2024
Temporal change in PET myocardial flow reserve is predictive of cardiovascular outcomes
Nikolakopoulos I, Liu Y, Sinusas A, Miller E, Feher A. Temporal change in PET myocardial flow reserve is predictive of cardiovascular outcomes. European Heart Journal - Cardiovascular Imaging 2024, 25: jeae142.099. DOI: 10.1093/ehjci/jeae142.099.Peer-Reviewed Original ResearchPositron emission tomographyMyocardial flow reserveCoronary artery diseaseCardiovascular outcomesArtery diseaseFlow reserveEvaluation of coronary artery diseaseHistory of heart transplantationMedian interval timeKaplan-Meier methodPredictive of cardiovascular outcomesLong-term outcomesPerioperative risk stratificationCoronary bloodChest painHeart transplantationRisk stratificationSerial examsCox regressionMyocardial infarctionInterquartile rangeC-statisticEmission tomographyPatientsContinuous variables
2022
Validation of the OPEN-CLEAN Chronic Total Occlusion Percutaneous Coronary Intervention Perforation Score in a Multicenter Registry
Simsek B, Carlino M, Ojeda S, Pan M, Rinfret S, Vemmou E, Kostantinis S, Nikolakopoulos I, Karacsonyi J, Quadros A, Dens J, Abi Rafeh N, Agostoni P, Alaswad K, Avran A, Belli K, Choi J, Elguindy A, Jaffer F, Doshi D, Karmpaliotis D, Khatri J, Khelimskii D, Knaapen P, La Manna A, Krestyaninov O, Lamelas P, Padilla L, de Oliveira P, Spratt J, Tanabe M, Walsh S, Goktekin O, Gorgulu S, Mastrodemos O, Allana S, Rangan B, Kearney K, Lombardi W, Grantham J, Hirai T, Brilakis E, Azzalini L. Validation of the OPEN-CLEAN Chronic Total Occlusion Percutaneous Coronary Intervention Perforation Score in a Multicenter Registry. The American Journal Of Cardiology 2022, 188: 30-35. PMID: 36462272, DOI: 10.1016/j.amjcard.2022.11.023.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionCTO percutaneous coronary interventionCoronary artery perforationArtery perforationPerforation riskPrevious coronary artery bypass graftChronic total occlusion (CTO) percutaneous coronary interventionCoronary artery bypass graftModerate-severe calcificationUnfavorable angiographic characteristicsArtery bypass graftProximal cap ambiguityBlunt stumpAngiographic characteristicsMulticenter registryCoronary interventionFeared complicationBypass graftTechnical successPatientsPerforationGood calibrationCharacteristic curveScoresRiskOutcomes of patients undergoing bifurcation vs. nonbifurcation percutaneous coronary intervention at a large tertiary center
Gutierrez A, Kostantinis S, Karacsonyi J, Simsek B, Rangan B, Garcia S, Burke M, Gössl M, Nikolakopoulos I, Avula V, Schmidt C, Okeson B, Brilakis E. Outcomes of patients undergoing bifurcation vs. nonbifurcation percutaneous coronary intervention at a large tertiary center. Hellenic Journal Of Cardiology 2022, 70: 78-79. PMID: 36184034, DOI: 10.1016/j.hjc.2022.09.002.Peer-Reviewed Original Research
2021
TCT-68 Chronic Total Occlusion Percutaneous Coronary Intervention for Patients With Previous CABG: Insights From a Pooled Analysis of 4 Multicenter Registries
Vemmou E, Quadros A, Dens J, Rafeh N, Agostoni P, Alaswad K, Avran A, Belli K, Campos C, Carlino M, Choi J, De Los Santos F, ElGuindy A, Jaffer F, Karmpaliotis D, Khatri J, Khelimskii D, Knaapen P, Krestyaninov O, La Manna A, Lamelas P, Ojeda S, Padilla L, Pan M, de Oliveira P, Rinfret S, Santiago R, Spratt J, Walsh S, Kostantinis S, Simsek B, Karacsonyi J, Nikolakopoulos I, Rangan B, Brilakis E, Azzalini L. TCT-68 Chronic Total Occlusion Percutaneous Coronary Intervention for Patients With Previous CABG: Insights From a Pooled Analysis of 4 Multicenter Registries. Journal Of The American College Of Cardiology 2021, 78: b28. DOI: 10.1016/j.jacc.2021.09.918.Peer-Reviewed Original ResearchTCT-464 Outcomes of Patients With Bifurcation Lesions: Preliminary Results From the Prospective Global Registry for the Study of Bifurcation Lesion Interventions (PROGRESS-BIFURCATION) Registry
Karacsonyi J, Kostantinis S, Gutierrez A, Avula V, Simsek B, Burke M, Garcia S, Goessl M, Sorajja P, Chavez I, Mooney M, Poulose A, Traverse J, Wang Y, Ungi I, Nikolakopoulos I, Vemmou E, Guddeti R, Rangan B, Brilakis E. TCT-464 Outcomes of Patients With Bifurcation Lesions: Preliminary Results From the Prospective Global Registry for the Study of Bifurcation Lesion Interventions (PROGRESS-BIFURCATION) Registry. Journal Of The American College Of Cardiology 2021, 78: b191. DOI: 10.1016/j.jacc.2021.09.1317.Peer-Reviewed Original ResearchCharacteristics and in-hospital outcomes of patients undergoing complex bifurcation versus nonbifurcation percutaneous coronary intervention
Nikolakopoulos I, Vemmou E, Karacsonyi J, Garberich R, Stanberry L, Mueller DL, Kostantinis ST, Simsek B, Rangan BV, Burke MN, Brilakis ES. Characteristics and in-hospital outcomes of patients undergoing complex bifurcation versus nonbifurcation percutaneous coronary intervention. Coronary Artery Disease 2021, 33: 242-244. PMID: 34074912, DOI: 10.1097/mca.0000000000001063.Peer-Reviewed Original ResearchCHRONIC TOTAL OCCLUSION PERCUTANEOUS CORONARY INTERVENTION IN YOUNG PATIENTS: INSIGHTS FROM THE PROGRESS-CTO REGISTRY
Nikolakopoulos I, Vemmou E, Karacsonyi J, Alaswad K, Karmpaliotis D, Schimmel D, Benzuly K, Flaherty J, Krestianinov O, Khelimskii D, Rafeh N, Ahmed E, Goktekin O, Gorgulu S, Reddy N, Khatri J, Jaffer F, Koutouzis M, Tsiafoutis I, Riley R, Choi J, Jaber W, Samady H, Burke M, Brilakis E. CHRONIC TOTAL OCCLUSION PERCUTANEOUS CORONARY INTERVENTION IN YOUNG PATIENTS: INSIGHTS FROM THE PROGRESS-CTO REGISTRY. Journal Of The American College Of Cardiology 2021, 77: 915. DOI: 10.1016/s0735-1097(21)02274-9.Peer-Reviewed Original ResearchOUTCOMES OF PATIENTS WITH ST SEGMENT ELEVATION MYOCARDIAL INFARCTION AND HISTORY OF PRIOR CORONARY ARTERY BYPASS GRAFT SURGERY: UPDATE FROM THE MIDWEST STEMI CONSORTIUM
Karacsonyi J, Okeson B, Schmidt C, Garcia S, Henry T, Nikolakopoulos I, Vemmou E, Xenogiannis I, Rangan B, Goessl M, Sorajja P, Chavez I, Mooney M, Poulose A, Traverse J, Wang Y, Baran K, Bradley S, Garberich R, Ungi I, Burke M, Brilakis E. OUTCOMES OF PATIENTS WITH ST SEGMENT ELEVATION MYOCARDIAL INFARCTION AND HISTORY OF PRIOR CORONARY ARTERY BYPASS GRAFT SURGERY: UPDATE FROM THE MIDWEST STEMI CONSORTIUM. Journal Of The American College Of Cardiology 2021, 77: 1062. DOI: 10.1016/s0735-1097(21)02421-9.Peer-Reviewed Original ResearchCan History of Myocardial Infarction Reliably Indicate Myocardial Viability in Patients With a Coronary Chronic Total Occlusion and Good Collateral Circulation?
Nikolakopoulos I, Vemmou E, Karacsonyi J, Xenogiannis I, Rangan BV, Garcia S, Burke MN, Brilakis ES. Can History of Myocardial Infarction Reliably Indicate Myocardial Viability in Patients With a Coronary Chronic Total Occlusion and Good Collateral Circulation? Journal Of Invasive Cardiology 2021, 33: e135. PMID: 33531443.Peer-Reviewed Original ResearchConceptsCoronary chronic total occlusionsGood collateral circulationChronic total occlusionMyocardial infarctionCollateral circulationTotal occlusionPrior Q-wave myocardial infarctionQ-wave myocardial infarctionPercutaneous coronary interventionPrior myocardial infarctionPROGRESS CTOMulticenter registryCoronary interventionEjection fractionPredominant symptomViable myocardiumMyocardial viabilityPatientsViability testingOcclusionDyspneaInfarctionRegistrySymptomsMyocardium
2020
Systematic review and meta-analysis of short-term outcomes with drug-coated balloons vs. stenting in acute myocardial infarction
Megaly M, Buda KG, Xenogiannis I, Vemmou E, Nikolakopoulos I, Saad M, Rinfret S, Abbott JD, Aronow HD, Garcia S, Pershad A, Burke MN, Brilakis ES. Systematic review and meta-analysis of short-term outcomes with drug-coated balloons vs. stenting in acute myocardial infarction. Cardiovascular Intervention And Therapeutics 2020, 36: 481-489. PMID: 33037991, DOI: 10.1007/s12928-020-00713-y.Peer-Reviewed Original ResearchConceptsDrug-coated balloonsAcute myocardial infarctionMyocardial infarctionAMI patientsOutcomes of DCBMajor adverse cardiovascular eventsAdverse cardiovascular eventsLate lumen lossShort-term outcomesLesion revascularizationCardiovascular eventsCause mortalityAngiographic outcomesCardiac deathLumen lossSimilar riskClinical utilityPatientsSystematic reviewLarger studyInfarctionStatistical differenceOutcomesMonthsBalloonCombined use of intravascular lithotripsy and brachytherapy: A new approach for the treatment of recurrent coronary in‐stent restenosis
Nikolakopoulos I, Vemmou E, Xenogiannis I, Brilakis ES. Combined use of intravascular lithotripsy and brachytherapy: A new approach for the treatment of recurrent coronary in‐stent restenosis. Catheterization And Cardiovascular Interventions 2020, 97: 1402-1406. PMID: 33031640, DOI: 10.1002/ccd.29332.Peer-Reviewed Original ResearchConceptsIntravascular lithotripsyMultiple treatment modalitiesTreatment modalitiesStent restenosisCoronary intravascular lithotripsyFrench guide cathetersIntravascular ultrasound resultsISR casesRadial accessGuide catheterUltrasound resultsPatientsRestenosisTreatmentBrachytherapyLithotripsyModalitiesAnginaCombined useAngiographicCatheterMonthsCoronary Intravascular Brachytherapy for Recurrent Coronary Drug-Eluting Stent In-Stent Restenosis: A Systematic Review and Meta-Analysis
Megaly M, Glogoza M, Xenogiannis I, Vemmou E, Nikolakopoulos I, Omer M, Saad M, Willson L, Monyak DJ, Sullivan P, Pershad A, Chavez I, Mooney M, Traverse J, Wang Y, Garcia S, Poulose A, Burke MN, Brilakis ES. Coronary Intravascular Brachytherapy for Recurrent Coronary Drug-Eluting Stent In-Stent Restenosis: A Systematic Review and Meta-Analysis. Cardiovascular Revascularization Medicine 2020, 23: 28-35. PMID: 32883584, DOI: 10.1016/j.carrev.2020.08.035.Peer-Reviewed Original ResearchConceptsTarget vessel revascularizationIncidence of TVRIncidence of MIRecurrent ISRMyocardial infarctionCause mortalityStent restenosisSystematic reviewIntravascular brachytherapyOutcomes of interestVessel revascularizationCoronary DrugObservational studyMeta-AnalysisIncidencePrevious treatmentBrachytherapyTwo yearsPatientsRestenosisMortalityStentsOutcomesTreatmentLimited studiesEquipment utilization in chronic total occlusion percutaneous coronary interventions: Insights from the PROGRESS‐CTO registry
Nikolakopoulos I, Choi JW, Alaswad K, Khatri JJ, Krestyaninov O, Khelimskii D, Yeh RW, Jaffer FA, Toma C, Patel M, Mahmud E, Lembo NJ, Parikh M, Kirtane AJ, Ali ZA, Gkargkoulas F, Uretsky B, Sheikh AM, Vemmou E, Xenogiannis I, Rangan BV, Garcia S, Abdullah S, Banerjee S, Burke MN, Brilakis ES, Karmpaliotis D. Equipment utilization in chronic total occlusion percutaneous coronary interventions: Insights from the PROGRESS‐CTO registry. Catheterization And Cardiovascular Interventions 2020, 97: 658-667. PMID: 32597031, DOI: 10.1002/ccd.29106.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionChronic total occlusion (CTO) percutaneous coronary interventionCTO percutaneous coronary interventionCoronary interventionHigh-complexity lesionsPolymer-jacketed guidewiresPROGRESS-CTO RegistryAntegrade guidewireMedian numberMicrocatheterGuidewireFielder XTInterventionRetrograde casesPatientsAntegradeRegistryLesionsUsing big data to retrospectively validate the COMPASS-CAT risk assessment model: considerations on methodology
Nikolakopoulos I, Nourabadi S, Eldredge JB, Anand L, Zhang M, Qiu M, Rosenberg D, Spyropoulos AC. Using big data to retrospectively validate the COMPASS-CAT risk assessment model: considerations on methodology. Journal Of Thrombosis And Thrombolysis 2020, 51: 12-16. PMID: 32564180, DOI: 10.1007/s11239-020-02191-8.Peer-Reviewed Original ResearchConceptsExternal validation studyThromboembolic risk assessmentRisk of biasValidation studyMultiple validation studiesVenous thromboembolismRisk factorsProspective comparisonClinical practiceClinical perceptionRisk assessment modelExternal validationReporting guidelinesScarce findingsTransparent reportingStructured planAdministrative codesThromboembolismPatientsRisk assessmentTime-sensitive variablesCancerStudyThe Impact of Novel X-Ray Systems and X-Ray System Optimization on Patient Radiation Dose Administered During Cardiac Catheterization.
Vemmou E, Nikolakopoulos I, Xenogiannis I, Megaly M, Omer MA, Stanberry L, Garberich R, Rangan BV, Baran KW, Gössl M, Sorajja P, Chavez I, Mooney M, Traverse J, Wang Y, Garcia S, Poulose A, Burke MN, Brilakis ES. The Impact of Novel X-Ray Systems and X-Ray System Optimization on Patient Radiation Dose Administered During Cardiac Catheterization. Journal Of Invasive Cardiology 2020, 32: 218-221. PMID: 32385193.Peer-Reviewed Original ResearchConceptsPatient radiation dosePCI groupAngiography groupOverall groupRadiation doseSingle tertiary care centerTertiary care centerRadiation dose administeredAir kerma doseCardiac catheterization proceduresDAP doseCardiac catheterizationDose administeredDiagnostic angiographyCatheterization proceduresDoseProduct doseSignificant changesGroupLimited studiesExposureCatheterizationAdministeredPatientsAngiographyTemporal Trends in Chronic Total Occlusion Percutaneous Coronary Interventions: Insights From the PROGRESS-CTO Registry.
Xenogiannis I, Gkargkoulas F, Karmpaliotis D, Alaswad K, Jaffer FA, Yeh RW, Patel M, Mahmud E, Choi JW, Burke MN, Garcia S, Doing AH, Dattilo P, Toma C, Uretsky B, Krestyaninov O, Khelimskii D, Moses JW, Lembo NJ, Parikh M, Kirtane AJ, Ali ZA, Russo JJ, Hakemi E, Hall AB, Nikolakopoulos I, Vemmou E, Karatasakis A, Danek B, Rangan BV, Abdullah S, Banerjee S, Brilakis ES. Temporal Trends in Chronic Total Occlusion Percutaneous Coronary Interventions: Insights From the PROGRESS-CTO Registry. Journal Of Invasive Cardiology 2020, 32: 153-160. PMID: 32198318.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionChronic total occlusion (CTO) percutaneous coronary interventionEarly era patientsProcedural success rateERA patientsCTO-PCICoronary interventionRetrograde crossingSuccess rateHospital major cardiovascular eventsPROGRESS-CTO RegistryMajor cardiovascular eventsJ-CTO scoreTechnical success rateAntegrade wire escalationHospital MACECardiovascular eventsMulticenter registryProcedural outcomesStage IIICurrent eraAntegrade dissectionPatientsWire escalationRegistryINTRAVASCULAR ULTRASOUND USE FOR STENT OPTIMIZATION AND 1-YEAR OUTCOMES IN PATIENTS UNDERGOING CTO-PCI: INSIGHTS FROM THE PROGRESS-CTO REGISTRY
Vemmou E, Khatri J, Doing A, Dattilo P, Toma C, Jaffer F, Karmpaliotis D, Sheikh A, Samady H, Alaswad K, Chandwaney R, Garcia S, Megaly M, Omer M, Stanberry L, Xenogiannis I, Nikolakopoulos I, Gkargkoulas F, Jaber W, Patel T, Jefferson B, Rangan B, Burke M, Banerjee S, Brilakis E. INTRAVASCULAR ULTRASOUND USE FOR STENT OPTIMIZATION AND 1-YEAR OUTCOMES IN PATIENTS UNDERGOING CTO-PCI: INSIGHTS FROM THE PROGRESS-CTO REGISTRY. Journal Of The American College Of Cardiology 2020, 75: 1117. DOI: 10.1016/s0735-1097(20)31744-7.Peer-Reviewed Original Research
2019
Use of the DyeVert System in Chronic Total Occlusion Percutaneous Coronary Intervention.
Tajti P, Xenogiannis I, Hall A, Burke MN, Chavez I, Garcia S, Gössl M, Mooney M, Poulose A, Sorajja P, Wang Y, Vemmou E, Nikolakopoulos I, Morley P, Rangan BV, Ungi I, Brilakis ES. Use of the DyeVert System in Chronic Total Occlusion Percutaneous Coronary Intervention. Journal Of Invasive Cardiology 2019, 31: 253-259. PMID: 31478890.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionChronic total occlusion (CTO) percutaneous coronary interventionCTO-PCIContrast volumeCoronary interventionCommon target vesselMedian contrast volumeContrast-induced nephropathyAdditional larger studiesPrimary clinical endpointRight coronary arteryHospital major complicationsLarger contrast volumeAmount of contrastMost patientsCardiac catheterizationMajor complicationsProcedural complicationsCircumflex arterySingle centerCoronary arteryMean ageClinical endpointsProcedural outcomesPatients