2024
Salty, Sweet, and Severe: A Case of Linagliptin-induced Severe Hyponatremia
Renzetti M, Potnis K, Vemmou E, Hansen B, Lin D, Yaggi H. Salty, Sweet, and Severe: A Case of Linagliptin-induced Severe Hyponatremia. 2024, a7036-a7036. DOI: 10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a7036.Peer-Reviewed Original ResearchINSTANT DIGITAL CONSULT FOR EVIDENCE-BASED INTERPRETATION OF HIGH-SENSITIVITY SERUM TROPONIN IN MYOCARDIAL INJURY
Ye Z, Maayah M, Wang P, See C, Grubman S, Akhlaghi N, Allen S, Dong W, Ghare M, Gokhan I, Grubman D, Mezue K, Mottola G, Park D, Trejo-Paredes C, Shen M, Vemmou E, Abdullah A, Alaiwi S, Sharma S, Gupta N, Gandhi P, Wang Y, Kwan J, Hu J. INSTANT DIGITAL CONSULT FOR EVIDENCE-BASED INTERPRETATION OF HIGH-SENSITIVITY SERUM TROPONIN IN MYOCARDIAL INJURY. Journal Of The American College Of Cardiology 2024, 83: 2522. DOI: 10.1016/s0735-1097(24)04512-1.Peer-Reviewed Original ResearchUNDERSTANDING THE IMPORTANCE OF AGE IN SELECTING A TESTING STRATEGY FOR STABLE SYMPTOMATIC PATIENTS WITH SUSPECTED CORONARY ARTERY DISEASE: A PRESPECIFIED ANALYSIS FROM THE PRECISE RANDOMIZED TRIAL
Vemmou E, Kelsey M, Vemulapalli S, Mark D, Rogers C, Mullen S, Huey W, Chiswell K, Clare R, Caune A, Yow E, Leipsic J, Byrne R, Ng N, Pier K, Udelson J, Douglas P, Nanna M. UNDERSTANDING THE IMPORTANCE OF AGE IN SELECTING A TESTING STRATEGY FOR STABLE SYMPTOMATIC PATIENTS WITH SUSPECTED CORONARY ARTERY DISEASE: A PRESPECIFIED ANALYSIS FROM THE PRECISE RANDOMIZED TRIAL. Journal Of The American College Of Cardiology 2024, 83: 1183. DOI: 10.1016/s0735-1097(24)03173-5.Peer-Reviewed Original ResearchClinical Interpretation of Serum Troponin in the Era of High-Sensitivity Testing
Maayah M, Grubman S, Allen S, Ye Z, Park D, Vemmou E, Gokhan I, Sun W, Possick S, Kwan J, Gandhi P, Hu J. Clinical Interpretation of Serum Troponin in the Era of High-Sensitivity Testing. Diagnostics 2024, 14: 503. PMID: 38472975, PMCID: PMC10930800, DOI: 10.3390/diagnostics14050503.Peer-Reviewed Original ResearchAcute coronary syndromeTn elevationCoronary syndromeTreatment of acute coronary syndromesNon-cardiac etiologyManagement of myocardial injuryEvaluation of patientsHigh-sensitivity assaySerum troponinHighly sensitive testPrognostic implicationsCardiac troponinMyocardial injuryPhysical examMyocardial ischemiaPoor specificityLaboratory dataClinical judgmentClinical interpretationTroponinSyndromeAnalytical sensitivityTN measurementsPresentationElevation
2023
CONTEMPORARY IN-HOSPITAL OUTCOMES OF CHRONIC TOTAL OCCLUSION INTERVENTIONS: UPDATE FROM MENATA (MIDDLE EAST, NORTH AFRICA, TURKEY AND ASIA) CHAPTER OF THE PROGRESS-CTO (PROSPECTIVE GLOBAL REGISTRY FOR THE STUDY OF CHRONIC TOTAL OCCLUSION INTERVENTION) REGISTRY
Kostantinis S, ElGuindy A, Goktekin O, Simsek B, Karacsonyi J, kalay N, Samir A, Maalouf A, soylu K, Yildirim U, Tigen K, cincin A, Kalyanasundaram A, Aygul N, sayed A, Jbara K, Shelton C, Vemmou E, Nikolakopoulos I, Allana S, Mastrodemos O, Rempakos A, Rangan B, Brilakis E, Rafeh N. CONTEMPORARY IN-HOSPITAL OUTCOMES OF CHRONIC TOTAL OCCLUSION INTERVENTIONS: UPDATE FROM MENATA (MIDDLE EAST, NORTH AFRICA, TURKEY AND ASIA) CHAPTER OF THE PROGRESS-CTO (PROSPECTIVE GLOBAL REGISTRY FOR THE STUDY OF CHRONIC TOTAL OCCLUSION INTERVENTION) REGISTRY. Journal Of The American College Of Cardiology 2023, 81: 937. DOI: 10.1016/s0735-1097(23)01381-5.Peer-Reviewed Original ResearchVALIDATION OF THE OPEN-CLEAN CHRONIC TOTAL OCCLUSION PERCUTANEOUS CORONARY INTERVENTION PERFORATION SCORE IN A MULTICENTER REGISTRY
Simsek B, Carlino M, Pan M, Vemmou E, Nikolakopoulos I, Kostantinis S, Karacsonyi J, Agostoni P, Alexandre A, Knaapen P, La Manna A, Spratt J, Tanabe M, Walsh S, Goktekin O, Allana S, Rangan B, Rempakos A, Choi J, Kearney K, Lombardi W, Grantham J, Hirai T, Brilakis E, Azzalini L. VALIDATION OF THE OPEN-CLEAN CHRONIC TOTAL OCCLUSION PERCUTANEOUS CORONARY INTERVENTION PERFORATION SCORE IN A MULTICENTER REGISTRY. Journal Of The American College Of Cardiology 2023, 81: 774. DOI: 10.1016/s0735-1097(23)01218-4.Peer-Reviewed Original ResearchEXTERNAL VALIDATION OF THE PROGRESS-CTO COMPLICATION RISK SCORES: INDIVIDUAL PATIENT DATA POOLED ANALYSIS OF 3 REGISTRIES
Simsek B, Tajti P, Carlino M, Rinfret S, Vemmou E, Kostantinis S, Nikolakopoulos I, Karacsonyi J, Agostoni P, Alaswad K, Megaly M, Avran A, Choi J, Khatri J, Knaapen P, La Manna A, Spratt J, Rangan B, Goktekin O, Kearney K, Lombardi W, Grantham J, Mashayekhi K, Brilakis E, Azzalini L. EXTERNAL VALIDATION OF THE PROGRESS-CTO COMPLICATION RISK SCORES: INDIVIDUAL PATIENT DATA POOLED ANALYSIS OF 3 REGISTRIES. Journal Of The American College Of Cardiology 2023, 81: 777. DOI: 10.1016/s0735-1097(23)01221-4.Peer-Reviewed Original ResearchTRENDS AND IMPACT OF INTRAVASCULAR ULTRASOUND AND OPTICAL COHERENCE TOMOGRAPHY ON PERCUTANEOUS CORONARY INTERVENTION FOR MYOCARDIAL INFARCTION
Vemmou E, Park D, An S, Nikolakopoulos I, Regan C, Cambi B, Frampton J, Vij A, Brilakis E, Nanna M. TRENDS AND IMPACT OF INTRAVASCULAR ULTRASOUND AND OPTICAL COHERENCE TOMOGRAPHY ON PERCUTANEOUS CORONARY INTERVENTION FOR MYOCARDIAL INFARCTION. Journal Of The American College Of Cardiology 2023, 81: 1013. DOI: 10.1016/s0735-1097(23)01457-2.Peer-Reviewed Original ResearchTrends and impact of intravascular ultrasound and optical coherence tomography on percutaneous coronary intervention for myocardial infarction
Park D, Vemmou E, An S, Nikolakopoulos I, Regan C, Cambi B, Frampton J, Vij A, Brilakis E, Nanna M. Trends and impact of intravascular ultrasound and optical coherence tomography on percutaneous coronary intervention for myocardial infarction. IJC Heart & Vasculature 2023, 45: 101186. PMID: 36852085, PMCID: PMC9957744, DOI: 10.1016/j.ijcha.2023.101186.Peer-Reviewed Original ResearchIntravascular imaging-guided percutaneous coronary interventionImaging-guided percutaneous coronary interventionPercutaneous coronary interventionOptical coherence tomographyMyocardial infarctionIntravascular ultrasoundCoronary interventionIntravascular imagingIVUS-guided percutaneous coronary interventionCoherence tomographyNumber of PCIsNational Inpatient SampleMultivariable logistic regressionCochran-Armitage trend testIVUS useHospital mortalityClinical outcomesOCT guidanceInpatient SampleImproved outcomesLower oddsLower mortalityLogistic regressionContinuous outcomesOutcomesSingle vs. multiple operators for chronic total occlusion percutaneous coronary interventions: From the PROGRESS‐CTO Registry
Karacsonyi J, Alaswad K, Krestyaninov O, Karmpaliotis D, Kirtane A, Ali Z, McEntegart M, Masoumi A, Poomipanit P, Jaffer F, Khatri J, Choi J, Patel M, Koutouzis M, Tsiafoutis I, Gorgulu S, Sheikh A, Elbarouni B, Jaber W, ElGuindy A, Yeh R, Kostantinis S, Simsek B, Rangan B, Mastrodemos O, Vemmou E, Nikolakopoulos I, Ungi I, Rafeh N, Goktekin O, Burke M, Brilakis E, Sandoval Y. Single vs. multiple operators for chronic total occlusion percutaneous coronary interventions: From the PROGRESS‐CTO Registry. Catheterization And Cardiovascular Interventions 2023, 101: 543-552. PMID: 36695421, DOI: 10.1002/ccd.30564.Peer-Reviewed Original ResearchConceptsCTO-PCIChronic total occlusion (CTO) percutaneous coronary interventionAir kerma radiation dosePercutaneous coronary intervention outcomesChronic total occlusion interventionLow MACE ratePROGRESS-CTO RegistryProspective global registryProcedural success ratePercutaneous coronary interventionHigh technical successRisk of complicationsMO casesCTO PCI casesMACE rateCoronary interventionMulticenter registryPatient ageMultivariable analysisProcedural successContrast volumeGlobal RegistryTechnical successProcedural outcomesPCI casesExternal validation of the PROGRESS‐CTO perforation risk score: Individual patient data pooled analysis of three registries
Simsek B, Tajti P, Carlino M, Ojeda S, Pan M, Rinfret S, Vemmou E, Kostantinis S, Nikolakopoulos I, Karacsonyi J, Rempakos A, Dens J, Agostoni P, Alaswad K, Megaly M, Avran A, Choi J, Jaffer F, Doshi D, Karmpaliotis D, Khatri J, Knaapen P, La Manna A, Spratt J, Tanabe M, Walsh S, Mastrodemos O, Allana S, Rangan B, Goktekin O, Gorgulu S, Poommipanit P, Kearney K, Lombardi W, Grantham J, Mashayekhi K, Brilakis E, Azzalini L. External validation of the PROGRESS‐CTO perforation risk score: Individual patient data pooled analysis of three registries. Catheterization And Cardiovascular Interventions 2023, 101: 326-332. PMID: 36617391, DOI: 10.1002/ccd.30551.Peer-Reviewed Original ResearchPercutaneous coronary interventionCTO percutaneous coronary interventionCoronary artery perforationArtery perforationRisk scorePrior coronary artery bypass graftChronic total occlusion (CTO) percutaneous coronary interventionCoronary artery bypass graftIndividual patient-level dataModerate-severe calcificationUnfavorable angiographic characteristicsArtery bypass graftIndividual patient dataRisk of perforationPatient-level dataProximal cap ambiguityGood discriminative performanceBlunt stumpAngiographic characteristicsCoronary interventionCommon complicationBypass graftTechnical successPerforation riskIndependent cohort
2022
External validation of the PROGRESS-CTO complication risk scores: Individual patient data pooled analysis of 3 registries
Simsek B, Tajti P, Carlino M, Ojeda S, Pan M, Rinfret S, Vemmou E, Kostantinis S, Nikolakopoulos I, Karacsonyi J, Dens J, Agostoni P, Alaswad K, Megaly M, Avran A, Choi J, Jaffer F, Doshi D, Karmpaliotis D, Khatri J, Knaapen P, La Manna A, Spratt J, Tanabe M, Walsh S, Mastrodemos O, Allana S, Rempakos A, Rangan B, Goktekin O, Gorgulu S, Poommipanit P, Kearney K, Lombardi W, Grantham J, Mashayekhi K, Brilakis E, Azzalini L. External validation of the PROGRESS-CTO complication risk scores: Individual patient data pooled analysis of 3 registries. International Journal Of Cardiology 2022, 375: 14-20. PMID: 36565956, DOI: 10.1016/j.ijcard.2022.12.036.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsPercutaneous coronary interventionCTO percutaneous coronary interventionComplication risk scoreIndividual patient dataComplication scoreRisk scorePrior coronary artery bypass graft surgeryCoronary artery bypass graft surgeryChronic total occlusion (CTO) percutaneous coronary interventionArtery bypass graft surgeryObserved complication rateAdverse cardiovascular eventsBypass graft surgeryPatient dataJ-CTO scoreRisk of complicationsGood discriminative performanceBlunt stumpMACE rateMACE scoresCardiovascular eventsGraft surgeryCoronary interventionComplication rateValidation of the OPEN-CLEAN Chronic Total Occlusion Percutaneous Coronary Intervention Perforation Score in a Multicenter Registry
Simsek B, Carlino M, Ojeda S, Pan M, Rinfret S, Vemmou E, Kostantinis S, Nikolakopoulos I, Karacsonyi J, Quadros A, Dens J, Abi Rafeh N, Agostoni P, Alaswad K, Avran A, Belli K, Choi J, Elguindy A, Jaffer F, Doshi D, Karmpaliotis D, Khatri J, Khelimskii D, Knaapen P, La Manna A, Krestyaninov O, Lamelas P, Padilla L, de Oliveira P, Spratt J, Tanabe M, Walsh S, Goktekin O, Gorgulu S, Mastrodemos O, Allana S, Rangan B, Kearney K, Lombardi W, Grantham J, Hirai T, Brilakis E, Azzalini L. Validation of the OPEN-CLEAN Chronic Total Occlusion Percutaneous Coronary Intervention Perforation Score in a Multicenter Registry. The American Journal Of Cardiology 2022, 188: 30-35. PMID: 36462272, DOI: 10.1016/j.amjcard.2022.11.023.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionCTO percutaneous coronary interventionCoronary artery perforationArtery perforationPerforation riskPrevious coronary artery bypass graftChronic total occlusion (CTO) percutaneous coronary interventionCoronary artery bypass graftModerate-severe calcificationUnfavorable angiographic characteristicsArtery bypass graftProximal cap ambiguityBlunt stumpAngiographic characteristicsMulticenter registryCoronary interventionFeared complicationBypass graftTechnical successPatientsPerforationGood calibrationCharacteristic curveScoresRiskA Systematic Review and Meta-Analysis of Clinical Outcomes of Patients Undergoing Chronic Total Occlusion Percutaneous Coronary Intervention.
Simsek B, Kostantinis S, Karacsonyi J, Alaswad K, Megaly M, Karmpaliotis D, Masoumi A, Jaber W, Nicholson W, Rinfret S, Mashayekhi K, Werner G, McEntegart M, Lee S, Khatri J, Harding S, Avran A, Jaffer F, Doshi D, Kao H, Sianos G, Yamane M, Milkas A, Azzalini L, Garbo R, Tammam K, Abi Rafeh N, Nikolakopoulos I, Vemmou E, Rangan B, Burke M, Garcia S, Croce K, Wu E, Tsuchikane E, Di Mario C, Galassi A, Gagnor A, Knaapen P, Jang Y, Kim B, Poommipanit P, Brilakis E. A Systematic Review and Meta-Analysis of Clinical Outcomes of Patients Undergoing Chronic Total Occlusion Percutaneous Coronary Intervention. Journal Of Invasive Cardiology 2022, 34: e763-e775. PMID: 36227013.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsPercutaneous coronary interventionChronic total occlusion (CTO) percutaneous coronary interventionSubsequent clinical outcomesClinical outcomesCTO-PCIObservational studyMyocardial infarctionCause mortalityCoronary interventionOdds ratioSubsequent coronary artery bypass surgerySystematic reviewCoronary artery bypass surgeryAdverse cardiovascular eventsHeart failure hospitalizationTarget vessel revascularizationArtery bypass surgeryBetter clinical outcomesConfidence intervalsRandom-effects modelWeb of ScienceCardiovascular deathCardiovascular eventsFailure hospitalizationThe impact of ST-segment elevation on the prognosis of patients with Takotsubo cardiomyopathy
Xenogiannis I, Vemmou E, Nikolakopoulos I, Nowariak M, Schmidt C, Brilakis E, Sharkey S. The impact of ST-segment elevation on the prognosis of patients with Takotsubo cardiomyopathy. Journal Of Electrocardiology 2022, 75: 60-65. PMID: 36202658, DOI: 10.1016/j.jelectrocard.2022.09.009.Peer-Reviewed Original ResearchConceptsST-segment elevationFive-year mortalityTakotsubo cardiomyopathyInitial left ventricular ejection fractionSTE groupVentricular outflow tract obstructionLeft ventricular ejection fractionAnterior Q wavesApical ballooning patternDisease related complicationsMid-ventricular ballooningMinneapolis Heart InstituteOutflow tract obstructionVentricular outflow obstructionST-segment depressionLV thrombus formationVentricular ejection fractionPrognosis of patientsTerms of prognosisT-wave inversionBundle branch blockBallooning patternHospital mortalityInitial EKGVasopressor supportOutcomes and challenges of the provisional stenting technique: Insights from the PROGRESS‐BIFURCATION registry
Simsek B, Kostantinis S, Karacsonyi J, Allana S, Vemmou E, Nikolakopoulos I, Burke M, Garcia S, Wang Y, Chavez I, Gössl M, Sorajja P, Mooney M, Poulose A, Sandoval Y, Traverse J, Rangan B, Brilakis E. Outcomes and challenges of the provisional stenting technique: Insights from the PROGRESS‐BIFURCATION registry. Catheterization And Cardiovascular Interventions 2022, 100: 749-755. PMID: 36121014, DOI: 10.1002/ccd.30401.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionTwo-stent strategyProvisional stentingProcedural successTechnical successHospital major adverse cardiovascular eventsMajor adverse cardiovascular eventsAdverse cardiovascular eventsLower technical successProspective global registrySimilar procedural successProvisional stenting techniqueAngiographic characteristicsCardiovascular eventsCoronary interventionDiameter stenosisGlobal RegistryDistal lesionsProcedural outcomesSB involvementSB lesion lengthBifurcation lesionsSide branch diameterStenting techniquesStentingTCT-150 Evaluation of Commonly Used Measurements of Side Branch Clinical Significance in Bifurcation Lesions: A Pilot Substudy From the PROGRESS-BIFURCATION Registry
Nikolakopoulos I, Karacsonyi J, Vemmou E, Simsek B, Kostantinis S, Mastrodemos O, Garcia S, Sharkey S, Burke M, Sorajja P, Traverse J, Chavez I, Wang Y, Poulose A, Mooney M, Rangan B, Tousoulis D, Aggeli K, Hur D, Ahmad Y, Tsioufis K, Brilakis E. TCT-150 Evaluation of Commonly Used Measurements of Side Branch Clinical Significance in Bifurcation Lesions: A Pilot Substudy From the PROGRESS-BIFURCATION Registry. Journal Of The American College Of Cardiology 2022, 80: b61. DOI: 10.1016/j.jacc.2022.08.176.Peer-Reviewed Original ResearchPrimary vs Secondary Retrograde Approach in Chronic Total Occlusion Percutaneous Coronary Interventions.
Kostantinis S, Alaswad K, Karmpaliotis D, Jaffer F, Jaber W, Nicholson W, Rinfret S, Khatri J, Poommipanit P, Karacsonyi J, Simsek B, Vemmou E, Nikolakopoulos I, Koutouzis M, Tsiafoutis I, Riley R, Sheikh A, Patel M, Gorgulu S, ElGuindy A, Goktekin O, Abi Rafeh N, Rangan B, Garcia S, Burke M, Brilakis E. Primary vs Secondary Retrograde Approach in Chronic Total Occlusion Percutaneous Coronary Interventions. Journal Of Invasive Cardiology 2022, 34: e672-e677. PMID: 35969839.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionCoronary chronic total occlusionsRetrograde approachRetrograde CTO-PCICoronary interventionCTO-PCIHospital major adverse cardiac eventsCoronary artery bypass graft surgeryChronic total occlusion (CTO) percutaneous coronary interventionMajor adverse cardiac eventsMajor adverse event rateArtery bypass graft surgeryCTO percutaneous coronary interventionAdverse cardiac eventsBypass graft surgeryAdverse event ratesProcedural success rateVentricular ejection fractionChronic total occlusionPROGRESS CTO scoresAngiographic characteristicsGraft surgeryCardiac eventsEjection fractionProcedural successSerial T-Wave Changes in a Patient With Chest Pain
Xenogiannis I, Vemmou E, Sharkey S. Serial T-Wave Changes in a Patient With Chest Pain. JAMA Internal Medicine 2022, 182: 874-875. PMID: 35759277, DOI: 10.1001/jamainternmed.2022.2389.Peer-Reviewed Original ResearchE-18 | Intravascular Lithotripsy in Chronic Total Occlusion Percutaneous Coronary Intervention
Kostantinis S, Simsek B, Karacsonyi J, Alaswad K, Basir M, Megaly M, Khatri J, Young L, Benton S, Davies R, Poommipanit P, Jaber W, Dattilo P, Rafeh N, Elguindy A, Göktekin Ö, Schimmel D, Sheikh A, Vemmou E, Nikolakopoulos I, Mastrodemos O, Rangan B, Brilakis E. E-18 | Intravascular Lithotripsy in Chronic Total Occlusion Percutaneous Coronary Intervention. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100278. DOI: 10.1016/j.jscai.2022.100278.Peer-Reviewed Original Research