2023
Injectable hydrogel for sustained delivery of progranulin derivative Atsttrin in treating diabetic fracture healing
Moradi L, Witek L, Vivekanand Nayak V, Cabrera Pereira A, Kim E, Good J, Liu C. Injectable hydrogel for sustained delivery of progranulin derivative Atsttrin in treating diabetic fracture healing. Biomaterials 2023, 301: 122289. PMID: 37639975, PMCID: PMC11232488, DOI: 10.1016/j.biomaterials.2023.122289.Peer-Reviewed Original ResearchConceptsΒ-GP hydrogelPorous interconnected structureAmount of GOTissue engineering applicationsEngineering applicationsLong-term storage stabilityInjectable biomaterialsGrowth factor deliveryInjectable hydrogelsInterconnected structureHigh viscosityRapid sol-gel transitionHydrogelsSustained-release propertiesFactor deliveryBiomechanical environmentStorage stabilitySustained deliverySol-gel transitionExcellent candidateCartilage regenerationGel networkSustained releaseChitosanFracture healing
2020
Delivery of injectable thermo-sensitive hydrogel releasing nerve growth factor for spinal cord regeneration in rat animal model
Alizadeh A, Moradi L, Katebi M, Ai J, Azami M, Moradveisi B, Ostad S. Delivery of injectable thermo-sensitive hydrogel releasing nerve growth factor for spinal cord regeneration in rat animal model. Journal Of Tissue Viability 2020, 29: 359-366. PMID: 32839065, DOI: 10.1016/j.jtv.2020.06.008.Peer-Reviewed Original ResearchConceptsSpinal cord injuryHuman adipose-derived mesenchymal stem cellsNerve growth factorSpinal cord regenerationCord regenerationGrowth factorBetter locomotor functionBetter therapeutic strategiesPositive control groupRat animal modelAdipose-derived mesenchymal stem cellsSCI treatmentSham groupSurgical interventionCord injuryLocomotor functionSCI siteTherapeutic strategiesAnimal modelsControl groupMesenchymal stem cellsHistological studyBeneficial effectsRats animalsOne week
2019
Natural biomacromolecule based composite scaffolds from silk fibroin, gelatin and chitosan toward tissue engineering applications
Asadpour S, Kargozar S, Moradi L, Ai A, Nosrati H, Ai J. Natural biomacromolecule based composite scaffolds from silk fibroin, gelatin and chitosan toward tissue engineering applications. International Journal Of Biological Macromolecules 2019, 154: 1285-1294. PMID: 31733251, DOI: 10.1016/j.ijbiomac.2019.11.003.Peer-Reviewed Original ResearchConceptsComposite scaffoldsTissue engineering applicationsSilk fibroinMechanical strengthEngineering applicationsFabricated composite scaffoldsNatural extra cellular matrixBiocompatibility of scaffoldsDifferent blending ratiosFreeze-drying techniqueSilk fibroin-chitosanGood interconnectivityTensile testsSuitable porositySurface wettabilityBlending ratioDegradation measurementsBombyx mori silkwormPore sizeChitosan-gelatinFibroinCell affinityDegradation rateExtra-cellular matrixWater uptake