Manisha Juthani, MD
Cards
Appointments
Additional Titles
Professor, Epidemiology of Microbial Diseases
Contact Info
Appointments
Additional Titles
Professor, Epidemiology of Microbial Diseases
Contact Info
Appointments
Additional Titles
Professor, Epidemiology of Microbial Diseases
Contact Info
About
Titles
Professor of Medicine (Infectious Diseases)
Professor, Epidemiology of Microbial Diseases
Biography
Dr. Juthani is a Professor of Medicine and an Infectious Diseases physician at Yale School of Medicine. She completed her undergraduate training at the University of Pennsylvania, attended Cornell University Medical College, completed residency training at New York-Presbyterian Hospital/Weill Cornell Campus, and was a Chief Resident at Memorial-Sloan Kettering Cancer Center. She arrived at Yale School of Medicine in 2002 for Infectious Diseases Fellowship Training and joined the full-time faculty in 2006. She assumed the role of Infectious Diseases Fellowship Program Director in 2012. During the COVID-19 pandemic, she has been instrumental in leading the ID efforts at Yale School of Medicine and Yale New Haven Hospital. Her federally funded research focused on infections in older adults, specifically urinary tract infections and pneumonia. Most notably, she was the Principal Investigator of an R01-funded research project that resulted in the 2016 JAMA publication entitled, “Effect of Cranberry Capsules on Bacteriuria Plus Pyuria Among Older Women in Nursing Homes: A Randomized Clinical Trial.” This publication received widespread attention in the lay press, including The New York Times and CNN to name a few, and achieved an Almetric Attention Score of 1546, placing it in the top 5% of all research outputs scored by Altmetric. In December 2016, The New Yorker identified this research as one of the most notable medical findings of 2016, and Dr. Juthani was interviewed and featured in the GeriPal and Gastropod podcasts. Additionally, in her parallel work with pneumonia prevention, she was the first author on the 2015 Clinical Infectious Diseases publication entitled, “A Cluster-Randomized Controlled Trial of a Multicomponent Intervention Protocol for Pneumonia Prevention Among Nursing Home Elders.” In addition to her academic responsibilities, Dr. Juthani enjoys talking and writing about medical topics in the lay press. During the COVID-19 pandemic, she has been featured on CNN, WTNH, ABC's 20/20, CT Public Radio/NPR, BBC's News Hour, The Wall Street Journal, The New York Times, USA Today, and CGTN. Her written pieces have been featured in The Boston Globe, The Huffington Post, Pacific Standard, and Next Avenue. Her most recent area of research interest was at the interface of infectious diseases and palliative care, specifically the role of antibiotics at the end of life. Additional areas of interest include antibiotic resistant organisms, the emergence and spread of resistant organisms, hospital epidemiology, and medical education. Since 2021, Dr. Juthani has been on a leave for public service to serve as Commissioner of the Connecticut Department of Public Health.
Appointments
Infectious Diseases
ProfessorPrimaryEpidemiology of Microbial Diseases
ProfessorSecondary
Other Departments & Organizations
Education & Training
- Fellow
- Yale University School of Medicine (2005)
- Chief Resident
- Memorial Sloan Kettering Cancer Center (2002)
- Intern and Resident
- New York-Presbyterian Hospital, Weill Cornell (2001)
- Assistant Chief Resident
- New York-Presbyterian Hospital, Weill Cornell (2001)
- MD
- Cornell University Medical College (1998)
- BA
- University of Pennsylvania (1994)
Research
Overview
Dr. Juthani has focused her investigative efforts on improving the diagnosis, management, and prevention of infections in older adults. Her federally funded research program has conducted studies on improving the diagnosis and management of UTI in nursing home residents. She was the Principal Investigator for a clinical trial of cranberry capsules vs placebo for the reduction of UTI in nursing home women published in JAMA. In addition, she was an investigator on a cluster randomized controlled trial to prevent pneumonia in nursing home elders. These avenues of investigation have led to her current interests in the role of antimicrobial therapy at the end of life. Her overlying research interests include hospital epidemiology, hospital acquired infections, and multi drug resistant organisms.
Additionally, this research experience has led her to a new avenue of investigation regarding the use of antibiotics with cancer patients at the end of life. Her long-term cancer goals include: 1) to have patient preferences regarding use of antibiotics addressed early on and sequentially in the trajectory of a cancer patient’s care; 2) to develop a symptom guided algorithm towards the judicious use of antimicrobial agents at the end of life; 3) to reduce hospital readmissions for infections in cancer patients where the goal of care is primarily comfort.
Medical Subject Headings (MeSH)
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Vincent Quagliarello, MD
Rupak Datta, MD/PhD, MPH
Mary Tinetti, MD
Heather Allore, PhD
Louise-Marie Dembry, MD, FACP, MS, MBA, FIDSA, BS
Andrea Rink
Urinary Tract Infections
Nursing Homes
Pneumonia
Aging
Publications
2024
Cohort study of patients with advanced cancer: outcomes associated with duration of antibiotic therapy for non-ventilator hospital-acquired pneumonia
Lee S, Benson J, Cohen A, Quagliarello V, Juthani-Mehta M, Datta R. Cohort study of patients with advanced cancer: outcomes associated with duration of antibiotic therapy for non-ventilator hospital-acquired pneumonia. Antimicrobial Stewardship & Healthcare Epidemiology 2024, 4: e48. PMID: 38655023, PMCID: PMC11036428, DOI: 10.1017/ash.2024.54.Peer-Reviewed Original ResearchAltmetricConceptsNon-ventilator hospital-acquired pneumoniaAdvanced cancerPalliative care settingHospital-acquired pneumoniaCohort study of patientsCare settingsOlder adultsAdjusted oddsDuration of antibiotic therapyAssociated with reduced adjusted oddsSingle-center observational studyCohort studyProlonged antibiotic durationObservational studyStudy of patientsAntimicrobial stewardship effortsAntibiotic durationAntibiotic therapyStewardship effortsPneumoniaCancerOddsReadmissionAdultsCohort
2023
Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study
Datta R, Han L, Doyle M, Allore H, Sanft T, Quagliarello V, Juthani-Mehta M. Antibiotic therapy is associated with adverse drug events among older adults with advanced cancer: A cohort study. Palliative Medicine 2023, 37: 793-798. PMID: 36999898, DOI: 10.1177/02692163231162889.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsAdverse drug eventsAntibiotic therapyDrug eventsAdvanced cancerOlder adultsIndex admissionPalliative chemotherapyCohort studyTertiary care centerHospitalized older adultsPalliative care providersMultidrug-resistant organismsMean ageCommon tumorsCare centerCare providersRatio of daysSolid tumorsMultivariable testingPatientsTherapyStandardized criteriaCancerMean timeAdults
2022
Prevalence and treatment of postobstructive pneumonia among older adults with advanced cancer
Lee S, O’Donovan L, Cohen A, Gautam S, Quagliarello V, Juthani-Mehta M, Datta R. Prevalence and treatment of postobstructive pneumonia among older adults with advanced cancer. Antimicrobial Stewardship & Healthcare Epidemiology 2022, 2: e152. PMID: 36483405, PMCID: PMC9726473, DOI: 10.1017/ash.2022.293.Peer-Reviewed Original ResearchCitationsAltmetricNational Cohort Study of Homebound Persons Living With Dementia: Antibiotic Prescribing Trends and Opportunities for Antibiotic Stewardship
Datta R, Fried T, O’Leary J, Zullo AR, Allore H, Han L, Juthani-Mehta M, Cohen A. National Cohort Study of Homebound Persons Living With Dementia: Antibiotic Prescribing Trends and Opportunities for Antibiotic Stewardship. Open Forum Infectious Diseases 2022, 9: ofac453. PMID: 36147594, PMCID: PMC9487603, DOI: 10.1093/ofid/ofac453.Peer-Reviewed Original ResearchCitationsAltmetricConceptsHome-based primary careDays of therapyAntibiotic use ratesAntibiotic useHomebound personsOverall median lengthPhysician home visitsNational cohort studyAntibiotic prescribing trendsVeterans Health AdministrationUse ratesProvider visitsAntibiotic prescriptionsCohort studyPrescribing trendsTelephone visitsMedian agePrescription fillsMedian lengthAntibiotic stewardshipNational cohortPrimary careHome visitsHealth AdministrationPrescribed classComparison of traditional instruction versus nontraditional learning to improve trainee knowledge of urine culture practices in catheterized patients
Gao CA, Datta R, Dunne D, Dembry LM, Martinello RA, Juthani-Mehta M, Advani SD. Comparison of traditional instruction versus nontraditional learning to improve trainee knowledge of urine culture practices in catheterized patients. Antimicrobial Stewardship & Healthcare Epidemiology 2022, 2: e81. PMID: 35647610, PMCID: PMC9139028, DOI: 10.1017/ash.2022.225.Peer-Reviewed Original ResearchCitationsAltmetric
2020
Clinical implications of SARS-CoV-2 cycle threshold values in solid organ transplant recipients
Gaston DC, Malinis M, Osborn R, Peaper DR, Landry M, Juthani-Mehta M, Azar MM. Clinical implications of SARS-CoV-2 cycle threshold values in solid organ transplant recipients. American Journal Of Transplantation 2020, 21: 1304-1311. PMID: 33043603, PMCID: PMC7675520, DOI: 10.1111/ajt.16357.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsSolid organ transplant recipientsOrgan transplant recipientsClinical implicationsCycle threshold valuesSOT patientsTransplant recipientsSymptom onsetYale New Haven Health SystemUpper respiratory tract samplesSARS-CoV-2 viral RNASARS-CoV-2 viral dynamicsAdult SOT recipientsRetrospective chart reviewRespiratory tract samplesSARS-CoV-2 cycle threshold valuesInfection prevention measuresCOVID-19 severityViral RNAHigher clinical acuityPrimary diagnostic testRT-PCR assaysSOT recipientsChart reviewViral loadAdmission severityNanima
Juthani-Mehta M. Nanima. New England Journal Of Medicine 2020, 384: 1488-1489. PMID: 33108099, DOI: 10.1056/nejmp2028693.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsEducation needed to improve antimicrobial use during end-of-life care of older adults with advanced cancer: A cross-sectional survey
Datta R, Topal J, McManus D, Sanft T, Dembry LM, Morrison LJ, Quagliarello V, Juthani-Mehta M. Education needed to improve antimicrobial use during end-of-life care of older adults with advanced cancer: A cross-sectional survey. Palliative Medicine 2020, 35: 236-241. PMID: 32928066, DOI: 10.1177/0269216320956811.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsEscalation of careAdvance care planningLife careAdvanced cancerCross-sectional surveyIntravenous antimicrobialsOlder adultsAntimicrobial useCare planningSingle-center cross-sectional surveyEducational interventionAdvance care plansRole of antimicrobialsClinical deteriorationPercent of respondentsAdverse eventsOral antimicrobialsMedicine subspecialistsCare plansInpatient medicineCareCancerPatientsAdultsSubspecialistsAdverse Events and Healthcare Utilization Associated With Outpatient Parenteral Antimicrobial Therapy Among Older Versus Younger Adults
Brzozowski K, Datta R, Canterino J, Malinis M, Juthani-Mehta M. Adverse Events and Healthcare Utilization Associated With Outpatient Parenteral Antimicrobial Therapy Among Older Versus Younger Adults. Open Forum Infectious Diseases 2020, 7: ofaa358. PMID: 33094112, PMCID: PMC7566523, DOI: 10.1093/ofid/ofaa358.Peer-Reviewed Original ResearchCitationsInconsistent Addiction Treatment for Patients Undergoing Cardiac Surgery for Injection Drug Use-associated Infective Endocarditis.
Nguemeni Tiako MJ, Hong S, Bin Mahmood SU, Mori M, Mangi A, Yun J, Juthani-Mehta M, Geirsson A. Inconsistent Addiction Treatment for Patients Undergoing Cardiac Surgery for Injection Drug Use-associated Infective Endocarditis. Journal Of Addiction Medicine 2020, 14: e350-e354. PMID: 32732685, DOI: 10.1097/adm.0000000000000710.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsActive drug useInjection drug use-associated infective endocarditisOpioid use disorderPsychosocial consultationAddiction treatmentDrug rehabilitation programInfective endocarditisRehabilitation programUse disordersDrug use-associated infective endocarditisDrug useEvidence of enrollmentTertiary care centerInjection drug useUS opioid epidemicDrug rehabilitationRehabilitation attendanceMost patientsCardiac surgeryRetrospective reviewCare centerOpioid epidemicPatientsMedicationsIDUs
Academic Achievements and Community Involvement
honor Leadership Institute, Community of Leaders
National AwardInfectious Diseases Society of America (IDSA)Details05/01/2021United Statesactivity Open Forum Infectious Diseases
Journal ServiceReviewerDetails2014 - 2021activity Journal of the American Medical Association (JAMA)
Journal ServiceReviewerDetails2013 - 2021activity British Medical Journal
Journal ServiceReviewerDetails2013 - 2021activity Annals of Internal Medicine
Journal ServiceReviewerDetails2013 - 2021
Clinical Care
Overview
Manisha Juthani, MD, specializes in the diagnosis, management and prevention of infections in older adults. “My interest in palliative care makes me uniquely qualified to help address goals of care with older patients with underlying diseases who have recurrent infections,” she says.
Getting to know patients and the challenges they face in their home lives can go a long way, says Dr. Juthani, who recalls one patient who had end-stage renal disease, as well as a teenager at home and an ill husband. “When I took the time to understand her frustration with the recurrence of her infection and the challenging home situation, she immediately developed confidence in my care of her,” she says.
An associate professor of medicine (infectious diseases) at Yale School of Medicine, Dr. Juthani also pursues federally funded research to learn more about infections in older adults, specifically urinary tract infections and pneumonia. Her most recent area of interest is at the interface of infectious diseases and palliative care, including the role of antibiotics at the end of life.
Clinical Specialties
Fact Sheets
Pneumonia
Learn More on Yale MedicineClostridium difficile ( C. diff )
Learn More on Yale MedicineSepsis
Learn More on Yale MedicinePediatric Sepsis
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