2013
A randomized, placebo-controlled, double-blind trial of sertraline for postpartum depression
Hantsoo L, Ward-O’Brien D, Czarkowski KA, Gueorguieva R, Price LH, Epperson CN. A randomized, placebo-controlled, double-blind trial of sertraline for postpartum depression. Psychopharmacology 2013, 231: 939-948. PMID: 24173623, PMCID: PMC3945214, DOI: 10.1007/s00213-013-3316-1.Peer-Reviewed Original ResearchConceptsDSM-IV criteriaDouble-blind placebo-controlled trialSelective serotonin reuptake inhibitor sertralineSerotonin reuptake inhibitor sertralineClinical Global Impression scoresHamilton Depression Rating ScaleRating ScaleStrict DSM-IV criteriaDouble-blind trialPlacebo-controlled studyPlacebo-controlled trialHamilton Anxiety Rating ScaleMonths of deliverySubset of womenPrimary outcome variableWeeks of childbirthDepression Rating ScaleGlobal Impression scoresGreater response rateMajor depressive disorderOnset of depressionAnxiety Rating ScaleSignificant groupSertraline 50Remission rate
2001
Maternal Sertraline Treatment and Serotonin Transport in Breast-Feeding Mother-Infant Pairs
Epperson N, Czarkowski KA, Ward-O'Brien D, Weiss E, Gueorguieva R, Jatlow P, Anderson GM. Maternal Sertraline Treatment and Serotonin Transport in Breast-Feeding Mother-Infant Pairs. American Journal Of Psychiatry 2001, 158: 1631-1637. PMID: 11578995, DOI: 10.1176/appi.ajp.158.10.1631.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsPlasma sertralineSertraline treatmentTransporter blockadeBreast-feeding mother-infant pairsMaternal breast milkBreast feeding mothersBreast milk levelsSerotonin reuptake inhibitorsDrug metabolite concentrationsMother-infant pairsSSRI exposureReuptake inhibitorsInfant pairsMaternal treatmentPostpartum onsetBreast milkPharmacological treatmentNursing infantsNursing resultsSerotonin reuptakePlatelet levelsClinical dosesPostpartum depressionMajor depression