2023
Physiology-guided PCI versus CABG for left main coronary artery disease: insights from the DEFINE-LM registry
Warisawa T, Cook C, Kawase Y, Howard J, Ahmad Y, Seligman H, Rajkumar C, Toya T, Doi S, Nakajima A, Tanigaki T, Omori H, Nakayama M, Vera-Urquiza R, Yuasa S, Sato T, Kikuta Y, Nishina H, Al-Lamee R, Sen S, Lerman A, Akashi Y, Escaned J, Matsuo H, Davies J. Physiology-guided PCI versus CABG for left main coronary artery disease: insights from the DEFINE-LM registry. Cardiovascular Intervention And Therapeutics 2023, 38: 287-298. PMID: 37017899, PMCID: PMC10247826, DOI: 10.1007/s12928-023-00932-z.Peer-Reviewed Original ResearchConceptsUnprotected left main coronary diseasePercutaneous coronary interventionInstantaneous wave-free ratioMain coronary artery diseaseNon-fatal myocardial infarctionCoronary artery bypassCoronary artery diseasePrimary endpointCause deathLesion revascularizationArtery bypassSYNTAX scoreCoronary interventionArtery diseaseClinical outcomesMyocardial infarctionIschemia-driven target lesion revascularizationLeft main coronary artery diseaseArt percutaneous coronary interventionLeft main coronary diseaseLower cardiovascular event ratesMajor adverse cardiovascular eventsLong-term clinical outcomesPropensity scorePhysiology-guided percutaneous coronary intervention
2021
Usefulness of Computed Tomography to Predict Mitral Stenosis After Transcatheter Mitral Valve Edge-to-Edge Repair
Kaewkes D, Patel V, Ochiai T, Flint N, Ahmad Y, Kim I, Koseki K, Sharma R, Joseph J, Yoon SH, Chakravarty T, Nakamura M, Makar M, Makkar R. Usefulness of Computed Tomography to Predict Mitral Stenosis After Transcatheter Mitral Valve Edge-to-Edge Repair. The American Journal Of Cardiology 2021, 153: 109-118. PMID: 34210503, DOI: 10.1016/j.amjcard.2021.05.025.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac CatheterizationEchocardiographyEchocardiography, TransesophagealFemaleHumansMaleMiddle AgedMitral ValveMitral Valve AnnuloplastyMitral Valve InsufficiencyMitral Valve StenosisMultidetector Computed TomographyPostoperative ComplicationsPreoperative PeriodRisk AssessmentConceptsMitral valve orifice areaMitraClip implantationMitral stenosisMDCT parametersPredictive valuePre-discharge transthoracic echocardiographyTranscatheter mitral valve edgeTranscatheter mitral valve interventionsMitral valve interventionMitral valve edgeMitral annulus areaOptimal cutoff valueValve orifice areaCharacteristic curve analysisMitral annulus diameterNegative predictive valuePositive predictive valueTransthoracic echocardiographyConsecutive patientsValve interventionMitraClip procedureMitral regurgitationAP diameterAnnulus diameterEdge repairCorrelation of Intravascular Ultrasound and Instantaneous Wave-Free Ratio in Patients With Intermediate Left Main Coronary Artery Disease
Hajj S, Toya T, Warisawa T, Nan J, Lewis BR, Cook CM, Rajkumar C, Howard JP, Seligman H, Ahmad Y, Doi S, Nakajima A, Nakayama M, Goto S, Vera-Urquiza R, Sato T, Kikuta Y, Kawase Y, Nishina H, Nakamura S, Matsuo H, Escaned J, Akashi YJ, Davies JE, Lerman A. Correlation of Intravascular Ultrasound and Instantaneous Wave-Free Ratio in Patients With Intermediate Left Main Coronary Artery Disease. Circulation Cardiovascular Interventions 2021, 14: e009830. PMID: 34092096, PMCID: PMC8206001, DOI: 10.1161/circinterventions.120.009830.Peer-Reviewed Original ResearchConceptsInstantaneous wave-free ratioMinimum lumen areaUse of iFRBody surface areaLumen areaArtery diseaseIntravascular ultrasoundMain coronary artery diseaseMulticenter retrospective observational studyCurve analysisCircumflex artery diseaseMain coronary diseaseVisual angiographic assessmentIndependent core laboratoryRetrospective observational studyCoronary artery diseaseIntravascular ultrasound evaluationFractional flow reserveCoronary diseaseUltrasound evaluationAngiographic assessmentIntravascular ultrasound dataFlow reserveObservational studyPatients
2020
Impella percutaneous left ventricular assist device as mechanical circulatory support for cardiogenic shock: A retrospective analysis from a tertiary academic medical center
Nouri SN, Malick W, Masoumi A, Fried JA, Topkara VK, Brener MI, Ahmad Y, Prasad M, Rabbani LE, Takeda K, Karmpaliotis D, Moses JW, Leon MB, Kirtane AJ, Garan AR. Impella percutaneous left ventricular assist device as mechanical circulatory support for cardiogenic shock: A retrospective analysis from a tertiary academic medical center. Catheterization And Cardiovascular Interventions 2020, 99: 37-47. PMID: 33325612, DOI: 10.1002/ccd.29434.Peer-Reviewed Original ResearchConceptsPercutaneous left ventricular assist deviceMechanical circulatory supportImpella percutaneous left ventricular assist deviceLeft ventricular assist deviceCardiogenic shockExtracorporeal membrane oxygenationVentricular assist deviceCirculatory supportCS patientsAssist deviceTertiary academic medical centerMultivariable logistic regression modelAcute myocardial infarctionDevice-related outcomesAcademic medical centerLogistic regression modelsHospital mortalityClinical characteristicsHemodynamic statusMembrane oxygenationClinical outcomesHemodynamic efficacyDevice implantationEntire cohortMyocardial infarctionComplete Revascularization by Percutaneous Coronary Intervention for Patients With ST‐Segment–Elevation Myocardial Infarction and Multivessel Coronary Artery Disease: An Updated Meta‐Analysis of Randomized Trials
Ahmad Y, Howard JP, Arnold A, Prasad M, Seligman H, Cook CM, Warisawa T, Shun‐Shun M, Ali Z, Parikh MA, Al‐Lamee R, Sen S, Francis D, Moses JW, Leon MB, Stone GW, Karmpaliotis D. Complete Revascularization by Percutaneous Coronary Intervention for Patients With ST‐Segment–Elevation Myocardial Infarction and Multivessel Coronary Artery Disease: An Updated Meta‐Analysis of Randomized Trials. Journal Of The American Heart Association 2020, 9: e015263. PMID: 32476540, PMCID: PMC7429036, DOI: 10.1161/jaha.119.015263.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionMultivessel coronary artery diseasePercutaneous coronary interventionCulprit-only revascularizationCoronary artery diseaseComplete revascularizationCoronary interventionMyocardial infarctionCardiovascular deathArtery diseaseUnplanned revascularizationMultivessel diseaseCause mortalityEnd pointPrimary efficacy end pointHard clinical outcomesEfficacy end pointSecondary end pointsClinical end pointsElevation myocardial infarctionClinical practice guidelinesTreat basisClinical outcomesRandomized trialsOptimal treatmentInter-observer differences in interpretation of coronary pressure-wire pullback data by non-expert interventional cardiologists
Warisawa T, Howard JP, Cook CM, Ahmad Y, Doi S, Nakayama M, Goto S, Yakuta Y, Karube K, Seike F, Uetani T, Murai T, Kikuta Y, Shiono Y, Kawase Y, Shun-Shin MJ, Kaihara T, Higuma T, Ishibashi Y, Matsuda H, Nishina H, Matsuo H, Escaned J, Akashi YJ, Davies JE. Inter-observer differences in interpretation of coronary pressure-wire pullback data by non-expert interventional cardiologists. Cardiovascular Intervention And Therapeutics 2020, 36: 289-297. PMID: 32430763, DOI: 10.1007/s12928-020-00673-3.Peer-Reviewed Original ResearchConceptsInterventional cardiologistsInter-observer differencesCoronary artery diseaseLow-volume centersHigh-volume centersExpert interventional cardiologistsExpertise of physiciansPhysiological patternsArtery diseaseRisk stratificationCenter volumeNon-expert doctorsPooled accuracyDisease patternsCardiologistsYears of experienceReference standardDiseaseDoctorsRevascularizationPatientsYearsPhysiciansSafety of Revascularization Deferral of Left Main Stenosis Based on Instantaneous Wave-Free Ratio Evaluation
Warisawa T, Cook CM, Rajkumar C, Howard JP, Seligman H, Ahmad Y, El Hajj S, Doi S, Nakajima A, Nakayama M, Goto S, Vera-Urquiza R, Sato T, Kikuta Y, Kawase Y, Nishina H, Petraco R, Al-Lamee R, Nijjer S, Sen S, Nakamura S, Lerman A, Matsuo H, Francis DP, Akashi YJ, Escaned J, Davies JE. Safety of Revascularization Deferral of Left Main Stenosis Based on Instantaneous Wave-Free Ratio Evaluation. JACC Cardiovascular Interventions 2020, 13: 1655-1664. PMID: 32417088, DOI: 10.1016/j.jcin.2020.02.035.Peer-Reviewed Original ResearchMeSH KeywordsAgedClinical Decision-MakingCoronary Artery BypassCoronary Artery DiseaseCoronary StenosisEuropeFemaleFractional Flow Reserve, MyocardialHumansJapanMaleMiddle AgedPercutaneous Coronary InterventionPredictive Value of TestsProspective StudiesRegistriesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTime-to-TreatmentTreatment OutcomeUnited StatesConceptsInstantaneous wave-free ratioNonfatal myocardial infarctionPrimary endpointLM stenosisCause deathLesion revascularizationSecondary endpointsCardiac deathMyocardial infarctionIschemia-driven target lesion revascularizationSimilar long-term outcomesStable coronary artery diseaseMain coronary artery stenosisLong-term clinical outcomesSafety of deferralMulticenter observational studyTarget lesion revascularizationLeft main stenosisCoronary artery diseaseLong-term outcomesCoronary artery stenosisDeferred groupLM revascularizationMedian followRevascularization deferralDifference in functional assessment of individual stenosis severity in serial coronary lesions between resting and hyperemic pressure-wire pullback: Insights from the GIFT registry
Warisawa T, Howard JP, Kawase Y, Tanigaki T, Omori H, Cook CM, Ahmad Y, Francis DP, Akashi YJ, Matsuo H, Davies JE. Difference in functional assessment of individual stenosis severity in serial coronary lesions between resting and hyperemic pressure-wire pullback: Insights from the GIFT registry. International Journal Of Cardiology 2020, 312: 10-15. PMID: 32376416, DOI: 10.1016/j.ijcard.2020.05.001.Peer-Reviewed Original ResearchConceptsFractional flow reserveInstantaneous wave-free ratioCoronary lesionsPressure-wire pullbackCoronary artery lesionsPhysiological assessmentArtery lesionsConsecutive patientsCoronary stenosisHemodynamic significanceWave-free periodFlow reserveHemodynamic interactionSerial lesionsSerial stenosesFunctional assessmentStenosis severityLesionsStenosisHyperemic conditionsStatistical differenceWhole cardiac cycleReference standardCardiac cyclePredominancePer-Vessel Level Analysis of Fractional Flow Reserve and Instantaneous Wave-Free Ratio Discordance ― Insights From the AJIP Registry ―
Warisawa T, Cook CM, Seligman H, Howard JP, Ahmad Y, Rajkumar C, Doi S, Nakayama M, Tanigaki T, Omori H, Nakajima A, Yamanaka F, Goto S, Yakuta Y, Karube K, Uetani T, Kikuta Y, Shiono Y, Kawase Y, Nishina H, Nakamura S, Escaned J, Akashi YJ, Matsuo H, Davies JE. Per-Vessel Level Analysis of Fractional Flow Reserve and Instantaneous Wave-Free Ratio Discordance ― Insights From the AJIP Registry ―. Circulation Journal 2020, 84: 1034-1038. PMID: 32321880, DOI: 10.1253/circj.cj-19-0785.Peer-Reviewed Original ResearchHow Do Fractional Flow Reserve, Whole-Cycle PdPa, and Instantaneous Wave-Free Ratio Correlate With Exercise Coronary Flow Velocity During Exercise-Induced Angina?
Cook CM, Howard JP, Ahmad Y, Shun-Shin MJ, Sethi A, Clesham GJ, Tang KH, Nijjer SS, Kelly PA, Davies JR, Malik IS, Kaprielian R, Mikhail G, Petraco R, Warisawa T, Al-Janabi F, Karamasis GV, Mohdnazri S, Gamma R, de Waard GA, Al-Lamee R, Keeble TR, Mayet J, Sen S, Francis DP, Davies JE. How Do Fractional Flow Reserve, Whole-Cycle PdPa, and Instantaneous Wave-Free Ratio Correlate With Exercise Coronary Flow Velocity During Exercise-Induced Angina? Circulation Cardiovascular Interventions 2020, 13: e008460. PMID: 32200646, DOI: 10.1161/circinterventions.119.008460.Peer-Reviewed Original ResearchLong‐Term Effects of Transcatheter Aortic Valve Implantation on Coronary Hemodynamics in Patients With Concomitant Coronary Artery Disease and Severe Aortic Stenosis
Vendrik J, Ahmad Y, Eftekhari A, Howard JP, Wijntjens GWM, Stegehuis VE, Cook C, Terkelsen CJ, Christiansen EH, Koch KT, Piek JJ, Sen S, Baan J. Long‐Term Effects of Transcatheter Aortic Valve Implantation on Coronary Hemodynamics in Patients With Concomitant Coronary Artery Disease and Severe Aortic Stenosis. Journal Of The American Heart Association 2020, 9: e015133. PMID: 32102615, PMCID: PMC7335578, DOI: 10.1161/jaha.119.015133.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationSevere aortic stenosisConcomitant coronary artery diseaseAortic stenosisAortic valve implantationCoronary artery diseasePost-TAVICoronary flowArtery diseaseValve implantationCoronary hemodynamicsLarge-scale prospective randomized trialsFractional flow reserve assessmentProspective randomized trialsLow-risk patientsHyperemic coronary flowInstantaneous wave-free ratioFractional flow reserveCoronary stenosis severityYounger patientsCoronary lesionsRandomized trialsDiastolic flowPatient populationWave-free periodEffects of Percutaneous Coronary Intervention on Death and Myocardial Infarction Stratified by Stable and Unstable Coronary Artery Disease
Chacko L, Howard J, Rajkumar C, Nowbar AN, Kane C, Mahdi D, Foley M, Shun-Shin M, Cole G, Sen S, Al-Lamee R, Francis DP, Ahmad Y. Effects of Percutaneous Coronary Intervention on Death and Myocardial Infarction Stratified by Stable and Unstable Coronary Artery Disease. Circulation Cardiovascular Quality And Outcomes 2020, 13: e006363-e006363. PMID: 32063040, PMCID: PMC7034389, DOI: 10.1161/circoutcomes.119.006363.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAdultAgedAged, 80 and overCause of DeathClinical Decision-MakingCoronary Artery DiseaseFemaleHumansMaleMiddle AgedNon-ST Elevated Myocardial InfarctionPercutaneous Coronary InterventionRandomized Controlled Trials as TopicRisk AssessmentRisk FactorsST Elevation Myocardial InfarctionTime FactorsTreatment OutcomeYoung AdultConceptsST-segment elevation myocardial infarctionStable coronary artery diseaseUnstable coronary artery diseasePercutaneous coronary interventionCoronary artery diseaseSegment elevation acute coronary syndromesAcute coronary syndromeMyocardial infarctionCardiac deathMultivessel diseaseCoronary syndromeCoronary interventionArtery diseaseBenefits of PCITrials of PCITreatment of CADCulprit-only revascularization strategyEarly percutaneous coronary interventionPrimary percutaneous coronary interventionPatients post-myocardial infarctionResidual coronary lesionsPrimary end pointComparative Health EffectivenessPost-myocardial infarctionImmediate revascularization
2019
Determining the Predominant Lesion in Patients With Severe Aortic Stenosis and Coronary Stenoses
Ahmad Y, Vendrik J, Eftekhari A, Howard JP, Cook C, Rajkumar C, Malik I, Mikhail G, Ruparelia N, Hadjiloizou N, Nijjer S, Al-Lamee R, Petraco R, Warisawa T, Wijntjens GWM, Koch KT, van de Hoef T, de Waard G, Echavarria-Pinto M, Frame A, Sutaria N, Kanaganayagam G, Ariff B, Anderson J, Chukwuemeka A, Fertleman M, Koul S, Iglesias JF, Francis D, Mayet J, Serruys P, Davies J, Escaned J, van Royen N, Götberg M, Terkelsen C, Christiansen E, Piek JJ, Baan J, Sen S. Determining the Predominant Lesion in Patients With Severe Aortic Stenosis and Coronary Stenoses. Circulation Cardiovascular Interventions 2019, 12: e008263-e008263. PMID: 31752515, PMCID: PMC6924937, DOI: 10.1161/circinterventions.119.008263.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisBlood Flow VelocityCardiac CatheterizationCoronary Artery DiseaseCoronary CirculationCoronary StenosisCoronary VesselsEuropeFemaleHemodynamicsHumansMaleMicrocirculationPercutaneous Coronary InterventionPredictive Value of TestsRecovery of FunctionSeverity of Illness IndexTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsTranscatheter aortic valve implantationSevere aortic stenosisPercutaneous coronary interventionAortic stenosisCoronary artery diseaseCoronary stenosisIntermediate coronary stenosisCoronary diseaseCoronary interventionArtery diseaseCoronary microcirculationWave-free periodInstantaneous wave-free ratio valueConcomitant coronary artery diseaseConcomitant coronary diseaseAortic valve implantationInstantaneous wave-free ratioPhysiology-guided revascularizationExertional symptomsPost-TAVIHemodynamic improvementHemodynamic benefitsValve implantationCoronary lesionsMicrovascular resistanceDobutamine Stress Echocardiography Ischemia as a Predictor of the Placebo-Controlled Efficacy of Percutaneous Coronary Intervention in Stable Coronary Artery Disease: The Stress Echocardiography-Stratified Analysis of ORBITA
Al-Lamee RK, Shun-Shin MJ, Howard JP, Nowbar AN, Rajkumar C, Thompson D, Sen S, Nijjer S, Petraco R, Davies J, Keeble T, Tang K, Malik I, Bual N, Cook C, Ahmad Y, Seligman H, Sharp ASP, Gerber R, Talwar S, Assomull R, Cole G, Keenan NG, Kanaganayagam G, Sehmi J, Wensel R, Harrell FE, Mayet J, Thom S, Davies JE, Francis DP. Dobutamine Stress Echocardiography Ischemia as a Predictor of the Placebo-Controlled Efficacy of Percutaneous Coronary Intervention in Stable Coronary Artery Disease: The Stress Echocardiography-Stratified Analysis of ORBITA. Circulation 2019, 140: 1971-1980. PMID: 31707827, PMCID: PMC6903430, DOI: 10.1161/circulationaha.119.042918.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionDobutamine stress echocardiographyStable coronary artery diseasePlacebo-controlled effectsPlacebo-controlled efficacyCoronary artery diseaseStress echocardiographyEchocardiography scoreCoronary interventionArtery diseaseCanadian Cardiovascular Society angina classEffect of PCIAngina frequency scoreTreadmill exercise timeDegree of ischemiaQuality of lifeAngina classEchocardiography abnormalitiesORBITA trialAngina frequencyPCI armPlacebo armAkinetic segmentsDyskinetic segmentsLife scoresPhysiological Pattern of Disease Assessed by Pressure-Wire Pullback Has an Influence on Fractional Flow Reserve/Instantaneous Wave-Free Ratio Discordance
Warisawa T, Cook CM, Howard JP, Ahmad Y, Doi S, Nakayama M, Goto S, Yakuta Y, Karube K, Shun-Shin MJ, Petraco R, Sen S, Nijjer S, Lamee R, Ishibashi Y, Matsuda H, Escaned J, di Mario C, Francis DP, Akashi YJ, Davies JE. Physiological Pattern of Disease Assessed by Pressure-Wire Pullback Has an Influence on Fractional Flow Reserve/Instantaneous Wave-Free Ratio Discordance. Circulation Cardiovascular Interventions 2019, 12: e007494-e007494. PMID: 31084237, PMCID: PMC6553990, DOI: 10.1161/circinterventions.118.007494.Peer-Reviewed Original ResearchConceptsInstantaneous wave-free ratioFractional flow reservePressure-wire pullbackCoronary artery diseaseArtery diseaseCoronary lesionsHemodynamic significancePhysiological patternsInternational multicenter registryIntermediate coronary lesionsMedian fractional flow reserveMulticenter registryFlow reserveDiseaseLesionsCut pointsIFR measurementDiscordanceRegistryFactorsClinical Events After Deferral of LAD Revascularization Following Physiological Coronary Assessment
Sen S, Ahmad Y, Dehbi HM, Howard JP, Iglesias JF, Al-Lamee R, Petraco R, Nijjer S, Bhindi R, Lehman S, Walters D, Sapontis J, Janssens L, Vrints CJ, Khashaba A, Laine M, Van Belle E, Krackhardt F, Bojara W, Going O, Härle T, Indolfi C, Niccoli G, Ribichini F, Tanaka N, Yokoi H, Takashima H, Kikuta Y, Erglis A, Vinhas H, Silva PC, Baptista SB, Alghamdi A, Hellig F, Koo BK, Nam CW, Shin ES, Doh JH, Brugaletta S, Alegria-Barrero E, Meuwissen M, Piek JJ, van Royen N, Sezer M, Di Mario C, Gerber RT, Malik IS, Sharp ASP, Talwar S, Tang K, Samady H, Altman J, Seto AH, Singh J, Jeremias A, Matsuo H, Kharbanda RK, Patel MR, Serruys P, Escaned J, Davies JE. Clinical Events After Deferral of LAD Revascularization Following Physiological Coronary Assessment. Journal Of The American College Of Cardiology 2019, 73: 444-453. PMID: 30704577, PMCID: PMC6354033, DOI: 10.1016/j.jacc.2018.10.070.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsInstantaneous wave-free ratioFractional flow reserveLAD lesionsMyocardial infarctionUnplanned revascularizationLeft anterior descending (LAD) arteryEvent ratesLower myocardial infarctionAdverse cardiac eventsAnterior descending (LAD) arteryPhysiological assessmentLow event ratesMACE rateCardiac eventsCardiovascular deathClinical eventsFlow reserveHigh riskPatientsLesionsLADRevascularizationTrialsTreatment
2018
Coronary Hemodynamics in Patients With Severe Aortic Stenosis and Coronary Artery Disease Undergoing Transcatheter Aortic Valve Replacement Implications for Clinical Indices of Coronary Stenosis Severity
Ahmad Y, Götberg M, Cook C, Howard JP, Malik I, Mikhail G, Frame A, Petraco R, Rajkumar C, Demir O, Iglesias JF, Bhindi R, Koul S, Hadjiloizou N, Gerber R, Ramrakha P, Ruparelia N, Sutaria N, Kanaganayagam G, Ariff B, Fertleman M, Anderson J, Chukwuemeka A, Francis D, Mayet J, Serruys P, Davies J, Sen S. Coronary Hemodynamics in Patients With Severe Aortic Stenosis and Coronary Artery Disease Undergoing Transcatheter Aortic Valve Replacement Implications for Clinical Indices of Coronary Stenosis Severity. JACC Cardiovascular Interventions 2018, 11: 2019-2031. PMID: 30154062, PMCID: PMC6197079, DOI: 10.1016/j.jcin.2018.07.019.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic Valve StenosisBlood Flow VelocityCardiac CatheterizationCoronary Artery DiseaseCoronary StenosisFemaleFractional Flow Reserve, MyocardialHemodynamicsHumansHyperemiaLondonMalePredictive Value of TestsReproducibility of ResultsSeverity of Illness IndexSwedenTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsSevere aortic stenosisTranscatheter aortic valve replacementCoronary artery diseaseCoronary stenosis severityAortic stenosisHyperemic coronary flowFractional flow reserveArtery diseaseCoronary flowStenosis severityWave-free periodClinical indicesHyperemic flowFlow reserveInstantaneous wave-free ratio valueIntracoronary pressureConcomitant coronary artery diseaseAortic valve replacementStenotic aortic valvesInstantaneous wave-free ratioPhasic coronary flowValve replacementHyperemic indexAortic valveCoronary pressureImpact of Percutaneous Revascularization on Exercise Hemodynamics in Patients With Stable Coronary Disease
Cook CM, Ahmad Y, Howard JP, Shun-Shin MJ, Sethi A, Clesham GJ, Tang KH, Nijjer SS, Kelly PA, Davies JR, Malik IS, Kaprielian R, Mikhail G, Petraco R, Al-Janabi F, Karamasis GV, Mohdnazri S, Gamma R, Al-Lamee R, Keeble TR, Mayet J, Sen S, Francis DP, Davies JE. Impact of Percutaneous Revascularization on Exercise Hemodynamics in Patients With Stable Coronary Disease. Journal Of The American College Of Cardiology 2018, 72: 970-983. PMID: 30139442, PMCID: PMC6580361, DOI: 10.1016/j.jacc.2018.06.033.Peer-Reviewed Original ResearchConceptsStable coronary artery diseasePercutaneous coronary interventionSystemic hemodynamicsCoronary circulationImpact of PCIInstantaneous wave-free ratio valuePeak coronary flow velocitySingle-vessel coronary stenosisSingle-vessel stenosisStable coronary diseaseSystolic blood pressureCoronary artery diseaseCoronary flow velocityCoronary perfusion pressureFractional flow reserve (FFR) valuesCoronary flow reserve valuesPressure-flow measurementsPre-PCISupine ergometerPercutaneous revascularizationPost-PCIAngina symptomsCoronary interventionArtery diseaseCardiac catheterizationFractional Flow Reserve and Instantaneous Wave-Free Ratio as Predictors of the Placebo-Controlled Response to Percutaneous Coronary Intervention in Stable Single-Vessel Coronary Artery Disease: Physiology-Stratified Analysis of ORBITA
Al-Lamee R, Howard JP, Shun-Shin MJ, Thompson D, Dehbi HM, Sen S, Nijjer S, Petraco R, Davies J, Keeble T, Tang K, Malik IS, Cook C, Ahmad Y, Sharp ASP, Gerber R, Baker C, Kaprielian R, Talwar S, Assomull R, Cole G, Keenan NG, Kanaganayagam G, Sehmi J, Wensel R, Harrell FE, Mayet J, Thom SA, Davies JE, Francis DP. Fractional Flow Reserve and Instantaneous Wave-Free Ratio as Predictors of the Placebo-Controlled Response to Percutaneous Coronary Intervention in Stable Single-Vessel Coronary Artery Disease: Physiology-Stratified Analysis of ORBITA. Circulation 2018, 138: circulationaha.118.033801. PMID: 29789302, DOI: 10.1161/circulationaha.118.033801.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-1 Receptor AgonistsAgedAngina, StableCardiac CatheterizationCoronary AngiographyCoronary Artery DiseaseCoronary StenosisDobutamineEchocardiography, StressExercise TestExercise ToleranceFemaleFractional Flow Reserve, MyocardialHealth StatusHumansMaleMiddle AgedPercutaneous Coronary InterventionPredictive Value of TestsProgression-Free SurvivalQuality of LifeRecovery of FunctionSeverity of Illness IndexTime FactorsUnited KingdomConceptsPercutaneous coronary interventionInstantaneous wave-free ratioFractional flow reserveSingle-vessel coronary artery diseaseTreadmill exercise timeCoronary artery diseaseExercise timeEchocardiography scoreStable anginaCoronary interventionArtery diseaseFlow reserveCanadian Cardiovascular Society class IIEffect of PCISevere single-vessel diseaseSingle-vessel coronary diseaseMean fractional flow reserveAngina frequency scorePlacebo-controlled effectsPlacebo-controlled efficacyPlacebo-controlled trialTotal exercise timeSingle-vessel diseaseAngina severityEchocardiographic improvement
2017
Fractional Flow Reserve/Instantaneous Wave-Free Ratio Discordance in Angiographically Intermediate Coronary Stenoses An Analysis Using Doppler-Derived Coronary Flow Measurements
Cook CM, Jeremias A, Petraco R, Sen S, Nijjer S, Shun-Shin MJ, Ahmad Y, de Waard G, van de Hoef T, Echavarria-Pinto M, van Lavieren M, Lamee R, Kikuta Y, Shiono Y, Buch A, Meuwissen M, Danad I, Knaapen P, Maehara A, Koo BK, Mintz GS, Escaned J, Stone GW, Francis DP, Mayet J, Piek JJ, van Royen N, Davies JE. Fractional Flow Reserve/Instantaneous Wave-Free Ratio Discordance in Angiographically Intermediate Coronary Stenoses An Analysis Using Doppler-Derived Coronary Flow Measurements. JACC Cardiovascular Interventions 2017, 10: 2514-2524. PMID: 29268881, PMCID: PMC5743106, DOI: 10.1016/j.jcin.2017.09.021.Peer-Reviewed Original ResearchAgedBlood Flow VelocityCardiac CatheterizationCoronary AngiographyCoronary StenosisCoronary VesselsDatabases, FactualEchocardiography, DopplerFemaleFractional Flow Reserve, MyocardialHumansHyperemiaMaleMiddle AgedPredictive Value of TestsPrognosisReproducibility of ResultsRetrospective StudiesSeverity of Illness Index