2024
Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study
Puklin L, Irwin M, Sanft T, Ferrucci L, Harrigan M, McGowan C, Cartmel B, Zupa M, Winer E, Deyling M, Ligibel J, Basen-Engquist K, Spiegelman D, Sharifi M. Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study. Supportive Care In Cancer 2024, 32: 590. PMID: 39141176, DOI: 10.1007/s00520-024-08789-5.Peer-Reviewed Original ResearchConceptsPhysical activityLifestyle interventionSelf-reported PA questionnaireSelf-reported diet qualityBreast cancerHealthy Eating Index-2015Stage I-III breast cancerBenefits of PASequential mixed methods studyI-III breast cancerChemotherapy-related symptomsMixed methods studyThematic content analysisBehavioral goalsSense of controlBody mass indexPA questionnaireSemi-structured interviewsMean body mass indexTranscribed verbatimIntervention armTailored educationDiet qualityNutritional behaviorMental benefitsEffects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi‐centre factorial randomized trial
Brown J, Spielmann G, Yang S, Compton S, Jones L, Irwin M, Ligibel J, Meyerhardt J. Effects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi‐centre factorial randomized trial. Journal Of Cachexia Sarcopenia And Muscle 2024, 15: 1520-1527. PMID: 38887915, PMCID: PMC11294014, DOI: 10.1002/jcsm.13509.Peer-Reviewed Original ResearchAerobic exerciseMyokine concentrationsStage I-III breastColorectal cancer survivorsEffects of exerciseColorectal cancerLinear mixed-effects regression modelsMixed-effects regression modelsCancer survivorsPhysical activityType I error rateExerciseMyokinesPilot studyRegression modelsCancer patientsRandomized trialsHypothesis-generating analysisMultiple comparisonsBreastSkeletal muscleInterleukin-15Clinical outcomesCancerPatientsTrends and predictors of Quality of Life in lung cancer survivors
Bade B, Zhao J, Li F, Tanoue L, Lazowski H, Alfano C, Silvestri G, Irwin M. Trends and predictors of Quality of Life in lung cancer survivors. Lung Cancer 2024, 191: 107793. PMID: 38640687, DOI: 10.1016/j.lungcan.2024.107793.Peer-Reviewed Original ResearchConceptsFunctional Assessment of Cancer Therapy - LungNon-small cell lung cancerHR-QOL scoresLung cancer survivorsHR-QOLAdvanced stage non-small cell lung cancerEarly-stage non-small cell lung cancerStage non-small cell lung cancerQuality of lifeCancer survivorsPhysical activityCell lung cancerEarly-stage diseasePredictors of quality of lifeHealth-related quality of lifeFollow-upHealth-related qualityHealthy weight maintenancePerformance statusAdvanced-stage non-small cell lung cancerLung cancerClinical significanceAssociated with older ageDiagnosed NSCLCTreatment-related side effectsImproving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial
Puklin L, Ferrucci L, Harrigan M, McGowan C, Zupa M, Cartmel B, Li F, Ligibel J, Spiegelman D, Sharifi M, Sanft T, Irwin M. Improving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial. Cancer 2024, 130: 2440-2452. PMID: 38470431, PMCID: PMC11214600, DOI: 10.1002/cncr.35280.Peer-Reviewed Original ResearchPhysical activityDiet qualityHEI-2015Strength trainingLifestyle behaviorsHealthy Eating Index (HEI)-2015Breast cancerAssociated with baseline fatigueImprove physical activityImprove lifestyle behaviorsHigher HEI-2015Associated with higher oddsExercise interventionUsual careIntervention armIntervention groupBaseline fatigueLifestyle interventionYearlong interventionLower fatigueHigher oddsSecondary analysisLogistic regressionNewly diagnosed patientsStudy armsAssociation between diet quality and ovarian cancer risk and survival
Cao A, Esserman D, Cartmel B, Irwin M, Ferrucci L. Association between diet quality and ovarian cancer risk and survival. Journal Of The National Cancer Institute 2024, 116: 1095-1104. PMID: 38400738, PMCID: PMC11223874, DOI: 10.1093/jnci/djae040.Peer-Reviewed Original ResearchOvarian cancer riskAll-cause mortalityAssociated with lower all-cause mortalityDiet qualityCancer riskOvarian cancer diagnosisAssociated with ovarian cancer riskPre-diagnosisProspective NIH-AARP DietHealthy Eating Index-2015Cancer diagnosisNIH-AARP DietStop Hypertension scoreCancer registry dataEpithelial ovarian cancerMediterranean diet scoreFood frequency questionnaireCox proportional hazards regressionOvarian cancerProportional hazards regressionHEI-2015Health StudyHypertension scoreDiet scoreFrequency questionnaireUnited States Long-Term Trends in Adult BMI (1959–2018): Unraveling the Roots of the Obesity Epidemic
Banas J, Cook A, Raygoza-Cortez K, Davila D, Irwin M, Ferrucci L, Humphries D. United States Long-Term Trends in Adult BMI (1959–2018): Unraveling the Roots of the Obesity Epidemic. International Journal Of Environmental Research And Public Health 2024, 21: 73. PMID: 38248537, PMCID: PMC10815706, DOI: 10.3390/ijerph21010073.Peer-Reviewed Original ResearchNational Health Examination SurveyExamination SurveyObesity epidemicBody mass index (BMI) trendsOngoing obesity epidemicCritical public health challengeNutrition Examination SurveyHealth Examination SurveyRates of obesityPublic health challengePopulation-level interventionsBMI growth rateEffective population-level interventionsRace/ethnicityAverage BMIAdult BMINational HealthBMI trendsHigh school educationWhite adultsAge groupsBlack adultsHealth challengesBMIRacial disparities
2023
Exploring anxiety as an influencing factor of the impact of exercise and mind-body prehabilitation on cognitive functioning among women undergoing breast cancer surgery
Knoerl R, Sannes T, Giobbie-Hurder A, Frank E, McTiernan A, Winer E, Irwin M, Ligibel J. Exploring anxiety as an influencing factor of the impact of exercise and mind-body prehabilitation on cognitive functioning among women undergoing breast cancer surgery. Journal Of Psychosocial Oncology 2023, 42: 448-456. PMID: 38044630, DOI: 10.1080/07347332.2023.2282021.Peer-Reviewed Original ResearchCognitive functioningWorse cognitive functioningBreast cancer surgerySelf-report measuresTime of diagnosisAssessment of anxietyBreast cancerCancer surgeryCognitive functionGreater anxietyAnxiety managementPrehabilitation interventionsAnxietyLinear modelingFunctioningSignificant anxietyAcademic cancer centerImpact of exerciseImpact of baselinePrevalence of anxietyParticipantsOne-unit decreaseStudy enrollmentLinear regression modelingCancer CenterPost-diagnosis weight trajectories and mortality among women with breast cancer
Puklin L, Li F, Cartmel B, Zhao J, Sanft T, Lisevick A, Winer E, Lustberg M, Spiegelman D, Sharifi M, Irwin M, Ferrucci L. Post-diagnosis weight trajectories and mortality among women with breast cancer. Npj Breast Cancer 2023, 9: 98. PMID: 38042922, PMCID: PMC10693588, DOI: 10.1038/s41523-023-00603-5.Peer-Reviewed Original ResearchBody mass indexBreast cancer diagnosisWeight changeCause mortalityClinical characteristicsWeight gainWeight lossBreast cancerWeight trajectoriesPost-diagnosis weight changeBreast cancer-specific mortalityCox proportional hazards modelModern treatment eraCancer-specific mortalityCancer diagnosisModerate weight lossModerate weight gainProportional hazards modelAdverse health outcomesElectronic health recordsTreatment eraBaseline characteristicsTumor RegistryMass indexWeight managementA qualitative study on the role of financial toxicity on adoption of healthy lifestyle behavior after breast cancer among Black and Latina women.
Nsubayi C, Pichardo M, Ginader A, Peña K, Nguyen T, Irwin M, Sanft T, Fayanju O, Molina Y. A qualitative study on the role of financial toxicity on adoption of healthy lifestyle behavior after breast cancer among Black and Latina women. JCO Oncology Practice 2023, 19: 273-273. DOI: 10.1200/op.2023.19.11_suppl.273.Peer-Reviewed Original ResearchLocal organizationsBreast cancer survivorsQualitative interview dataLatina breast cancer survivorsLatina womenLifestyle behavior changeHousing insecuritySocial workersCancer survivorsInstitutional levelLevel of accessInterview dataIdentified strategiesFinancial toxicityInterpersonal levelCommunity levelFinancial resourcesQualitative studyBreast cancerInductive approachContent analysisTypes of resourcesFinancial hardshipThematic categoriesBehavior changeRandomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors
Puklin L, Harrigan M, Cartmel B, Sanft T, Gottlieb L, Zhou B, Ferrucci L, Li F, Spiegelman D, Sharifi M, Irwin M. Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors. Cancers 2023, 15: 4719. PMID: 37835412, PMCID: PMC10571774, DOI: 10.3390/cancers15194719.Peer-Reviewed Original ResearchBreast cancer survivorsCancer survivorsLifestyle interventionPhysical activityQuality of lifeBody weightWaitlist groupDiet qualitySelf-reported body weightWeight lossFavorable weight changeHealthy weight lossBody mass indexHealthy body weightGreater weight lossEvidence-based materialsDiverse healthcare settingsIntervention armMass indexClinical practicePositive behavior changeHealthcare settingsSurvivorsWeight changeInterventionRandomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study
Sanft T, Harrigan M, McGowan C, Cartmel B, Zupa M, Li F, Ferrucci L, Puklin L, Cao A, Nguyen T, Neuhouser M, Hershman D, Basen-Engquist K, Jones B, Knobf T, Chagpar A, Silber A, Tanasijevic A, Ligibel J, Irwin M. Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study. Journal Of Clinical Oncology 2023, 41: 5285-5295. PMID: 37656930, PMCID: PMC10691793, DOI: 10.1200/jco.23.00871.Peer-Reviewed Original ResearchConceptsRelative dose intensityPathologic complete responseProportion of patientsBreast cancerNeoadjuvant chemotherapyChemotherapy completionComplete responseNutrition interventionsHigher pathologic complete responseHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Triple-negative breast cancerChemotherapy dose adjustmentsHome-based exerciseGrowth factor receptor 2Breast cancer outcomesEffects of exerciseFactor receptor 2Electronic medical recordsChi-square testUsual careDose intensityExercise interventionDose adjustmentRandomized trialsStructural Racism, Lifestyle Behaviors, and Obesity-related Cancers among Black and Hispanic/Latino Adults in the United States: A Narrative Review.
Pichardo M, Ferrucci L, Molina Y, Esserman D, Irwin M. Structural Racism, Lifestyle Behaviors, and Obesity-related Cancers among Black and Hispanic/Latino Adults in the United States: A Narrative Review. Cancer Epidemiology Biomarkers & Prevention 2023, 32: 1498-1507. PMID: 37650844, PMCID: PMC10872641, DOI: 10.1158/1055-9965.epi-22-1147.Peer-Reviewed Original ResearchConceptsHispanic/Latino adultsObesity-related cancersLifestyle behaviorsLatino adultsLifestyle guidelinesCancer preventionPoor lifestyle behaviorsU.S. Hispanic/Latino adultsHealthful lifestyle behaviorsCause of deathHealthy lifestyle choicesChronic diseasesCardiovascular diseaseCommon causeCancer riskNarrative reviewBlack adultsDisproportionate burdenObesityCancerAdultsLifestyle choicesDiseasePreventionDeathEffect of Exercise on Chemotherapy-Induced Peripheral Neuropathy Among Patients Treated for Ovarian Cancer
Cao A, Cartmel B, Li F, Gottlieb L, Harrigan M, Ligibel J, Gogoi R, Schwartz P, Esserman D, Irwin M, Ferrucci L. Effect of Exercise on Chemotherapy-Induced Peripheral Neuropathy Among Patients Treated for Ovarian Cancer. JAMA Network Open 2023, 6: e2326463. PMID: 37526937, PMCID: PMC10394582, DOI: 10.1001/jamanetworkopen.2023.26463.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyAerobic exercise interventionAttention control armExercise intervention armExercise interventionOvarian cancerControl armIntervention armSecondary analysisCIPN symptomsPeripheral neuropathyLifestyle StudyTreatment of CIPNModerate-intensity aerobic exerciseStandard oncology careEffects of exerciseSevere adverse effectsBetween-group differencesAmerican Cancer SocietyQuality of lifeAttention controlCIPN severityPrimary outcomeOncology careAerobic exerciseLongitudinal associations among physical activity, inflammatory markers, and quality of life in patients with head and neck cancer
Huang S, Zhan Y, Jeon S, Bruner D, Miller A, Felger J, Wommack E, Saba N, Higgins K, Irwin M, Gary R, Xiao C. Longitudinal associations among physical activity, inflammatory markers, and quality of life in patients with head and neck cancer. Head & Neck 2023, 45: 1952-1966. PMID: 37288586, PMCID: PMC10330673, DOI: 10.1002/hed.27420.Peer-Reviewed Original ResearchConceptsPhysical activityInflammatory markersQuality of lifeLower inflammationNeck cancerTotal QOL scoreHigh physical activityObservational longitudinal studyInactive patientsQOL scoresActive patientsStrength exercisesPatientsInflammationLongitudinal associationsMixed effects modelsSTNFR2Longitudinal studyCancerMarkersAssociationMore researchSubject correlationLow levelsPostradiotherapyRandomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer
Cartmel B, Li F, Zhou Y, Gottlieb L, Lu L, Mszar R, Harrigan M, Ligibel J, Gogoi R, Schwartz P, Risch H, Irwin M. Randomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer. Cancer Medicine 2023, 12: 15492-15503. PMID: 37269192, PMCID: PMC10417064, DOI: 10.1002/cam4.6187.Peer-Reviewed Original ResearchConceptsExercise interventionOvarian cancerTrial of exerciseExercise-induced changesMin/weekGroup differencesSubset of participantsCause mortalityExercise groupOverall survivalStudy armsCA 125Randomized trialsBlood biomarkersBlood drawBreast cancerClinical significanceIGF-1Effect model analysisSecondary analysisBeneficial effectsCancerBiomarkersTrialsWomenA review of the impact of energy balance on triple-negative breast cancer
Akingbesote N, Owusu D, Liu R, Cartmel B, Ferrucci L, Zupa M, Lustberg M, Sanft T, Blenman K, Irwin M, Perry R. A review of the impact of energy balance on triple-negative breast cancer. JNCI Monographs 2023, 2023: 104-124. PMID: 37139977, DOI: 10.1093/jncimonographs/lgad011.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTriple-negative breast cancerInterventional studyBreast cancerCancer treatmentClinical interventional studyClinical observationalImmune activationCancer outcomesCancer careClinical studiesOverall healthEnergy intakeNarrative reviewCancer cellsEnergy expenditureCancerTreatmentEnergy balanceOutcomesExerciseReviewDetrimental effectsImmunotherapyStudyIntakeTranslational and transdisciplinary research in energy balance and cancer: past is prologue
Irwin M, Sears D, Ligibel J. Translational and transdisciplinary research in energy balance and cancer: past is prologue. JNCI Monographs 2023, 2023: 1-2. PMID: 37139974, PMCID: PMC10157745, DOI: 10.1093/jncimonographs/lgad009.Peer-Reviewed Original ResearchKey takeaways for knowledge expansion of early-career scientists conducting Transdisciplinary Research in Energetics and Cancer (TREC): a report from the TREC Training Workshop 2022
Kung C, Skiba M, Crosby E, Gorzelitz J, Kennedy M, Kerr B, Li Y, Nash S, Potiaumpai M, Kleckner A, James D, Coleman M, Fairman C, Galván G, Garcia D, Gordon M, His M, Hornbuckle L, Kim S, Kim T, Kumar A, Mahé M, McDonnell K, Moore J, Oh S, Sun X, Irwin M. Key takeaways for knowledge expansion of early-career scientists conducting Transdisciplinary Research in Energetics and Cancer (TREC): a report from the TREC Training Workshop 2022. JNCI Monographs 2023, 2023: 149-157. PMID: 37139978, PMCID: PMC10157760, DOI: 10.1093/jncimonographs/lgad005.Peer-Reviewed Original ResearchDiet and physical activity interventions in Black and Latina women with breast cancer: A scoping review
Pichardo M, Sanft T, Ferrucci L, Romero-Ramos Y, Cartmel B, Harrigan M, Velazquez A, Fayanju O, Winer E, Irwin M. Diet and physical activity interventions in Black and Latina women with breast cancer: A scoping review. Frontiers In Oncology 2023, 13: 1079293. PMID: 36994212, PMCID: PMC10040823, DOI: 10.3389/fonc.2023.1079293.Peer-Reviewed Original ResearchBreast cancer survivorsPhysical activity interventionsLifestyle interventionCancer survivorsActivity interventionsLatina womenEfficacy trialsBreast cancerLatina breast cancer survivorsTrial of dietOne-year followFavorable behavioral changesBreast cancer diagnosisPrimary outcomeAvailable peer-reviewed literatureFuture trialsInformal care giversPilot trialSustained behavior changeEfficacy studiesHealthful lifestyleCare giversTrialsWeight lossCancer diagnosisTranslating energy balance research from the bench to the clinic to the community: Parallel animal‐human studies in cancer
Garcia M, Schadler K, Chandra J, Clinton S, Courneya K, Cruz‐Monserrate Z, Daniel C, Dannenberg A, Demark‐Wahnefried W, Dewhirst M, Fabian C, Hursting S, Irwin M, Iyengar N, McQuade J, Schmitz K, Basen‐Engquist K. Translating energy balance research from the bench to the clinic to the community: Parallel animal‐human studies in cancer. CA A Cancer Journal For Clinicians 2023, 73: 425-442. PMID: 36825928, PMCID: PMC11225601, DOI: 10.3322/caac.21773.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsParallel studyHealthy survivorshipCancer outcomesDietary intakePhysical activityAnimal modelsClinical observationsAnimal studiesBody compositionCancer developmentPractice changeCancerPopulation studiesCancer researchEnergy balance researchEnergy balancePatientsSubstantial benefitsClinicStudyIntake