2024
Stepped Care for Patients to Optimize Whole Recovery (SC-POWR): An Effectiveness Trial Evaluating a Stepped Care Model for Individuals With Opioid Use Disorder and Chronic Pain.
Rossi R, Cutter C, Beitel M, Covelli M, Fiellin D, Kerns R, Vassilieva S, Olabisi D, Barry D. Stepped Care for Patients to Optimize Whole Recovery (SC-POWR): An Effectiveness Trial Evaluating a Stepped Care Model for Individuals With Opioid Use Disorder and Chronic Pain. Substance Use & Addiction Journal 2024, 29767342241245095. PMID: 38606900, DOI: 10.1177/29767342241245095.Peer-Reviewed Original ResearchTreatment-as-usualOpioid use disorderChronic painCognitive behavioral therapyStepped careNonmedical opioid useEffectiveness trialOpioid useAlcohol useSession of exerciseStepped care modelWeekly group sessionsPain-related outcomesStress reductionDecreased pain intensityUse disorderNational Institutes of HealthOpioid use disorder treatmentCare modelInstitutes of HealthAssociated with higher levelsPain intensityPilot study of patientsPain improvementDurability of treatment response
2023
Long-term opioid therapy trajectories and overdose in patients with and without cancer.
Merlin J, Black A, Midboe A, Troszak L, Asch S, Bohnert A, Fenton B, Giannitrapani K, Glassman P, Kerns R, Silveira M, Lorenz K, Abel E, Becker W. Long-term opioid therapy trajectories and overdose in patients with and without cancer. BMJ Oncology 2023, 2: e000023. PMID: 38259328, PMCID: PMC10802123, DOI: 10.1136/bmjonc-2022-000023.Peer-Reviewed Original ResearchLong-term opioid therapyVeterans Health Administration databaseRetrospective cohort studyCornerstone of managementOpioid overdose riskHealth Administration databaseOpioid-related overdosesPresence of cancerRole of cancerOpioid receiptOpioid therapyCohort studyConclusions PatientsMost patientsObjective painOpioid risksDose/Opioid overdoseOverdose riskInternational ClassificationLower riskPatientsEffect of trajectoriesCancerAdministration databaseResearch objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement
Hohenschurz-Schmidt D, Cherkin D, Rice A, Dworkin R, Turk D, McDermott M, Bair M, DeBar L, Edwards R, Farrar J, Kerns R, Markman J, Rowbotham M, Sherman K, Wasan A, Cowan P, Desjardins P, Ferguson M, Freeman R, Gewandter J, Gilron I, Grol-Prokopczyk H, Hertz S, Iyengar S, Kamp C, Karp B, Kleykamp B, Loeser J, Mackey S, Malamut R, McNicol E, Patel K, Sandbrink F, Schmader K, Simon L, Steiner D, Veasley C, Vollert J. Research objectives and general considerations for pragmatic clinical trials of pain treatments: IMMPACT statement. Pain 2023, 164: 1457-1472. PMID: 36943273, PMCID: PMC10281023, DOI: 10.1097/j.pain.0000000000002888.Peer-Reviewed Original ResearchConceptsPragmatic trialPain treatmentClinical careSystematic reviewAddiction Clinical Trial TranslationsNetworks (ACTTION) public-private partnershipTraditional efficacy trialsRoutine clinical careDaily clinical carePragmatic clinical trialsEvidence-based treatmentsRelated health policiesInternal validityPain assessmentClinical managementClinical trialsEfficacy trialsConsensus meetingTrial designConsensus discussionTrial objectivesSuch trialsHealth policyTrialsExpert presentationsReal-world data and evidence in pain research: a qualitative systematic review of methods in current practice
Vollert J, Kleykamp B, Farrar J, Gilron I, Hohenschurz-Schmidt D, Kerns R, Mackey S, Markman J, McDermott M, Rice A, Turk D, Wasan A, Dworkin R. Real-world data and evidence in pain research: a qualitative systematic review of methods in current practice. PAIN Reports 2023, 8: e1057. PMID: 36741790, PMCID: PMC9891449, DOI: 10.1097/pr9.0000000000001057.Peer-Reviewed Original Research
2022
Intervention Fidelity in Pain Pragmatic Trials for Nonpharmacologic Pain Management: Nuanced Considerations for Determining PRECIS-2 Flexibility in Delivery and Adherence
Kerns R, Davis A, Fritz J, Keefe F, Peduzzi P, Rhon D, Taylor S, Vining R, Yu Q, Zeliadt S, George S. Intervention Fidelity in Pain Pragmatic Trials for Nonpharmacologic Pain Management: Nuanced Considerations for Determining PRECIS-2 Flexibility in Delivery and Adherence. Journal Of Pain 2022, 24: 568-574. PMID: 36574858, PMCID: PMC10079571, DOI: 10.1016/j.jpain.2022.12.008.Peer-Reviewed Original ResearchConceptsPragmatic clinical trialsDelivery of interventionsClinical trialsNonpharmacologic pain managementPain management strategiesRoutine clinical settingPain managementNonpharmacological treatmentsRoutine careNonpharmacological interventionsPragmatic trialIntervention core componentsProvider trainingReal-world settingClinical settingIntervention fidelityTreatment flexibilityTrialsInterventionTreatment effectsDegree of pragmatismImplementation barriersAdherenceIntervention monitoringDeliveryOptimizing and Accelerating the Development of Precision Pain Treatments for Chronic Pain: IMMPACT Review and Recommendations
Edwards RR, Schreiber KL, Dworkin RH, Turk DC, Baron R, Freeman R, Jensen TS, Latremoliere A, Markman JD, Rice ASC, Rowbotham M, Staud R, Tate S, Woolf CJ, Andrews NA, Carr DB, Colloca L, Cosma-Roman D, Cowan P, Diatchenko L, Farrar J, Gewandter JS, Gilron I, Kerns RD, Marchand S, Niebler G, Patel KV, Simon LS, Tockarshewsky T, Vanhove GF, Vardeh D, Walco GA, Wasan AD, Wesselmann U. Optimizing and Accelerating the Development of Precision Pain Treatments for Chronic Pain: IMMPACT Review and Recommendations. Journal Of Pain 2022 PMID: 36198371, DOI: 10.1016/j.jpain.2022.08.010.Peer-Reviewed Original ResearchMental Health Diagnoses are Not Associated With Indicators of Lower Quality Pain Care in Electronic Health Records of a National Sample of Veterans Treated in Veterans Health Administration Primary Care Settings
Dobscha SK, Luther SL, Kerns RD, Finch DK, Goulet JL, Brandt CA, Skanderson M, Bathulapalli H, Fodeh SJ, Hahm B, Bouayad L, Lee A, Han L. Mental Health Diagnoses are Not Associated With Indicators of Lower Quality Pain Care in Electronic Health Records of a National Sample of Veterans Treated in Veterans Health Administration Primary Care Settings. Journal Of Pain 2022, 24: 273-281. PMID: 36167230, PMCID: PMC9898089, DOI: 10.1016/j.jpain.2022.08.009.Peer-Reviewed Original ResearchConceptsPain care qualityQuality pain careMental health conditionsPrimary care cliniciansVeterans Health AdministrationPain carePCQ scoresHealth conditionsCare cliniciansUse disordersCare qualitySevere musculoskeletal painRetrospective cohort studyPrimary care visitsGeneral medical carePrimary care settingElectronic health record dataFinal adjusted modelMental health diagnosesEquation Poisson modelsHealth record dataBipolar disorder diagnosisSubstance use disordersAlcohol use disorderPost-traumatic stress disorderAn Analysis of the Role of Mental Health in a Randomized Trial of a Walking Intervention for Black Veterans With Chronic Pain
Hammett PJ, Eliacin J, Makris UE, Allen KD, Kerns RD, Heapy A, Goldsmith ES, Meis LA, Taylor BC, Saenger M, Cross LJS, Do T, Branson M, Burgess DJ. An Analysis of the Role of Mental Health in a Randomized Trial of a Walking Intervention for Black Veterans With Chronic Pain. Journal Of Pain 2022, 24: 55-67. PMID: 36162790, DOI: 10.1016/j.jpain.2022.07.002.Peer-Reviewed Original ResearchConceptsMental health disordersPain-related disabilityCo-occurring mental health disordersUsual careChronic painHealth disordersIntensive treatmentBlack veteransVA health care systemChronic musculoskeletal painChronic pain patientsMental health diagnosesTelephone coaching sessionsHealth care systemMusculoskeletal painPain patientsBlack patientsPainSecondary analysisPatientsMental healthCare systemHealth diagnosisIntervention effectivenessDisordersPerspectives on participation in clinical trials among individuals with pain, depression, and/or anxiety: an ACTTION scoping review.
Ferguson MC, McNicol E, Kleykamp BA, Sandoval K, Haroutounian S, Holzer KJ, Kerns RD, Veasley C, Turk DC, Dworkin RH. Perspectives on participation in clinical trials among individuals with pain, depression, and/or anxiety: an ACTTION scoping review. The Journal Of Pain : Official Journal Of The American Pain Society 2022 PMID: 36152760, DOI: 10.1016/j.jpain.2022.09.001.Peer-Reviewed Original ResearchPatient-Centered Pain Care Using Artificial Intelligence and Mobile Health Tools
Piette JD, Newman S, Krein SL, Marinec N, Chen J, Williams DA, Edmond SN, Driscoll M, LaChappelle KM, Kerns RD, Maly M, Kim HM, Farris KB, Higgins DM, Buta E, Heapy AA. Patient-Centered Pain Care Using Artificial Intelligence and Mobile Health Tools. JAMA Internal Medicine 2022, 182: 975-983. PMID: 35939288, PMCID: PMC9361183, DOI: 10.1001/jamainternmed.2022.3178.Peer-Reviewed Original ResearchConceptsCBT-CPComparative effectiveness trialTherapist timeSecondary outcomesMore patientsEffectiveness trialInteractive voice responseCP groupMeaningful improvementsPatient-centered pain careRoland-Morris Disability QuestionnaireVeterans Affairs Health SystemMorris Disability QuestionnairePain intensity scoresChronic back painLess therapist timeMobile health toolsCognitive behavioral therapyRandomized noninferiorityDisability QuestionnaireNoninferiority criteriaOpioid analgesicsPain intensityPain therapyPrimary outcomeTIDieR-telehealth: precision in reporting of telehealth interventions used in clinical trials - unique considerations for the Template for the Intervention Description and Replication (TIDieR) checklist
Rhon DI, Fritz JM, Kerns RD, McGeary DD, Coleman BC, Farrokhi S, Burgess DJ, Goertz CM, Taylor SL, Hoffmann T. TIDieR-telehealth: precision in reporting of telehealth interventions used in clinical trials - unique considerations for the Template for the Intervention Description and Replication (TIDieR) checklist. BMC Medical Research Methodology 2022, 22: 161. PMID: 35655144, PMCID: PMC9161193, DOI: 10.1186/s12874-022-01640-7.Peer-Reviewed Original ResearchConceptsTelehealth interventionsReplication (TIDieR) checklistIntervention DescriptionMethodsA working groupPain Management CollaboratoryFuture clinical trialsRemote care deliveryClinical trialsCare deliveryHealth interventionsHealth systemPrimary investigatorHealth eventsIntervention guidelinesRelevant interventionsComplete reportingInterventionUnique considerationsTrialsChecklist developmentReporting guideChecklistWorking GroupPast yearReportingSelf-Management of Chronic Pain: Psychologically Guided Core Competencies for Providers
Kerns RD, Burgess DJ, Coleman BC, Cook CE, Farrokhi S, Fritz JM, Goertz C, Heapy A, Lisi AJ, Rhon DI, Vining R. Self-Management of Chronic Pain: Psychologically Guided Core Competencies for Providers. Pain Medicine 2022, 23: 1815-1819. PMID: 35642906, PMCID: PMC9629397, DOI: 10.1093/pm/pnac083.Peer-Reviewed Original ResearchBrief Educational Video plus Telecare to Enhance Recovery for Older Emergency Department Patients with Acute Musculoskeletal Pain: an update to the study protocol for a randomized controlled trial
Hurka-Richardson K, Platts-Mills TF, McLean SA, Weinberger M, Stearns SC, Bush M, Quackenbush E, Chari S, Aylward A, Kroenke K, Kerns RD, Weaver MA, Keefe FJ, Berkoff D, Meyer ML. Brief Educational Video plus Telecare to Enhance Recovery for Older Emergency Department Patients with Acute Musculoskeletal Pain: an update to the study protocol for a randomized controlled trial. Trials 2022, 23: 400. PMID: 35550175, PMCID: PMC9096747, DOI: 10.1186/s13063-022-06310-z.Peer-Reviewed Original ResearchConceptsUrgent care clinicMusculoskeletal painCare clinicsOlder emergency department (ED) patientsAcute care visitsAcute musculoskeletal painEmergency department patientsWeeks of enrollmentCOVID-19 pandemicBrief educational videoCare visitsOpioid useDepartment patientsChronic painEmergency departmentStudy protocolFavorable outcomeInclusion criteriaRecruitment sitesEligibility criteriaMedical treatmentBETTER trialRemote recruitmentPainParticipant enrollmentSelf-Reported Cannabis Use and HIV Viral Control among Patients with HIV Engaged in Care: Results from a National Cohort Study
Bahji A, Li Y, Vickers-Smith R, Crystal S, Kerns RD, Gordon KS, Macmadu A, Skanderson M, So-Armah K, Sung ML, Bhondoekhan F, Marshall BDL, Edelman EJ. Self-Reported Cannabis Use and HIV Viral Control among Patients with HIV Engaged in Care: Results from a National Cohort Study. International Journal Of Environmental Research And Public Health 2022, 19: 5649. PMID: 35565045, PMCID: PMC9101884, DOI: 10.3390/ijerph19095649.Peer-Reviewed Original ResearchConceptsDetectable viral loadPast-year cannabis useViral loadAntiretroviral therapyCannabis useCohort studyUnadjusted analysesViral controlDetectable HIV viral loadVeterans Aging Cohort StudyHIV viral controlHIV viral loadAging Cohort StudyFirst study visitHIV-1 RNANational cohort studyBenefits of cannabisSelf-reported cannabis usePast-year useMean ageStudy visitHigher oddsPWHSignificant associationSubstance useLong-term Opioid Therapy and Overdose in Patients with and without Cancer
Merlin J, Black A, Midboe A, Troszak L, Asch S, Bohnert A, Fenton B, Giannitrapani K, Glassman P, Kerns R, Silveira M, Lorenz K, Becker W. Long-term Opioid Therapy and Overdose in Patients with and without Cancer. Journal Of Pain 2022, 23: 60. DOI: 10.1016/j.jpain.2022.03.225.Peer-Reviewed Original ResearchLong-term opioid therapyOpioid therapyCox proportional hazard modelingElectronic health record databaseCancer pain managementRetrospective cohort studyProportional hazard modelingOpioid overdose riskHealth record databasePresence of cancerRole of cancerOpioid receiptCohort entryCohort studyHazard ratioMost patientsPain managementOpioid risksDose/Inclusion criteriaOpioid overdoseOverdose riskLatent growth mixture modelingLower riskPatientsAssociation Between Exposure to Complementary and Integrative Therapies and Opioid Analgesic Daily Dose Among Patients on Long-term Opioid Therapy
Black AC, Zeliadt SB, Kerns RD, Skanderson M, Wang R, Gelman H, Douglas JH, Becker WC. Association Between Exposure to Complementary and Integrative Therapies and Opioid Analgesic Daily Dose Among Patients on Long-term Opioid Therapy. The Clinical Journal Of Pain 2022, 38: 405-409. PMID: 35440528, DOI: 10.1097/ajp.0000000000001039.Peer-Reviewed Original ResearchConceptsLong-term opioid therapyMorphine equivalent daily doseVeterans Health AdministrationDaily doseCIH exposureOpioid doseOpioid therapyWhole health systemCIH useVHA electronic health recordsIntegrative health modalitiesOpioid analgesic doseMean starting doseMental health diagnosesElectronic health recordsAnalgesic doseCIH therapiesNonopioid treatmentCohort entryOpioid taperingStarting doseAdverse eventsPain intensityChiropractic careVHA facilitiesLongitudinal analysis of the prevalence and correlates of heavy episodic drinking and self‐reported opioid use among a national cohort of patients with HIV
Oldfield BJ, Li Y, Vickers‐Smith R, Barry DT, Crystal S, Gordon KS, Kerns RD, Williams EC, Marshall BDL, Edelman EJ. Longitudinal analysis of the prevalence and correlates of heavy episodic drinking and self‐reported opioid use among a national cohort of patients with HIV. Alcohol Clinical And Experimental Research 2022, 46: 600-613. PMID: 35257397, PMCID: PMC9018502, DOI: 10.1111/acer.14801.Peer-Reviewed Original ResearchConceptsSelf-reported opioid useOpioid useHeavy episodic drinkingNational cohortRisk factorsDepressive symptomsVeterans Aging Cohort StudyVeterans Health Administration sitesOpioid-related risksHIV disease progressionModifiable risk factorsPast-year cigarette smokingAging Cohort StudyGreater illness severityEpisodic drinkingOpioid-related overdoseHigh-risk drinkingCohort studyProspective cohortIllness severityCigarette smokingClinical correlatesDisease progressionLower oddsMultinomial logistic regressionIf you personalize it, will they use it?: Self-reported and observed use of a tailored, internet-based pain self-management program
Reuman L, Solar C, MacLean RR, Halat AM, Rajeevan H, Williams DA, Heapy AA, Bair MJ, Krein SL, Kerns RD, Higgins DM. If you personalize it, will they use it?: Self-reported and observed use of a tailored, internet-based pain self-management program. Translational Behavioral Medicine 2022, 12: 693-701. PMID: 35192703, PMCID: PMC9154266, DOI: 10.1093/tbm/ibab165.Peer-Reviewed Original ResearchEngaging Veterans and Military Service Members to Optimize Pragmatic Clinical Trials of Nonpharmacological Approaches for Pain Management
Anicich A, Katsovich L, Kerns RD. Engaging Veterans and Military Service Members to Optimize Pragmatic Clinical Trials of Nonpharmacological Approaches for Pain Management. Pain Medicine 2022, 23: pnac020-. PMID: 35143672, PMCID: PMC9425849, DOI: 10.1093/pm/pnac020.Peer-Reviewed Original ResearchTaking ACTION to Reduce Pain: a Randomized Clinical Trial of a Walking-Focused, Proactive Coaching Intervention for Black Patients with Chronic Musculoskeletal Pain
Burgess DJ, Hagel Campbell E, Hammett P, Allen KD, Fu SS, Heapy A, Kerns RD, Krein SL, Meis LA, Bangerter A, Cross LJS, Do T, Saenger M, Taylor BC. Taking ACTION to Reduce Pain: a Randomized Clinical Trial of a Walking-Focused, Proactive Coaching Intervention for Black Patients with Chronic Musculoskeletal Pain. Journal Of General Internal Medicine 2022, 37: 3585-3593. PMID: 35132545, PMCID: PMC9585120, DOI: 10.1007/s11606-021-07376-2.Peer-Reviewed Original ResearchConceptsBlack patientsUsual careSecondary outcomesPain intensityPrimary outcomeChronic painIntervention participantsVA health care systemMasked outcome assessmentChronic musculoskeletal painMental health comorbiditiesChronic pain outcomesAverage daily stepsTelephone coaching sessionsMain MeasuresPrimary outcomesCoaching interventionHealth care systemResultsThe interventionHealth comorbiditiesMusculoskeletal painPain outcomesSevere chronicPain interferenceGlobal ImpressionMeasuresPrimary outcomes