2021
Changes in ST segment elevation myocardial infarction hospitalisations in China from 2011 to 2015
Zhou T, Li X, Lu Y, Murugiah K, Bai X, Hu S, Gao Y, Masoudi FA, Krumholz HM, Li J, . Changes in ST segment elevation myocardial infarction hospitalisations in China from 2011 to 2015. Open Heart 2021, 8: e001666. PMID: 34599073, PMCID: PMC8488733, DOI: 10.1136/openhrt-2021-001666.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionPrehospital delayMyocardial infarctionSegment elevation myocardial infarctionProportion of patientsElevation myocardial infarctionAcute cardiovascular careAcute myocardial infarctionWeighted national estimateHealth service capacityRisk-adjusted ratesAcute reperfusionEligible patientsHospital deathReperfusion therapyMedical chartsPatient characteristicsHospital treatmentPatient outcomesRandom cohortCardiovascular diseaseCardiovascular carePatientsNational estimatesStandardised definitions
2016
The china patient‐centered evaluative assessment of cardiac events (PEACE) prospective study of percutaneous coronary intervention: Study design
Du X, Pi Y, Dreyer RP, Li J, Li X, Downing NS, Li L, Feng F, Zhan L, Zhang H, Guan W, Xu X, Li S, Lin Z, Masoudi FA, Spertus JA, Krumholz HM, Jiang L, Group F. The china patient‐centered evaluative assessment of cardiac events (PEACE) prospective study of percutaneous coronary intervention: Study design. Catheterization And Cardiovascular Interventions 2016, 88: e212-e221. PMID: 26945565, PMCID: PMC5215582, DOI: 10.1002/ccd.26461.Peer-Reviewed Original ResearchMeSH KeywordsChinaClinical ProtocolsCoronary AngiographyHealth StatusHealthcare DisparitiesHumansMedication AdherenceMyocardial InfarctionPatient Reported Outcome MeasuresPatient-Centered CarePercutaneous Coronary InterventionPredictive Value of TestsProspective StudiesResearch DesignRisk AssessmentRisk FactorsSecondary PreventionTime FactorsTreatment OutcomeConceptsPercutaneous coronary interventionPatient-reported outcomesCardiovascular risk factor controlRisk factor controlProspective studyHealth statusMedical historyLong-term clinical outcomesLong-term patient outcomesHospital-level factorsIndependent core laboratoryNationwide prospective studyLong-term outcomesPatient's medical historyHospital outcomesCoronary interventionPatient demographicsSecondary preventionConsecutive patientsMedical chartsPCI indicationPrimary outcomeClinical outcomesClinical presentationHealthcare utilizationChina Patient-centered Evaluative Assessment of Cardiac Events Prospective Study of Acute Myocardial Infarction: Study Design
Li J, Dreyer RP, Li X, Du X, Downing NS, Li L, Zhang HB, Feng F, Guan WC, Xu X, Li SX, Lin ZQ, Masoudi FA, Spertus JA, Krumholz HM, Jiang LX, Group T. China Patient-centered Evaluative Assessment of Cardiac Events Prospective Study of Acute Myocardial Infarction: Study Design. Chinese Medical Journal 2016, 129: 72-80. PMID: 26712436, PMCID: PMC4797546, DOI: 10.4103/0366-6999.172596.Peer-Reviewed Original ResearchConceptsPatient-reported outcomesAcute myocardial infarctionChina PatientMedical historyMyocardial infarctionPatient experienceLong-term adverse eventsRisk factor controlConsecutive AMI patientsAMI studyPatient's medical historyQuality of lifeNational Coordinating CentreQuality improvement activitiesHospital outcomesCardiac eventsPatient demographicsAdverse eventsMedical chartsHealthcare utilizationAMI patientsMedication adherenceProspective studyHospitalization eventsRisk factors
2014
Place of Residence and Outcomes of Patients With Heart Failure
Bikdeli B, Wayda B, Bao H, Ross JS, Xu X, Chaudhry SI, Spertus JA, Bernheim SM, Lindenauer PK, Krumholz HM. Place of Residence and Outcomes of Patients With Heart Failure. Circulation Cardiovascular Quality And Outcomes 2014, 7: 749-756. PMID: 25074375, PMCID: PMC5323058, DOI: 10.1161/circoutcomes.113.000911.Peer-Reviewed Original ResearchConceptsNeighborhood socioeconomic statusIndividual socioeconomic statusOutcomes of patientsHeart failureHigher SES neighborhoodsSocioeconomic statusClinical factorsHeart Failure Outcomes trialPrimary end pointPatient-level factorsUS internal medicineCause mortalityCause readmissionMultivariable adjustmentOutcome trialsMedical chartsPatient interviewsLow-SES neighborhoodsCardiology practiceMortality ratePatientsPlace of residenceInternal medicineReadmissionEnd point
2007
Assessing surrogacy of data sources for institutional comparisons
Normand S, Wang Y, Krumholz H. Assessing surrogacy of data sources for institutional comparisons. Health Services And Outcomes Research Methodology 2007, 7: 79-96. DOI: 10.1007/s10742-006-0018-8.Peer-Reviewed Original Research
2000
Intracranial Hemorrhage Associated With Thrombolytic Therapy for Elderly Patients With Acute Myocardial Infarction
Brass L, Lichtman J, Wang Y, Gurwitz J, Radford M, Krumholz H. Intracranial Hemorrhage Associated With Thrombolytic Therapy for Elderly Patients With Acute Myocardial Infarction. Stroke 2000, 31: 1802-1811. PMID: 10926938, DOI: 10.1161/01.str.31.8.1802.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionThrombolytic therapyIntracranial hemorrhageMyocardial infarctionElderly patientsIntracranial Hemorrhage AssociatedRetrospective cohort studyRisk stratification scaleMain outcome measuresAcute care hospitalsTissue plasminogen activatorExcessive anticoagulationPrior strokeCohort studyOlder patientsBlood pressureHemorrhage AssociatedIndependent predictorsMedical chartsSerious complicationsMedian weightAlternate therapyBlack racePrincipal diagnosisMedicare patientsMental Disorders and Use of Cardiovascular Procedures After Myocardial Infarction
Druss BG, Bradford DW, Rosenheck RA, Radford MJ, Krumholz HM. Mental Disorders and Use of Cardiovascular Procedures After Myocardial Infarction. JAMA 2000, 283: 506-511. PMID: 10659877, DOI: 10.1001/jama.283.4.506.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryCardiac CatheterizationCohort StudiesComorbidityCoronary Artery BypassFemaleHumansLogistic ModelsMaleMental DisordersMultivariate AnalysisMyocardial InfarctionOutcome Assessment, Health CareRetrospective StudiesSocioeconomic FactorsSurvival AnalysisUnited StatesConceptsPercutaneous transluminal coronary angioplastyComorbid mental disordersAcute myocardial infarctionCardiac catheterizationMyocardial infarctionMental disordersProvider factorsCardiovascular proceduresRates of PTCACoronary artery bypass graft surgeryArtery bypass graft surgeryBypass graft surgeryPatients 65 yearsRetrospective cohort studyTransluminal coronary angioplastyLong-term outcomesCooperative Cardiovascular ProjectCoronary revascularization proceduresSex-based differencesGraft surgeryIndex hospitalizationCohort studyCoronary angioplastyMedical chartsRevascularization procedures
1998
National Use and Effectiveness of β-Blockers for the Treatment of Elderly Patients After Acute Myocardial Infarction: National Cooperative Cardiovascular Project
Krumholz HM, Radford MJ, Wang Y, Chen J, Heiat A, Marciniak TA. National Use and Effectiveness of β-Blockers for the Treatment of Elderly Patients After Acute Myocardial Infarction: National Cooperative Cardiovascular Project. JAMA 1998, 280: 623-629. PMID: 9718054, DOI: 10.1001/jama.280.7.623.Peer-Reviewed Original ResearchConceptsBeta-blocker therapyAcute myocardial infarctionDischarge medicationsElderly patientsMyocardial infarctionPrescribed useNational Cooperative Cardiovascular ProjectBeta-blocker prescriptionRetrospective cohort studyVentricular ejection fractionLow-risk populationCalcium channel blockersCooperative Cardiovascular ProjectFamily practice physiciansBetter survival rateEligible patientsCohort studyHospital dischargeOlder patientsSecondary preventionEjection fractionMedical chartsTreatment patternsClinical variablesPotential confoundersTrends in the Quality of Care for Medicare Beneficiaries Admitted to the Hospital With Unstable Angina
Krumholz H, Philbin D, Wang Y, Vaccarino V, Murillo J, Therrien M, Williams J, Radford M. Trends in the Quality of Care for Medicare Beneficiaries Admitted to the Hospital With Unstable Angina. Journal Of The American College Of Cardiology 1998, 31: 957-963. PMID: 9561993, DOI: 10.1016/s0735-1097(98)00106-5.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngina, UnstableAnticoagulantsAspirinConnecticutFemaleGuideline AdherenceHeparinHospitalsHumansMaleMedicarePlatelet Aggregation InhibitorsPractice Guidelines as TopicQuality Indicators, Health CareQuality of Health CareRetrospective StudiesSurvival AnalysisUnited StatesConceptsUse of aspirinUnstable anginaElderly patientsConsecutive patientsHospital admissionRetrospective cohort studyPrincipal discharge diagnosisPatterns of treatmentCare of patientsGuideline-based useQuality of careHealth care policyAHCPR guidelinesChest painHospital dischargeCohort studyMedical chartsPatient factorsDischarge diagnosisPatient outcomesPractice patternsConnecticut hospitalsPractice guidelinesAnginaMedicare beneficiaries
1997
Thrombolytic Therapy for Eligible Elderly Patients With Acute Myocardial Infarction
Krumholz HM, Murillo JE, Chen J, Vaccarino V, Radford MJ, Ellerbeck EF, Wang Y. Thrombolytic Therapy for Eligible Elderly Patients With Acute Myocardial Infarction. JAMA 1997, 277: 1683-1688. PMID: 9169894, DOI: 10.1001/jama.1997.03540450039032.Peer-Reviewed Original ResearchConceptsST-segment elevationAcute myocardial infarctionThrombolytic therapyBundle branch blockMyocardial infarctionChest painElderly patientsMental statusBranch blockTotal ST-segment elevationEligible elderly patientsThrombolytic therapy useRetrospective cohort studyHours of symptomsOnset of symptomsPopulation-based sampleLack of treatmentDirect angioplastyEligible patientsAbsolute contraindicationBypass surgeryCohort studyMedical chartsTherapy useContiguous leads
1996
Aspirin for secondary prevention after acute myocardial infarction in the elderly: prescribed use and outcomes.
Krumholz HM, Radford MJ, Ellerbeck EF, Hennen J, Meehan TP, Petrillo M, Wang Y, Jencks SF. Aspirin for secondary prevention after acute myocardial infarction in the elderly: prescribed use and outcomes. Annals Of Internal Medicine 1996, 124: 292-8. PMID: 8554223, DOI: 10.7326/0003-4819-124-3-199602010-00002.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrescription of aspirinMyocardial infarctionPatient characteristicsPrescribed useMortality rate 6 monthsBetter overall health statusRate 6 monthsBeta-blocker therapyPatients 65 yearsUse of aspirinPatient demographic characteristicsAcute care hospitalsOverall health statusPrescribed aspirinDischarge medicationsElderly patientsHospital dischargeSecondary preventionCare hospitalClinical factorsMedical chartsMultivariable analysisCardiac proceduresTreatment characteristics