2024
Ischemic Stroke and Reduced Left Ventricular Ejection Fraction: A Multidisciplinary Approach to Optimize Brain and Cardiac Health
McNamara K, Merkler A, Freeman J, Krumholz H, Ahmad T, Sharma R. Ischemic Stroke and Reduced Left Ventricular Ejection Fraction: A Multidisciplinary Approach to Optimize Brain and Cardiac Health. Stroke 2024, 55: 1720-1727. PMID: 38660813, DOI: 10.1161/strokeaha.123.045623.Peer-Reviewed Original ResearchConceptsReduced left ventricular ejection fractionLeft ventricular ejection fractionIschemic strokeVentricular ejection fractionAdverse cardiac outcomesRecurrent acute ischemic strokeAcute ischemic stroke hospitalizationsIschemic stroke hospitalizationsAcute ischemic strokeCardiac healthEjection fractionCardiac outcomesStroke hospitalizationsRisk factorsCare paradigmOptimal brainMultidisciplinary approachHealthBrainBurden of Ischemic and Hemorrhagic Stroke Across the US From 1990 to 2019
Renedo D, Acosta J, Leasure A, Sharma R, Krumholz H, de Havenon A, Alahdab F, Aravkin A, Aryan Z, Bärnighausen T, Basu S, Burkart K, Coberly K, Criqui M, Dai X, Desai R, Dharmaratne S, Doshi R, Elgendy I, Feigin V, Filip I, Gad M, Ghozy S, Hafezi-Nejad N, Kalani R, Karaye I, Kisa A, Krishnamoorthy V, Lo W, Mestrovic T, Miller T, Misganaw A, Mokdad A, Murray C, Natto Z, Radfar A, Ram P, Roth G, Seylani A, Shah N, Sharma P, Sheikh A, Singh J, Song S, Sotoudeh H, Vervoort D, Wang C, Xiao H, Xu S, Zand R, Falcone G, Sheth K. Burden of Ischemic and Hemorrhagic Stroke Across the US From 1990 to 2019. JAMA Neurology 2024, 81: 394-404. PMID: 38436973, PMCID: PMC10913004, DOI: 10.1001/jamaneurol.2024.0190.Peer-Reviewed Original ResearchBurden of strokeHemorrhagic strokeBurden trendsGlobal burdenGlobal Burden of Disease StudyBurden of Disease StudyAge-standardized ratesAge-standardized estimatesPublic health policiesStroke-related outcomesIschemic strokeCross-sectional studyPublic health challengeCross-sectional analysisStroke mortalityStroke burdenHealth policyOlder adultsMain OutcomesStroke incidenceStroke casesIntracerebral hemorrhageEscalating burdenHealth challengesSignificant disparitiesFibrinolytic Agents in Thromboembolic Diseases: Historical Perspectives and Approved Indications
Rashedi S, Greason C, Sadeghipour P, Talasaz A, O'Donoghue M, Jimenez D, Monreal M, Anderson C, Elkind M, Kreuziger L, Lang I, Goldhaber S, Konstantinides S, Piazza G, Krumholz H, Braunwald E, Bikdeli B. Fibrinolytic Agents in Thromboembolic Diseases: Historical Perspectives and Approved Indications. Seminars In Thrombosis And Hemostasis 2024, 50: 773-789. PMID: 38428841, DOI: 10.1055/s-0044-1781451.Peer-Reviewed Original ResearchST-segment elevation myocardial infarctionTissue plasminogen activatorFood and Drug AdministrationFibrinolytic agentsThromboembolic diseasePlasminogen activatorFood and Drug Administration approvalArterial thromboembolic eventsElevation myocardial infarctionCentral venous access device occlusionPlasma half-lifeU.S. Food and Drug AdministrationAcute ischemic strokePulmonary embolismThromboembolic eventsHemodynamic compromiseDevice occlusionTreated patientsRecanalize occluded vesselsActive protease plasminDrug AdministrationMyocardial infarctionApproved indicationsOccluded vesselIschemic stroke
2022
Percutaneous Left Atrial Appendage Occlusion in Comparison to Non‐Vitamin K Antagonist Oral Anticoagulant Among Patients With Atrial Fibrillation
Noseworthy PA, Van Houten HK, Krumholz HM, Kent DM, Abraham NS, Graff‐Radford J, Alkhouli M, Henk HJ, Shah ND, Gersh BJ, Friedman PA, Holmes DR, Yao X. Percutaneous Left Atrial Appendage Occlusion in Comparison to Non‐Vitamin K Antagonist Oral Anticoagulant Among Patients With Atrial Fibrillation. Journal Of The American Heart Association 2022, 11: e027001. PMID: 36172961, PMCID: PMC9673739, DOI: 10.1161/jaha.121.027001.Peer-Reviewed Original ResearchConceptsComposite end pointAtrial appendage occlusionOral anticoagulantsAtrial fibrillationLower riskMajor bleedingSystemic embolismIntracranial bleedingAppendage occlusionNon-Vitamin K Antagonist Oral AnticoagulantsIschemic stroke/systemic embolismK Antagonist Oral AnticoagulantsPrimary composite end pointPropensity score overlap weightingStroke/systemic embolismEnd pointHigh bleeding riskSignificant differencesAntithrombotic regimensBleeding riskCause mortalityBaseline characteristicsComposite outcomeIschemic strokeSecondary outcomes
2021
Association of neighbourhood-level poverty with outcomes and clinical care following atrial fibrillation diagnosis in a universal healthcare system
Akioyamen L, Abdel-Qadir H, Pang A, Ha A, Jackevicius C, Alter D, Bhatia R, Dhalla I, Krumholz H, Roifman I, Wijeysundera H, Atzema C, Ko D, Schull M, Lee D, Investigators T. Association of neighbourhood-level poverty with outcomes and clinical care following atrial fibrillation diagnosis in a universal healthcare system. European Heart Journal 2021, 42: ehab724.0447. DOI: 10.1093/eurheartj/ehab724.0447.Peer-Reviewed Original ResearchAF diagnosisAtrial fibrillation diagnosisUniversal healthcare systemCardiology visitsIschemic strokeDeprivation quintileMedication coverageVascular diseaseCause-specific hazard regression modelStroke/transient ischemic attackPopulation-based cohort studyNeighborhood-level povertyAnti-arrhythmic medicationsHighest deprivation quintileRhythm control interventionsWorse baseline healthHeart failure hospitalizationTransient ischemic attackUniversal healthcareHazards regression modelsHealthcare systemProcess of careCommunity-dwelling adultsEquitable health careLong-term care
2020
Secondary prevention of cardiovascular disease in China
Lu J, Zhang L, Lu Y, Su M, Li X, Liu J, Zhang H, Nasir K, Masoudi F, Krumholz H, Li J, Zheng X. Secondary prevention of cardiovascular disease in China. Heart 2020, 106: 1349-1356. PMID: 31980439, DOI: 10.1136/heartjnl-2019-315884.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAlcohol DrinkingCardiovascular DiseasesChinaFemaleHealthy LifestyleHeart Disease Risk FactorsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedPlatelet Aggregation InhibitorsRisk AssessmentRisk Reduction BehaviorSecondary PreventionSex FactorsSmoking CessationTime FactorsTreatment OutcomeConceptsSecondary prevention drugsIschemic heart diseaseCardiovascular diseasePrevention drugsIschemic strokeSecondary preventionAntiplatelet drugsCardiac Events Million Persons ProjectHistory of IHDMillion Persons ProjectSecondary prevention therapiesPopulation subgroupsMultivariable mixed modelsPublic health programsCommunities of ChinaCurrent smokersCurrent useMedication usePrevention therapyMultivariable analysisChina PatientHeart diseaseCurrent drinkersHealth programsDrugs
2019
P834Secondary prevention medications of cardiovascular diseases in China: findings from China PEACE million persons project
Lu J, Zhang L, Lu Y, Su M, Li X, Li J, Liu J, Zhang H, Nasir K, Masoudi F, Krumholz H, Zheng X. P834Secondary prevention medications of cardiovascular diseases in China: findings from China PEACE million persons project. European Heart Journal 2019, 40: ehz747.0433. DOI: 10.1093/eurheartj/ehz747.0433.Peer-Reviewed Original ResearchSecondary prevention medicationsIschemic heart diseasePrevention medicationsAnti-platelet drugsCardiovascular diseaseMultivariable mixed modelsIschemic strokePopulation subgroupsCardiac Events Million Persons ProjectHistory of IHDPrognosis of CVDMillion Persons ProjectHealth behavior factorsSecondary prevention drugsCause of deathCurrent usePublic health programsPersons ProjectNational Health CommissionCurrent smokersSecondary preventionMedication useMultivariable analysisChina PatientPrevention drugs
2016
Incidence and Determinants of Traumatic Intracranial Bleeding Among Older Veterans Receiving Warfarin for Atrial Fibrillation
Dodson JA, Petrone A, Gagnon DR, Tinetti ME, Krumholz HM, Gaziano JM. Incidence and Determinants of Traumatic Intracranial Bleeding Among Older Veterans Receiving Warfarin for Atrial Fibrillation. JAMA Cardiology 2016, 1: 65. PMID: 27437657, PMCID: PMC5600874, DOI: 10.1001/jamacardio.2015.0345.Peer-Reviewed Original ResearchConceptsTraumatic intracranial bleedingIntracranial bleedingInternational normalized ratioIschemic strokeAtrial fibrillationIncidence rateAnticonvulsant useWarfarin therapyNormalized ratioRisk factorsOlder adultsVeterans AffairsCox proportional hazards regressionVA electronic medical recordsMean patient agePatients 75 yearsRetrospective cohort studyClinical Modification codesCoronary artery diseaseProportional hazards regressionService claims dataVA administrative dataSignificant predictorsHealth care professionalsElectronic medical records
2014
Trends in Hospitalizations and Outcomes for Acute Cardiovascular Disease and Stroke, 1999–2011
Krumholz HM, Normand SL, Wang Y. Trends in Hospitalizations and Outcomes for Acute Cardiovascular Disease and Stroke, 1999–2011. Circulation 2014, 130: 966-975. PMID: 25135276, PMCID: PMC4171056, DOI: 10.1161/circulationaha.113.007787.Peer-Reviewed Original ResearchConceptsAcute cardiovascular diseaseCardiovascular diseaseIschemic strokeUnstable anginaHeart failureMyocardial infarctionNational Medicare dataYears of ageQuality of careDemographic subgroupsReadmission outcomesHospitalization ratesMortality overallService patientsCardiovascular conditionsAdjusted ratesHospitalizationMedicare dataMortality rateStrokeMortalityDiseaseAnginaReadmissionInfarctionNational trends in stroke after acute myocardial infarction among Medicare patients in the United States: 1999 to 2010
Wang Y, Lichtman JH, Dharmarajan K, Masoudi FA, Ross JS, Dodson JA, Chen J, Spertus JA, Chaudhry SI, Nallamothu BK, Krumholz HM. National trends in stroke after acute myocardial infarction among Medicare patients in the United States: 1999 to 2010. American Heart Journal 2014, 169: 78-85.e4. PMID: 25497251, PMCID: PMC4824179, DOI: 10.1016/j.ahj.2014.06.011.Peer-Reviewed Original ResearchRisk Adjustment of Ischemic Stroke Outcomes for Comparing Hospital Performance
Katzan IL, Spertus J, Bettger JP, Bravata DM, Reeves MJ, Smith EE, Bushnell C, Higashida RT, Hinchey JA, Holloway RG, Howard G, King RB, Krumholz HM, Lutz BJ, Yeh RW. Risk Adjustment of Ischemic Stroke Outcomes for Comparing Hospital Performance. Stroke 2014, 45: 918-944. PMID: 24457296, DOI: 10.1161/01.str.0000441948.35804.77.Peer-Reviewed Original ResearchMeSH KeywordsAmerican Heart AssociationBrain IschemiaHospitalsHumansModels, OrganizationalOutcome Assessment, Health CarePatient ReadmissionPredictive Value of TestsPrognosisQuality of Health CareRecovery of FunctionReproducibility of ResultsRisk AdjustmentSample SizeStrokeTreatment OutcomeUnited StatesConceptsIschemic stroke outcomeRisk-adjustment modelsStroke severityStroke outcomeStroke careOutcome measuresHospital levelRisk-adjusted outcome comparisonsRisk adjustmentHospital-level outcomesHospital performanceVascular risk factorsImportant prognostic factorIschemic stroke careIndividual patient levelStroke severity measuresRisk-adjusted modelsHospital-level performanceQuality of strokeComparison of qualityIschemic strokePrognostic factorsComorbid conditionsFunctional outcomeMajor disability
2002
Risk and Predictors of Stroke After Myocardial Infarction Among the Elderly
Lichtman JH, Krumholz HM, Wang Y, Radford MJ, Brass LM. Risk and Predictors of Stroke After Myocardial Infarction Among the Elderly. Circulation 2002, 105: 1082-1087. PMID: 11877359, DOI: 10.1161/hc0902.104708.Peer-Reviewed Original ResearchConceptsMonths of dischargeRisk of strokeAcute myocardial infarctionMyocardial infarctionIschemic strokeOlder patientsStroke admission ratesPatients 75 yearsPeripheral vascular diseasePredictors of strokeRisk stratification scoresRate of admissionSimple clinical factorsPrior strokeStroke admissionsClinical factorsHospital admissionIndependent predictorsStratification scoresAtrial fibrillationBlack racePrincipal diagnosisVascular diseaseAdmission ratesMedicare patients
1998
Warfarin Use Following Ischemic Stroke Among Medicare Patients With Atrial Fibrillation
Brass LM, Krumholz HM, Scinto JD, Mathur D, Radford M. Warfarin Use Following Ischemic Stroke Among Medicare Patients With Atrial Fibrillation. JAMA Internal Medicine 1998, 158: 2093-2100. PMID: 9801175, DOI: 10.1001/archinte.158.19.2093.Peer-Reviewed Original ResearchConceptsUse of warfarinAtrial fibrillationIschemic strokeRecurrent strokeWarfarin useElderly patientsPrincipal diagnosisMedicare patientsLower riskConnecticut Peer Review OrganizationRegimen of warfarinElderly stroke patientsRisk of strokeAcute myocardial infarctionHigh-risk populationHigh rateChart reviewPeer review organizationsStroke patientsMyocardial infarctionWarfarin sodiumPatientsWarfarinFibrillationAnticoagulation