Francis Shue

Project Title: CSF Inflammatory molecules and Alzheimer’s disease biomarkers for predicting cognitive impairment risk in the elderly

Francis Shue is a PhD Candidate in the Neuroscience and Regenerative Medicine tracks at the Mayo Clinic. Her interests include the association of vascular related impacts on Alzheimer’s disease development and how APOE carrier status alters disease pathogenesis. Her CERSI Scholar project aims to identify Alzheimer’s disease biomarkers in asymptomatic human cerebral spinal fluid, taking into consideration an individual patient’s overall clinical diagnostic landscape and APOE genotype. Her project also creates a prediction model system, using known and newly identified inflammatory biomarkers from elderly presymptomatic subjects, that can readily identify a patient’s propensity for normal to a mild cognitive impairment conversion diagnosis.