2010
Induction of Nogo‐A in Cardiomyopathy
Martin J, Kartje W, Goldspink P, Akar J, Paul C, Sarkey J. Induction of Nogo‐A in Cardiomyopathy. The FASEB Journal 2010, 24: lb563-lb563. DOI: 10.1096/fasebj.24.1_supplement.lb563.Peer-Reviewed Original ResearchHuman cardiac fibroblastsHuman heart samplesAxonal sproutingAgonist treatmentNeuronal plasticityFold increaseCardiac fibroblastsNogo proteinHeart samplesMechanical stretchRT-PCRTissue distributionReticulon protein familyNogoCardiomyocyte experimentsHeart extractsCyclic stretchWestern analysisHeartIsoforms ANonfailingCardiomyopathy
2007
Regulation of ion channels and arrhythmias in the ischemic heart
Akar JG, Akar FG. Regulation of ion channels and arrhythmias in the ischemic heart. Journal Of Electrocardiology 2007, 40: s37-s41. PMID: 17993326, DOI: 10.1016/j.jelectrocard.2007.05.020.Peer-Reviewed Original ResearchConceptsIschemic injuryElectrophysiological changesIschemic heart diseaseBest treatment strategyCoronary eventsReperfusion phaseVentricular arrhythmiasIschemic episodesHeart diseaseLeading causeElectrical dysfunctionTreatment strategiesIschemic heartMetabolic substratesPatientsArrhythmiasKey cellularTime courseInjuryIon channelsHeartDysfunctionMortalityDisease
2006
Mapping arrhythmias in the failing heart: from Langendorff to patient
Akar JG, Akar FG. Mapping arrhythmias in the failing heart: from Langendorff to patient. Journal Of Electrocardiology 2006, 39: s19-s23. PMID: 16920143, DOI: 10.1016/j.jelectrocard.2006.03.011.Peer-Reviewed Educational MaterialsConceptsHeart failureVentricular arrhythmiasOptical action potential mappingSudden cardiac deathCardiac deathIntact tissue preparationsCardiac remodelingMost arrhythmiasArrhythmic substrateArrhythmiasElectrophysiological propertiesMapping arrhythmiasTissue levelsIndividual myocytesMajor causeReentrant excitationOrgan system levelPatientsMultiple mechanismsTissue preparationsHeartRecent findingsHost of changesCellular studiesLangendorff