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Guido J. Falcone

MD, ScD, MPH

Associate Professor of Neurology; Academic Chief, Division of Neurocritical Care, Neurology; Director of Clinical Research in Neurocritical Care, Neurology; Training Director, Yale/AHA Bugher Center for Intracerebral Hemorrhage Research, Neurology; Staff Neurointensivist, Neurology

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Research Summary

My research lies at the interphase of clinical neurology, neuroimaging, population and medical genetics, and Big Data. I am interested in understanding how common and rare genetic variation influences the occurrence, severity, functional outcome and recurrence of stroke, both hemorrhagic and ischemic. Genetic variants influencing these phenotypes can be used for numerous applications, including: (1) identification of novel biological mechanisms involved in causing stroke and determining its severity and outcome, (2) answering non-genetic epidemiological questions using gene mutations as instruments (in the statistical sense of the word), and (3) risk stratification of patients according to their genetic profile. Through the International Stroke Genetics Consortium, I work in close collaboration with numerous investigators interested in stroke genomics from around the world.

Coauthors

Selected Publications

Improvement in the Prediction of Cerebrovascular Events With White Matter Hyperintensityde Havenon A, Smith E, Sharma R, Falcone G, Bangad A, Prabhakaran S, Sheth K. Improvement in the Prediction of Cerebrovascular Events With White Matter Hyperintensity. Journal Of The American Heart Association 2023, 12: e029374. PMID: 37345754, PMCID: PMC10356061, DOI: 10.1161/jaha.123.029374.
Polygenic Susceptibility to Hypertension and Cognitive Performance in Middle-aged Persons Without Stroke or DementiaRivier C, Szejko N, Renedo D, Noche R, Acosta J, Both C, Sharma R, Torres-Lopez V, Payabvash S, de Havenon A, Sheth K, Gill T, Falcone G. Polygenic Susceptibility to Hypertension and Cognitive Performance in Middle-aged Persons Without Stroke or Dementia. Neurology 2023, 101: e512-e521. PMID: 37295956, PMCID: PMC10401683, DOI: 10.1212/wnl.0000000000207427.
Identification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imagingde Havenon A, Parasuram N, Crawford A, Mazurek M, Chavva I, Yadlapalli V, Iglesias J, Rosen M, Falcone G, Payabvash S, Sze G, Sharma R, Schiff S, Safdar B, Wira C, Kimberly W, Sheth K. Identification of White Matter Hyperintensities in Routine Emergency Department Visits Using Portable Bedside Magnetic Resonance Imaging. Journal Of The American Heart Association 2023, 12: e029242. PMID: 37218590, PMCID: PMC10381997, DOI: 10.1161/jaha.122.029242.
Higher Hospital Frailty Risk Score Is Associated With Increased Risk of Stroke: Observational and Genetic AnalysesRenedo D, Acosta J, Koo A, Rivier C, Sujijantarat N, de Havenon A, Sharma R, Gill T, Sheth K, Falcone G, Matouk C. Higher Hospital Frailty Risk Score Is Associated With Increased Risk of Stroke: Observational and Genetic Analyses. Stroke 2023, 54: 1538-1547. PMID: 37216451, PMCID: PMC10212531, DOI: 10.1161/strokeaha.122.041891.
Association of Body Mass Index and Waist Circumference With Imaging Metrics of Brain Integrity and Functional Connectivity in Children Aged 9 to 10 Years in the US, 2016-2018Kaltenhauser S, Weber C, Lin H, Mozayan A, Malhotra A, Constable R, Acosta J, Falcone G, Taylor S, Ment L, Sheth K, Payabvash S. Association of Body Mass Index and Waist Circumference With Imaging Metrics of Brain Integrity and Functional Connectivity in Children Aged 9 to 10 Years in the US, 2016-2018. JAMA Network Open 2023, 6: e2314193. PMID: 37200030, PMCID: PMC10196880, DOI: 10.1001/jamanetworkopen.2023.14193.
Aldosterone Level Predicts Hypertension After ICH in the REDUCE Trial (P3-5.013)Zabinska J, Peng T, Forman R, Schwartz A, Leasure A, Schlechter M, Falcone G, De Havenon A, Sansing L, Lalwani D, Parasuram N, Yadlapalli V, Bushnell C, Mullen M, Cohen J, Cohen D, Messe S, Sheth K. Aldosterone Level Predicts Hypertension After ICH in the REDUCE Trial (P3-5.013). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000203612.
Neighborhood Disadvantage and Outcomes Following Intracerebral Hemorrhage (S29.002)Kim J, Kitlen E, Torres-Lopez V, Rivier C, Renedo D, Schlechter M, Kleinberg L, Pish M, Kampp M, Jasak S, Sansing L, Sheth K, Falcone G. Neighborhood Disadvantage and Outcomes Following Intracerebral Hemorrhage (S29.002). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000203392.
Neighborhood Deprivation and Polygenic Contribution to Acute Ischemic Stroke: Results from the All of Us Research Program (S49.007)Rivier C, Acosta J, Renedo D, Gill T, Sheth K, Falcone G. Neighborhood Deprivation and Polygenic Contribution to Acute Ischemic Stroke: Results from the All of Us Research Program (S49.007). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000202793.
Diabetes-Related Polygenic Risk Is Associated with Poor Glycemic Control and Higher Risk of Acute Cardiovascular Events in Stroke Survivors (P3-5.015)Demarais Z, Conlon C, Huo S, Rivier C, Renedo D, Sheth K, Falcone G. Diabetes-Related Polygenic Risk Is Associated with Poor Glycemic Control and Higher Risk of Acute Cardiovascular Events in Stroke Survivors (P3-5.015). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000202585.
Sleep Duration is Associated with Clinically Silent Brain Injury in Middle-Aged Persons without Stroke (P1-13.004)Clocchiatti-Tuozzo S, Rivier C, Renedo D, Torres-Lopez V, Payabvash S, Sheth K, Gill T, Falcone G. Sleep Duration is Associated with Clinically Silent Brain Injury in Middle-Aged Persons without Stroke (P1-13.004). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000202523.
Genetic Analyses of Oral Health and Neuroimaging Markers of Brain Health in Persons without Stroke (S49.001)Rivier C, Renedo D, De Havenon A, Payabvash S, Torres-Lopez V, Gill T, Sheth K, Falcone G. Genetic Analyses of Oral Health and Neuroimaging Markers of Brain Health in Persons without Stroke (S49.001). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000202220.
Genetically-Determined LDL Negatively Impacts Clinical Evolution of Ischemic Stroke Survivors (S3.003)Wu K, Rivier C, Demarais Z, Conlon C, Renedo D, Torres-Lopez V, Sharma R, De Havenon A, Sheth K, Falcone G. Genetically-Determined LDL Negatively Impacts Clinical Evolution of Ischemic Stroke Survivors (S3.003). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000202173.
Neighborhood Deprivation and Race Synergistically Contribute to Undiagnosed Hypertension Leading to Acute Ischemic Stroke: Results from the All of Us Research Program (P6-9.001)Torres-Lopez V, Renedo D, Acosta J, Gill T, Sheth K, Falcone G, Rivier C. Neighborhood Deprivation and Race Synergistically Contribute to Undiagnosed Hypertension Leading to Acute Ischemic Stroke: Results from the All of Us Research Program (P6-9.001). Neurology 2023, 100 DOI: 10.1212/wnl.0000000000202154.
Impact of genetic polymorphisms on the risk of epilepsy amongst patients with acute brain injury: A systematic reviewMisra S, Quinn T, Falcone G, Sharma V, de Havenon A, Zhao Y, Eldem E, French J, Yasuda C, Dawson J, Liebeskind D, Kwan P, Mishra N. Impact of genetic polymorphisms on the risk of epilepsy amongst patients with acute brain injury: A systematic review. European Journal Of Neurology 2023, 30: 1791-1800. PMID: 36912749, DOI: 10.1111/ene.15777.
A genome-wide association study of frailty identifies significant genetic correlation with neuropsychiatric, cardiovascular, and inflammation pathwaysYe Y, Noche R, Szejko N, Both C, Acosta J, Leasure A, Brown S, Sheth K, Gill T, Zhao H, Falcone G. A genome-wide association study of frailty identifies significant genetic correlation with neuropsychiatric, cardiovascular, and inflammation pathways. GeroScience 2023, 45: 2511-2523. PMID: 36928559, PMCID: PMC10651618, DOI: 10.1007/s11357-023-00771-z.
Blood pressure-related white matter microstructural disintegrity and associated cognitive function impairment in asymptomatic adultsAcosta J, Haider S, Rivier C, Leasure A, Sheth K, Falcone G, Payabvash S. Blood pressure-related white matter microstructural disintegrity and associated cognitive function impairment in asymptomatic adults. Stroke And Vascular Neurology 2023, 8: 358-367. PMID: 36878613, PMCID: PMC10647862, DOI: 10.1136/svn-2022-001929.
A Genomic Risk Score Identifies Individuals at High Risk for Intracerebral HemorrhageMyserlis E, Georgakis M, Demel S, Sekar P, Chung J, Malik R, Hyacinth H, Comeau M, Falcone G, Langefeld C, Rosand J, Woo D, Anderson C. A Genomic Risk Score Identifies Individuals at High Risk for Intracerebral Hemorrhage. Stroke 2023, 54: 973-982. PMID: 36799223, PMCID: PMC10050100, DOI: 10.1161/strokeaha.122.041701.
Whole-Exome Sequencing Analyses Support a Role of Vitamin D Metabolism in Ischemic StrokeXie Y, Acosta J, Ye Y, Demarais Z, Conlon C, Chen M, Zhao H, Falcone G. Whole-Exome Sequencing Analyses Support a Role of Vitamin D Metabolism in Ischemic Stroke. Stroke 2023, 54: 800-809. PMID: 36762557, PMCID: PMC10467223, DOI: 10.1161/strokeaha.122.040883.
Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfaAmmar A, Elsamadicy A, Ammar M, Reeves B, Koo A, Falcone G, Hwang D, Petersen N, Kim J, Beekman R, Prust M, Magid-Bernstein J, Acosta J, Herbert R, Sheth K, Matouk C, Gilmore E. Emergent external ventricular drain placement in patients with factor Xa inhibitor-associated intracerebral hemorrhage after reversal with andexanet alfa. Clinical Neurology And Neurosurgery 2023, 226: 107621. PMID: 36791588, DOI: 10.1016/j.clineuro.2023.107621.
Abstract WP130: Intracerebral Hemorrhage Outcomes And Trends During The Covid-19 Pandemic. An Observational Study Of 61,417 Cases.Renedo D, Leasure A, Acosta J, Young R, Alhanti B, Grory B, Spudich S, Messe S, Reeves M, Hassan A, Schwamm L, Matouk C, Sheth K, Falcone G. Abstract WP130: Intracerebral Hemorrhage Outcomes And Trends During The Covid-19 Pandemic. An Observational Study Of 61,417 Cases. Stroke 2023, 54: awp130-awp130. DOI: 10.1161/str.54.suppl_1.wp130.
Abstract WMP75: Community Deprivation And Healthcare Access/Utilization In Patients With Carotid Stenosis: Results From The All Of UsResearch ProgramClocchiatti-Tuozzo S, Renedo D, Rivier C, Lopez V, Matouk C, Sheth K, Gill T, Falcone G. Abstract WMP75: Community Deprivation And Healthcare Access/Utilization In Patients With Carotid Stenosis: Results From The All Of UsResearch Program. Stroke 2023, 54: awmp75-awmp75. DOI: 10.1161/str.54.suppl_1.wmp75.
Abstract WMP62: Stroke Severity Is The Primary Mediator Of Increased Stroke Mortality In The Elderlyde Havenon A, Bangad A, Yaghi S, Sharma R, Falcone G, Sheth K. Abstract WMP62: Stroke Severity Is The Primary Mediator Of Increased Stroke Mortality In The Elderly. Stroke 2023, 54: awmp62-awmp62. DOI: 10.1161/str.54.suppl_1.wmp62.
Abstract WMP102: Diabetes-Related Polygenic Risk Is Associated With Poor Glycemic Control And Higher Risk Of Acute Cardiovascular Events In Stroke SurvivorsDemarais Z, Conlon C, Huo S, Rivier C, Renedo D, Sheth K, Falcone G. Abstract WMP102: Diabetes-Related Polygenic Risk Is Associated With Poor Glycemic Control And Higher Risk Of Acute Cardiovascular Events In Stroke Survivors. Stroke 2023, 54: awmp102-awmp102. DOI: 10.1161/str.54.suppl_1.wmp102.
Abstract TP229: Impact Of Genetic Polymorphisms On The Risk Of Epilepsy Amongst Patients With Acute Brain Injury: A Systematic ReviewMisra S, Quinn T, Falcone G, Sharma V, De Havenon A, Zhao Y, Eldem E, Yasuda C, Dawson J, Liebeskind D, Kwan P, Mishra N. Abstract TP229: Impact Of Genetic Polymorphisms On The Risk Of Epilepsy Amongst Patients With Acute Brain Injury: A Systematic Review. Stroke 2023, 54: atp229-atp229. DOI: 10.1161/str.54.suppl_1.tp229.
Abstract TP115: Racial/ethnic Differences In Subacute Blood Pressure Trajectories Following Intracerebral HemorrhageTorres-Lopez V, Hawkes M, Rivier C, Kim J, Kitlen E, Schlechter M, Kampp M, Jasak S, Petersen N, Kim J, De Havenon A, Sansing L, Sheth K, Falcone G. Abstract TP115: Racial/ethnic Differences In Subacute Blood Pressure Trajectories Following Intracerebral Hemorrhage. Stroke 2023, 54: atp115-atp115. DOI: 10.1161/str.54.suppl_1.tp115.
Abstract TMP99: Neighborhood Disadvantage And Outcomes Following Intracerebral HemorrhageKim J, Rivier C, Renedo D, Lopez V, Schlechter M, Kitlen E, Kampp M, Jasak S, Sansing L, Sheth K, Falcone G. Abstract TMP99: Neighborhood Disadvantage And Outcomes Following Intracerebral Hemorrhage. Stroke 2023, 54: atmp99-atmp99. DOI: 10.1161/str.54.suppl_1.tmp99.
Abstract TMP80: Sex Is Associated With Location, Severity And Outcome Of Intracerebral Hemorrhage: A Combined Analysis Of Four Landmark StudiesRivier C, Acosta J, Renedo D, Marini S, Magid-Bernstein J, Rosand J, Hanley D, Ziai W, Mayer S, Woo D, Sansing L, Sheth K, Anderson C, Falcone G. Abstract TMP80: Sex Is Associated With Location, Severity And Outcome Of Intracerebral Hemorrhage: A Combined Analysis Of Four Landmark Studies. Stroke 2023, 54: atmp80-atmp80. DOI: 10.1161/str.54.suppl_1.tmp80.
Abstract TMP79: Deep Learning Model For Prediction Of Supratentorial Intracerebral Hemorrhage (ich) ExpansionTran A, Zeevi T, Berson E, Tharmaseelan H, Haider S, Qureshi A, Sansing L, Falcone G, Sheth K, Payabvash S. Abstract TMP79: Deep Learning Model For Prediction Of Supratentorial Intracerebral Hemorrhage (ich) Expansion. Stroke 2023, 54: atmp79-atmp79. DOI: 10.1161/str.54.suppl_1.tmp79.
Abstract HUP6: Community Deprivation And Healthcare Access/Utilization In Patients With Carotid Stenosis: Results From The All Of Us Research ProgramClocchiatti-Tuozzo S, Renedo D, Rivier C, Lopez V, Matouk C, Sheth K, Gill T, Falcone G. Abstract HUP6: Community Deprivation And Healthcare Access/Utilization In Patients With Carotid Stenosis: Results From The All Of Us Research Program. Stroke 2023, 54: ahup6-ahup6. DOI: 10.1161/str.54.suppl_1.hup6.
Abstract HUP1: Neighborhood Deprivation And Polygenic Contribution To Acute Ischemic Stroke: Results From The All Of Us Research ProgramRivier C, Acosta J, Renedo D, Sheth K, Falcone G. Abstract HUP1: Neighborhood Deprivation And Polygenic Contribution To Acute Ischemic Stroke: Results From The All Of Us Research Program. Stroke 2023, 54: ahup1-ahup1. DOI: 10.1161/str.54.suppl_1.hup1.
Abstract 9: Autoregulation-based Blood Pressure Targets After Endovascular ThrombectomyPetersen N, Begunova Y, Olexa M, Bartolome D, Kumar A, Chen Y, Dhar R, Peng T, Ortega-Gutierrez S, Falcone G, gilmore E, Kim J, Schindler J, Sansing L, Matouk C, Sheth K. Abstract 9: Autoregulation-based Blood Pressure Targets After Endovascular Thrombectomy. Stroke 2023, 54: a9-a9. DOI: 10.1161/str.54.suppl_1.9.
Abstract 87: Area Deprivation And Race Synergistically Contribute To Undiagnosed Hypertension Leading To Acute Ischemic StrokeRivier C, Acosta J, Renedo D, Sheth K, Falcone G. Abstract 87: Area Deprivation And Race Synergistically Contribute To Undiagnosed Hypertension Leading To Acute Ischemic Stroke. Stroke 2023, 54: a87-a87. DOI: 10.1161/str.54.suppl_1.87.
Abstract 57: Sleep Duration Is Associated With Clinically Silent Brain Injury In Middle-aged Persons Without StrokeClocchiatti-Tuozzo S, Rivier C, Renedo D, Lopez V, Payabvash S, Sheth K, Gill T, Falcone G. Abstract 57: Sleep Duration Is Associated With Clinically Silent Brain Injury In Middle-aged Persons Without Stroke. Stroke 2023, 54: a57-a57. DOI: 10.1161/str.54.suppl_1.57.
Abstract 51: Apoe Epsilon 4 And Risk Of Bleeding Patients With Brain Arteriovenous Malformations. A Combined Genetic Study In The Uk Biobank And All Of UsRenedo D, Rivier C, Acosta J, Clocchiatti S, Wu K, Torres-Lopez V, Sheth K, Gunel M, Matouk C, Falcone G. Abstract 51: Apoe Epsilon 4 And Risk Of Bleeding Patients With Brain Arteriovenous Malformations. A Combined Genetic Study In The Uk Biobank And All Of Us. Stroke 2023, 54: a51-a51. DOI: 10.1161/str.54.suppl_1.51.
Abstract 32: Neighborhood Deprivation And Polygenic Contribution To Acute Ischemic Stroke: Results From The All Of Us Research ProgramRivier C, Acosta J, Renedo D, Sheth K, Falcone G. Abstract 32: Neighborhood Deprivation And Polygenic Contribution To Acute Ischemic Stroke: Results From The All Of Us Research Program. Stroke 2023, 54: a32-a32. DOI: 10.1161/str.54.suppl_1.32.
Abstract 164: Cerebral Amyloid Angiopathy Is Associated With A Higher Risk Of Subdural Hemorrhage: Combined Analysis Of The Uk Biobank And All Of UsRivier C, Kamel H, Sheth K, Iadecola C, Gupta A, de Leon M, Ross M, Falcone G, Murthy S. Abstract 164: Cerebral Amyloid Angiopathy Is Associated With A Higher Risk Of Subdural Hemorrhage: Combined Analysis Of The Uk Biobank And All Of Us. Stroke 2023, 54: a164-a164. DOI: 10.1161/str.54.suppl_1.164.
Abstract 15: Single-cell Immune Landscape Of Human Clot Retrieved At Mechanical Thrombectomy. Association With Stroke Origin.Renedo D, Sujijantarat N, Antonios J, Koo A, Acosta J, Falcone G, Hebert R, Sansing L, Navaratnam D, Matouk C. Abstract 15: Single-cell Immune Landscape Of Human Clot Retrieved At Mechanical Thrombectomy. Association With Stroke Origin. Stroke 2023, 54: a15-a15. DOI: 10.1161/str.54.suppl_1.15.
Abstract 148: Genetically-Determined LDL Negatively Impacts Clinical Evolution Of Ischemic Stroke SurvivorsWu K, Rivier C, Demarais Z, Conlon C, Renedo D, Lopez V, Sharma R, De Havenon A, Sheth K, Falcone G. Abstract 148: Genetically-Determined LDL Negatively Impacts Clinical Evolution Of Ischemic Stroke Survivors. Stroke 2023, 54: a148-a148. DOI: 10.1161/str.54.suppl_1.148.
Abstract 131: Brain Mri Biomarkers Of Impaired Balance And Slow Walk Speed: Atherosclerosis Risk In Communities And UK Biobank StudiesSharma R, De Havenon A, Rivier C, Payabvash S, Forman R, Krumholz H, Falcone G, Sheth K, Kernan W. Abstract 131: Brain Mri Biomarkers Of Impaired Balance And Slow Walk Speed: Atherosclerosis Risk In Communities And UK Biobank Studies. Stroke 2023, 54: a131-a131. DOI: 10.1161/str.54.suppl_1.131.
Abstract 127: White Matter Hyperintensity And Atherosclerotic Cardiovascular Disease Riskde Havenon A, Bangad A, Prabhakaran S, Sharma R, Yaghi S, Falcone G, Sheth K. Abstract 127: White Matter Hyperintensity And Atherosclerotic Cardiovascular Disease Risk. Stroke 2023, 54: a127-a127. DOI: 10.1161/str.54.suppl_1.127.
Abstract 126: Genetic Analyses Of Oral Health And Neuroimaging Markers Of Brain Health In Persons Without StrokeRivier C, Renedo D, De Havenon A, Payabvash S, Sheth K, Falcone G. Abstract 126: Genetic Analyses Of Oral Health And Neuroimaging Markers Of Brain Health In Persons Without Stroke. Stroke 2023, 54: a126-a126. DOI: 10.1161/str.54.suppl_1.126.
Polygenic Susceptibility to Hypertension and Blood Pressure Control in Stroke SurvivorsAcosta J, Both C, Demarais Z, Conlon C, Leasure A, Torres-Lopez V, de Havenon A, Petersen N, Gill T, Sansing L, Sheth K, Falcone G. Polygenic Susceptibility to Hypertension and Blood Pressure Control in Stroke Survivors. Neurology 2023, 100: e1587-e1597. PMID: 36690452, PMCID: PMC10103110, DOI: 10.1212/wnl.0000000000206763.
Association of Soluble ST2 With Functional Outcome, Perihematomal Edema, and Immune Response After Intraparenchymal HemorrhageBevers M, Booraem C, Li K, Sreekrishnan A, Sastre C, Falcone G, Sheth K, Sansing L, Kimberly W. Association of Soluble ST2 With Functional Outcome, Perihematomal Edema, and Immune Response After Intraparenchymal Hemorrhage. Neurology 2022, 100: e1329-e1338. PMID: 36549913, PMCID: PMC10065211, DOI: 10.1212/wnl.0000000000206764.
Baseline Serum Biomarkers of Inflammation and Subsequent Visit-to-Visit Blood Pressure Variability: A Post Hoc Analysis of MESAWong KH, Muddasani V, Peterson C, Sheibani N, Arkin C, Cheong I, Majersik JJ, Biffi A, Petersen N, Falcone GJ, Sansing LH, de Havenon AH. Baseline Serum Biomarkers of Inflammation and Subsequent Visit-to-Visit Blood Pressure Variability: A Post Hoc Analysis of MESA. American Journal Of Hypertension 2022, 36: 144-147. PMID: 36315490, DOI: 10.1093/ajh/hpac122.
Multimodal biomedical AIAcosta JN, Falcone GJ, Rajpurkar P, Topol EJ. Multimodal biomedical AI. Nature Medicine 2022, 28: 1773-1784. PMID: 36109635, DOI: 10.1038/s41591-022-01981-2.
Association of Chronic Kidney Disease With Risk of Intracerebral HemorrhageVanent KN, Leasure AC, Acosta JN, Kuohn LR, Woo D, Murthy SB, Kamel H, Messé SR, Mullen MT, Cohen JB, Cohen DL, Townsend RR, Petersen NH, Sansing LH, Gill TM, Sheth KN, Falcone GJ. Association of Chronic Kidney Disease With Risk of Intracerebral Hemorrhage. JAMA Neurology 2022, 79: 911-918. PMID: 35969388, PMCID: PMC9379821, DOI: 10.1001/jamaneurol.2022.2299.
One-Year Outcome Trajectories and Factors Associated with Functional Recovery Among Survivors of Intracerebral and Intraventricular Hemorrhage With Initial Severe DisabilityShah VA, Thompson RE, Yenokyan G, Acosta JN, Avadhani R, Dlugash R, McBee N, Li Y, Hansen BM, Ullman N, Falcone G, Awad IA, Hanley DF, Ziai WC. One-Year Outcome Trajectories and Factors Associated with Functional Recovery Among Survivors of Intracerebral and Intraventricular Hemorrhage With Initial Severe Disability. JAMA Neurology 2022, 79: 856-868. PMID: 35877105, PMCID: PMC9316056, DOI: 10.1001/jamaneurol.2022.1991.
Dataset on acute stroke risk stratification from CT angiographic radiomicsAvery EW, Behland J, Mak A, Haider SP, Zeevi T, Sanelli PC, Filippi CG, Malhotra A, Matouk CC, Griessenauer CJ, Zand R, Hendrix P, Abedi V, Falcone GJ, Petersen N, Sansing LH, Sheth KN, Payabvash S. Dataset on acute stroke risk stratification from CT angiographic radiomics. Data In Brief 2022, 44: 108542. PMID: 36060820, PMCID: PMC9428796, DOI: 10.1016/j.dib.2022.108542.
Development and Validation of a Model to Identify Critical Brain Injuries Using Natural Language Processing of Text Computed Tomography ReportsTorres-Lopez VM, Rovenolt GE, Olcese AJ, Garcia GE, Chacko SM, Robinson A, Gaiser E, Acosta J, Herman AL, Kuohn LR, Leary M, Soto AL, Zhang Q, Fatima S, Falcone GJ, Payabvash MS, Sharma R, Struck AF, Sheth KN, Westover MB, Kim JA. Development and Validation of a Model to Identify Critical Brain Injuries Using Natural Language Processing of Text Computed Tomography Reports. JAMA Network Open 2022, 5: e2227109. PMID: 35972739, PMCID: PMC9382443, DOI: 10.1001/jamanetworkopen.2022.27109.
Deep Learning Applications for Acute Stroke ManagementChavva IR, Crawford AL, Mazurek MH, Yuen MM, Prabhat AM, Payabvash S, Sze G, Falcone GJ, Matouk CC, de Havenon A, Kim JA, Sharma R, Schiff SJ, Rosen MS, Kalpathy‐Cramer J, Gonzalez J, Kimberly WT, Sheth KN. Deep Learning Applications for Acute Stroke Management. Annals Of Neurology 2022, 92: 574-587. PMID: 35689531, DOI: 10.1002/ana.26435.
Racial/Ethnic Variation in White Matter Hyperintensity Progression in the ACCORDION MIND StudyHerman AL, de Havenon A, Falcone GJ, Prabhakaran S, Sheth KN. Racial/Ethnic Variation in White Matter Hyperintensity Progression in the ACCORDION MIND Study. The Neurologist 2022, 28: 157-159. PMID: 35834785, DOI: 10.1097/nrl.0000000000000454.
Genetically‐Proxied Levels of Vitamin D and Risk of Intracerebral HemorrhageSzejko N, Acosta JN, Both CP, Leasure A, Matouk C, Sansing L, Gill TM, Hongyu Z, Sheth K, Falcone GJ. Genetically‐Proxied Levels of Vitamin D and Risk of Intracerebral Hemorrhage. Journal Of The American Heart Association 2022, 11: e024141. PMID: 35730641, PMCID: PMC9333362, DOI: 10.1161/jaha.121.024141.
CT angiographic radiomics signature for risk stratification in anterior large vessel occlusion strokeAvery EW, Behland J, Mak A, Haider SP, Zeevi T, Sanelli PC, Filippi CG, Malhotra A, Matouk CC, Griessenauer CJ, Zand R, Hendrix P, Abedi V, Falcone GJ, Petersen N, Sansing LH, Sheth KN, Payabvash S. CT angiographic radiomics signature for risk stratification in anterior large vessel occlusion stroke. NeuroImage Clinical 2022, 34: 103034. PMID: 35550243, PMCID: PMC9108990, DOI: 10.1016/j.nicl.2022.103034.
Association of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-AnalysisKuramatsu JB, Gerner ST, Ziai W, Bardutzky J, Sembill JA, Sprügel MI, Mrochen A, Kölbl K, Ram M, Avadhani R, Falcone GJ, Selim MH, Lioutas VA, Endres M, Zweynert S, Vajkoczy P, Ringleb PA, Purrucker JC, Volkmann J, Neugebauer H, Erbguth F, Schellinger PD, Knappe UJ, Fink GR, Dohmen C, Minnerup J, Reichmann H, Schneider H, Röther J, Reimann G, Schwarz M, Bäzner H, Claßen J, Michalski D, Witte OW, Günther A, Hamann GF, Lücking H, Dörfler A, Ishfaq MF, Chang JJ, Testai FD, Woo D, Alexandrov AV, Staykov D, Goyal N, Tsivgoulis G, Sheth KN, Awad IA, Schwab S, Hanley DF, Huttner HB, Sansing L, Matouk C, Leasure A, Sobesky J, Bauer M, Schurig J, Rizos T, Haeusler K, Müllges W, Kraft P, Schubert A, Stösser S, Ludolph A, Nueckel M, Glahn J, Stetefeld H, Rahmig J, Fisse A, Michels P, Schwert H, Hagemann G, Rakers F, Wöhrle J, Alshammari F, Horn M, Bahner D, Urbanek C, Palm F, Grau A. Association of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis. Stroke 2022, 53: 2876-2886. PMID: 35521958, PMCID: PMC9398945, DOI: 10.1161/strokeaha.121.038455.
Effect of Intensive Blood Pressure Control on Incident Stroke Risk in Patients With Mild Cognitive Impairmentde Havenon A, Sharma R, Falcone GJ, Prabhakaran S, Sheth KN. Effect of Intensive Blood Pressure Control on Incident Stroke Risk in Patients With Mild Cognitive Impairment. Stroke 2022, 53: e242-e245. PMID: 35502662, PMCID: PMC9246875, DOI: 10.1161/strokeaha.122.038818.
Analysis of Clinical Traits Associated With Cardiovascular Health, Genomic Profiles, and Neuroimaging Markers of Brain Health in Adults Without Stroke or DementiaAcosta JN, Both CP, Rivier C, Szejko N, Leasure AC, Gill TM, Payabvash S, Sheth KN, Falcone GJ. Analysis of Clinical Traits Associated With Cardiovascular Health, Genomic Profiles, and Neuroimaging Markers of Brain Health in Adults Without Stroke or Dementia. JAMA Network Open 2022, 5: e2215328. PMID: 35622359, PMCID: PMC9142873, DOI: 10.1001/jamanetworkopen.2022.15328.
Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic strokeYuen MM, Prabhat AM, Mazurek MH, Chavva IR, Crawford A, Cahn BA, Beekman R, Kim JA, Gobeske KT, Petersen NH, Falcone GJ, Gilmore EJ, Hwang DY, Jasne AS, Amin H, Sharma R, Matouk C, Ward A, Schindler J, Sansing L, de Havenon A, Aydin A, Wira C, Sze G, Rosen MS, Kimberly WT, Sheth KN. Portable, low-field magnetic resonance imaging enables highly accessible and dynamic bedside evaluation of ischemic stroke. Science Advances 2022, 8: eabm3952. PMID: 35442729, PMCID: PMC9020661, DOI: 10.1126/sciadv.abm3952.
The Need for Medical Artificial Intelligence That Incorporates Prior Images.Acosta JN, Falcone GJ, Rajpurkar P. The Need for Medical Artificial Intelligence That Incorporates Prior Images. Radiology 2022, 304: 283-288. PMID: 35438563, DOI: 10.1148/radiol.212830.
Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traitsPathak GA, Singh K, Wendt FR, Fleming TW, Overstreet C, Koller D, Tylee DS, De Angelis F, Cabrera Mendoza B, Levey DF, Koenen KC, Krystal JH, Pietrzak RH, O’ Donell C, Gaziano JM, Falcone G, Stein MB, Gelernter J, Pasaniuc B, Mancuso N, Davis LK, Polimanti R. Genetically regulated multi-omics study for symptom clusters of posttraumatic stress disorder highlights pleiotropy with hematologic and cardio-metabolic traits. Molecular Psychiatry 2022, 27: 1394-1404. PMID: 35241783, PMCID: PMC9210390, DOI: 10.1038/s41380-022-01488-9.
WORSE VASCULAR RISK FACTOR CONTROL IN PATIENTS WITH STROKE COMPARED TO PATIENTS WITH MYOCARDIAL INFARCTIONLeasure A, Acosta J, Schwartz A, Forman R, Sharma R, de Havenon A, Falcone G, Inzucchi S, Kernan W, Sheth K. WORSE VASCULAR RISK FACTOR CONTROL IN PATIENTS WITH STROKE COMPARED TO PATIENTS WITH MYOCARDIAL INFARCTION. Journal Of The American College Of Cardiology 2022, 79: 1504. DOI: 10.1016/s0735-1097(22)02495-0.
The authors replyAcosta JN, Leasure AC, Sheth KN, Falcone GJ. The authors reply. Critical Care Medicine 2022, 50: e215-e216. PMID: 35100204, PMCID: PMC8842829, DOI: 10.1097/ccm.0000000000005388.
Carotid Artery Disease Among Broadly Defined Underrepresented Groups: The All of Us Research ProgramRenedo D, Acosta JN, Sujijantarat N, Antonios JP, Koo AB, Sheth KN, Matouk CC, Falcone GJ. Carotid Artery Disease Among Broadly Defined Underrepresented Groups: The All of Us Research Program. Stroke 2022, 53: e88-e89. PMID: 35109680, PMCID: PMC8944776, DOI: 10.1161/strokeaha.121.037554.
Maximizing Brain Health After Hemorrhagic Stroke: Bugher Foundation Centers of ExcellenceSheth KN, Anderson CD, Biffi A, Dlamini N, Falcone GJ, Fox CK, Fullerton HJ, Greenberg SM, Hemphill JC, Kim A, Kim H, Ko NU, Roland JL, Sansing LH, van Veluw SJ, Rosand J. Maximizing Brain Health After Hemorrhagic Stroke: Bugher Foundation Centers of Excellence. Stroke 2022, 53: 1020-1029. PMID: 35109678, PMCID: PMC8885885, DOI: 10.1161/strokeaha.121.036197.
Association Between Systemic Amyloidosis and Intracranial HemorrhageChen D, Zhang C, Parikh N, Merkler AE, Navi BB, Fink ME, Sheth KN, Falcone GJ, de Leon MJ, Gupta A, Kamel H, Murthy SB. Association Between Systemic Amyloidosis and Intracranial Hemorrhage. Stroke 2022, 53: e92-e93. PMID: 35109677, PMCID: PMC8885899, DOI: 10.1161/strokeaha.121.038451.
Abstract 123: Carotid Artery Stenosis In Underrepresented Populations Defined By Factors Other Than Race/ethnicity: Results From All Of UsRenedo D, Acosta J, Sheth K, Matouk C, Falcone G. Abstract 123: Carotid Artery Stenosis In Underrepresented Populations Defined By Factors Other Than Race/ethnicity: Results From All Of Us. Stroke 2022, 53: a123-a123. DOI: 10.1161/str.53.suppl_1.123.
Abstract 9: Pervasive White Matter Microstructure Dysintegrity Related To High Blood Pressure Among Asymptomatic PopulationAcosta J, Haider S, Rivier C, Leasure A, Sheth K, Falcone G, Payabvash S. Abstract 9: Pervasive White Matter Microstructure Dysintegrity Related To High Blood Pressure Among Asymptomatic Population. Stroke 2022, 53: a9-a9. DOI: 10.1161/str.53.suppl_1.9.
Abstract 107: Effect Of Intensive Blood Pressure Control On Incident Stroke Risk In Patients With Mild Cognitive Impairmentde Havenon A, Sharma R, Falcone G, Prabhakaran S, Sheth K. Abstract 107: Effect Of Intensive Blood Pressure Control On Incident Stroke Risk In Patients With Mild Cognitive Impairment. Stroke 2022, 53: a107-a107. DOI: 10.1161/str.53.suppl_1.107.
Abstract 103: Burden Of Ischemic And Hemorrhagic Stroke Across The Us From 1990-2019: A Global Burden Of Disease StudyLeasure A, Acosta J, Sharma R, Krumholz H, de Havenon A, Falcone G, Sheth K. Abstract 103: Burden Of Ischemic And Hemorrhagic Stroke Across The Us From 1990-2019: A Global Burden Of Disease Study. Stroke 2022, 53: a103-a103. DOI: 10.1161/str.53.suppl_1.103.
Abstract 67: Observed And Genomic Life’S Simple 7 Influence Brain Health-related Neuroimaging Traits In Persons Without Stroke Or DementiaAcosta J, Both C, Rivier C, Leasure A, Gill T, Payabvash S, Sheth K, Falcone G. Abstract 67: Observed And Genomic Life’S Simple 7 Influence Brain Health-related Neuroimaging Traits In Persons Without Stroke Or Dementia. Stroke 2022, 53: a67-a67. DOI: 10.1161/str.53.suppl_1.67.
Abstract 149: Differences In Self-reported Health Status Among Underrepresented Populations In Stroke Survivors Enrolled In All Of UsDemarais Z, Conlon C, Acosta J, Falcone G. Abstract 149: Differences In Self-reported Health Status Among Underrepresented Populations In Stroke Survivors Enrolled In All Of Us. Stroke 2022, 53: a149-a149. DOI: 10.1161/str.53.suppl_1.149.
Abstract 105: Polygenic Burden Of Hypertension-related Alleles Leads To Non-traumatic Subarachnoid Hemorrhage At Younger AgesVanent K, Acosta J, Both C, Leasure A, Noche R, Levitt M, Matouk C, Gunel M, Sheth K, Falcone G. Abstract 105: Polygenic Burden Of Hypertension-related Alleles Leads To Non-traumatic Subarachnoid Hemorrhage At Younger Ages. Stroke 2022, 53: a105-a105. DOI: 10.1161/str.53.suppl_1.105.
Abstract WP191: Genetic Analyses Support A Causal Role Of Lung Cancer In Ischemic StrokeVanent K, Acosta J, Both C, Leasure A, Lopez V, Szejko N, Rivier C, de Havenon A, Sharma R, Levitt M, Sheth K, Falcone G. Abstract WP191: Genetic Analyses Support A Causal Role Of Lung Cancer In Ischemic Stroke. Stroke 2022, 53: awp191-awp191. DOI: 10.1161/str.53.suppl_1.wp191.
Abstract TP134: Association Of Neutrophil-lymphocyte Ratio With Functional Outcome In Spontaneous Intracerebral HemorrhageAtillasoy J, Leasure A, Schwartz A, Reznik M, Moody S, Bevers M, Matouk C, Falcone G, Sansing L, Kimberly W, Sheth K. Abstract TP134: Association Of Neutrophil-lymphocyte Ratio With Functional Outcome In Spontaneous Intracerebral Hemorrhage. Stroke 2022, 53: atp134-atp134. DOI: 10.1161/str.53.suppl_1.tp134.
Abstract WP178: Biological Age Influences Clinically-evident And Asymptomatic Cerebrovascular Disease: Combined Analysis In The Uk Biobank And All Of UsRivier C, Szejko N, Acosta J, Both C, Leasure A, Lopez V, Gill T, Sheth K, Falcone G. Abstract WP178: Biological Age Influences Clinically-evident And Asymptomatic Cerebrovascular Disease: Combined Analysis In The Uk Biobank And All Of Us. Stroke 2022, 53: awp178-awp178. DOI: 10.1161/str.53.suppl_1.wp178.
Abstract TP137: Ethnic/racial Variations Of Intracerebral Hemorrhage Genetics (erich-gene) Study ProtocolFalcone G, Vagal A, Khandwala V, Maloney T, Flaherty M, Demel S, Parodi L, Gilkerson L, Fortes-Monteiro C, Worrall B, Nyquist P, Ziai W, Langefeld C, Rosand J, Anderson C, Woo D. Abstract TP137: Ethnic/racial Variations Of Intracerebral Hemorrhage Genetics (erich-gene) Study Protocol. Stroke 2022, 53: atp137-atp137. DOI: 10.1161/str.53.suppl_1.tp137.
Abstract WMP81: Association Between Systemic Amyloidosis And Intracranial HemorrhageChen D, Zhang C, Jalil S, Parikh N, Merkler A, Fink M, Gupta A, Sheth K, Falcone G, Navi B, Kamel H, Murthy S. Abstract WMP81: Association Between Systemic Amyloidosis And Intracranial Hemorrhage. Stroke 2022, 53: awmp81-awmp81. DOI: 10.1161/str.53.suppl_1.wmp81.
Abstract 71: Cognitive Impairment And The Risk Of Incident Stroke In Hypertensive Patientsde Havenon A, Sharma R, Falcone G, Sheth K. Abstract 71: Cognitive Impairment And The Risk Of Incident Stroke In Hypertensive Patients. Stroke 2022, 53: a71-a71. DOI: 10.1161/str.53.suppl_1.71.
Abstract TMP22: Genetic Predisposition To Cardiovascular Disease Is Associated With Higher Risk Of Stroke In Persons With COVID-19Both C, Abdelhakim S, Acosta J, Szejko N, Leasure A, Jasne A, Sharma R, Sheth K, Falcone G. Abstract TMP22: Genetic Predisposition To Cardiovascular Disease Is Associated With Higher Risk Of Stroke In Persons With COVID-19. Stroke 2022, 53: atmp22-atmp22. DOI: 10.1161/str.53.suppl_1.tmp22.
Bedside detection of intracranial midline shift using portable magnetic resonance imagingSheth KN, Yuen MM, Mazurek MH, Cahn BA, Prabhat AM, Salehi S, Shah JT, By S, Welch EB, Sofka M, Sacolick LI, Kim JA, Payabvash S, Falcone GJ, Gilmore EJ, Hwang DY, Matouk C, Gordon-Kundu B, RN AW, Petersen N, Schindler J, Gobeske KT, Sansing LH, Sze G, Rosen MS, Kimberly WT, Kundu P. Bedside detection of intracranial midline shift using portable magnetic resonance imaging. Scientific Reports 2022, 12: 67. PMID: 34996970, PMCID: PMC8742125, DOI: 10.1038/s41598-021-03892-7.
Cerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III TrialsMagid-Bernstein JR, Li Y, Cho SM, Piran PJ, Roh DJ, Gupta A, Shoamanesh A, Merkler A, Zhang C, Avadhani R, Montano N, Iadecola C, Falcone G, Sheth K, Qureshi AI, Rosand J, Goldstein J, Awad I, Hanley D, Kamel H, Ziai WC, Murthy SB. Cerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials. Neurology 2021, 98: e1013-e1020. PMID: 34937780, PMCID: PMC8967392, DOI: 10.1212/wnl.0000000000013247.
Real-Time Imaging of Aneurysmal Rupture Causing an Isolated Acute Subdural HematomaHong C, Renedo D, Sujijantarat N, Koo A, Falcone GJ, Malhotra A, Petersen NH, Matouk C. Real-Time Imaging of Aneurysmal Rupture Causing an Isolated Acute Subdural Hematoma. Neurology 2021, 98: 373-374. PMID: 34937782, PMCID: PMC10508646, DOI: 10.1212/wnl.0000000000013251.
Genetically Determined Low‐Density Lipoprotein Cholesterol and Risk of Subarachnoid HemorrhageAcosta JN, Both CP, Szejko N, Leasure AC, Abdelhakim S, Torres‐Lopez V, Brown SC, Matouk CC, Gunel M, Sheth KN, Falcone GJ. Genetically Determined Low‐Density Lipoprotein Cholesterol and Risk of Subarachnoid Hemorrhage. Annals Of Neurology 2021, 91: 145-149. PMID: 34709661, DOI: 10.1002/ana.26250.
The coronal plane maximum diameter of deep intracerebral hemorrhage predicts functional outcome more accurately than hematoma volumeHaider SP, Qureshi AI, Jain A, Tharmaseelan H, Berson ER, Majidi S, Filippi CG, Mak A, Werring DJ, Acosta JN, Malhotra A, Kim JA, Sansing LH, Falcone G, Sheth K, Payabvash S. The coronal plane maximum diameter of deep intracerebral hemorrhage predicts functional outcome more accurately than hematoma volume. International Journal Of Stroke 2021, 17: 777-784. PMID: 34569877, PMCID: PMC9005571, DOI: 10.1177/17474930211050749.
Similar admission NIHSS may represent larger tissue-at-risk in patients with right-sided versus left-sided large vessel occlusionMak A, Matouk C, Avery EW, Behland J, Frey D, Madai VI, Vajkoczy P, Malhotra A, Karam A, Sanelli P, Falcone GJ, Petersen NH, Sansing L, Sheth KN, Payabvash S. Similar admission NIHSS may represent larger tissue-at-risk in patients with right-sided versus left-sided large vessel occlusion. Journal Of NeuroInterventional Surgery 2021, 14: 985-991. PMID: 34645705, DOI: 10.1136/neurintsurg-2021-017785.
Prior Stroke and Age Predict Acute Ischemic Stroke Among Hospitalized COVID-19 Patients: A Derivation and Validation StudyPeng TJ, Jasne AS, Simonov M, Abdelhakim S, Kone G, Cheng YK, Rethana M, Tarasaria K, Herman AL, Baker AD, Yaghi S, Frontera JA, Sansing LH, Falcone GJ, Spudich S, Schindler J, Sheth KN, Sharma R. Prior Stroke and Age Predict Acute Ischemic Stroke Among Hospitalized COVID-19 Patients: A Derivation and Validation Study. Frontiers In Neurology 2021, 12: 741044. PMID: 34675873, PMCID: PMC8524436, DOI: 10.3389/fneur.2021.741044.
Association of lichen planus with cardiovascular disease: A combined analysis of the UK Biobank and All of Us StudyLeasure AC, Acosta JN, Sansing LH, Sheth KN, Cohen JM, Falcone GJ. Association of lichen planus with cardiovascular disease: A combined analysis of the UK Biobank and All of Us Study. Journal Of The American Academy Of Dermatology 2021, 87: 454-456. PMID: 34562549, DOI: 10.1016/j.jaad.2021.09.030.
Cardiovascular Health Disparities in Racial and Other Underrepresented Groups: Initial Results From the All of Us Research ProgramAcosta JN, Leasure AC, Both CP, Szejko N, Brown S, Torres‐Lopez V, Abdelhakim S, Schindler J, Petersen N, Sansing L, Gill TM, Sheth KN, Falcone GJ. Cardiovascular Health Disparities in Racial and Other Underrepresented Groups: Initial Results From the All of Us Research Program. Journal Of The American Heart Association 2021, 10: e021724. PMID: 34431358, PMCID: PMC8649271, DOI: 10.1161/jaha.121.021724.
Portable, bedside, low-field magnetic resonance imaging for evaluation of intracerebral hemorrhageMazurek MH, Cahn BA, Yuen MM, Prabhat AM, Chavva IR, Shah JT, Crawford AL, Welch EB, Rothberg J, Sacolick L, Poole M, Wira C, Matouk CC, Ward A, Timario N, Leasure A, Beekman R, Peng TJ, Witsch J, Antonios JP, Falcone GJ, Gobeske KT, Petersen N, Schindler J, Sansing L, Gilmore EJ, Hwang DY, Kim JA, Malhotra A, Sze G, Rosen MS, Kimberly WT, Sheth KN. Portable, bedside, low-field magnetic resonance imaging for evaluation of intracerebral hemorrhage. Nature Communications 2021, 12: 5119. PMID: 34433813, PMCID: PMC8387402, DOI: 10.1038/s41467-021-25441-6.
Mendelian Randomization in Stroke: A Powerful Approach to Causal Inference and Drug Target ValidationAcosta JN, Szejko N, Falcone GJ. Mendelian Randomization in Stroke: A Powerful Approach to Causal Inference and Drug Target Validation. Frontiers In Genetics 2021, 12: 683082. PMID: 34456968, PMCID: PMC8387928, DOI: 10.3389/fgene.2021.683082.
Powassan Meningoencephalitis: A Case Report Highlighting Diagnosis and ManagementPach JJ, Zubair AS, Traner C, Falcone GJ, Dewey JJ, Traner C. Powassan Meningoencephalitis: A Case Report Highlighting Diagnosis and Management. Cureus 2021, 13: e16592. PMID: 34430178, PMCID: PMC8378285, DOI: 10.7759/cureus.16592.
Admission computed tomography radiomic signatures outperform hematoma volume in predicting baseline clinical severity and functional outcome in the ATACH‐2 trial intracerebral hemorrhage populationHaider SP, Qureshi AI, Jain A, Tharmaseelan H, Berson ER, Zeevi T, Majidi S, Filippi CG, Iseke S, Gross M, Acosta JN, Malhotra A, Kim JA, Sansing LH, Falcone GJ, Sheth KN, Payabvash S. Admission computed tomography radiomic signatures outperform hematoma volume in predicting baseline clinical severity and functional outcome in the ATACH‐2 trial intracerebral hemorrhage population. European Journal Of Neurology 2021, 28: 2989-3000. PMID: 34189814, PMCID: PMC8818333, DOI: 10.1111/ene.15000.
Risk of Mortality After an Arterial Ischemic Event Among Intracerebral Hemorrhage SurvivorsParasram M, Parikh NS, Merkler AE, Falcone GJ, Sheth KN, Navi BB, Kamel H, Zhang C, Murthy SB. Risk of Mortality After an Arterial Ischemic Event Among Intracerebral Hemorrhage Survivors. The Neurohospitalist 2021, 12: 19-23. PMID: 34950382, PMCID: PMC8689534, DOI: 10.1177/19418744211026709.
Stroke Disparities Among Nonracial Minorities in the All of Us Research ProgramLeasure AC, Acosta JN, Both C, Szejko N, Brown SC, Sheth KN, Falcone GJ. Stroke Disparities Among Nonracial Minorities in the All of Us Research Program. Stroke 2021, 52: e488-e490. PMID: 34139858, PMCID: PMC8316290, DOI: 10.1161/strokeaha.121.034903.
Intracerebral Hemorrhage in Patients With COVID-19Leasure AC, Khan YM, Iyer R, Elkind MSV, Sansing LH, Falcone GJ, Sheth KN. Intracerebral Hemorrhage in Patients With COVID-19. Stroke 2021, 52: e321-e323. PMID: 34082576, PMCID: PMC8238884, DOI: 10.1161/strokeaha.121.034215.
Genetic determinants of LDL cholesterol and risk of intracerebral haemorrhageSzejko N, Kirsch E, Falcone GJ. Genetic determinants of LDL cholesterol and risk of intracerebral haemorrhage. Current Opinion In Lipidology 2021, 32: 244-248. PMID: 34010223, PMCID: PMC10273781, DOI: 10.1097/mol.0000000000000761.
270 Association of lichen planus with cardiovascular disease: An international cohort studyLeasure A, Acosta J, Cohen J, Falcone G. 270 Association of lichen planus with cardiovascular disease: An international cohort study. Journal Of Investigative Dermatology 2021, 141: s48. DOI: 10.1016/j.jid.2021.02.292.
Obstructive Sleep Apnea as a Risk Factor for Intracerebral HemorrhageGeer JH, Falcone GJ, Vanent KN, Leasure AC, Woo D, Molano JR, Sansing LH, Langefeld CD, Pisani MA, Yaggi HK, Sheth KN. Obstructive Sleep Apnea as a Risk Factor for Intracerebral Hemorrhage. Stroke 2021, 52: 1835-1838. PMID: 33827242, PMCID: PMC8085039, DOI: 10.1161/strokeaha.120.033342.
Association of Serum IL-6 (Interleukin 6) With Functional Outcome After Intracerebral HemorrhageLeasure AC, Kuohn LR, Vanent KN, Bevers MB, Kimberly WT, Steiner T, Mayer SA, Matouk CC, Sansing LH, Falcone GJ, Sheth KN. Association of Serum IL-6 (Interleukin 6) With Functional Outcome After Intracerebral Hemorrhage. Stroke 2021, 52: 1733-1740. PMID: 33682454, PMCID: PMC8085132, DOI: 10.1161/strokeaha.120.032888.
Abstract P91: Excess Cerebrovascular Mortality in the U.S. During the Covid-19 PandemicSharma R, Kuohn L, Weinberger D, Warren J, Sansing L, Jasne A, Falcone G, Dhand A, Sheth K. Abstract P91: Excess Cerebrovascular Mortality in the U.S. During the Covid-19 Pandemic. Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p91.
Abstract P879: Differences in Statistical Performance of Polygenic Risk Scores for Cardiovascular Disease Across Different Race/EthnicitiesAcosta J, Both C, Szejko N, Brown S, Sheth K, Falcone G. Abstract P879: Differences in Statistical Performance of Polygenic Risk Scores for Cardiovascular Disease Across Different Race/Ethnicities. Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p879.
Abstract P633: Polygenic Susceptibility to Hypertension is Associated With Uncontrolled and Resistant Hypertension in Stroke SurvivorsAcosta J, Both C, Szejko N, Brown S, Petersen N, Sansing L, Sheth K, Falcone G. Abstract P633: Polygenic Susceptibility to Hypertension is Associated With Uncontrolled and Resistant Hypertension in Stroke Survivors. Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p633.
Abstract P629: Genome-Wide Association Study of Individuals of Native Hawaiian Ancestry Reveals Unique Genetic Risk Factors for Stroke and Myocardial InfarctionBrown S, Both C, Acosta J, Szejko N, Torres V, Leasure A, Nakagawa K, Gerschenson M, Seto T, Sheth K, Falcone G. Abstract P629: Genome-Wide Association Study of Individuals of Native Hawaiian Ancestry Reveals Unique Genetic Risk Factors for Stroke and Myocardial Infarction. Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p629.
Abstract P622: Racial Variation in White Matter Hyperintensity Progression in the ACCORDION MIND StudyHerman A, De Havenon A, Falcone G, Yaghi S, Prabhakaran S, Sheth K. Abstract P622: Racial Variation in White Matter Hyperintensity Progression in the ACCORDION MIND Study. Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p622.
Abstract P510: Ct Angiographic Radiomics Signature Predicts Functional Outcome Following Endovascular Thrombectomy in Large Vessel Occlusion StrokeAvery E, Behland J, Haider S, Zeevi T, Nguyen C, Peshwe K, Petersen N, Falcone G, Sansing L, Malhotra A, Matouk C, Sheth K, Payabvash S. Abstract P510: Ct Angiographic Radiomics Signature Predicts Functional Outcome Following Endovascular Thrombectomy in Large Vessel Occlusion Stroke. Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p510.
Abstract P439: Mortality After an Arterial Ischemic Event Among Intracerebral Hemorrhage SurvivorsParasram M, Parikh N, Merkler A, Falcone G, Sheth K, Navi B, Kamel H, Zhang C, Murthy S. Abstract P439: Mortality After an Arterial Ischemic Event Among Intracerebral Hemorrhage Survivors. Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p439.
Abstract P423: Race and Ethnicity Influence Perihematomal Edema Volume in Supratentorial Intracerebral HemorrhageAcosta J, Chen Y, Both C, Leasure A, Testai F, Woo D, Lee J, Sheth K, Dhar R, Falcone G. Abstract P423: Race and Ethnicity Influence Perihematomal Edema Volume in Supratentorial Intracerebral Hemorrhage. Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p423.
Abstract P412: Klotho -vS Heterozygosity is Associated With Lower Risk of Non-Traumatic Subarachnoid HemorrhageAcosta J, Szejko N, Torres Lopez V, Both C, Sansing L, Sheth K, Matouk C, Gunel M, Falcone G. Abstract P412: Klotho -vS Heterozygosity is Associated With Lower Risk of Non-Traumatic Subarachnoid Hemorrhage. Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p412.
Abstract P410: Association of Serum GFAP With Hematoma Expansion and Poor Outcome After Intracerebral Hemorrhage: The Factor VII for ICH TrialLeasure A, Vanent K, Bevers M, Kimberly W, Mayer S, Steiner T, Matouk C, Sansing L, Falcone G, Sheth K. Abstract P410: Association of Serum GFAP With Hematoma Expansion and Poor Outcome After Intracerebral Hemorrhage: The Factor VII for ICH Trial. Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p410.
Abstract P27: Safety and Efficacy of Alteplase in Ischemic Stroke Patients > 80 Years of Age in the Extended Time WindowStretz C, Mac Grory B, Fakhri N, Boyanpally A, Asad S, Modak J, Effendi M, Kucher O, Owusu K, Yaghi S, Nouh A, Reznik M, Burton T, Cutting S, Sacchetti D, El JAMAL S, Madsen T, Falcone G, Petersen N, Furie K, gilmore E. Abstract P27: Safety and Efficacy of Alteplase in Ischemic Stroke Patients > 80 Years of Age in the Extended Time Window. Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.p27.
Abstract MP53: Intensive Blood Pressure Reduction and Secondary Stroke Risk: A Posthoc Analysis of the Sps3 Trialde Havenon A, Lansberg M, Falcone G, Noche R, Yaghi S, Sheth K. Abstract MP53: Intensive Blood Pressure Reduction and Secondary Stroke Risk: A Posthoc Analysis of the Sps3 Trial. Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.mp53.
Abstract MP40: Klotho -vS Heterozygosity is Associated With Lower Risk of Lobar Intracerebral HemorrhageAcosta J, Szejko N, Both C, Leasure A, Woo D, Langefeld C, Biffi A, Anderson C, Rosand J, Gill T, Sansing L, Sheth K, Falcone G. Abstract MP40: Klotho -vS Heterozygosity is Associated With Lower Risk of Lobar Intracerebral Hemorrhage. Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.mp40.
Abstract MP13: Polygenic Susceptibility to Atrial Fibrillation is Associated With Silent Cerebrovascular Disease in Stroke-Free Persons Without Atrial FibrillationBoth C, Acosta J, Szejko N, Vanent K, Leasure A, Payabvash S, Sharma R, Murthy S, Sheth K, Kamel H, Falcone G. Abstract MP13: Polygenic Susceptibility to Atrial Fibrillation is Associated With Silent Cerebrovascular Disease in Stroke-Free Persons Without Atrial Fibrillation. Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.mp13.
Abstract 33: Qualitative Description of Ischemic Stroke Appearance on Low-Field, Point-Of-Care Magnetic Resonance ImagingYuen M, Mazurek M, Cahn B, Prabhat A, By S, Hu H, Welch E, Sacolick L, O’Halloran R, Ward A, Timario N, Falcone G, Gilmore E, Hwang D, Kim J, Kaddouh F, Sharma R, Amin H, Schindler J, Matouk C, Hebert R, Wira C, Sze G, Rosen M, Kimberly W, Sheth K. Abstract 33: Qualitative Description of Ischemic Stroke Appearance on Low-Field, Point-Of-Care Magnetic Resonance Imaging. Stroke 2021, 52 DOI: 10.1161/str.52.suppl_1.33.
Admission Hemoglobin Levels Are Associated With Functional Outcome in Spontaneous Intracerebral HemorrhageAcosta JN, Leasure AC, Kuohn LR, Both CP, Petersen NH, Sansing LH, Matouk CC, Testai F, Langefeld CD, Woo D, Kamel H, Murthy SB, Qureshi A, Mayer SA, Sheth KN, Falcone GJ. Admission Hemoglobin Levels Are Associated With Functional Outcome in Spontaneous Intracerebral Hemorrhage. Critical Care Medicine 2021, 49: 828-837. PMID: 33591003, PMCID: PMC8611893, DOI: 10.1097/ccm.0000000000004891.
Intracerebral Hemorrhage with Intraventricular Extension Associated with Loss of Consciousness at Symptom OnsetWitsch J, Falcone GJ, Leasure AC, Matouk C, Endres M, Sansing L, Woo D, Sheth KN. Intracerebral Hemorrhage with Intraventricular Extension Associated with Loss of Consciousness at Symptom Onset. Neurocritical Care 2021, 35: 418-427. PMID: 33479920, PMCID: PMC8578176, DOI: 10.1007/s12028-020-01180-2.
Diffusion-Weighted Imaging Lesions After Intracerebral Hemorrhage and Risk of StrokeMurthy SB, Zhang C, Gupta A, Cho SM, Rivera-Lara L, Avadhani R, Gruber J, Iadecola C, Falcone GJ, Sheth KN, Qureshi AI, Goldstein JN, Hanley DF, Kamel H, Ziai WC. Diffusion-Weighted Imaging Lesions After Intracerebral Hemorrhage and Risk of Stroke. Stroke 2021, 52: 595-602. PMID: 33467877, PMCID: PMC8340082, DOI: 10.1161/strokeaha.120.031628.
Genetically Determined Smoking Behavior and Risk of Nontraumatic Subarachnoid HemorrhageAcosta JN, Szejko N, Both CP, Vanent K, Noche RB, Gill TM, Matouk CC, Sheth KN, Gunel M, Falcone GJ. Genetically Determined Smoking Behavior and Risk of Nontraumatic Subarachnoid Hemorrhage. Stroke 2021, 52: 582-587. PMID: 33440997, PMCID: PMC7856108, DOI: 10.1161/strokeaha.120.031622.
Excess Cerebrovascular Mortality in the United States During the COVID-19 PandemicSharma R, Kuohn LR, Weinberger DM, Warren JL, Sansing LH, Jasne A, Falcone G, Dhand A, Sheth KN. Excess Cerebrovascular Mortality in the United States During the COVID-19 Pandemic. Stroke 2021, 52: 563-572. PMID: 33430638, PMCID: PMC7834664, DOI: 10.1161/strokeaha.120.031975.
Vessel wall MRI in ruptured cranial dural arteriovenous fistulasCord BJ, Renedo D, Santarosa C, Sujijantarat N, Antonios J, Kim JA, Falcone GJ, Sheth KN, Malhotra A, Matouk CC. Vessel wall MRI in ruptured cranial dural arteriovenous fistulas. Interventional Neuroradiology 2021, 27: 553-557. PMID: 33430655, PMCID: PMC8580544, DOI: 10.1177/1591019920988205.
Andexanet Alfa Versus 4-Factor Prothrombin Complex Concentrate for Reversal of Factor Xa Inhibitors in Intracranial HemorrhageAmmar AA, Ammar MA, Owusu KA, Brown SC, Kaddouh F, Elsamadicy AA, Acosta JN, Falcone GJ. Andexanet Alfa Versus 4-Factor Prothrombin Complex Concentrate for Reversal of Factor Xa Inhibitors in Intracranial Hemorrhage. Neurocritical Care 2021, 35: 255-261. PMID: 33403588, PMCID: PMC10273779, DOI: 10.1007/s12028-020-01161-5.
30-Day Outcomes of Trans-Carotid Artery Revascularization with Proximal Protection Through ICA Flow Reversal in Neurosurgical PracticeCord B, Santarosa C, Sujijantarat N, Koo A, Elsamadicy A, Sheth K, Falcone G, Sansing L, Schindler J, Petersen N, Matouk C. 30-Day Outcomes of Trans-Carotid Artery Revascularization with Proximal Protection Through ICA Flow Reversal in Neurosurgical Practice. Neurosurgery 2020, 67 DOI: 10.1093/neuros/nyaa447_334.
Plasma neurofilament light predicts mortality in patients with strokeGendron TF, Badi MK, Heckman MG, Jansen-West KR, Vilanilam GK, Johnson PW, Burch AR, Walton RL, Ross OA, Brott TG, Miller TM, Berry JD, Nicholson KA, Wszolek ZK, Oskarsson BE, Sheth KN, Sansing LH, Falcone GJ, Cucchiara BL, Meschia JF, Petrucelli L. Plasma neurofilament light predicts mortality in patients with stroke. Science Translational Medicine 2020, 12 PMID: 33177179, PMCID: PMC9534269, DOI: 10.1126/scitranslmed.aay1913.
Statin treatment and cerebral microbleeds: A systematic review and meta-analysisKatsanos AH, Lioutas VA, Charidimou A, Catanese L, Ng KKH, Perera K, de Sa Boasquevisque D, Falcone GJ, Sheth KN, Romero JR, Tsivgoulis G, Smith EE, Sharma M, Selim MH, Shoamanesh A, Initiative T. Statin treatment and cerebral microbleeds: A systematic review and meta-analysis. Journal Of The Neurological Sciences 2020, 420: 117224. PMID: 33183779, DOI: 10.1016/j.jns.2020.117224.
A Pooled Analysis of Diffusion-Weighted Imaging Lesions in Patients With Acute Intracerebral HemorrhageMurthy SB, Cho SM, Gupta A, Shoamanesh A, Navi BB, Avadhani R, Gruber J, Li Y, Greige T, Lioutas VA, Norton C, Zhang C, Mandava P, Iadecola C, Falcone GJ, Sheth KN, Biffi A, Rosand J, Qureshi AI, Goldstein JN, Kidwell C, Awad I, Selim M, Hanley DF, Woo D, Kamel H, Ziai WC. A Pooled Analysis of Diffusion-Weighted Imaging Lesions in Patients With Acute Intracerebral Hemorrhage. JAMA Neurology 2020, 77: 1390-1397. PMID: 32687564, PMCID: PMC7372494, DOI: 10.1001/jamaneurol.2020.2349.
Prior antiplatelet therapy and haematoma expansion after primary intracerebral haemorrhage: an individual patient-level analysis of CLEAR III, MISTIE III and VISTA-ICHMurthy S, Roh DJ, Chatterjee A, McBee N, Parikh NS, Merkler AE, Navi BB, Falcone GJ, Sheth KN, Awad I, Hanley D, Kamel H, Ziai WC. Prior antiplatelet therapy and haematoma expansion after primary intracerebral haemorrhage: an individual patient-level analysis of CLEAR III, MISTIE III and VISTA-ICH. Journal Of Neurology Neurosurgery & Psychiatry 2020, 92: 364-369. PMID: 33106367, PMCID: PMC8071838, DOI: 10.1136/jnnp-2020-323458.
Genetic Stroke SyndromesFalcone G, Amin H. Genetic Stroke Syndromes. 2020, 123-133. DOI: 10.1007/978-3-030-52552-1_10.
Cause of death in spontaneous intracerebral hemorrhage survivors: Multistate longitudinal study.Kuohn LR, Leasure AC, Acosta JN, Vanent K, Murthy SB, Kamel H, Matouk CC, Sansing LH, Falcone GJ, Sheth KN. Cause of death in spontaneous intracerebral hemorrhage survivors: Multistate longitudinal study. Neurology 2020, 95: e2736-e2745. PMID: 32917797, PMCID: PMC7734723, DOI: 10.1212/wnl.0000000000010736.
Association of race and ethnicity to incident epilepsy, or epileptogenesis, after subdural hematoma.Brown SC, King ZA, Kuohn L, Kamel H, Gilmore EJ, Frontera JA, Murthy S, Kim JA, Omay SB, Falcone GJ, Sheth KN. Association of race and ethnicity to incident epilepsy, or epileptogenesis, after subdural hematoma. Neurology 2020, 95: e2890-e2899. PMID: 32907969, PMCID: PMC7734738, DOI: 10.1212/wnl.0000000000010742.
Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill PatientsSheth KN, Mazurek MH, Yuen MM, Cahn BA, Shah JT, Ward A, Kim JA, Gilmore EJ, Falcone GJ, Petersen N, Gobeske KT, Kaddouh F, Hwang DY, Schindler J, Sansing L, Matouk C, Rothberg J, Sze G, Siner J, Rosen MS, Spudich S, Kimberly WT. Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill Patients. JAMA Neurology 2020, 78: 41-47. PMID: 32897296, PMCID: PMC7489395, DOI: 10.1001/jamaneurol.2020.3263.
Direct carotid puncture for mechanical thrombectomy in acute ischemic stroke patients with prohibitive vascular access.Cord BJ, Kodali S, Strander S, Silverman A, Wang A, Chouairi F, Koo AB, Nguyen CK, Peshwe K, Kimmel A, Porto CM, Hebert RM, Falcone GJ, Sheth KN, Sansing LH, Schindler JL, Matouk CC, Petersen NH. Direct carotid puncture for mechanical thrombectomy in acute ischemic stroke patients with prohibitive vascular access. Journal Of Neurosurgery 2020, 135: 53-63. PMID: 32796146, PMCID: PMC9491727, DOI: 10.3171/2020.5.jns192737.
Effects of Collateral Status on Infarct Distribution Following Endovascular Therapy in Large Vessel Occlusion StrokeAl-Dasuqi K, Payabvash S, Torres-Flores GA, Strander SM, Nguyen CK, Peshwe KU, Kodali S, Silverman A, Malhotra A, Johnson MH, Matouk CC, Schindler JL, Sansing LH, Falcone GJ, Sheth KN, Petersen NH. Effects of Collateral Status on Infarct Distribution Following Endovascular Therapy in Large Vessel Occlusion Stroke. Stroke 2020, 51: e193-e202. PMID: 32781941, PMCID: PMC7484023, DOI: 10.1161/strokeaha.120.029892.
Stroke Code Presentations, Interventions, and Outcomes Before and During the COVID-19 PandemicJasne AS, Chojecka P, Maran I, Mageid R, Eldokmak M, Zhang Q, Nystrom K, Vlieks K, Askenase M, Petersen N, Falcone GJ, Wira CR, Lleva P, Zeevi N, Narula R, Amin H, Navaratnam D, Loomis C, Hwang DY, Schindler J, Hebert R, Matouk C, Krumholz HM, Spudich S, Sheth KN, Sansing LH, Sharma R. Stroke Code Presentations, Interventions, and Outcomes Before and During the COVID-19 Pandemic. Stroke 2020, 51: 2664-2673. PMID: 32755347, PMCID: PMC7446978, DOI: 10.1161/str.0000000000000347.
Ultra‐Early Blood Pressure Reduction Attenuates Hematoma Growth and Improves Outcome in Intracerebral HemorrhageLi Q, Warren AD, Qureshi AI, Morotti A, Falcone GJ, Sheth KN, Shoamanesh A, Dowlatshahi D, Viswanathan A, Goldstein JN. Ultra‐Early Blood Pressure Reduction Attenuates Hematoma Growth and Improves Outcome in Intracerebral Hemorrhage. Annals Of Neurology 2020, 88: 388-395. PMID: 32453453, PMCID: PMC8697414, DOI: 10.1002/ana.25793.
Combining Imaging and Genetics to Predict Recurrence of Anticoagulation-Associated Intracerebral HemorrhageBiffi A, Urday S, Kubiszewski P, Gilkerson L, Sekar P, Rodriguez-Torres A, Bettin M, Charidimou A, Pasi M, Kourkoulis C, Schwab K, DiPucchio Z, Behymer T, Osborne J, Morgan M, Moomaw CJ, James ML, Greenberg SM, Viswanathan A, Gurol ME, Worrall BB, Testai FD, McCauley JL, Falcone GJ, Langefeld CD, Anderson CD, Kamel H, Woo D, Sheth KN, Rosand J. Combining Imaging and Genetics to Predict Recurrence of Anticoagulation-Associated Intracerebral Hemorrhage. Stroke 2020, 51: 2153-2160. PMID: 32517581, PMCID: PMC7311289, DOI: 10.1161/strokeaha.120.028310.
Genetic underpinnings of cerebral edema in acute brain injury: an opportunity for pathway discoveryKirsch E, Szejko N, Falcone GJ. Genetic underpinnings of cerebral edema in acute brain injury: an opportunity for pathway discovery. Neuroscience Letters 2020, 730: 135046. PMID: 32464484, PMCID: PMC7372633, DOI: 10.1016/j.neulet.2020.135046.
Genetically Elevated LDL Associates with Lower Risk of Intracerebral HemorrhageFalcone GJ, Kirsch E, Acosta JN, Noche RB, Leasure A, Marini S, Chung J, Selim M, Meschia JF, Brown DL, Worrall BB, Tirschwell DL, Jagiella JM, Schmidt H, Jimenez‐Conde J, Fernandez‐Cadenas I, Lindgren A, Slowik A, Gill D, Holmes M, Phuah C, Petersen NH, Matouk CN, Gunel M, Sansing L, Bennett D, Chen Z, Sun LL, Clarke R, Walters RG, Gill TM, Biffi A, Kathiresan S, Langefeld CD, Woo D, Rosand J, Sheth KN, Anderson CD, Consortium F. Genetically Elevated LDL Associates with Lower Risk of Intracerebral Hemorrhage. Annals Of Neurology 2020, 88: 56-66. PMID: 32277781, PMCID: PMC7523882, DOI: 10.1002/ana.25740.
The CSF Diversion via Lumbar Drainage to Treat Dialysis Disequilibrium Syndrome in the Critically Ill Neurological PatientHong CS, Wang K, Falcone GJ. The CSF Diversion via Lumbar Drainage to Treat Dialysis Disequilibrium Syndrome in the Critically Ill Neurological Patient. Neurocritical Care 2020, 33: 312-316. PMID: 32378129, PMCID: PMC7223300, DOI: 10.1007/s12028-020-00972-w.
Obstructive Sleep Apnea: A Prevalent and Novel Risk Factor for Intracerebral HemorrhageGeer J, Vanent K, Leasure A, Pisani M, Sansing L, Woo D, Langefeld C, Falcone G, Sheth K, Yaggi H. Obstructive Sleep Apnea: A Prevalent and Novel Risk Factor for Intracerebral Hemorrhage. 2020, a2713-a2713. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a2713.
Anticoagulation after intracerebral hemorrhage: a perfect clinical scenario for genetics-based precision medicineBrown SC, Sheth KN, Falcone GJ. Anticoagulation after intracerebral hemorrhage: a perfect clinical scenario for genetics-based precision medicine. Pharmacogenomics 2020, 21: 307-309. PMID: 32238090, DOI: 10.2217/pgs-2019-0181.
Genetic Variation and Response to Neurocritical Illness: a Powerful Approach to Identify Novel Pathophysiological Mechanisms and Therapeutic TargetsAcosta JN, Brown SC, Falcone GJ. Genetic Variation and Response to Neurocritical Illness: a Powerful Approach to Identify Novel Pathophysiological Mechanisms and Therapeutic Targets. Neurotherapeutics 2020, 17: 581-592. PMID: 31975153, PMCID: PMC7283396, DOI: 10.1007/s13311-020-00837-2.
Non-Traumatic Subdural Hemorrhage and Risk of Arterial Ischemic EventsMurthy SB, Wu X, Diaz I, Parasram M, Parikh NS, Iadecola C, Merkler AE, Falcone GJ, Brown S, Biffi A, Ch'ang J, Knopman J, Stieg PE, Navi BB, Sheth KN, Kamel H. Non-Traumatic Subdural Hemorrhage and Risk of Arterial Ischemic Events. Stroke 2020, 51: 1464-1469. PMID: 32178587, PMCID: PMC7188584, DOI: 10.1161/strokeaha.119.028510.
Fixed Compared With Autoregulation-Oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic StrokePetersen NH, Silverman A, Strander SM, Kodali S, Wang A, Sansing LH, Schindler JL, Falcone GJ, Gilmore EJ, Jasne AS, Cord B, Hebert RM, Johnson M, Matouk CC, Sheth KN. Fixed Compared With Autoregulation-Oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke. Stroke 2020, 51: 914-921. PMID: 32078493, PMCID: PMC7050651, DOI: 10.1161/strokeaha.119.026596.
Abstract WP410: Hemoglobin Levels and Poor Outcome in Intracerebral Hemorrhage: An Exploratory Analysis of Individual Patient Data Across Multiple StudiesAcosta J, Leasure A, Kuohn L, Petersen N, Sansing L, Matouk C, Testai F, Langefeld C, Woo D, Qureshi A, Mayer S, Sheth K, Falcone G. Abstract WP410: Hemoglobin Levels and Poor Outcome in Intracerebral Hemorrhage: An Exploratory Analysis of Individual Patient Data Across Multiple Studies. Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.wp410.
Abstract WP400: Causes of Death in a Longitudinal Analysis of Spontaneous Intracerebral Hemorrhage SurvivorsKuohn L, Leasure A, Acosta J, Vanent K, Murthy S, Kamel H, Matouk C, Sansing L, Falcone G, Sheth K. Abstract WP400: Causes of Death in a Longitudinal Analysis of Spontaneous Intracerebral Hemorrhage Survivors. Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.wp400.
Abstract WP235: Risk of Arterial Ischemic Events After Non-Traumatic Subdural HemorrhageMurthy S, Wu X, Diaz I, Parasram M, Parikh N, Merkler A, Falcone G, Navi B, Sheth K, Kamel H. Abstract WP235: Risk of Arterial Ischemic Events After Non-Traumatic Subdural Hemorrhage. Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.wp235.
Abstract WP214: Risk Factors for Recurrence of Vascular Events in Middle-Aged Stroke SurvivorsVanent K, Leasure A, Kuohn L, Benavente O, Shoamanesh A, Biffi A, Sheth K, Falcone G. Abstract WP214: Risk Factors for Recurrence of Vascular Events in Middle-Aged Stroke Survivors. Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.wp214.
Abstract WP11: Timing of Blood Pressure Decreases During Mechanical Thrombectomy for Ischemic StrokeKimmel A, Silverman A, Kodali S, Strander S, Nguyen C, Peshwe K, Wang A, Lopez G, Holcombe A, Zevallos C, Dandapat S, Sansing L, Schindler J, Falcone G, Matouk C, Sheth K, Ortega-Gutiérrez S, Petersen N. Abstract WP11: Timing of Blood Pressure Decreases During Mechanical Thrombectomy for Ischemic Stroke. Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.wp11.
Abstract WMP101: Prediction of Clinical Outcome in Supratentorial Intracerebral Hemorrhage: Application of Baseline Ct Scan Radiomics Feature Extraction and Machine Learning ClassifiersPayabvash S, Acosta J, Haider S, Noche R, Kirsch E, Matouk C, Sansing L, Sheth K, Falcone G. Abstract WMP101: Prediction of Clinical Outcome in Supratentorial Intracerebral Hemorrhage: Application of Baseline Ct Scan Radiomics Feature Extraction and Machine Learning Classifiers. Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.wmp101.
Abstract TP347: Obstructive Sleep Apnea Frequency in Intracerebral HemorrhageGeer J, Leasure A, Vanent K, Sansing L, Woo D, Langefeld C, Yaggi H, Falcone G, Sheth K. Abstract TP347: Obstructive Sleep Apnea Frequency in Intracerebral Hemorrhage. Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.tp347.
Abstract 71: Sex and Genetic Predisposition Synergistically Influence Risk of Stroke and Myocardial Infarction in Middle-Aged Persons Without Risk FactorsFalcone G, Acosta J, Leasure A, Vanent K, Noche R, Kirsch E, Petersen N, Schindler J, Sansing L, Gill T, Matouk C, Gunel M, Sheth K. Abstract 71: Sex and Genetic Predisposition Synergistically Influence Risk of Stroke and Myocardial Infarction in Middle-Aged Persons Without Risk Factors. Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.71.
Abstract 66: Causal Associations Between Genetically-determined Smoking and Risk of Subarachnoid HemorrhageAcosta J, Both C, Brown S, Leasure A, Vanent K, Noche R, Kirsch E, Petersen N, Matouk C, Gunel M, Gill T, Sheth K, Falcone G. Abstract 66: Causal Associations Between Genetically-determined Smoking and Risk of Subarachnoid Hemorrhage. Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.66.
Abstract 57: Deployment of Portable, Bedside, Low-Field Magnetic Resonance Imaging for Evaluation of Stroke PatientsCahn B, Shah J, Dyvorne H, O'Halloran R, Poole M, Yuen M, Mazurek M, Ward A, Payabvash S, Beekman R, Brown S, Falcone G, Gobeske K, Petersen N, Jasne A, Sharma R, Schindler J, Sansing L, Gilmore E, Wira C, Matouk C, Sze G, Rosen M, Kimberly W, Sheth K. Abstract 57: Deployment of Portable, Bedside, Low-Field Magnetic Resonance Imaging for Evaluation of Stroke Patients. Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.57.
Abstract 18: Diffusion Weighted Imaging Lesions in Patients With Acute Intracerebral Hemorrhage: A Pooled Analysis of Individual Patient Data From MISTIE-III, ATACH-II, I-DEF, and ERICHMurthy S, Cho S, Gupta A, Shoamanesh A, Avadhani R, Gruber J, Greige T, Lioutas V, Norton C, Mandava P, Falcone G, Sheth K, Qureshi A, Goldstein J, Kidwell C, Selim M, Woo D, Kamel H, Ziai W, Hanley D. Abstract 18: Diffusion Weighted Imaging Lesions in Patients With Acute Intracerebral Hemorrhage: A Pooled Analysis of Individual Patient Data From MISTIE-III, ATACH-II, I-DEF, and ERICH. Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.18.
Abstract 156: Recurrent Stroke in Middle-Aged Lacunar Stroke Survivors: Understanding Risk Factors and Vulnerability in an Important Target PopulationNoche R, Biffi A, Sansing L, Shoamanesh A, Benavente O, Falcone G, Sheth K. Abstract 156: Recurrent Stroke in Middle-Aged Lacunar Stroke Survivors: Understanding Risk Factors and Vulnerability in an Important Target Population. Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.156.
Abstract 117: Fixed Compared to Autoregulation-oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic StrokePetersen N, Silverman A, Strander S, Kodali S, Wang A, Sansing L, Schindler J, Falcone G, Gilmore E, Jasne A, Cord B, Hebert R, Johnson M, Matouk C, Sheth K. Abstract 117: Fixed Compared to Autoregulation-oriented Blood Pressure Thresholds After Mechanical Thrombectomy for Ischemic Stroke. Stroke 2020, 51 DOI: 10.1161/str.51.suppl_1.117.
Race/ethnicity influences outcomes in young adults with supratentorial intracerebral hemorrhage.Miyares LC, Falcone GJ, Leasure A, Adeoye O, Shi FD, Kittner SJ, Langefeld C, Vagal A, Sheth KN, Woo D. Race/ethnicity influences outcomes in young adults with supratentorial intracerebral hemorrhage. Neurology 2020, 94: e1271-e1280. PMID: 31969467, PMCID: PMC7274930, DOI: 10.1212/wnl.0000000000008930.
Liver Fibrosis Indices and Outcomes After Primary Intracerebral HemorrhageParikh NS, Kamel H, Navi BB, Iadecola C, Merkler AE, Jesudian A, Dawson J, Falcone GJ, Sheth KN, Roh DJ, Elkind MSV, Hanley DF, Ziai WC, Murthy SB, Hanley D, Butcher K, Davis S, Gregson B, Lees K, Lyden P, Mayer S, Muir K, Steiner T. Liver Fibrosis Indices and Outcomes After Primary Intracerebral Hemorrhage. Stroke 2020, 51: 830-837. PMID: 31906832, PMCID: PMC7048169, DOI: 10.1161/strokeaha.119.028161.
Racial/ethnic disparities in the risk of intracerebral hemorrhage recurrence.Leasure AC, King ZA, Torres-Lopez V, Murthy SB, Kamel H, Shoamanesh A, Al-Shahi Salman R, Rosand J, Ziai WC, Hanley DF, Woo D, Matouk CC, Sansing LH, Falcone GJ, Sheth KN. Racial/ethnic disparities in the risk of intracerebral hemorrhage recurrence. Neurology 2019, 94: e314-e322. PMID: 31831597, PMCID: PMC7108806, DOI: 10.1212/wnl.0000000000008737.
Differences in Admission Blood Pressure Among Causes of Intracerebral HemorrhageLin J, Piran P, Lerario MP, Ong H, Gupta A, Murthy SB, Díaz I, Stieg PE, Knopman J, Falcone GJ, Sheth KN, Fink ME, Merkler AE, Kamel H. Differences in Admission Blood Pressure Among Causes of Intracerebral Hemorrhage. Stroke 2019, 51: 644-647. PMID: 31818231, PMCID: PMC9578686, DOI: 10.1161/strokeaha.119.028009.
Deep Learning for Automated Measurement of Hemorrhage and Perihematomal Edema in Supratentorial Intracerebral HemorrhageDhar R, Falcone GJ, Chen Y, Hamzehloo A, Kirsch EP, Noche RB, Roth K, Acosta J, Ruiz A, Phuah CL, Woo D, Gill TM, Sheth KN, Lee JM. Deep Learning for Automated Measurement of Hemorrhage and Perihematomal Edema in Supratentorial Intracerebral Hemorrhage. Stroke 2019, 51: 648-651. PMID: 31805845, PMCID: PMC6993878, DOI: 10.1161/strokeaha.119.027657.
Stenting for Acute Carotid Artery DissectionBrown SC, Falcone GJ, Hebert RM, Yaghi S, Mac Grory B, Stretz C. Stenting for Acute Carotid Artery Dissection. Stroke 2019, 51: e3-e6. PMID: 31795908, DOI: 10.1161/strokeaha.119.027827.
Poor Outcomes Related to Anterior Extension of Large Hemispheric Infarction: Topographic Analysis of GAMES-RP Trial MRI ScansPayabvash S, Falcone GJ, Sze GK, Jain A, Beslow LA, Petersen NH, Sheth KN, Kimberly WT. Poor Outcomes Related to Anterior Extension of Large Hemispheric Infarction: Topographic Analysis of GAMES-RP Trial MRI Scans. Journal Of Stroke And Cerebrovascular Diseases 2019, 29: 104488. PMID: 31787498, PMCID: PMC8820410, DOI: 10.1016/j.jstrokecerebrovasdis.2019.104488.
Perihematomal Edema After Intracerebral Hemorrhage in Patients With Active MalignancyGusdon AM, Nyquist PA, Torres-Lopez VM, Leasure AC, Falcone GJ, Sheth KN, Sansing LH, Hanley DF, Malani R. Perihematomal Edema After Intracerebral Hemorrhage in Patients With Active Malignancy. Stroke 2019, 51: 129-136. PMID: 31744426, PMCID: PMC7048624, DOI: 10.1161/strokeaha.119.027085.
Association of Surgical Hematoma Evacuation vs Conservative Treatment With Functional Outcome in Patients With Cerebellar Intracerebral HemorrhageKuramatsu JB, Biffi A, Gerner ST, Sembill JA, Sprügel MI, Leasure A, Sansing L, Matouk C, Falcone GJ, Endres M, Haeusler KG, Sobesky J, Schurig J, Zweynert S, Bauer M, Vajkoczy P, Ringleb PA, Purrucker J, Rizos T, Volkmann J, Müllges W, Kraft P, Schubert AL, Erbguth F, Nueckel M, Schellinger PD, Glahn J, Knappe UJ, Fink GR, Dohmen C, Stetefeld H, Fisse AL, Minnerup J, Hagemann G, Rakers F, Reichmann H, Schneider H, Rahmig J, Ludolph AC, Stösser S, Neugebauer H, Röther J, Michels P, Schwarz M, Reimann G, Bäzner H, Schwert H, Claßen J, Michalski D, Grau A, Palm F, Urbanek C, Wöhrle JC, Alshammari F, Horn M, Bahner D, Witte OW, Günther A, Hamann GF, Hagen M, Roeder SS, Lücking H, Dörfler A, Testai FD, Woo D, Schwab S, Sheth KN, Huttner HB. Association of Surgical Hematoma Evacuation vs Conservative Treatment With Functional Outcome in Patients With Cerebellar Intracerebral Hemorrhage. JAMA 2019, 322: 1392-1403. PMID: 31593272, PMCID: PMC6784768, DOI: 10.1001/jama.2019.13014.
Antiplatelet Therapy After Spontaneous Intracerebral Hemorrhage and Functional OutcomesMurthy SB, Biffi A, Falcone GJ, Sansing LH, Torres Lopez V, Navi BB, Roh DJ, Mandava P, Hanley DF, Ziai WC, Kamel H, Rosand J, Sheth KN, Butcher K, Davis S, Gregson B, Lees K, Lyden P, Mayer S, Muir K, Steiner T. Antiplatelet Therapy After Spontaneous Intracerebral Hemorrhage and Functional Outcomes. Stroke 2019, 50: 3057-3063. PMID: 31895618, PMCID: PMC6941441, DOI: 10.1161/strokeaha.119.025972.
Genetic underpinnings of recovery after stroke: an opportunity for gene discovery, risk stratification, and precision medicineAcosta JN, Brown SC, Falcone GJ. Genetic underpinnings of recovery after stroke: an opportunity for gene discovery, risk stratification, and precision medicine. Genome Medicine 2019, 11: 58. PMID: 31519204, PMCID: PMC6743185, DOI: 10.1186/s13073-019-0671-5.
Deviation From Personalized Blood Pressure Targets Is Associated With Worse Outcome After Subarachnoid HemorrhageSilverman A, Kodali S, Strander S, Gilmore EJ, Kimmel A, Wang A, Cord B, Falcone G, Hebert R, Matouk C, Sheth KN, Petersen NH. Deviation From Personalized Blood Pressure Targets Is Associated With Worse Outcome After Subarachnoid Hemorrhage. Stroke 2019, 50: 2729-2737. PMID: 31495332, PMCID: PMC6756936, DOI: 10.1161/strokeaha.119.026282.
Preliminary Experience With Proximal Flow Reversal During Intracranial Balloon Angioplasty and Stenting for Symptomatic, Severe Intracranial StenosisCord B, Santarosa C, Sujijantarat N, Kundishora A, Falcone G, Sheth K, Sansing L, Schindler J, Petersen N, Matouk C. Preliminary Experience With Proximal Flow Reversal During Intracranial Balloon Angioplasty and Stenting for Symptomatic, Severe Intracranial Stenosis. Neurosurgery 2019, 66: 310-675. DOI: 10.1093/neuros/nyz310_675.
Deviation from Dynamic and Personalized Optimal Blood Pressure Targets is Associated With Worse Functional Outcomes After Aneurysmal Subarachnoid HemorrhageSilverman A, Kodali S, Strander S, Gilmore E, Kimmel A, Wang A, Cord B, Falcone G, Hebert R, Matouk C, Sheth K, Petersen N. Deviation from Dynamic and Personalized Optimal Blood Pressure Targets is Associated With Worse Functional Outcomes After Aneurysmal Subarachnoid Hemorrhage. Neurosurgery 2019, 66: 310-186. DOI: 10.1093/neuros/nyz310_186.
Percutaneous Trans-Carotid Puncture for Mechanical Thrombectomy in Acute Ischemic Stroke Patients is Safe and Effective: A Large, Single-Center Case SeriesCord B, Wang A, Chouairi F, Koo A, Porto C, Silverman A, Kodali S, Strander S, Falcone G, Sheth K, Hebert R, Sansing L, Schindler J, Petersen N, Matouk C. Percutaneous Trans-Carotid Puncture for Mechanical Thrombectomy in Acute Ischemic Stroke Patients is Safe and Effective: A Large, Single-Center Case Series. Neurosurgery 2019, 66: 310-167. DOI: 10.1093/neuros/nyz310_167.
Association of Intensive Blood Pressure Reduction With Risk of Hematoma Expansion in Patients With Deep Intracerebral HemorrhageLeasure AC, Qureshi AI, Murthy SB, Kamel H, Goldstein JN, Woo D, Ziai WC, Hanley DF, Salman R, Matouk CC, Sansing LH, Sheth KN, Falcone GJ. Association of Intensive Blood Pressure Reduction With Risk of Hematoma Expansion in Patients With Deep Intracerebral Hemorrhage. JAMA Neurology 2019, 76: 949-955. PMID: 31081862, PMCID: PMC6515816, DOI: 10.1001/jamaneurol.2019.1141.
Early Prognostication of 1-Year Outcome After Subarachnoid Hemorrhage: The FRESH Score ValidationWitsch J, Kuohn L, Hebert R, Cord B, Sansing L, Gilmore EJ, Hwang DY, Petersen N, Falcone GJ, Matouk C, Sheth KN. Early Prognostication of 1-Year Outcome After Subarachnoid Hemorrhage: The FRESH Score Validation. Journal Of Stroke And Cerebrovascular Diseases 2019, 28: 104280. PMID: 31326270, DOI: 10.1016/j.jstrokecerebrovasdis.2019.06.038.
Subtype Specificity of Genetic Loci Associated With Stroke in 16 664 Cases and 32 792 ControlsTraylor M, Anderson CD, Rutten-Jacobs LCA, Falcone GJ, Comeau ME, Ay H, Sudlow CLM, Xu H, Mitchell BD, Cole JW, Rexrode K, Jimenez-Conde J, Schmidt R, Grewal RP, Sacco R, Ribases M, Rundek T, Rosand J, Dichgans M, Lee JM, Langefeld CD, Kittner SJ, Markus HS, Woo D, Malik R, Consortium O. Subtype Specificity of Genetic Loci Associated With Stroke in 16 664 Cases and 32 792 Controls. Circulation Genomic And Precision Medicine 2019, 12: e002338. PMID: 31306060, PMCID: PMC7477820, DOI: 10.1161/circgen.118.002338.
Intensive Blood Pressure Reduction and Perihematomal Edema Expansion in Deep Intracerebral HemorrhageLeasure AC, Qureshi AI, Murthy SB, Kamel H, Goldstein JN, Walsh KB, Woo D, Shi FD, Huttner HB, Ziai WC, Hanley DF, Matouk CC, Sansing LH, Falcone GJ, Sheth KN. Intensive Blood Pressure Reduction and Perihematomal Edema Expansion in Deep Intracerebral Hemorrhage. Stroke 2019, 50: 2016-2022. PMID: 31272326, PMCID: PMC6646091, DOI: 10.1161/strokeaha.119.024838.
Identification and Validation of Hematoma Volume Cutoffs in Spontaneous, Supratentorial Deep Intracerebral HemorrhageLeasure AC, Sheth KN, Comeau M, Aldridge C, Worrall BB, Vashkevich A, Rosand J, Langefeld C, Moomaw CJ, Woo D, Falcone GJ. Identification and Validation of Hematoma Volume Cutoffs in Spontaneous, Supratentorial Deep Intracerebral Hemorrhage. Stroke 2019, 50: 2044-2049. PMID: 31238829, PMCID: PMC6646054, DOI: 10.1161/strokeaha.118.023851.
Decreases in Blood Pressure During Thrombectomy Are Associated With Larger Infarct Volumes and Worse Functional OutcomePetersen NH, Ortega-Gutierrez S, Wang A, Lopez GV, Strander S, Kodali S, Silverman A, Zheng-Lin B, Dandapat S, Sansing LH, Schindler JL, Falcone GJ, Gilmore EJ, Amin H, Cord B, Hebert RM, Matouk C, Sheth KN. Decreases in Blood Pressure During Thrombectomy Are Associated With Larger Infarct Volumes and Worse Functional Outcome. Stroke 2019, 50: 1797-1804. PMID: 31159701, PMCID: PMC6787912, DOI: 10.1161/strokeaha.118.024286.
One Step Closer to Precision Medicine Strategies Based on Genetic InformationGeorge BP, Falcone GJ. One Step Closer to Precision Medicine Strategies Based on Genetic Information. JAMA Neurology 2019, 76: 523-525. PMID: 30742212, DOI: 10.1001/jamaneurol.2018.4404.
Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/EthnicityMarini S, Crawford K, Morotti A, Lee MJ, Pezzini A, Moomaw CJ, Flaherty ML, Montaner J, Roquer J, Jimenez-Conde J, Giralt-Steinhauer E, Elosua R, Cuadrado-Godia E, Soriano-Tarraga C, Slowik A, Jagiella JM, Pera J, Urbanik A, Pichler A, Hansen BM, McCauley JL, Tirschwell DL, Selim M, Brown DL, Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Testai FD, Kittner SJ, Schmidt H, Enzinger C, Deary IJ, Rannikmae K, Samarasekera N, Salman RA, Sudlow CL, Klijn CJM, van Nieuwenhuizen KM, Fernandez-Cadenas I, Delgado P, Norrving B, Lindgren A, Goldstein JN, Viswanathan A, Greenberg SM, Falcone GJ, Biffi A, Langefeld CD, Woo D, Rosand J, Anderson CD. Association of Apolipoprotein E With Intracerebral Hemorrhage Risk by Race/Ethnicity. JAMA Neurology 2019, 76: 480-491. PMID: 30726504, PMCID: PMC6459133, DOI: 10.1001/jamaneurol.2018.4519.
Abstract WP223: Ischemic and Hemorrhagic Stroke in Native AmericansKing Z, Beekman R, Chu S, Leasure A, Orgrass H, Gilmore E, Sansing L, Matouk C, Sheth K, Falcone G. Abstract WP223: Ischemic and Hemorrhagic Stroke in Native Americans. Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.wp223.
Abstract WMP97: Racial/Ethnic Disparities in the Risk of Intracerebral Hemorrhage RecurrenceKing Z, Leasure A, Torres-Lopez V, Woo D, Hanley D, Ziai W, Murthy S, Matouk C, Sansing L, Falcone G, Sheth K. Abstract WMP97: Racial/Ethnic Disparities in the Risk of Intracerebral Hemorrhage Recurrence. Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.wmp97.
Abstract TP15: Percutaneous Transcarotid Puncture is a Viable Alternative for Thrombectomy in Acute Ischemic Stroke Patients With Difficult Vascular AccessWang A, Cord B, Chouairi F, Koo A, Porto C, Silverman A, Kodali S, Strander S, Hebert R, Falcone G, Sheth K, Sansing L, Schindler J, Matouk C, Petersen N. Abstract TP15: Percutaneous Transcarotid Puncture is a Viable Alternative for Thrombectomy in Acute Ischemic Stroke Patients With Difficult Vascular Access. Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.tp15.
Abstract 77: Perihematomal Edema Expansion Rate is Associated With Poor Functional Outcomes in Basal Ganglia Intracerebral HemorrhageLeasure A, Qureshi A, Goldstein J, Murthy S, Kamel H, Woo D, Matouk C, Sansing L, Falcone G, Sheth K. Abstract 77: Perihematomal Edema Expansion Rate is Associated With Poor Functional Outcomes in Basal Ganglia Intracerebral Hemorrhage. Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.77.
Abstract 76: Intensive Blood Pressure Reduction is Associated With Reduced Hematoma Expansion in Deep Intracerebral Hemorrhage: A Secondary Analysis of ATACH-2Leasure A, Qureshi A, Goldstein J, Murthy S, Kamel H, Woo D, Matouk C, Sansing L, Sheth K, Falcone G. Abstract 76: Intensive Blood Pressure Reduction is Associated With Reduced Hematoma Expansion in Deep Intracerebral Hemorrhage: A Secondary Analysis of ATACH-2. Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.76.
Abstract 18: Genetically-Determined Cholesterol Levels are Associated with Risk of Spontaneous Intracerebral HemorrhageKirsch E, Leasure A, Matouk C, Sansing L, Crawford K, Kourkoulis C, Woo D, Rosand J, Anderson C, Sheth K, Falcone G. Abstract 18: Genetically-Determined Cholesterol Levels are Associated with Risk of Spontaneous Intracerebral Hemorrhage. Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.18.
Abstract 17: Apolipoprotein E and Intracerebral Hemorrhage: A Trans-Ethnic Meta-AnalysisMarini S, Morotti A, Pezzini A, Moomaw C, Flaherty M, Montaner J, Jimenez-Conde J, Cuadrado-Godia E, Slowik A, Pichler A, Tirschwell D, Selim M, Brown D, Silliman S, Worrall B, Meschia J, Kidwell C, Testai F, Kittner S, Deary I, Al-Shahi Salman R, Sudlow C, Klijn C, Fernandez-Cadenas I, Lindgren A, Goldstein J, Viswanathan A, Greenberg S, Falcone G, Langefeld C, Woo D, Rosand J, Anderson C. Abstract 17: Apolipoprotein E and Intracerebral Hemorrhage: A Trans-Ethnic Meta-Analysis. Stroke 2019, 50 DOI: 10.1161/str.50.suppl_1.17.
Cardioembolic Stroke Risk and Recovery After Anticoagulation-Related Intracerebral HemorrhageMurphy MP, Kuramatsu JB, Leasure A, Falcone GJ, Kamel H, Sansing LH, Kourkoulis C, Schwab K, Elm JJ, Gurol ME, Tran H, Greenberg SM, Viswanathan A, Anderson CD, Schwab S, Rosand J, Shi FD, Kittner SJ, Testai FD, Woo D, Langefeld CD, James ML, Koch S, Huttner HB, Biffi A, Sheth KN. Cardioembolic Stroke Risk and Recovery After Anticoagulation-Related Intracerebral Hemorrhage. Stroke 2018, 49: 2652-2658. PMID: 30355194, PMCID: PMC6211810, DOI: 10.1161/strokeaha.118.021799.
The Subjective Experience of Patients Undergoing Shunt Surgery for Idiopathic Normal Pressure HydrocephalusSubramanian HE, Mahajan A, Sommaruga S, Falcone GJ, Kahle KT, Matouk CC. The Subjective Experience of Patients Undergoing Shunt Surgery for Idiopathic Normal Pressure Hydrocephalus. World Neurosurgery 2018, 119: e46-e52. PMID: 29981467, DOI: 10.1016/j.wneu.2018.06.209.
Cholesterol levels, statins, and spontaneous intracerebral hemorrhageFalcone GJ, Gurol ME. Cholesterol levels, statins, and spontaneous intracerebral hemorrhage. Neurology 2018, 91: 197-198. PMID: 29970403, DOI: 10.1212/wnl.0000000000005898.
Analysis of shared heritability in common disorders of the brainConsortium T, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, Lee PH, Turley P, Grenier-Boley B, Chouraki V, Kamatani Y, Berr C, Letenneur L, Hannequin D, Amouyel P, Boland A, Deleuze JF, Duron E, Vardarajan BN, Reitz C, Goate AM, Huentelman MJ, Kamboh MI, Larson EB, Rogaeva E, St George-Hyslop P, Hakonarson H, Kukull WA, Farrer LA, Barnes LL, Beach TG, Demirci FY, Head E, Hulette CM, Jicha GA, Kauwe JSK, Kaye JA, Leverenz JB, Levey AI, Lieberman AP, Pankratz VS, Poon WW, Quinn JF, Saykin AJ, Schneider LS, Smith AG, Sonnen JA, Stern RA, Van Deerlin VM, Van Eldik LJ, Harold D, Russo G, Rubinsztein DC, Bayer A, Tsolaki M, Proitsi P, Fox NC, Hampel H, Owen MJ, Mead S, Passmore P, Morgan K, Nöthen MM, Schott J, Rossor M, Lupton M, Hoffmann P, Kornhuber J, Lawlor B, McQuillin A, Al-Chalabi A, Bis J, Ruiz A, Boada M, 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Petryshen T, Quested D, Roussos P, Sanders A, Schall U, Schwab S, Sim K, So H, Stögmann E, Subramaniam M, Toncheva D, Waddington J, Walters J, Weiser M, Cheng W, Cloninger R, Curtis D, Gejman P, Henskens F, Mattingsdal M, Oh S, Scott R, Webb B, Breen G, Churchhouse C, Bulik C, Daly M, Dichgans M, Faraone S, Guerreiro R, Holmans P, Kendler K, Koeleman B, Mathews C, Price A, Scharf J, Sklar P, Williams J, Wood N, Cotsapas C, Palotie A, Smoller J, Sullivan P, Rosand J, Corvin A, Neale B. Analysis of shared heritability in common disorders of the brain. Science 2018, 360 PMID: 29930110, PMCID: PMC6097237, DOI: 10.1126/science.aap8757.
17p12 Influences Hematoma Volume and Outcome in Spontaneous Intracerebral HemorrhageMarini S, Devan WJ, Radmanesh F, Miyares L, Poterba T, Hansen BM, Norrving B, Jimenez-Conde J, Giralt-Steinhauer E, Elosua R, Cuadrado-Godia E, Soriano C, Roquer J, Kourkoulis CE, Ayres AM, Schwab K, Tirschwell DL, Selim M, Brown DL, Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Montaner J, Fernandez-Cadenas I, Delgado P, Greenberg SM, Lindgren A, Matouk C, Sheth KN, Woo D, Anderson CD, Rosand J, Falcone GJ. 17p12 Influences Hematoma Volume and Outcome in Spontaneous Intracerebral Hemorrhage. Stroke 2018, 49: 1618-1625. PMID: 29915124, PMCID: PMC6085089, DOI: 10.1161/strokeaha.117.020091.
Minority Patients are Less Likely to Undergo Withdrawal of Care After Spontaneous Intracerebral HemorrhageOrmseth CH, Falcone GJ, Jasak SD, Mampre DM, Leasure AC, Miyares LC, Hwang DY, James ML, Testai FD, Becker KJ, Tirschwell DL, Langefeld CD, Woo D, Sheth KN. Minority Patients are Less Likely to Undergo Withdrawal of Care After Spontaneous Intracerebral Hemorrhage. Neurocritical Care 2018, 29: 419-425. PMID: 29949003, PMCID: PMC6286261, DOI: 10.1007/s12028-018-0554-4.
Predictors of Vessel Wall Enhancement in Unruptured Intracranial AneurysmsSommaruga S, Cord B, Santarosa C, Malhotra A, Jonhson M, Sheth K, Gunel M, Herbert R, Bijlenga P, Schaller K, Falcone G, Matouk C. Predictors of Vessel Wall Enhancement in Unruptured Intracranial Aneurysms. Journal Of Neurological Surgery Part A Central European Neurosurgery 2018, 79: s1-s27. DOI: 10.1055/s-0038-1660769.
Spontaneous Intracerebral Hemorrhage in the Elderly PopulationSommaruga S, Beekman R, Chu S, King Z, Matouk C, Hwang D, Sheth K, Falcone G. Spontaneous Intracerebral Hemorrhage in the Elderly Population. Journal Of Neurological Surgery Part A Central European Neurosurgery 2018, 79: s1-s27. DOI: 10.1055/s-0038-1660768.
History of Intracranial Hemorrhage Is Associated with In-Hospital Mortality in Ischemic Stroke Patients Treated with Intravenous ThrombolyticsSommaruga S, Chu S, Hwang D, Dearborn J, Sansing L, Cord B, Santarosa C, Samarth G, Petersen N, Gilmore E, Schindler J, Bijlenga P, Schaller K, Matouk C, Sheth K, Falcone G. History of Intracranial Hemorrhage Is Associated with In-Hospital Mortality in Ischemic Stroke Patients Treated with Intravenous Thrombolytics. Journal Of Neurological Surgery Part A Central European Neurosurgery 2018, 79: s1-s27. DOI: 10.1055/s-0038-1660745.
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypesMalik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD, Butterworth AS, Carrera C, Carty CL, Chasman DI, Chen WM, Cole JW, Correa A, Cotlarciuc I, Cruchaga C, Danesh J, de Bakker PIW, DeStefano AL, den Hoed M, Duan Q, Engelter ST, Falcone GJ, Gottesman RF, Grewal RP, Gudnason V, Gustafsson S, Haessler J, Harris TB, Hassan A, Havulinna AS, Heckbert SR, Holliday EG, Howard G, Hsu FC, Hyacinth HI, Ikram MA, Ingelsson E, Irvin MR, Jian X, Jiménez-Conde J, Johnson JA, Jukema JW, Kanai M, Keene KL, Kissela BM, Kleindorfer DO, Kooperberg C, Kubo M, Lange LA, Langefeld CD, Langenberg C, Launer LJ, Lee JM, Lemmens R, Leys D, Lewis CM, Lin WY, Lindgren AG, Lorentzen E, Magnusson PK, Maguire J, Manichaikul A, McArdle PF, Meschia JF, Mitchell BD, Mosley TH, Nalls MA, Ninomiya T, O’Donnell M, Psaty BM, Pulit SL, Rannikmäe K, Reiner AP, Rexrode KM, Rice K, Rich SS, Ridker PM, Rost NS, Rothwell PM, Rotter JI, Rundek T, Sacco RL, Sakaue S, Sale MM, Salomaa V, Sapkota BR, Schmidt R, Schmidt CO, Schminke U, Sharma P, Slowik A, Sudlow CLM, Tanislav C, Tatlisumak T, Taylor KD, Thijs VNS, Thorleifsson G, Thorsteinsdottir U, Tiedt S, Trompet S, Tzourio C, van Duijn CM, Walters M, Wareham NJ, Wassertheil-Smoller S, Wilson JG, Wiggins KL, Yang Q, Yusuf S, Bis J, Pastinen T, Ruusalepp A, Schadt E, Koplev S, Björkegren J, Codoni V, Civelek M, Smith N, Trégouët D, Christophersen I, Roselli C, Lubitz S, Ellinor P, Tai E, Kooner J, Kato N, He J, van der Harst P, Elliott P, Chambers J, Takeuchi F, Johnson A, Sanghera D, Melander O, Jern C, Strbian D, Fernandez-Cadenas I, Longstreth W, Rolfs A, Hata J, Woo D, Rosand J, Pare G, Hopewell J, Saleheen D, Stefansson K, Worrall B, Kittner S, Seshadri S, Fornage M, Markus H, Howson J, Kamatani Y, Debette S, Dichgans M. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nature Genetics 2018, 50: 524-537. PMID: 29531354, PMCID: PMC5968830, DOI: 10.1038/s41588-018-0058-3.
Abstract WMP96: Racial Variation in Comfort Measures Only Status in Patients With Intracerebral HemorrhageOrmseth C, Falcone G, Jasak S, Mampre D, Leasure A, Miyares L, Hwang D, James M, Testai F, Becker K, Tirschwell D, Langefeld C, Woo D, Sheth K. Abstract WMP96: Racial Variation in Comfort Measures Only Status in Patients With Intracerebral Hemorrhage. Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.wmp96.
Abstract WMP31: Vessel Wall Enhancement is Associated With Clinical and Imaging Markers of Aneurysm InstabilitySommaruga S, Cord B, Molhotra A, Johnson M, Minja F, Gunel M, Sheth K, Herbert R, Melnikov F, Schaller K, Mandell D, Bijlenga P, Falcone G, Matouk C. Abstract WMP31: Vessel Wall Enhancement is Associated With Clinical and Imaging Markers of Aneurysm Instability. Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.wmp31.
Abstract WMP101: Soluble St2 Predicts Functional Outcome After Spontaneous Intraparenchymal HemorrhageBevers M, Wolcott Z, Leasure A, Falcone G, Sansing L, Sheth K, Kimberly W. Abstract WMP101: Soluble St2 Predicts Functional Outcome After Spontaneous Intraparenchymal Hemorrhage. Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.wmp101.
Abstract TP331: Plasma IL-6 Levels are Independently Associated With Functional Outcome and Markers of Secondary Injury in Spontaneous Intracerebral HemorrhageLeasure A, Steinschneider A, Falcone G, Gilmore E, Sansing L, Sheth K. Abstract TP331: Plasma IL-6 Levels are Independently Associated With Functional Outcome and Markers of Secondary Injury in Spontaneous Intracerebral Hemorrhage. Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.tp331.
Abstract TP304: Stroke-Specific Quality of Life as an Independent Outcome in Intracerebral HemorrhageLeasure A, Sreekrishnan A, Ormseth C, Miyares L, Mampre D, McLaughlin C, Amin H, Sansing L, Falcone G, Sheth K. Abstract TP304: Stroke-Specific Quality of Life as an Independent Outcome in Intracerebral Hemorrhage. Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.tp304.
Abstract TP277: The Neurointensivists’ Role in Management of Cerebral Venous Sinus ThrombosisStretz C, Ghoshal S, Marcolini E, Hwang D, Petersen N, Schindler J, Sheth K, Falcone G, Gilmore E. Abstract TP277: The Neurointensivists’ Role in Management of Cerebral Venous Sinus Thrombosis. Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.tp277.
Abstract TP161: The Cerebrovascular Disease Knowledge Portal: an Open Access Data Resource to Accelerate Genomic Discoveries in StrokeCrawford K, Kourkoulis C, Miyares L, Burtt N, Flannick J, Hall J, Rosand J, Falcone G. Abstract TP161: The Cerebrovascular Disease Knowledge Portal: an Open Access Data Resource to Accelerate Genomic Discoveries in Stroke. Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.tp161.
Abstract TMP14: Thrombolysis in Ischemic Stroke Patients with Prior History of Intracranial HemorrhageChu S, Sommaruga S, Hwang D, Dearborn J, Sansing L, Matouk C, Samarth G, Petersen N, Gilmore E, Schindler J, Sheth K, Falcone G. Abstract TMP14: Thrombolysis in Ischemic Stroke Patients with Prior History of Intracranial Hemorrhage. Stroke 2018, 49 DOI: 10.1161/str.49.suppl_1.tmp14.
Cerebrovascular Disease Knowledge PortalCrawford KM, Gallego-Fabrega C, Kourkoulis C, Miyares L, Marini S, Flannick J, Burtt NP, von Grotthuss M, Alexander B, Costanzo MC, Vaishnav NH, Malik R, Hall JL, Chong M, Rosand J, Falcone GJ. Cerebrovascular Disease Knowledge Portal. Stroke 2018, 49: 470-475. PMID: 29335331, PMCID: PMC5780219, DOI: 10.1161/strokeaha.117.018922.
Genetics of Spontaneous Intracerebral HemorrhageFalcone GJ, Woo D. Genetics of Spontaneous Intracerebral Hemorrhage. Stroke 2017, 48: 3420-3424. PMID: 29114093, PMCID: PMC5777521, DOI: 10.1161/strokeaha.117.017072.
COL4A2 is associated with lacunar ischemic stroke and deep ICHRannikmäe K, Sivakumaran V, Millar H, Malik R, Anderson CD, Chong M, Dave T, Falcone GJ, Fernandez-Cadenas I, Jimenez-Conde J, Lindgren A, Montaner J, O'Donnell M, Paré G, Radmanesh F, Rost NS, Slowik A, Söderholm M, Traylor M, Pulit SL, Seshadri S, Worrall BB, Woo D, Markus HS, Mitchell BD, Dichgans M, Rosand J, Sudlow CLM, McArdle P, Wong Q, Gwinn K, Achterberg S, Algra A, Amouyel P, Arnett D, Arsava E, Attia J, Ay H, Bartz T, Battey T, Benavente O, Bevan S, Biffi A, Bis J, Blanton S, P J, Boncoraglio G, Brown R, Burgess A, Carrera C, Chapman Smith S, Chasman D, Chauhan G, Wei-Min Chen F, Cheng Y, Cloonan L, Cole J, Cotlarciuc I, Cruchaga C, Cuadrado-Godia E, Dawson J, Debette S, Delavaran H, Dell C, Doheny K, Dong C, Duggan D, Engström G, Evans M, Pallejà X, Faul J, Fornage M, Frossard P, Furie K, Gamble D, Gieger C, Giese A, Giralt-Steinhauer E, González H, Goris A, Gretarsdottir S, Grewal R, Grittner U, Gustafsson S, Han B, Hankey G, Heitsch L, Higgins P, Hochberg M, Holliday E, Hopewell J, Horenstein R, Howard G, Ikram M, Ilinca A, Ingelsson E, Irvin M, Jackson R, Jern C, Johnson J, Jood K, Kahn M, Kaplan R, Kappelle L, Kardia S, Keene K, Kissela B, Kleindorfer D, Koblar S, Labovitz D, Launer L, Laurie C, Laurie C, Lee C, Lee J, Lemmens R, Levi C, Leys D, Longstreth W, Maguire J, Manichaikul A, McClure L, McDonough C, Meisinger C, Melander O, Meschia J, Mola-Caminal M, Mosley T, Müller-Nurasyid M, Nalls M, O’Connell J, Ois Á, Papanicolaou G, Peddareddygari L, Pedersén A, Pera J, Peters A, Poole D, Psaty B, Rabionet R, Raffeld M, Rasheed A, Redfors P, Reiner A, Rexrode K, Ribasés M, Rich S, Robberecht W, Rodríguez-Campello A, Rolfs A, Roquer J, Rose L, Rosenbaum D, Rost N, Rothwell P, Rundek T, Ryan K, Sacco R, Sale M, Saleheen D, Salomaa V, Sánchez-Mora C, Schmidt C, Schmidt H, Schmidt R, Schürks M, Scott R, Segal H, Seiler S, Sharma P, Shuldiner A, Silver B, Smith J, Bsc C, Sparks M, Stanne T, Stefansson K, Stine O, Strauch K, Sturm J, Tajuddin S, Talbert R, Tatlisumak T, Thijs V, Thorleifsson G, Thorsteindottir U, Trompet S, Valant V, Waldenberger M, Walters M, Wang L, P J, Wang X, Wassertheil-Smoller S, Weir D, Wiggins K, Williams S, Wloch-Kopec D, Woodfield R, Wu O, Xu H, Zonderman A, de Bakker P, Kittner S, Bevan S, Hopewell J, Holliday E, Zhao W, Abrantes P, Amouyel P, Attia J, Battey T, Berger K, Boncoraglio G, Chauhan G, Cheng Y, Chen W, Clarke R, Cotlarciuc I, Debette S, Ferro J, Gamble D, Ilinca A, Kittner S, Lemmens R, Levi C, Lichtner P, Liu J, Meschia J, Oliveira S, Pera J, Reiner A, Rothwell P, Sharma P, Tatlisumak T, Thijs V, Vicente A, Saleheen D, Thorsteinsdottir U, DeStefano A, Gretarsdottir S, Donnelly P, Barroso I, Blackwell J, Bramon E, Brown M, Casas J, Corvin A, Deloukas P, Duncanson A, Jankowski J, Markus H, Mathew C, Palmer C, Plomin R, Rautanen A, sawcer S, Trembath R, Viswanathan A, Wood N, Spencer C. COL4A2 is associated with lacunar ischemic stroke and deep ICH. Neurology 2017, 89: 1829-1839. PMID: 28954878, PMCID: PMC5664302, DOI: 10.1212/wnl.0000000000004560.
168 Wall Enhancement in Unruptured Aneurysms is Associated with Symptomatic Presentation and SizeCord B, Sommaruga S, Hebert R, Malhotra A, Johnson M, Minja F, Gunel M, Sheth K, Falcone G, Matouk C. 168 Wall Enhancement in Unruptured Aneurysms is Associated with Symptomatic Presentation and Size. Neurosurgery 2017, 64: 243. DOI: 10.1093/neuros/nyx417.168.
Proceedings of the 19th and 20th International Stroke Genetics Consortium WorkshopsAnderson C, Boncoraglio G, Falcone G. Proceedings of the 19th and 20th International Stroke Genetics Consortium Workshops. Neurology Genetics 2017, 3: e137. PMCID: PMC5390738, DOI: 10.1212/nxg.0000000000000137.
Abstract 154: Genetic Variants in CETP That Increase HDL Levels also Increase Risk of Intracerebral HemorrhageFalcone G, Phuah C, Radmanesh F, Peloso G, Meschia J, Selim M, Brown D, Worrall B, Silliman S, Tirschwell D, Jimenez-Conde J, Klijn C, Sudlow C, Rannikmae K, Pezzini A, Norrving B, Montaner J, Lindgren A, Slowik A, Kidwell C, Kittner S, Langefeld C, Abecasis G, Willer C, Kathiresan S, Woo D, Rosand J, Anderson C. Abstract 154: Genetic Variants in CETP That Increase HDL Levels also Increase Risk of Intracerebral Hemorrhage. Stroke 2017, 48 DOI: 10.1161/str.48.suppl_1.154.
Genetic variants in CETP increase risk of intracerebral hemorrhageAnderson CD, Falcone GJ, Phuah C, Radmanesh F, Brouwers HB, Battey TW, Biffi A, Peloso GM, Liu DJ, Ayres AM, Goldstein JN, Viswanathan A, Greenberg SM, Selim M, Meschia JF, Brown DL, Worrall BB, Silliman SL, Tirschwell DL, Flaherty ML, Kraft P, Jagiella JM, Schmidt H, Hansen BM, Jimenez‐Conde J, Giralt‐Steinhauer E, Elosua R, Cuadrado‐Godia E, Soriano C, van Nieuwenhuizen K, Klijn CJ, Rannikmae K, Samarasekera N, Salman R, Sudlow CL, Deary IJ, Morotti A, Pezzini A, Pera J, Urbanik A, Pichler A, Enzinger C, Norrving B, Montaner J, Fernandez‐Cadenas I, Delgado P, Roquer J, Lindgren A, Slowik A, Schmidt R, Kidwell CS, Kittner SJ, Waddy SP, Langefeld CD, Abecasis G, Willer CJ, Kathiresan S, Woo D, Rosand J, Consortium O. Genetic variants in CETP increase risk of intracerebral hemorrhage. Annals Of Neurology 2016, 80: 730-740. PMID: 27717122, PMCID: PMC5115931, DOI: 10.1002/ana.24780.
Cortical superficial siderosis predicts early recurrent lobar hemorrhageRoongpiboonsopit D, Charidimou A, William CM, Lauer A, Falcone GJ, Martinez-Ramirez S, Biffi A, Ayres A, Vashkevich A, Awosika OO, Rosand J, Gurol ME, Silverman SB, Greenberg SM, Viswanathan A. Cortical superficial siderosis predicts early recurrent lobar hemorrhage. Neurology 2016, 87: 1863-1870. PMID: 27694268, PMCID: PMC5100711, DOI: 10.1212/wnl.0000000000003281.
Genetic Determinants of Risk, Severity, and Outcome in Intracerebral HemorrhageFalcone GJ, Rosand J. Genetic Determinants of Risk, Severity, and Outcome in Intracerebral Hemorrhage. Seminars In Neurology 2016, 36: 298-305. PMID: 27214705, DOI: 10.1055/s-0036-1582134.
Low-frequency and common genetic variation in ischemic strokeMalik R, Traylor M, Pulit SL, Bevan S, Hopewell JC, Holliday EG, Zhao W, Abrantes P, Amouyel P, Attia JR, Battey TW, Berger K, Boncoraglio GB, Chauhan G, Cheng YC, Chen WM, Clarke R, Cotlarciuc I, Debette S, Falcone GJ, Ferro JM, Gamble DM, Ilinca A, Kittner SJ, Kourkoulis CE, Lemmens R, Levi CR, Lichtner P, Lindgren A, Liu J, Meschia JF, Mitchell BD, Oliveira SA, Pera J, Reiner AP, Rothwell PM, Sharma P, Slowik A, Sudlow CL, Tatlisumak T, Thijs V, Vicente AM, Woo D, Seshadri S, Saleheen D, Rosand J, Markus HS, Worrall BB, Dichgans M. Low-frequency and common genetic variation in ischemic stroke. Neurology 2016, 86: 1217-1226. PMID: 26935894, PMCID: PMC4818561, DOI: 10.1212/wnl.0000000000002528.
Abstract TP372: CT Angiography Spot Sign, Hematoma Expansion and Outcome in Primary Pontine Intracerebral HemorrhageMorotti A, Jessel M, Brouwers B, Falcone G, Schwab K, Ayres A, Vashkevich A, Anderson C, Romero J, Gurol E, Viswanathan A, Greenberg S, Rosand J, Goldstein J. Abstract TP372: CT Angiography Spot Sign, Hematoma Expansion and Outcome in Primary Pontine Intracerebral Hemorrhage. Stroke 2016, 47 DOI: 10.1161/str.47.suppl_1.tp372.
Abstract 122: Cortical Superficial Siderosis is a Predictor of Early Recurrent Intracerebral Hemorrhage in Cerebral Amyloid AngiopathyRoongpiboonsopit D, Charidimou A, William C, Lauer A, Falcone G, Raminez S, Biffi A, Ayres A, Vashkevich A, Awosika O, Rosand J, Silverman S, Gurol M, Greenberg S, Viswanathan A. Abstract 122: Cortical Superficial Siderosis is a Predictor of Early Recurrent Intracerebral Hemorrhage in Cerebral Amyloid Angiopathy. Stroke 2016, 47 DOI: 10.1161/str.47.suppl_1.122.
CT Angiography Spot Sign, Hematoma Expansion, and Outcome in Primary Pontine Intracerebral HemorrhageMorotti A, Jessel MJ, Brouwers HB, Falcone GJ, Schwab K, Ayres AM, Vashkevich A, Anderson CD, Viswanathan A, Greenberg SM, Gurol ME, Romero JM, Rosand J, Goldstein JN. CT Angiography Spot Sign, Hematoma Expansion, and Outcome in Primary Pontine Intracerebral Hemorrhage. Neurocritical Care 2016, 25: 79-85. PMID: 26759226, PMCID: PMC4940347, DOI: 10.1007/s12028-016-0241-2.
Genetic Risk Factors of Intracerebral HemorrhageFalcone G, Rosand J. Genetic Risk Factors of Intracerebral Hemorrhage. 2016, 85-98. DOI: 10.1093/med/9780199895847.003.0006.
Endovascular Stroke Treatment Outcomes After Patient Selection Based on Magnetic Resonance Imaging and Clinical CriteriaLeslie-Mazwi TM, Hirsch JA, Falcone GJ, Schaefer PW, Lev MH, Rabinov JD, Rost NS, Schwamm L, González RG. Endovascular Stroke Treatment Outcomes After Patient Selection Based on Magnetic Resonance Imaging and Clinical Criteria. JAMA Neurology 2016, 73: 1-7. PMID: 26524074, DOI: 10.1001/jamaneurol.2015.3000.
Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with strokeTraylor M, Zhang CR, Adib-Samii P, Devan WJ, Parsons OE, Lanfranconi S, Gregory S, Cloonan L, Falcone GJ, Radmanesh F, Fitzpatrick K, Kanakis A, Barrick TR, Moynihan B, Lewis CM, Boncoraglio GB, Lemmens R, Thijs V, Sudlow C, Wardlaw J, Rothwell PM, Meschia JF, Worrall BB, Levi C, Bevan S, Furie KL, Dichgans M, Rosand J, Markus HS, Rost N, Smoller S, Sorkin J, Wang X, Selim M, Pikula A, Wolf P, Debette S, Seshadri S, de Bakker P, Chasman D, Rexrode K, Chen I, Rotter J, Luke M, Sale M, Lee T, Chang K, Elkind M, Goldstein L, James M, Breteler M, O'Donnell C, Leys D, Carty C, Kidwell C, Olesen J, Sharma P, Rich S, Tatlisumak T, Happola O, Bijlenga P, Soriano C, Giralt E, Roquer J, Jimenez-Conde J, Cotlarcius I, Hardy J, Korostynski M, Boncoraglio G, Ballabio E, Parati E, Mateusz A, Urbanik A, Dziedzic T, Jagiella J, Gasowski J, Wnuk M, Olszanecki R, Pera J, Slowik A, Juchniewicz K, Levi C, Nyquist P, Cendes I, Cabral N, Franca P, Goncalves A, Keller L, Crisby M, Kostulas K, Lemmens R, Ahmadi K, Opherk C, Duering M, Dichgans M, Malik R, Gonik M, Staals J, Melander O, Burri P, Sadr-Nabavi A, Romero J, Biffi A, Anderson C, Falcone G, Brouwers B, Rosand J, Rost N, Du R, Kourkoulis C, Battey T, Lubitz S, Mueller-Myhsok B, Meschia J, Brott T, Pare G, Pichler A, Enzinger C, Schmidt H, Schmidt R, Seiler S, Blanton S, Yamada Y, Bersano A, Rundek T, Sacco R, Yvonne Chan Y, Gschwendtner A, Deng Z, Barr T, Gwinn K, Corriveau R, Singleton A, Waddy S, Launer L, Chen C, Le K, Lee W, Tan E, Olugbodi A, Rothwell P, Schilling S, Mok V, Lebedeva E, Jern C, Jood K, Olsson S, Kim H, Lee C, Kilarski L, Markus H, Peycke J, Bevan S, Sheu W, Chiou H, Chern J, Giraldo E, Taqi M, Jain V, Lam O, Howard G, Woo D, Kittner S, Mitchell B, Cole J, O'Connell J, Milewicz D, Illoh K, Worrall B, Stine C, Karaszewski B, Werring D, Sofat R, Smalley J, Lindgren A, Hansen B, Norrving B, Smith G, Martín J, Thijs V, Klijn K, van't Hof F, Algra A, Macleod M, Perry R, Arnett D, Pezzini A, Padovani A, Cramer S, Fisher M, Saleheen D, Broderick J, Kissela B, Doney A, Sudlow C, Rannikmae K, Silliman S, McDonough C, Walters M, Pedersen A, Nakagawa K, Chang C, Dobbins M, McArdle P, Chang Y, Brown R, Brown D, Holliday E, Kalaria R, Maguire J, Attia J, Farrall M, Giese A, Fornage M, Majersik J, Cushman M, Keene K, Bennett S, Tirschwell D, Psaty B, Reiner A, Longstreth W, Spence D, Montaner J, Fernandez-Cadenas I, Langefeld C, Bushnell C, Heitsch L, Lee J, Sheth K. Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke. Neurology 2015, 86: 146-153. PMID: 26674333, PMCID: PMC4731688, DOI: 10.1212/wnl.0000000000002263.
Stroke is ascendant: is it time for TICI to be more than just a score?Hirsch JA, Falcone GJ, Brook AL, Fiorella D, Gonzalez RG, Leslie-Mazwi TM. Stroke is ascendant: is it time for TICI to be more than just a score? Journal Of NeuroInterventional Surgery 2015, 8: 221. PMID: 26658463, DOI: 10.1136/neurintsurg-2015-012160.
Rate of Contrast Extravasation on Computed Tomographic Angiography Predicts Hematoma Expansion and Mortality in Primary Intracerebral HemorrhageBrouwers HB, Battey TW, Musial HH, Ciura VA, Falcone GJ, Ayres AM, Vashkevich A, Schwab K, Viswanathan A, Anderson CD, Greenberg SM, Pomerantz SR, Ortiz CJ, Goldstein JN, Gonzalez RG, Rosand J, Romero JM. Rate of Contrast Extravasation on Computed Tomographic Angiography Predicts Hematoma Expansion and Mortality in Primary Intracerebral Hemorrhage. Stroke 2015, 46: 2498-2503. PMID: 26243220, PMCID: PMC4550492, DOI: 10.1161/strokeaha.115.009659.
Rare Coding Variation and Risk of Intracerebral HemorrhageRadmanesh F, Falcone GJ, Anderson CD, McWilliams D, Devan WJ, Brown WM, Battey TW, Ayres AM, Raffeld MR, Schwab K, Sun G, Deka R, Viswanathan A, Goldstein JN, Greenberg SM, Tirschwell DL, Silliman SL, Selim M, Meschia JF, Brown DL, Worrall BB, Langefeld CD, Woo D, Rosand J. Rare Coding Variation and Risk of Intracerebral Hemorrhage. Stroke 2015, 46: 2299-2301. PMID: 26111891, PMCID: PMC4519408, DOI: 10.1161/strokeaha.115.009838.
Epidemiology of multiple sclerosis: results from a large observational study in the UKJick SS, Li L, Falcone GJ, Vassilev ZP, Wallander M. Epidemiology of multiple sclerosis: results from a large observational study in the UK. Journal Of Neurology 2015, 262: 2033-2041. PMID: 26067217, PMCID: PMC4768220, DOI: 10.1007/s00415-015-7796-2.
Intakes of caffeine, coffee and tea and risk of amyotrophic lateral sclerosis: Results from five cohort studiesFondell E, O’Reilly É, Fitzgerald KC, Falcone GJ, Kolonel LN, Park Y, Gapstur SM, Ascherio A. Intakes of caffeine, coffee and tea and risk of amyotrophic lateral sclerosis: Results from five cohort studies. Amyotrophic Lateral Sclerosis And Frontotemporal Degeneration 2015, 16: 366-371. PMID: 25822002, PMCID: PMC4589421, DOI: 10.3109/21678421.2015.1020813.
Genetic overlap between diagnostic subtypes of ischemic stroke.Holliday EG, Traylor M, Malik R, Bevan S, Falcone G, Hopewell JC, Cheng YC, Cotlarciuc I, Bis JC, Boerwinkle E, Boncoraglio GB, Clarke R, Cole JW, Fornage M, Furie KL, Ikram MA, Jannes J, Kittner SJ, Lincz LF, Maguire JM, Meschia JF, Mosley TH, Nalls MA, Oldmeadow C, Parati EA, Psaty BM, Rothwell PM, Seshadri S, Scott RJ, Sharma P, Sudlow C, Wiggins KL, Worrall BB, Rosand J, Mitchell BD, Dichgans M, Markus HS, Levi C, Attia J, Wray NR. Genetic overlap between diagnostic subtypes of ischemic stroke. Stroke; A Journal Of Cerebral Circulation 2015, 46: 615-9. PMID: 25613305, PMCID: PMC4342266, DOI: 10.1161/STROKEAHA.114.007930.
Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel diseaseRannikmäe K, Davies G, Thomson PA, Bevan S, Devan WJ, Falcone GJ, Traylor M, Anderson CD, Battey TW, Radmanesh F, Deka R, Woo JG, Martin LJ, Jimenez-Conde J, Selim M, Brown DL, Silliman SL, Kidwell CS, Montaner J, Langefeld CD, Slowik A, Hansen BM, Lindgren AG, Meschia JF, Fornage M, Bis JC, Debette S, Ikram MA, Longstreth WT, Schmidt R, Zhang CR, Yang Q, Sharma P, Kittner SJ, Mitchell BD, Holliday EG, Levi CR, Attia J, Rothwell PM, Poole DL, Boncoraglio GB, Psaty BM, Malik R, Rost N, Worrall BB, Dichgans M, Van Agtmael T, Woo D, Markus HS, Seshadri S, Rosand J, Sudlow CL. Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease. Neurology 2015, 84: 918-926. PMID: 25653287, PMCID: PMC4351667, DOI: 10.1212/wnl.0000000000001309.
Genetic Architecture of White Matter Hyperintensities Differs in Hypertensive and Nonhypertensive Ischemic StrokeAdib-Samii P, Devan W, Traylor M, Lanfranconi S, Zhang CR, Cloonan L, Falcone GJ, Radmanesh F, Fitzpatrick K, Kanakis A, Rothwell PM, Sudlow C, Boncoraglio GB, Meschia JF, Levi C, Dichgans M, Bevan S, Rosand J, Rost NS, Markus HS. Genetic Architecture of White Matter Hyperintensities Differs in Hypertensive and Nonhypertensive Ischemic Stroke. Stroke 2014, 46: 348-353. PMID: 25550368, PMCID: PMC4306538, DOI: 10.1161/strokeaha.114.006849.
Recommendations From the International Stroke Genetics Consortium, Part 2Battey TW, Valant V, Kassis SB, Kourkoulis C, Lee C, Anderson CD, Falcone GJ, Jimenez-Conde J, Fernandez-Cadenas I, Pare G, Rundek T, James ML, Lemmens R, Lee TH, Tatlisumak T, Kittner SJ, Lindgren A, Mateen FJ, Berkowitz AL, Holliday EG, Majersik J, Maguire J, Sudlow C, Rosand J. Recommendations From the International Stroke Genetics Consortium, Part 2. Stroke 2014, 46: 285-290. PMID: 25492904, PMCID: PMC4276505, DOI: 10.1161/strokeaha.114.006851.
Interrelationship of superficial siderosis and microbleeds in cerebral amyloid angiopathyShoamanesh A, Martinez-Ramirez S, Oliveira-Filho J, Reijmer Y, Falcone GJ, Ayres A, Schwab K, Goldstein JN, Rosand J, Gurol ME, Viswanathan A, Greenberg SM. Interrelationship of superficial siderosis and microbleeds in cerebral amyloid angiopathy. Neurology 2014, 83: 1838-1843. PMID: 25320098, PMCID: PMC4240429, DOI: 10.1212/wnl.0000000000000984.
Aspirin Should Be Discontinued After Lobar Intracerebral HemorrhageFalcone GJ, Rosand J. Aspirin Should Be Discontinued After Lobar Intracerebral Hemorrhage. Stroke 2014, 45: 3151-3152. PMID: 25205309, DOI: 10.1161/strokeaha.114.005787.
Dietary ω-3 Polyunsaturated Fatty Acid Intake and Risk for Amyotrophic Lateral SclerosisFitzgerald KC, O’Reilly É, Falcone GJ, McCullough ML, Park Y, Kolonel LN, Ascherio A. Dietary ω-3 Polyunsaturated Fatty Acid Intake and Risk for Amyotrophic Lateral Sclerosis. JAMA Neurology 2014, 71: 1102-1110. PMID: 25023276, PMCID: PMC4160351, DOI: 10.1001/jamaneurol.2014.1214.
APOE &egr; variants increase risk of warfarin-related intracerebral hemorrhageFalcone GJ, Radmanesh F, Brouwers HB, Battey TW, Devan WJ, Valant V, Raffeld MR, Chitsike LP, Ayres AM, Schwab K, Goldstein JN, Viswanathan A, Greenberg SM, Selim M, Meschia JF, Brown DL, Worrall BB, Silliman SL, Tirschwell DL, Flaherty ML, Martini SR, Deka R, Biffi A, Kraft P, Woo D, Rosand J, Anderson CD. APOE &egr; variants increase risk of warfarin-related intracerebral hemorrhage. Neurology 2014, 83: 1139-1146. PMID: 25150286, PMCID: PMC4176027, DOI: 10.1212/wnl.0000000000000816.
CT angiography spot sign in intracerebral hemorrhage predicts active bleeding during surgeryBrouwers HB, Raffeld MR, van Nieuwenhuizen KM, Falcone GJ, Ayres AM, McNamara KA, Schwab K, Romero JM, Velthuis BK, Viswanathan A, Greenberg SM, Ogilvy CS, van der Zwan A, Rinkel GJ, Goldstein JN, Klijn CJ, Rosand J. CT angiography spot sign in intracerebral hemorrhage predicts active bleeding during surgery. Neurology 2014, 83: 883-889. PMID: 25098540, PMCID: PMC4153853, DOI: 10.1212/wnl.0000000000000747.
Mortality of patients with multiple sclerosis: a cohort study in UK primary careJick SS, Li L, Falcone GJ, Vassilev ZP, Wallander M. Mortality of patients with multiple sclerosis: a cohort study in UK primary care. Journal Of Neurology 2014, 261: 1508-1517. PMID: 24838537, PMCID: PMC4119255, DOI: 10.1007/s00415-014-7370-3.
Dopamine Genetic Risk Score Predicts Depressive Symptoms in Healthy Adults and Adults with DepressionPearson-Fuhrhop KM, Dunn EC, Mortero S, Devan WJ, Falcone GJ, Lee P, Holmes AJ, Hollinshead MO, Roffman JL, Smoller JW, Rosand J, Cramer SC. Dopamine Genetic Risk Score Predicts Depressive Symptoms in Healthy Adults and Adults with Depression. PLOS ONE 2014, 9: e93772. PMID: 24834916, PMCID: PMC4023941, DOI: 10.1371/journal.pone.0093772.
Risk Factors for Computed Tomography Angiography Spot Sign in Deep and Lobar Intracerebral Hemorrhage Are SharedRadmanesh F, Falcone GJ, Anderson CD, Battey TW, Ayres AM, Vashkevich A, McNamara KA, Schwab K, Romero JM, Viswanathan A, Greenberg SM, Goldstein JN, Rosand J, Brouwers HB. Risk Factors for Computed Tomography Angiography Spot Sign in Deep and Lobar Intracerebral Hemorrhage Are Shared. Stroke 2014, 45: 1833-1835. PMID: 24876264, PMCID: PMC4116606, DOI: 10.1161/strokeaha.114.005276.
Dietary Fiber and Amyotrophic Lateral Sclerosis: Results From 5 Large Cohort StudiesFondell E, O'Reilly É, Fitzgerald KC, Falcone GJ, Kolonel LN, Park Y, McCullough ML, Ascherio A. Dietary Fiber and Amyotrophic Lateral Sclerosis: Results From 5 Large Cohort Studies. American Journal Of Epidemiology 2014, 179: 1442-1449. PMID: 24816788, PMCID: PMC4051879, DOI: 10.1093/aje/kwu089.
Current concepts and clinical applications of stroke geneticsFalcone GJ, Malik R, Dichgans M, Rosand J. Current concepts and clinical applications of stroke genetics. The Lancet Neurology 2014, 13: 405-418. PMID: 24646874, DOI: 10.1016/s1474-4422(14)70029-8.
Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral HemorrhageWoo D, Falcone GJ, Devan WJ, Brown WM, Biffi A, Howard TD, Anderson CD, Brouwers HB, Valant V, Battey TW, Radmanesh F, Raffeld MR, Baedorf-Kassis S, Deka R, Woo JG, Martin LJ, Haverbusch M, Moomaw CJ, Sun G, Broderick JP, Flaherty ML, Martini SR, Kleindorfer DO, Kissela B, Comeau ME, Jagiella JM, Schmidt H, Freudenberger P, Pichler A, Enzinger C, Hansen BM, Norrving B, Jimenez-Conde J, Giralt-Steinhauer E, Elosua R, Cuadrado-Godia E, Soriano C, Roquer J, Kraft P, Ayres AM, Schwab K, McCauley JL, Pera J, Urbanik A, Rost NS, Goldstein JN, Viswanathan A, Stögerer EM, Tirschwell DL, Selim M, Brown DL, Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Montaner J, Fernandez-Cadenas I, Delgado P, Malik R, Dichgans M, Greenberg SM, Rothwell PM, Lindgren A, Slowik A, Schmidt R, Langefeld CD, Rosand J, Consortium T. Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage. American Journal Of Human Genetics 2014, 94: 511-521. PMID: 24656865, PMCID: PMC3980413, DOI: 10.1016/j.ajhg.2014.02.012.
Abstract W P257: Predictors of the CT Angiography Spot Sign in Deep and Lobar Intracerebral HemorrhageRadmanesh F, Falcone G, Anderson C, Battey T, Ayres A, Vashkevich A, Schwab K, Romero J, Viswanathan A, Greenberg S, Goldstein J, Rosand J, Brouwers H. Abstract W P257: Predictors of the CT Angiography Spot Sign in Deep and Lobar Intracerebral Hemorrhage. Stroke 2014, 45 DOI: 10.1161/str.45.suppl_1.wp257.
Abstract W MP90: APOE Variants are Associated With Increased Risk of Warfarin-Related Intracerebral HemorrhageFalcone G, Radmanesh F, Brouwers H, Chitsike L, Devan W, Battey T, Viswanathan A, Goldstein J, Greenberg S, Brown D, Worrall B, Meschia J, Silliman S, Selim M, Tirschwell D, Biffi A, Woo D, Rosand J, Anderson C. Abstract W MP90: APOE Variants are Associated With Increased Risk of Warfarin-Related Intracerebral Hemorrhage. Stroke 2014, 45 DOI: 10.1161/str.45.suppl_1.wmp90.
Predicting Hematoma Expansion After Primary Intracerebral HemorrhageBrouwers HB, Chang Y, Falcone GJ, Cai X, Ayres AM, Battey TW, Vashkevich A, McNamara KA, Valant V, Schwab K, Orzell SC, Bresette LM, Feske SK, Rost NS, Romero JM, Viswanathan A, Chou S, Greenberg SM, Rosand J, Goldstein JN. Predicting Hematoma Expansion After Primary Intracerebral Hemorrhage. JAMA Neurology 2014, 71: 158-164. PMID: 24366060, PMCID: PMC4131760, DOI: 10.1001/jamaneurol.2013.5433.
Accuracy of imputation to infer unobserved APOE epsilon alleles in genome-wide genotyping dataRadmanesh F, Devan WJ, Anderson CD, Rosand J, Falcone GJ. Accuracy of imputation to infer unobserved APOE epsilon alleles in genome-wide genotyping data. European Journal Of Human Genetics 2014, 22: 1239-1242. PMID: 24448547, PMCID: PMC4169533, DOI: 10.1038/ejhg.2013.308.
Apolipoprotein E, Statins, and Risk of Intracerebral HemorrhageWoo D, Deka R, Falcone GJ, Flaherty ML, Haverbusch M, Martini SR, Greenberg SM, Ayres AM, Sauerbeck L, Kissela BM, Kleindorfer DO, Moomaw CJ, Anderson CD, Broderick JP, Rosand J, Langefeld CD, Woo JG. Apolipoprotein E, Statins, and Risk of Intracerebral Hemorrhage. Stroke 2013, 44: 3013-3017. PMID: 24008570, PMCID: PMC3873717, DOI: 10.1161/strokeaha.113.001304.
Early-Onset Alopecia and Amyotrophic Lateral Sclerosis: A Cohort StudyFondell E, Fitzgerald KC, Falcone GJ, O'Reilly É, Ascherio A. Early-Onset Alopecia and Amyotrophic Lateral Sclerosis: A Cohort Study. American Journal Of Epidemiology 2013, 178: 1146-1149. PMID: 23942216, PMCID: PMC3783095, DOI: 10.1093/aje/kwt096.
Predictors of Hematoma Volume in Deep and Lobar Supratentorial Intracerebral HemorrhageFalcone GJ, Biffi A, Brouwers HB, Anderson CD, Battey TW, Ayres AM, Vashkevich A, Schwab K, Rost NS, Goldstein JN, Viswanathan A, Greenberg SM, Rosand J. Predictors of Hematoma Volume in Deep and Lobar Supratentorial Intracerebral Hemorrhage. JAMA Neurology 2013, 70: 988-994. PMID: 23733000, PMCID: PMC3808840, DOI: 10.1001/jamaneurol.2013.98.
Warfarin and Statins are Associated with Hematoma Volume in Primary Infratentorial Intracerebral HemorrhageFalcone GJ, Brouwers HB, Biffi A, Anderson CD, Battey TW, Ayres AM, Vashkevich A, Schwab KM, Rost NS, Goldstein JN, Viswanathan A, Greenberg SM, Rosand J. Warfarin and Statins are Associated with Hematoma Volume in Primary Infratentorial Intracerebral Hemorrhage. Neurocritical Care 2013, 21: 192-199. PMID: 23839705, PMCID: PMC4107188, DOI: 10.1007/s12028-013-9839-9.
Magnesium intake and risk of amyotrophic lateral sclerosis: Results from five large cohort studiesFondell E, O’Reilly É, Fitzgerald KC, Falcone GJ, McCullough ML, Park Y, Kolonel LN, Ascherio A. Magnesium intake and risk of amyotrophic lateral sclerosis: Results from five large cohort studies. Amyotrophic Lateral Sclerosis And Frontotemporal Degeneration 2013, 14: 356-361. PMID: 23777266, PMCID: PMC3743429, DOI: 10.3109/21678421.2013.803577.
Novel Insights Into the Genetics of Intracerebral HemorrhageBiffi A, Anderson CD, Falcone GJ, Kissela B, Norrving B, Tirschwell DL, Selim M, Brown DL, Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Broderick JP, Greenberg SM, Roquer J, Lindgren A, Slowik A, Schmidt R, Woo D, Rosand J. Novel Insights Into the Genetics of Intracerebral Hemorrhage. Stroke 2013, 44: s137. PMID: 23709713, DOI: 10.1161/strokeaha.113.001912.
17q25 Locus Is Associated With White Matter Hyperintensity Volume in Ischemic Stroke, But Not With Lacunar Stroke StatusAdib-Samii P, Rost N, Traylor M, Devan W, Biffi A, Lanfranconi S, Fitzpatrick K, Bevan S, Kanakis A, Valant V, Gschwendtner A, Malik R, Richie A, Gamble D, Segal H, Parati EA, Ciusani E, Holliday EG, Maguire J, Wardlaw J, Worrall B, Bis J, Wiggins KL, Longstreth W, Kittner SJ, Cheng YC, Mosley T, Falcone GJ, Furie KL, Leiva-Salinas C, Lau BC, Khan M, Sharma P, Fornage M, Mitchell B, Psaty B, Sudlow C, Levi C, Boncoraglio G, Rothwell P, Meschia J, Dichgans M, Rosand J, Markus H. 17q25 Locus Is Associated With White Matter Hyperintensity Volume in Ischemic Stroke, But Not With Lacunar Stroke Status. Stroke 2013, 44: 1609-1615. PMID: 23674528, PMCID: PMC3771337, DOI: 10.1161/strokeaha.113.679936.
Heritability Estimates Identify a Substantial Genetic Contribution to Risk and Outcome of Intracerebral HemorrhageDevan WJ, Falcone GJ, Anderson CD, Jagiella JM, Schmidt H, Hansen BM, Jimenez-Conde J, Giralt-Steinhauer E, Cuadrado-Godia E, Soriano C, Ayres AM, Schwab K, Kassis SB, Valant V, Pera J, Urbanik A, Viswanathan A, Rost NS, Goldstein JN, Freudenberger P, Stögerer EM, Norrving B, Tirschwell DL, Selim M, Brown DL, Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Montaner J, Fernandez-Cadenas I, Delgado P, Greenberg SM, Roquer J, Lindgren A, Slowik A, Schmidt R, Woo D, Rosand J, Biffi A. Heritability Estimates Identify a Substantial Genetic Contribution to Risk and Outcome of Intracerebral Hemorrhage. Stroke 2013, 44: 1578-1583. PMID: 23559261, PMCID: PMC3684199, DOI: 10.1161/strokeaha.111.000089.
Authors’ Reply: Confounding by Indication in Retrospective Studies of Intracerebral Hemorrhage: Antiepileptic Treatment and MortalityBattey TW, Falcone GJ, Sheth KN, Goldstein JN, Rosand J. Authors’ Reply: Confounding by Indication in Retrospective Studies of Intracerebral Hemorrhage: Antiepileptic Treatment and Mortality. Neurocritical Care 2013, 18: 287-288. PMID: 23408339, DOI: 10.1007/s12028-013-9820-7.
Abstract WP306: Determinants of Hematoma Volume Differ by Location in Intracerebral HemorrhageFalcone G, Biffi A, Brouwers H, Anderson C, Battey T, Ayres A, Vashkevich A, Schwab K, Rost N, Goldstein J, Viswanathan A, Greenberg S, Rosand J. Abstract WP306: Determinants of Hematoma Volume Differ by Location in Intracerebral Hemorrhage. Stroke 2013, 44 DOI: 10.1161/str.44.suppl_1.awp306.
Abstract WP294: CT Angiography Spot Sign Predicts Perioperative Bleeding in Primary Intracerebral HemorrhageBrouwers H, Raffeld M, Falcone G, Ayres A, Schwab K, Romero J, Viswanathan A, Greenberg S, Ogilvy C, Goldstein J, Rosand J. Abstract WP294: CT Angiography Spot Sign Predicts Perioperative Bleeding in Primary Intracerebral Hemorrhage. Stroke 2013, 44 DOI: 10.1161/str.44.suppl_1.awp294.
Abstract TMP84: A Prediction Score for Hematoma Expansion Following Acute Intracerebral HemorrhageBrouwers H, Chang Y, Falcone G, Ayres A, McNamara K, Vashkevich A, Battey T, Valant V, Schwab K, Rost N, Romero J, Viswanathan A, Greenberg S, Rosand J, Goldstein J. Abstract TMP84: A Prediction Score for Hematoma Expansion Following Acute Intracerebral Hemorrhage. Stroke 2013, 44 DOI: 10.1161/str.44.suppl_1.atmp84.
Abstract 118: Burden of Blood Pressure-Related Alleles is Associated with Larger Hematoma Volume and Worse Outcome in Intracerebral HemorrhageFalcone G, Biffi A, Devan W, Brouwers H, Anderson C, Valant V, Ayres A, Schwab K, Rost N, Goldstein J, Viswanathan A, Greenberg S, Selim M, Meschia J, Brown D, Worral B, Silliman S, Tirschwell D, Rosand J. Abstract 118: Burden of Blood Pressure-Related Alleles is Associated with Larger Hematoma Volume and Worse Outcome in Intracerebral Hemorrhage. Stroke 2013, 44 DOI: 10.1161/str.44.suppl_1.a118.
Intakes of vitamin C and carotenoids and risk of amyotrophic lateral sclerosis: Pooled results from 5 cohort studiesFitzgerald KC, O'Reilly ÉJ, Fondell E, Falcone GJ, McCullough ML, Park Y, Kolonel LN, Ascherio A. Intakes of vitamin C and carotenoids and risk of amyotrophic lateral sclerosis: Pooled results from 5 cohort studies. Annals Of Neurology 2013, 73: 236-245. PMID: 23362045, PMCID: PMC3608702, DOI: 10.1002/ana.23820.
Burden of Blood Pressure–Related Alleles Is Associated With Larger Hematoma Volume and Worse Outcome in Intracerebral HemorrhageFalcone GJ, Biffi A, Devan WJ, Brouwers HB, Anderson CD, Valant V, Ayres AM, Schwab K, Rost NS, Goldstein JN, Viswanathan A, Greenberg SM, Selim M, Meschia JF, Brown DL, Worrall BB, Silliman SL, Tirschwell DL, Rosand J. Burden of Blood Pressure–Related Alleles Is Associated With Larger Hematoma Volume and Worse Outcome in Intracerebral Hemorrhage. Stroke 2013, 44: 321-326. PMID: 23321443, PMCID: PMC3560332, DOI: 10.1161/strokeaha.112.675181.
Risk of Intracranial Hemorrhage With Protease-Activated Receptor-1 AntagonistsFalcone GJ, Brouwers HB, Rosand J. Risk of Intracranial Hemorrhage With Protease-Activated Receptor-1 Antagonists. Stroke 2012, 43: 3158-3159. PMID: 23160886, DOI: 10.1161/strokeaha.112.676932.
Premorbid body mass index and risk of amyotrophic lateral sclerosisO'Reilly ÉJ, Wang H, Weisskopf MG, Fitzgerald KC, Falcone G, McCullough ML, Thun M, Park Y, Kolonel LN, Ascherio A. Premorbid body mass index and risk of amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis And Frontotemporal Degeneration 2012, 14: 205-211. PMID: 23134505, PMCID: PMC3615420, DOI: 10.3109/21678421.2012.735240.
Confounding by Indication in Retrospective Studies of Intracerebral Hemorrhage: Antiepileptic Treatment and MortalityBattey TW, Falcone GJ, Ayres AM, Schwab K, Viswanathan A, McNamara KA, DiPucchio ZY, Greenberg SM, Sheth KN, Goldstein JN, Rosand J. Confounding by Indication in Retrospective Studies of Intracerebral Hemorrhage: Antiepileptic Treatment and Mortality. Neurocritical Care 2012, 17: 361-366. PMID: 22965324, PMCID: PMC3707622, DOI: 10.1007/s12028-012-9776-z.
Burden of Risk Alleles for Hypertension Increases Risk of Intracerebral HemorrhageFalcone GJ, Biffi A, Devan WJ, Jagiella JM, Schmidt H, Kissela B, Hansen BM, Jimenez-Conde J, Giralt-Steinhauer E, Elosua R, Cuadrado-Godia E, Soriano C, Ayres AM, Schwab K, Pera J, Urbanik A, Rost NS, Goldstein JN, Viswanathan A, Pichler A, Enzinger C, Norrving B, Tirschwell DL, Selim M, Brown DL, Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Montaner J, Fernandez-Cadenas I, Delgado P, Broderick JP, Greenberg SM, Roquer J, Lindgren A, Slowik A, Schmidt R, Flaherty ML, Kleindorfer DO, Langefeld CD, Woo D, Rosand J. Burden of Risk Alleles for Hypertension Increases Risk of Intracerebral Hemorrhage. Stroke 2012, 43: 2877-2883. PMID: 22933587, PMCID: PMC3479325, DOI: 10.1161/strokeaha.112.659755.
CTA Spot Sign Predicts Hematoma Expansion in Patients with Delayed Presentation After Intracerebral HemorrhageBrouwers HB, Falcone GJ, McNamara KA, Ayres AM, Oleinik A, Schwab K, Romero JM, Viswanathan A, Greenberg SM, Rosand J, Goldstein JN. CTA Spot Sign Predicts Hematoma Expansion in Patients with Delayed Presentation After Intracerebral Hemorrhage. Neurocritical Care 2012, 17: 421-428. PMID: 22878870, PMCID: PMC3707619, DOI: 10.1007/s12028-012-9765-2.
Non-steroidal anti-inflammatory drugs and amyotrophic lateral sclerosis: Results from five prospective cohort studiesFondell E, O'Reilly ÉJ, Fitzgerald KC, Falcone GJ, McCullough ML, Thun MJ, Park Y, Kolonel LN, Ascherio A. Non-steroidal anti-inflammatory drugs and amyotrophic lateral sclerosis: Results from five prospective cohort studies. Amyotrophic Lateral Sclerosis And Frontotemporal Degeneration 2012, 13: 573-579. PMID: 22871075, PMCID: PMC3474335, DOI: 10.3109/17482968.2012.703209.
Abstract 103: Genetic Markers for Hypertension and Body Mass Index are also Associated with Risk of Intracerebral HemorrhageFalcone G, Devan W, Biffi A, Cortellini L, Valant V, Ayres A, Schwab K, Rost N, Goldstein J, Viswanathan A, Greenberg S, Rosand J. Abstract 103: Genetic Markers for Hypertension and Body Mass Index are also Associated with Risk of Intracerebral Hemorrhage. Stroke 2012, 43 DOI: 10.1161/str.43.suppl_1.a103.

Clinical Trials

Conditions	Study Title
Diseases of the Cardiovascular System	Biomarker and Edema Attenuation in IntraCerebral Hemorrhage (BEACH)
Diseases of the Nervous System; Hypertension	Regulating Blood Pressure During Recovery from Intracerebral Hemorrhage and Ischemic Stroke (REDUCE)
Diseases of the Nervous System	Brain Oxygen Optimization in Severe TBI, Phase 3 (BOOST3)
Diseases of the Cardiovascular System; Diseases of the Nervous System	Anticoagulation for Stroke Prevention and Recovery After ICH (ASPIRE)
Diseases of the Nervous System	Transforming Acute Stroke Detection through Real Time Neurological Monitoring

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Guido J. Falcone

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