Adjunct Faculty
Adjunct faculty typically have an academic or research appointment at another institution and contribute or collaborate with one or more School of Medicine faculty members or programs.
Adjunct rank detailsMatthew Lawrence, MD, PhD
About
Research
Publications
2025
Proteomic Signatures of Epigenetic Age in African Green Monkey Cerebrospinal Fluid and Plasma
Elsworth J, Neutzner A, Roux J, Gordevicius J, Milciute M, Dzikiti L, Wakeman D, Danielsson B, Agca C, Lawrence M. Proteomic Signatures of Epigenetic Age in African Green Monkey Cerebrospinal Fluid and Plasma. Aging Cell 2025, e70168. PMID: 40729555, DOI: 10.1111/acel.70168.Peer-Reviewed Original ResearchGroup of proteinsProteomic signatureEpigenetic ageProteomic analysisSignaling pathwayBlood DNAAging biologyProteinPlasma proteinsMonkey cerebrospinal fluidIndividual CSFsBiomarkers of agingIndividual differencesHuman aging studiesPrimate speciesRate of biological agingIndices of agingBiological ageNonhuman primate modelStudy of agingLevels of circulating proteinsDNAPharmacological blocking of microfibrillar-associated protein 4 reduces retinal neoangiogenesis and vascular leakage
Schlosser A, Pilecki B, Allen C, Benest A, Lynch A, Hua J, Ved N, Blackley Z, Andersen T, Hennig D, Graversen J, Möller S, Skallerup S, Ormhøj M, Lange C, Agostini H, Grauslund J, Heegaard S, Dacheva I, Koss M, Hu W, Iglesias B, Lawrence M, Beck H, Steffensen L, Laursen N, Andersen G, Holmskov U, Bates D, Sorensen G. Pharmacological blocking of microfibrillar-associated protein 4 reduces retinal neoangiogenesis and vascular leakage. Molecular Therapy 2025, 33: 1048-1072. PMID: 39863929, PMCID: PMC11897753, DOI: 10.1016/j.ymthe.2025.01.038.Peer-Reviewed Original ResearchConceptsMicrofibrillar-associated protein 4Vascular leakageNeovascular age-related macular degenerationAge-related macular degenerationChoroidal neovascularization mouse modelDiabetic macular edemaProtein 4Treatment of neovascularizationLaser-induced choroidal neovascularization mouse modelVascular leakage areaDuration of efficacyVascular endothelial cellsRetinal neoangiogenesisMacular edemaRetinal neovascularizationMacular degenerationVision lossRetinal diseasesPharmacological blockMuller cellsRetinal astrocytesVascular permeabilityVascular mural cellsEndothelial cell motilityMouse model
2009
Exploration of the African green monkey as a preclinical pharmacokinetic model: oral pharmacokinetic parameters and drug–drug interactions
Ward KW, Coon DJ, Magiera D, Bhadresa S, Struharik M, Lawrence MS. Exploration of the African green monkey as a preclinical pharmacokinetic model: oral pharmacokinetic parameters and drug–drug interactions. Xenobiotica 2009, 39: 266-272. PMID: 19280525, DOI: 10.1080/00498250802657718.Peer-Reviewed Original ResearchConceptsDrug-drug interactionsAfrican green monkeysGreen monkeysPreclinical pharmacokinetic modelKetoconazole co-administrationCo-administration experimentsHuman oral exposureOral pharmacokinetic parametersNon-human primatesOral pharmacokinetic studyCo-administrationDrug interactionsOral exposurePharmacokinetic parametersPharmacokinetic resultsOral pharmacokineticsRhesus monkeysPharmacokinetic modelPharmacokinetic screeningPharmacokinetic studyErythromycinHuman exposureLidocainePropranololMonkeys
2008
Exploration of the African Green Monkey as a Preclinical Pharmacokinetic Model: Intravenous Pharmacokinetic Parameters
Ward KW, Coon DJ, Magiera D, Bhadresa S, Nisbett E, Lawrence MS. Exploration of the African Green Monkey as a Preclinical Pharmacokinetic Model: Intravenous Pharmacokinetic Parameters. Drug Metabolism And Disposition 2008, 36: 715-720. PMID: 18227143, DOI: 10.1124/dmd.107.019315.Peer-Reviewed Original Research
2004
Ocular tissue permeabilities.
Lawrence MS, Miller JW. Ocular tissue permeabilities. International Ophthalmology Clinics 2004, 44: 53-61. PMID: 15211177.Peer-Reviewed Original Research
2000
Gene therapies that enhance hippocampal neuron survival after an excitotoxic insult are not equivalent in their ability to maintain synaptic transmission.
Dumas TC, McLaughlin JR, Ho DY, Lawrence MS, Sapolsky RM. Gene therapies that enhance hippocampal neuron survival after an excitotoxic insult are not equivalent in their ability to maintain synaptic transmission. Experimental Neurology 2000, 166: 180-9. PMID: 11031094, DOI: 10.1006/exnr.2000.7500.Peer-Reviewed Original ResearchLimitations in the neuroprotective potential of gene therapy with Bcl-2.
Phillips RG, Lawrence MS, Ho DY, Sapolsky RM. Limitations in the neuroprotective potential of gene therapy with Bcl-2. Brain Research 2000, 859: 202-6. PMID: 10719065.Peer-Reviewed Original Research