Nenad Sestan, MD, PhD

2025

• PsychENCODE at 10: From genomic maps to mechanistic insights in mental illness

  Roussos P, Vaccarino F, Weng Z, Sestan N, Gerstein M, Geschwind D. PsychENCODE at 10: From genomic maps to mechanistic insights in mental illness. Neuron 2025, 113: 4099-4102. PMID: 41412064, DOI: 10.1016/j.neuron.2025.11.027.

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• Spatial dynamics of brain development and neuroinflammation

  Zhang D, Rubio Rodríguez-Kirby L, Lin Y, Wang W, Song M, Wang L, Wang L, Kanatani S, Jimenez-Beristain T, Dang Y, Zhong M, Kukanja P, Bao S, Wang S, Chen X, Gao F, Wang D, Xu H, Ma C, Lou X, Liu Y, Chen J, Sestan N, Uhlén P, Kriegstein A, Zhao H, Castelo-Branco G, Fan R. Spatial dynamics of brain development and neuroinflammation. Nature 2025, 647: 213-227. PMID: 41193846, PMCID: PMC12589135, DOI: 10.1038/s41586-025-09663-y.

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• The new frontier in understanding human and mammalian brain development

  Nowakowski T, Nano P, Matho K, Chen X, Corrigan E, Ding W, Gao Y, Heffel M, Jayakumar J, Kaplan H, Kronman F, Kovner R, Mannens C, Song M, Steyert M, Venkatesan S, Wallace J, Wang L, Werner J, Zhang D, Yuan G, Zuo G, Ament S, Colantuoni C, Dulac C, Fan R, Gillis J, Kriegstein A, Krienen F, Kim Y, Linnarsson S, Mitra P, Pollen A, Sestan N, Tward D, van Velthoven C, Yao Z, Bhaduri A, Zeng H. The new frontier in understanding human and mammalian brain development. Nature 2025, 647: 51-59. PMID: 41193845, DOI: 10.1038/s41586-025-09652-1.

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• Unique and divergent features of human brain development

  Salamon I, Doyle D, Bandler R, Pattabiraman K, Sestan N. Unique and divergent features of human brain development. Current Opinion In Neurobiology 2025, 95: 103133. PMID: 41187489, PMCID: PMC12626412, DOI: 10.1016/j.conb.2025.103133.

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• Early developmental origins of cortical disorders modeled in human neural stem cells

  Mato-Blanco X, Kim S, Jourdon A, Ma S, Choi S, Giani A, Paredes M, Tebbenkamp A, Liu F, Duque A, Vaccarino F, Sestan N, Colantuoni C, Rakic P, Santpere G, Micali N. Early developmental origins of cortical disorders modeled in human neural stem cells. Nature Communications 2025, 16: 6347. PMID: 40634286, PMCID: PMC12241556, DOI: 10.1038/s41467-025-61316-w.

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• Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques

  Joyce M, Ivanov T, Krienen F, Mitchell J, Ma S, Inoue W, Nandy A, Datta D, Duque A, Arellano J, Gupta R, Gonzalez-Burgos G, Lewis D, Sestan N, McCarroll S, Martinez-Trujillo J, Froudist-Walsh S, Arnsten A. Higher dopamine D1 receptor expression in prefrontal parvalbumin neurons underlies higher distractibility in marmosets versus macaques. Communications Biology 2025, 8: 974. PMID: 40594842, PMCID: PMC12214923, DOI: 10.1038/s42003-025-08297-0.

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• Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD

  Hwang A, Skarica M, Xu S, Coudriet J, Lee C, Lin L, Terwilliger R, Sliby A, Wang J, Nguyen T, Li H, Wu M, Dai Y, Duan Z, Srinivasan S, Zhang X, Lin Y, Cruz D, Deans P, Huber B, Levey D, Glausier J, Lewis D, Gelernter J, Holtzheimer P, Friedman M, Gerstein M, Sestan N, Brennand K, Xu K, Zhao H, Krystal J, Young K, Williamson D, Che A, Zhang J, Girgenti M. Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD. Nature 2025, 643: 744-754. PMID: 40533550, PMCID: PMC12267058, DOI: 10.1038/s41586-025-09083-y.

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• Spatial transcriptomics reveals human cortical layer and area specification

  Qian X, Coleman K, Jiang S, Kriz A, Marciano J, Luo C, Cai C, Manam M, Caglayan E, Lai A, Exposito-Alonso D, Otani A, Ghosh U, Shao D, Andersen R, Neil J, Johnson R, LeFevre A, Hecht J, Micali N, Sestan N, Rakic P, Miller M, Sun L, Stringer C, Li M, Walsh C. Spatial transcriptomics reveals human cortical layer and area specification. Nature 2025, 644: 153-163. PMID: 40369074, PMCID: PMC12328223, DOI: 10.1038/s41586-025-09010-1.

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• Decoding human brain evolution: Insights from genomics

  Liu Y, Li M, Segal A, Zhang M, Sestan N. Decoding human brain evolution: Insights from genomics. Current Opinion In Neurobiology 2025, 92: 103033. PMID: 40334295, DOI: 10.1016/j.conb.2025.103033.

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• 54. Molecular Specification of Claustro-Amygdalar and Paleocortical Excitatory Neurons and Connectivity

  Kaur N, Kovner R, Andrijevic D, Zhu T, Shibata M, Shibata A, Pattabiraman K, Minuer Y, Picciotto M, Huang H, Sestan N. 54. Molecular Specification of Claustro-Amygdalar and Paleocortical Excitatory Neurons and Connectivity. Biological Psychiatry 2025, 97: s117. DOI: 10.1016/j.biopsych.2025.02.291.

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