI: 10.1093/neuros/nyaa447_334.
  • Predictors of Extended Length of Stay following Treatment of Unruptured Adult Cerebral AneurysmsKoo A, Elsamadicy A, Lin I, David W, Freedman I, Sujijantarat N, Cord B, Hebert R, Bahrassa F, Malhotra A, Matouk C. Predictors of Extended Length of Stay following Treatment of Unruptured Adult Cerebral Aneurysms Neurosurgery 2020, 67 DOI: 10.1093/neuros/nyaa447_147.
  • Impact of Clot Location on Outcomes after Mechanical Thrombectomy for Anterior Circulation Acute Ischemic StrokeSujijantarat N, Koo A, Elsamadicy A, Hebert R, Cord B, Navaratnam D, Sansing L, Malhotra A, Matouk C. Impact of Clot Location on Outcomes after Mechanical Thrombectomy for Anterior Circulation Acute Ischemic Stroke Neurosurgery 2020, 67 DOI: 10.1093/neuros/nyaa447_387.
  • Stem Cell Therapy for StrokeRobert S, Matouk C. Stem Cell Therapy for Stroke 2020, 331-345. DOI: 10.1007/978-3-030-56954-9_15.
  • Stereotactic Radiosurgery for Pediatric Arteriovenous Malformations: A Case Series Reflecting One Institution’s Experience With TreatmentChoi R, An Y, Aneja S, Bindra R, Bond J, Chiang V, Hansen J, Hebert R, Matouk C, Yu J. Stereotactic Radiosurgery for Pediatric Arteriovenous Malformations: A Case Series Reflecting One Institution’s Experience With Treatment International Journal Of Radiation Oncology • Biology • Physics 2020, 108: e244. DOI: 10.1016/j.ijrobp.2020.07.589.
  • Vascular Malformations of the Brain and SpineMatouk C, Cord B. Vascular Malformations of the Brain and Spine 2020, 177-191. DOI: 10.1007/978-3-030-52552-1_14.
  • Abstract 117: Fixed Compared to Autoregulation-oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic StrokePetersen N, Silverman A, Strander S, Kodali S, Wang A, Sansing L, Schindler J, Falcone G, Gilmore E, Jasne A, Cord B, Hebert R, Johnson M, Matouk C, Sheth K. Abstract 117: Fixed Compared to Autoregulation-oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.117.
  • Abstract 57: Deployment of Portable, Bedside, Low-Field Magnetic Resonance Imaging for Evaluation of Stroke PatientsCahn B, Shah J, Dyvorne H, O'Halloran R, Poole M, Yuen M, Mazurek M, Ward A, Payabvash S, Beekman R, Brown S, Falcone G, Gobeske K, Petersen N, Jasne A, Sharma R, Schindler J, Sansing L, Gilmore E, Wira C, Matouk C, Sze G, Rosen M, Kimberly W, Sheth K. Abstract 57: Deployment of Portable, Bedside, Low-Field Magnetic Resonance Imaging for Evaluation of Stroke Patients Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.57.
  • Abstract 66: Causal Associations Between Genetically-determined Smoking and Risk of Subarachnoid HemorrhageAcosta J, Both C, Brown S, Leasure A, Vanent K, Noche R, Kirsch E, Petersen N, Matouk C, Gunel M, Gill T, Sheth K, Falcone G. Abstract 66: Causal Associations Between Genetically-determined Smoking and Risk of Subarachnoid Hemorrhage Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.66.
  • Abstract 71: Sex and Genetic Predisposition Synergistically Influence Risk of Stroke and Myocardial Infarction in Middle-Aged Persons Without Risk FactorsFalcone G, Acosta J, Leasure A, Vanent K, Noche R, Kirsch E, Petersen N, Schindler J, Sansing L, Gill T, Matouk C, Gunel M, Sheth K. Abstract 71: Sex and Genetic Predisposition Synergistically Influence Risk of Stroke and Myocardial Infarction in Middle-Aged Persons Without Risk Factors Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.71.
  • Abstract WMP101: Prediction of Clinical Outcome in Supratentorial Intracerebral Hemorrhage: Application of Baseline Ct Scan Radiomics Feature Extraction and Machine Learning ClassifiersPayabvash S, Acosta J, Haider S, Noche R, Kirsch E, Matouk C, Sansing L, Sheth K, Falcone G. Abstract WMP101: Prediction of Clinical Outcome in Supratentorial Intracerebral Hemorrhage: Application of Baseline Ct Scan Radiomics Feature Extraction and Machine Learning Classifiers Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.wmp101.
  • Abstract WP11: Timing of Blood Pressure Decreases During Mechanical Thrombectomy for Ischemic StrokeKimmel A, Silverman A, Kodali S, Strander S, Nguyen C, Peshwe K, Wang A, Lopez G, Holcombe A, Zevallos C, Dandapat S, Sansing L, Schindler J, Falcone G, Matouk C, Sheth K, Ortega-Gutiérrez S, Petersen N. Abstract WP11: Timing of Blood Pressure Decreases During Mechanical Thrombectomy for Ischemic Stroke Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.wp11.
  • Abstract WP410: Hemoglobin Levels and Poor Outcome in Intracerebral Hemorrhage: An Exploratory Analysis of Individual Patient Data Across Multiple StudiesAcosta J, Leasure A, Kuohn L, Petersen N, Sansing L, Matouk C, Testai F, Langefeld C, Woo D, Qureshi A, Mayer S, Sheth K, Falcone G. Abstract WP410: Hemoglobin Levels and Poor Outcome in Intracerebral Hemorrhage: An Exploratory Analysis of Individual Patient Data Across Multiple Studies Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.wp410.
  • Abstract TMP89: Impaired Cerebral Autoregulation Increases Risk of Worse Outcome After Endovascular Thrombectomy in Stroke Patients With High Blood Pressure VariabilityNguyen C, Silverman A, Wang A, Kodali S, Strander S, Kimmel A, Peshwe K, De Havenon A, Gilmore E, Matouk C, Sansing L, Schindler J, Sheth K, Petersen N. Abstract TMP89: Impaired Cerebral Autoregulation Increases Risk of Worse Outcome After Endovascular Thrombectomy in Stroke Patients With High Blood Pressure Variability Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.tmp89.
  • Abstract TP11: CTA Collateral Status and Final Infarct Distribution Following Thrombectomy in Stroke Patients With Large Vessel OcclusionAl-Dasuqi K, Payabvash S, Abou Karam A, Strander S, Kodali S, Silverman A, Sansing L, Schindler J, Matouk C, Sheth K, Malhotra A, Petersen N. Abstract TP11: CTA Collateral Status and Final Infarct Distribution Following Thrombectomy in Stroke Patients With Large Vessel Occlusion Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.tp11.
  • Abstract TP417: An Autoregulation-Derived Prediction Model for Midline Shift After Ischemic StrokeSilverman A, Wang A, Kodali S, Strander S, Kimmel A, Nguyen C, Peshwe K, Matouk C, Kimberly W, Sheth K, Tan C, Petersen N. Abstract TP417: An Autoregulation-Derived Prediction Model for Midline Shift After Ischemic Stroke Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.tp417.
  • Abstract TP40: Time From Stroke Onset to Reperfusion is Associated With Worse Functional Outcomes in Patients With Rapidly Progressing InfarctsWang A, Strander S, Kodali S, Silverman A, Kimmel A, Nguyen C, Peshwe K, Sansing L, Schindler J, Matouk C, Sheth K, Petersen N. Abstract TP40: Time From Stroke Onset to Reperfusion is Associated With Worse Functional Outcomes in Patients With Rapidly Progressing Infarcts Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.tp40.
  • Abstract WP374: High Frequency Blood Pressure Monitoring in the Acute Phase of Large Vessel Occlusion Ischemic StrokePeshwe K, Nguyen C, Kimmel A, Kodali S, Silverman A, Strander S, Wang A, Wira C, Sansing L, Matouk C, Sheth K, Petersen N. Abstract WP374: High Frequency Blood Pressure Monitoring in the Acute Phase of Large Vessel Occlusion Ischemic Stroke Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.wp374.
  • Percutaneous Trans-Carotid Puncture for Mechanical Thrombectomy in Acute Ischemic Stroke Patients is Safe and Effective: A Large, Single-Center Case SeriesCord B, Wang A, Chouairi F, Koo A, Porto C, Silverman A, Kodali S, Strander S, Falcone G, Sheth K, Hebert R, Sansing L, Schindler J, Petersen N, Matouk C. Percutaneous Trans-Carotid Puncture for Mechanical Thrombectomy in Acute Ischemic Stroke Patients is Safe and Effective: A Large, Single-Center Case Series Neurosurgery 2019, 66: 310-167. DOI: 10.1093/neuros/nyz310_167.
  • Deviation from Dynamic and Personalized Optimal Blood Pressure Targets is Associated With Worse Functional Outcomes After Aneurysmal Subarachnoid HemorrhageSilverman A, Kodali S, Strander S, Gilmore E, Kimmel A, Wang A, Cord B, Falcone G, Hebert R, Matouk C, Sheth K, Petersen N. Deviation from Dynamic and Personalized Optimal Blood Pressure Targets is Associated With Worse Functional Outcomes After Aneurysmal Subarachnoid Hemorrhage Neurosurgery 2019, 66: 310-186. DOI: 10.1093/neuros/nyz310_186.
  • Preliminary Experience With Proximal Flow Reversal During Intracranial Balloon Angioplasty and Stenting for Symptomatic, Severe Intracranial StenosisCord B, Cord B, Santarosa C, Santarosa C, Sujijantarat N, Kundishora A, Falcone G, Sheth K, Sansing L, Schindler J, Petersen N, Matouk C. Preliminary Experience With Proximal Flow Reversal During Intracranial Balloon Angioplasty and Stenting for Symptomatic, Severe Intracranial Stenosis Neurosurgery 2019, 66: 310-675. DOI: 10.1093/neuros/nyz310_675.
  • Implications of Achieving TICI 2b Versus TICI 3 Reperfusion in Patients With Ischemic Stroke: A Cost-Effectiveness AnalysisWu X, Gandhi D, Matouk C, Schindler J, Hughes D, Forman H, Sanelli P, Malhotra A. Implications of Achieving TICI 2b Versus TICI 3 Reperfusion in Patients With Ischemic Stroke: A Cost-Effectiveness Analysis Neurosurgery 2019, 66: 310-670. DOI: 10.1093/neuros/nyz310_670.
  • Abstract 18: Genetically-Determined Cholesterol Levels are Associated with Risk of Spontaneous Intracerebral HemorrhageKirsch E, Leasure A, Matouk C, Sansing L, Crawford K, Kourkoulis C, Woo D, Rosand J, Anderson C, Sheth K, Falcone G. Abstract 18: Genetically-Determined Cholesterol Levels are Associated with Risk of Spontaneous Intracerebral Hemorrhage Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.18.
  • Abstract 76: Intensive Blood Pressure Reduction is Associated With Reduced Hematoma Expansion in Deep Intracerebral Hemorrhage: A Secondary Analysis of ATACH-2Leasure A, Qureshi A, Goldstein J, Murthy S, Kamel H, Woo D, Matouk C, Sansing L, Sheth K, Falcone G. Abstract 76: Intensive Blood Pressure Reduction is Associated With Reduced Hematoma Expansion in Deep Intracerebral Hemorrhage: A Secondary Analysis of ATACH-2 Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.76.
  • Abstract 77: Perihematomal Edema Expansion Rate is Associated With Poor Functional Outcomes in Basal Ganglia Intracerebral HemorrhageLeasure A, Qureshi A, Goldstein J, Murthy S, Kamel H, Woo D, Matouk C, Sansing L, Falcone G, Sheth K. Abstract 77: Perihematomal Edema Expansion Rate is Associated With Poor Functional Outcomes in Basal Ganglia Intracerebral Hemorrhage Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.77.
  • Abstract TP15: Percutaneous Transcarotid Puncture is a Viable Alternative for Thrombectomy in Acute Ischemic Stroke Patients With Difficult Vascular AccessWang A, Cord B, Chouairi F, Koo A, Porto C, Silverman A, Kodali S, Strander S, Hebert R, Falcone G, Sheth K, Sansing L, Schindler J, Matouk C, Petersen N. Abstract TP15: Percutaneous Transcarotid Puncture is a Viable Alternative for Thrombectomy in Acute Ischemic Stroke Patients With Difficult Vascular Access Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.tp15.
  • Abstract WMP97: Racial/Ethnic Disparities in the Risk of Intracerebral Hemorrhage RecurrenceKing Z, Leasure A, Torres-Lopez V, Woo D, Hanley D, Ziai W, Murthy S, Matouk C, Sansing L, Falcone G, Sheth K. Abstract WMP97: Racial/Ethnic Disparities in the Risk of Intracerebral Hemorrhage Recurrence Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.wmp97.
  • Abstract WP223: Ischemic and Hemorrhagic Stroke in Native AmericansKing Z, Beekman R, Chu S, Leasure A, Orgrass H, Gilmore E, Sansing L, Matouk C, Sheth K, Falcone G. Abstract WP223: Ischemic and Hemorrhagic Stroke in Native Americans Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.wp223.
  • Abstract 147: Individualized Blood Pressure Management After Subarachnoid Hemorrhage Using Real-time Autoregulation Monitoring: A Pilot Study Using NIRS and ICP-derived Limits of AutoregulationSilverman A, Wang A, Kodali S, Strander S, Cord B, Hebert R, Matouk C, Gilmore E, Sheth K, Petersen N. Abstract 147: Individualized Blood Pressure Management After Subarachnoid Hemorrhage Using Real-time Autoregulation Monitoring: A Pilot Study Using NIRS and ICP-derived Limits of Autoregulation Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.147.
  • Abstract 95: Exceeding Personalized Blood Pressure Targets After Endovascular Stroke Therapy is Associated With Hemorrhagic Transformation and Worse Functional OutcomePetersen N, Wang A, Strander S, Kodali S, Silverman A, Gilmore E, Sansing L, Schindler J, Hebert R, Cord B, Matouk C, Sheth K. Abstract 95: Exceeding Personalized Blood Pressure Targets After Endovascular Stroke Therapy is Associated With Hemorrhagic Transformation and Worse Functional Outcome Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.95.
  • Abstract TP34: Malignant CT Perfusion Profile is Associated With Increased Sensitivity to Blood Pressure Reductions During Endovascular Stroke TherapyStrander S, Wang A, Kodali S, Silverman A, Agarwal T, Stretz C, Zheng-Lin B, Lopez Cardenas G, Sansing L, Schindler J, Matouk C, Hebert R, Sheth K, Ortega Gutierrez S, Petersen N. Abstract TP34: Malignant CT Perfusion Profile is Associated With Increased Sensitivity to Blood Pressure Reductions During Endovascular Stroke Therapy Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.tp34.
  • Abstract WP3: Decreases in Blood Pressure During Endovascular Stroke Therapy are Associated With Larger Infarct Volumes and Poor Functional OutcomePetersen N, Wang A, Zhen-Li B, Strander S, Kodali S, Silverman A, Sansing L, Lopez G, Schindler J, Matouk C, Hebert R, Sheth K, Ortega Gutierrez S. Abstract WP3: Decreases in Blood Pressure During Endovascular Stroke Therapy are Associated With Larger Infarct Volumes and Poor Functional Outcome Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.wp3.
  • 57 Improving the Safety and Quality of Inter-Hospital Transfer for Nontraumatic Intracerebral and Subarachnoid HemorrhageLittauer R, Sather J, Rothenberg C, Finn E, Yip M, Matouk C, Pham L, Sheth K, Ulrich A, Parwani Y, Venkatesh A. 57 Improving the Safety and Quality of Inter-Hospital Transfer for Nontraumatic Intracerebral and Subarachnoid Hemorrhage Annals Of Emergency Medicine 2018, 72: s25-s26. DOI: 10.1016/j.annemergmed.2018.08.062.
  • Intracranial vessel wall MRI: Principles and expert consensus Recommendations of the American Society of NeuroradiologyMandell D, Mossa-Basha M, Qiao Y, Hess C, Hui F, Matouk C, Johnson M, Daemen M, Vossough A, Edjlali M, Saloner D, Ansari S, Wasserman B, Mikulis D. Intracranial vessel wall MRI: Principles and expert consensus Recommendations of the American Society of Neuroradiology International Journal Of Cerebrovascular Diseases 2018, 26: 641-653. DOI: 10.3760/cma.j.issn.1673-4165.2018.09.001.
  • 105 Decreases in Blood Pressure During Endovascular Stroke Therapy Are Common and Associated With Poor Functional OutcomeMampre D, Wang A, Sheth K, Tan C, Hebert R, Matouk C, Petersen N. 105 Decreases in Blood Pressure During Endovascular Stroke Therapy Are Common and Associated With Poor Functional Outcome Neurosurgery 2018, 65: 82. DOI: 10.1093/neuros/nyy303.105.
  • 148 Management of Unruptured Intracranial Aneurysms in the ElderlyWu X, Cord B, Sommaruga S, Matouk C, Malhotra A. 148 Management of Unruptured Intracranial Aneurysms in the Elderly Neurosurgery 2018, 65: 97. DOI: 10.1093/neuros/nyy303.148.
  • 315 Comparative Effectiveness Analysis of Pipeline Embolization Device versus Coiling in Unruptured Aneurysms Less Than 10 mm in SizeWu X, Cord B, Sommaruga S, Matouk C, Malhotra A. 315 Comparative Effectiveness Analysis of Pipeline Embolization Device versus Coiling in Unruptured Aneurysms Less Than 10 mm in Size Neurosurgery 2018, 65: 127-128. DOI: 10.1093/neuros/nyy303.315.
  • 316 Screening for Intracranial Aneurysms in Patients With Autosomal Dominant Polycystic Kidney DiseaseWu X, Matouk C, Malhotra A. 316 Screening for Intracranial Aneurysms in Patients With Autosomal Dominant Polycystic Kidney Disease Neurosurgery 2018, 65: 128. DOI: 10.1093/neuros/nyy303.316.
  • Risk of Branch Occlusion and Ischemic Complications with the Pipeline Embolization Device in the Treatment of Posterior Circulation AneurysmsAdeeb N, Griessenauer C, Dmytriw A, Shallwani H, Gupta R, Foreman P, Shakir H, Moore J, Limbucci N, Mangiafico S, Kumar A, Michelozzi C, Zhang Y, Pereira V, Matouk C, Harrigan M, Siddiqui A, Levy E, Renieri L, Marotta T, Cognard C, Ogilvy C, Thomas A. Risk of Branch Occlusion and Ischemic Complications with the Pipeline Embolization Device in the Treatment of Posterior Circulation Aneurysms American Journal Of Neuroradiology 2018, 39: 1303-1309. PMID: 29880475, PMCID: PMC7655425, DOI: 10.3174/ajnr.a5696.
  • History of Intracranial Hemorrhage Is Associated with In-Hospital Mortality in Ischemic Stroke Patients Treated with Intravenous ThrombolyticsSommaruga S, Chu S, Hwang D, Dearborn J, Sansing L, Cord B, Santarosa C, Samarth G, Petersen N, Gilmore E, Schindler J, Bijlenga P, Schaller K, Matouk C, Sheth K, Falcone G. History of Intracranial Hemorrhage Is Associated with In-Hospital Mortality in Ischemic Stroke Patients Treated with Intravenous Thrombolytics Journal Of Neurological Surgery Part A Central European Neurosurgery 2018, 79: s1-s27. DOI: 10.1055/s-0038-1660745.
  • Spontaneous Intracerebral Hemorrhage in the Elderly PopulationSommaruga S, Beekman R, Chu S, King Z, Matouk C, Hwang D, Sheth K, Falcone G. Spontaneous Intracerebral Hemorrhage in the Elderly Population Journal Of Neurological Surgery Part A Central European Neurosurgery 2018, 79: s1-s27. DOI: 10.1055/s-0038-1660768.
  • Predictors of Vessel Wall Enhancement in Unruptured Intracranial AneurysmsSommaruga S, Cord B, Santarosa C, Malhotra A, Jonhson M, Sheth K, Gunel M, Herbert R, Bijlenga P, Schaller K, Falcone G, Matouk C. Predictors of Vessel Wall Enhancement in Unruptured Intracranial Aneurysms Journal Of Neurological Surgery Part A Central European Neurosurgery 2018, 79: s1-s27. DOI: 10.1055/s-0038-1660769.
  • High-Resolution Vessel Wall MRI in Ruptured Cranial Dural Arteriovenous FistulasSommaruga S, Cord B, Santarosa C, Yeung J, Johnson M, Hebert R, Bijlenga P, Schaller K, Matouk C. High-Resolution Vessel Wall MRI in Ruptured Cranial Dural Arteriovenous Fistulas Journal Of Neurological Surgery Part A Central European Neurosurgery 2018, 79: s1-s27. DOI: 10.1055/s-0038-1660759.
  • High-Resolution MRI with Black Blood Sequence Increases Physician Confidence in Identification of Rupture Site in Cerebral AVMs: Application to Treatment StrategiesSommaruga S, Cord B, Minja F, Malhotra A, Johnson M, Bijlenga P, Schaller K, Matouk C. High-Resolution MRI with Black Blood Sequence Increases Physician Confidence in Identification of Rupture Site in Cerebral AVMs: Application to Treatment Strategies Journal Of Neurological Surgery Part A Central European Neurosurgery 2018, 79: s1-s27. DOI: 10.1055/s-0038-1660760.
  • Abstract TMP14: Thrombolysis in Ischemic Stroke Patients with Prior History of Intracranial HemorrhageChu S, Sommaruga S, Hwang D, Dearborn J, Sansing L, Matouk C, Samarth G, Petersen N, Gilmore E, Schindler J, Sheth K, Falcone G. Abstract TMP14: Thrombolysis in Ischemic Stroke Patients with Prior History of Intracranial Hemorrhage Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.tmp14.
  • Abstract WMP31: Vessel Wall Enhancement is Associated With Clinical and Imaging Markers of Aneurysm InstabilitySommaruga S, Cord B, Molhotra A, Johnson M, Minja F, Gunel M, Sheth K, Herbert R, Melnikov F, Schaller K, Mandell D, Bijlenga P, Falcone G, Matouk C. Abstract WMP31: Vessel Wall Enhancement is Associated With Clinical and Imaging Markers of Aneurysm Instability Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.wmp31.
  • Abstract WP320: Blood Pressure Reduction During Endovascular Stroke Therapy is Associated With Poor Functional OutcomeWang A, Mampre D, Sheth K, Tan C, Matouk C, Hebert R, Petersen N. Abstract WP320: Blood Pressure Reduction During Endovascular Stroke Therapy is Associated With Poor Functional Outcome Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.wp320.
  • Abstract TP38: Drip and Ship versus Direct Transfer to Comprehensive Stroke Center: A Modelling Based AnalysisMalhotra A, Wu X, Wu X, Matouk C, Schindler J. Abstract TP38: Drip and Ship versus Direct Transfer to Comprehensive Stroke Center: A Modelling Based Analysis Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.tp38.
  • Carotid Artery Wall Imaging: Perspective and Guidelines from the ASNR Vessel Wall Imaging Study Group and Expert Consensus Recommendations of the American Society of NeuroradiologySaba L, Yuan C, Hatsukami T, Balu N, Qiao Y, DeMarco J, Saam T, Moody A, Li D, Matouk C, Johnson M, Jäger H, Mossa-Basha M, Kooi M, Fan Z, Saloner D, Wintermark M, Mikulis D, Wasserman B. Carotid Artery Wall Imaging: Perspective and Guidelines from the ASNR Vessel Wall Imaging Study Group and Expert Consensus Recommendations of the American Society of Neuroradiology American Journal Of Neuroradiology 2018, 39: e9-e31. PMID: 29326139, PMCID: PMC7410574, DOI: 10.3174/ajnr.a5488.
  • 295 Interhospital Transfer is Not a Predictor of In-Hospital Mortality for Patients With Nontraumatic Intracranial HemorrhageYip M, Sather J, Sheth K, Matouk C, Littauer R, Finn E, Rothenberg C, Costello D, Parwani V, Venkatesh A. 295 Interhospital Transfer is Not a Predictor of In-Hospital Mortality for Patients With Nontraumatic Intracranial Hemorrhage Annals Of Emergency Medicine 2017, 70: s116-s117. DOI: 10.1016/j.annemergmed.2017.07.273.
  • 168 Wall Enhancement in Unruptured Aneurysms is Associated with Symptomatic Presentation and SizeCord B, Sommaruga S, Hebert R, Malhotra A, Johnson M, Minja F, Gunel M, Sheth K, Falcone G, Matouk C. 168 Wall Enhancement in Unruptured Aneurysms is Associated with Symptomatic Presentation and Size Neurosurgery 2017, 64: 243. DOI: 10.1093/neuros/nyx417.168.
  • Aneurysmal Subarachnoid HemorrhageWhite J, Matouk C. Aneurysmal Subarachnoid Hemorrhage 2017, 55-74. DOI: 10.1007/978-3-319-48669-7_4.
  • O-018 Flow diversion for the treatment of basilar apex aneurysmsDmytriw, Adeeb N, Kumar A, Griessenauer C, Ogilvy C, Foreman P, Shallwani H, Limbucci N, Mangiafico S, Michelozzi C, Krings T, Pereira V, Matouk C, Zhang Y, Harrigan M, Phan K, Shakir H, Siqqiqui A, Levy E, Renieri L, Cognard C, Thomas A, Marotta T. O-018 Flow diversion for the treatment of basilar apex aneurysms Journal Of NeuroInterventional Surgery 2017, 9: a11. DOI: 10.1136/neurintsurg-2017-snis.18.
  • O-021 Pipeline embolization of posterior circulation aneurysms: a multicenter study of 131 aneurysmsGriessenauer C, Ogilvy C, Adeeb N, Dmytriw A, Foreman P, Shallwani H, Limbucci N, Mangiafico S, Kumar A, Michelozzi C, Krings T, Pereira V, Matouk C, Harrigan M, Shakir H, Siddiqui A, Levy E, Renieri L, Marotta T, Cognard C, Thomas A. O-021 Pipeline embolization of posterior circulation aneurysms: a multicenter study of 131 aneurysms Journal Of NeuroInterventional Surgery 2017, 9: a13. DOI: 10.1136/neurintsurg-2017-snis.21.
  • E-050 First-Line Treatment by Embolization with Intention-to-Cure in the Management of Cranial Dural Arteriovenous FistulasCord B, Sommaruga S, Yeung J, Johnson M, Matouk C. E-050 First-Line Treatment by Embolization with Intention-to-Cure in the Management of Cranial Dural Arteriovenous Fistulas Journal Of NeuroInterventional Surgery 2016, 8: a70. DOI: 10.1136/neurintsurg-2016-012589.122.
  • Regarding “Clinical and Imaging Follow-Up of Patients with Coiled Basilar Tip Aneurysms Up to 20 Years”Malhotra A, Wu X, Kalra V, Matouk C, Forman H. Regarding “Clinical and Imaging Follow-Up of Patients with Coiled Basilar Tip Aneurysms Up to 20 Years” American Journal Of Neuroradiology 2016, 37: e39-e39. PMID: 26822726, PMCID: PMC7960187, DOI: 10.3174/ajnr.a4708.
  • High-Resolution Vessel Wall Magnetic Resonance Imaging in Angiogram-Negative Non-Perimesencephalic Subarachnoid HemorrhageCoutinho J, Sacho R, Schaafsma J, Agid R, Krings T, Radovanovic I, Matouk C, Mikulis D, Mandell D. High-Resolution Vessel Wall Magnetic Resonance Imaging in Angiogram-Negative Non-Perimesencephalic Subarachnoid Hemorrhage Clinical Neuroradiology 2015, 27: 175-183. PMID: 26608742, DOI: 10.1007/s00062-015-0484-x.
  • Practical Microsurgical and Endovascular Treatment of VasospasmBulsara K, Grant R, Matouk C. Practical Microsurgical and Endovascular Treatment of Vasospasm 2015, 75-75. DOI: 10.5005/jp/books/12423_12.
  • Vessel Wall Magnetic Resonance Imaging Identifies the Site of Rupture in Patients With Multiple Intracranial AneurysmsProof of PrincipleMatouk CC, Mandell DM, Günel M, Bulsara KR, Malhotra A, Hebert R, Johnson MH, Mikulis DJ, Minja FJ. Vessel Wall Magnetic Resonance Imaging Identifies the Site of Rupture in Patients With Multiple Intracranial AneurysmsProof of Principle Neurosurgery 2013, 72: 492-496. PMID: 23151622, DOI: 10.1227/neu.0b013e31827d1012.
  • Epigenetics and stroke risk – beyond the static DNA codeMarsden P, Matouk C, Turgeon P. Epigenetics and stroke risk – beyond the static DNA code Advances In Genomics And Genetics 2012, Volume 2: 67-84. DOI: 10.2147/agg.s18697.
  • Long-Term Clinical and Imaging Follow-Up of Complex Intracranial Aneurysms Treated by Endovascular Parent Vessel OcclusionMatouk CC, Kaderali Z, terBrugge KG, Willinsky RA. Long-Term Clinical and Imaging Follow-Up of Complex Intracranial Aneurysms Treated by Endovascular Parent Vessel Occlusion American Journal Of Neuroradiology 2012, 33: 1991-1997. PMID: 22555575, PMCID: PMC7964607, DOI: 10.3174/ajnr.a3079.
  • Carotid Artery Angioplasty and Stenting for Patients Less than 70 Years-of-AgeAlkins R, Matouk CC, Cruz JP, Marotta T, Montanera W, Spears J. Carotid Artery Angioplasty and Stenting for Patients Less than 70 Years-of-Age Canadian Journal Of Neurological Sciences / Journal Canadien Des Sciences Neurologiques 2012, 39: 338-342. PMID: 22547514, DOI: 10.1017/s0317167100013470.
  • The Pipeline Flow-Diverting Stent for Exclusion of Ruptured Intracranial Aneurysms With Difficult MorphologiesMartin AR, Cruz JP, Matouk CC, Spears J, Marotta TR. The Pipeline Flow-Diverting Stent for Exclusion of Ruptured Intracranial Aneurysms With Difficult Morphologies Neurosurgery 2012, 70: ons21-ons28. PMID: 21841519, DOI: 10.1227/neu.0b013e3182315ee3.
  • Vessel Wall MRI to Differentiate Between Reversible Cerebral Vasoconstriction Syndrome and Central Nervous System VasculitisMandell DM, Matouk CC, Farb RI, Krings T, Agid R, terBrugge K, Willinsky RA, Swartz RH, Silver FL, Mikulis DJ. Vessel Wall MRI to Differentiate Between Reversible Cerebral Vasoconstriction Syndrome and Central Nervous System Vasculitis Stroke 2011, 43: 860-862. PMID: 22156692, DOI: 10.1161/strokeaha.111.626184.
  • Osteogenesis Imperfecta, Multiple Intra-Abdominal Arterial Dissections and a Ruptured Dissecting-Type Intracranial AneurysmMatouk C, Hanbidge A, Mandell D, Terbrugge K, Agid R. Osteogenesis Imperfecta, Multiple Intra-Abdominal Arterial Dissections and a Ruptured Dissecting-Type Intracranial Aneurysm Interventional Neuroradiology 2011, 17: 371-375. PMID: 22005702, PMCID: PMC3396044, DOI: 10.1177/159101991101700315.
  • Hydrocephalus Secondary to Hydrodynamic Disequilibrium in an Adult Patient with a Choroidal-Type Arteriovenous MalformationEbinu J, Matouk C, Wallace M, Terbrugge K, Krings T. Hydrocephalus Secondary to Hydrodynamic Disequilibrium in an Adult Patient with a Choroidal-Type Arteriovenous Malformation Interventional Neuroradiology 2011, 17: 212-216. PMID: 21696661, PMCID: PMC3287273, DOI: 10.1177/159101991101700212.
  • Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones.Fish J, Yan M, Matouk C, St. Bernard R, Ho J, Gavryushova A, Srivastava D, Marsden P. Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones. Journal Of Biological Chemistry 2010, 285: 11754. PMCID: PMC2857053, DOI: 10.1074/jbc.a109.067868.
  • Epigenetic Regulation of Vascular Endothelial Gene ExpressionMatouk CC, Marsden PA. Epigenetic Regulation of Vascular Endothelial Gene Expression Circulation Research 2008, 102: 873-887. PMID: 18436802, DOI: 10.1161/circresaha.107.171025.
  • Activation of ETB receptors regulates the abundance of ET‐1 mRNA in vascular endothelial cellsFarhat N, Matouk C, Mamarbachi A, Marsden P, Allen B, Thorin E. Activation of ETB receptors regulates the abundance of ET‐1 mRNA in vascular endothelial cells British Journal Of Pharmacology 2008, 153: 1420-1431. PMID: 18278064, PMCID: PMC2437912, DOI: 10.1038/bjp.2008.25.
  • Chapter 26 Molecular Insights into the Thrombotic MicroangiopathiesMatouk C, Marsden P. Chapter 26 Molecular Insights into the Thrombotic Microangiopathies 2008, 453-cp4. DOI: 10.1016/b978-1-4160-0252-9.50030-6.
  • Chapter 78 Midbrain GliomasMatouk C, McDonald P, Drake J. Chapter 78 Midbrain Gliomas 2005, 599-603. DOI: 10.1016/b978-0-7216-8148-1.50081-4.
  • Matouk C, Turgeon PJ, Marsden PA. Epigenetics and stroke risk - beyond the static DNA code. Adv Genomics Genet. 2012 Oct;2:67-84.Matouk C, Turgeon PJ, Marsden PA. Epigenetics and stroke risk - beyond the static DNA code. Adv Genomics Genet. 2012 Oct;2:67-84.

Clinical Trials

ConditionsStudy Title
Diseases of the Cardiovascular SystemINSPIRE Pipeline™ Shield Post Approval Study
Diseases of the Nervous SystemPilot Study to Evaluate the CereVasc® eShunt® System in the Treatment of Communicating Hydrocephalus
Diseases of the Cardiovascular SystemTHUNDER: Acute Ischemic Stroke Study With the Penumbra System® Including Thunderbolt™ Aspiration Tubing
Diseases of the Cardiovascular SystemFeasibility Study of the Treatment of Acute Ischemic Stroke Using the NOVIS Transcarotid Neuroprotection System (NITE1)
Diseases of the Cardiovascular SystemEvaLuate EndoVascular Treatment of Acutely Ruptured Shallow Intradural Aneurysms With the Pipeline™ Flex Embolization Device With Shield TEchnology™ (ELEVATE)
Diseases of the Nervous SystemUS Pilot Study of the CereVasc® eShunt® System in Normal Pressure Hydrocephalus
Diseases of the Cardiovascular SystemMiddle Meningeal Artery Embolization for the Treatment of Subdural Hematomas With TRUFILL® n-BCA (MEMBRANE)
Diseases of the Nervous SystemMIND: Artemis in the Removal of Intracerebral Hemorrhage
Diseases of the Cardiovascular SystemPHIL in the Treatment of Intracranial dAVF. (PHIL dAVF)
Diseases of the Cardiovascular SystemEvaluation of the Roadsaver Stent Used in Conjunction With the Nanoparasol Embolic Protection System for Carotid Artery Stenosis
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