2022
Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis.
Kelshiker MA, Seligman H, Howard JP, Rahman H, Foley M, Nowbar AN, Rajkumar CA, Shun-Shin MJ, Ahmad Y, Sen S, Al-Lamee R, Petraco R. Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis. European Heart Journal 2022, 43: 1582-1593. PMID: 36282780, DOI: 10.1093/eurheartj/ehab775.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeCardiovascular SystemCoronary Artery DiseaseFractional Flow Reserve, MyocardialHumansMyocardial IschemiaPrognosisProportional Hazards ModelsConceptsMajor adverse cardiovascular eventsAbnormal coronary flow reserveCoronary flow reserveCause mortalityCoronary flowHigh incidenceHazard ratioFlow reserveAdverse cardiovascular eventsCoronary microvascular dysfunctionAcute coronary syndromeRandom-effects modelEstimate of effectCardiovascular eventsCardiovascular outcomesCoronary syndromeMicrovascular dysfunctionHeart failureHeart transplantClinical outcomesPatient groupRisk modificationHigh riskClinical practiceSystematic review
2021
Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis
Kelshiker MA, Seligman H, Howard JP, Rahman H, Foley M, Nowbar AN, Rajkumar CA, Shun-Shin MJ, Ahmad Y, Sen S, Al-Lamee R, Petraco R, Cole G, Hoole S, Paul D, Rigo F, Francis D, Mayet J. Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis. European Heart Journal 2021, 43: 1582-1593. PMID: 34849697, PMCID: PMC9020988, DOI: 10.1093/eurheartj/ehab775.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeCardiovascular SystemCoronary Artery DiseaseFractional Flow Reserve, MyocardialHumansMyocardial IschemiaPrognosisProportional Hazards ModelsConceptsMajor adverse cardiovascular eventsAbnormal coronary flow reserveCoronary flow reserveCause mortalityCoronary flowHigh incidenceHazard ratioFlow reserveAdverse cardiovascular eventsCoronary microvascular dysfunctionAcute coronary syndromeRandom-effects modelEstimate of effectCardiovascular eventsCardiovascular outcomesCoronary syndromeMicrovascular dysfunctionHeart failureHeart transplantClinical outcomesPatient groupRisk modificationHigh riskClinical practiceSystematic reviewCorrelation of Intravascular Ultrasound and Instantaneous Wave-Free Ratio in Patients With Intermediate Left Main Coronary Artery Disease
Hajj S, Toya T, Warisawa T, Nan J, Lewis BR, Cook CM, Rajkumar C, Howard JP, Seligman H, Ahmad Y, Doi S, Nakajima A, Nakayama M, Goto S, Vera-Urquiza R, Sato T, Kikuta Y, Kawase Y, Nishina H, Nakamura S, Matsuo H, Escaned J, Akashi YJ, Davies JE, Lerman A. Correlation of Intravascular Ultrasound and Instantaneous Wave-Free Ratio in Patients With Intermediate Left Main Coronary Artery Disease. Circulation Cardiovascular Interventions 2021, 14: e009830. PMID: 34092096, PMCID: PMC8206001, DOI: 10.1161/circinterventions.120.009830.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery DiseaseFemaleFractional Flow Reserve, MyocardialHumansMaleMiddle AgedUltrasonographyUltrasonography, InterventionalConceptsInstantaneous wave-free ratioMinimum lumen areaUse of iFRBody surface areaLumen areaArtery diseaseIntravascular ultrasoundMain coronary artery diseaseMulticenter retrospective observational studyCurve analysisCircumflex artery diseaseMain coronary diseaseVisual angiographic assessmentIndependent core laboratoryRetrospective observational studyCoronary artery diseaseIntravascular ultrasound evaluationFractional flow reserveCoronary diseaseUltrasound evaluationAngiographic assessmentIntravascular ultrasound dataFlow reserveObservational studyPatientsPerformance of quantitative flow ratio in patients with aortic stenosis undergoing transcatheter aortic valve implantation
Sejr‐Hansen M, Christiansen EH, Ahmad Y, Vendrik J, Westra J, Holm NR, Thim T, Seligman H, Hall K, Sen S, Terkelsen CJ, Eftekhari A. Performance of quantitative flow ratio in patients with aortic stenosis undergoing transcatheter aortic valve implantation. Catheterization And Cardiovascular Interventions 2021, 99: 68-73. PMID: 33533535, DOI: 10.1002/ccd.29518.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationAortic valve stenosisCoronary artery diseaseInstantaneous wave-free ratioFractional flow reserveQuantitative flow ratioAortic valve implantationValve implantationDiagnostic performancePressure wirePresence of ASSevere aortic valve stenosisAortic valve replacementCoronary pressure wireGood diagnostic performanceValve replacementAortic stenosisArtery diseaseValve stenosisCoronary angiogramFlow reservePatientsCAD evaluationDiagnostic accuracyStenosis
2020
Safety of Revascularization Deferral of Left Main Stenosis Based on Instantaneous Wave-Free Ratio Evaluation
Warisawa T, Cook CM, Rajkumar C, Howard JP, Seligman H, Ahmad Y, El Hajj S, Doi S, Nakajima A, Nakayama M, Goto S, Vera-Urquiza R, Sato T, Kikuta Y, Kawase Y, Nishina H, Petraco R, Al-Lamee R, Nijjer S, Sen S, Nakamura S, Lerman A, Matsuo H, Francis DP, Akashi YJ, Escaned J, Davies JE. Safety of Revascularization Deferral of Left Main Stenosis Based on Instantaneous Wave-Free Ratio Evaluation. JACC Cardiovascular Interventions 2020, 13: 1655-1664. PMID: 32417088, DOI: 10.1016/j.jcin.2020.02.035.Peer-Reviewed Original ResearchMeSH KeywordsAgedClinical Decision-MakingCoronary Artery BypassCoronary Artery DiseaseCoronary StenosisEuropeFemaleFractional Flow Reserve, MyocardialHumansJapanMaleMiddle AgedPercutaneous Coronary InterventionPredictive Value of TestsProspective StudiesRegistriesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTime-to-TreatmentTreatment OutcomeUnited StatesConceptsInstantaneous wave-free ratioNonfatal myocardial infarctionPrimary endpointLM stenosisCause deathLesion revascularizationSecondary endpointsCardiac deathMyocardial infarctionIschemia-driven target lesion revascularizationSimilar long-term outcomesStable coronary artery diseaseMain coronary artery stenosisLong-term clinical outcomesSafety of deferralMulticenter observational studyTarget lesion revascularizationLeft main stenosisCoronary artery diseaseLong-term outcomesCoronary artery stenosisDeferred groupLM revascularizationMedian followRevascularization deferralDifference in functional assessment of individual stenosis severity in serial coronary lesions between resting and hyperemic pressure-wire pullback: Insights from the GIFT registry
Warisawa T, Howard JP, Kawase Y, Tanigaki T, Omori H, Cook CM, Ahmad Y, Francis DP, Akashi YJ, Matsuo H, Davies JE. Difference in functional assessment of individual stenosis severity in serial coronary lesions between resting and hyperemic pressure-wire pullback: Insights from the GIFT registry. International Journal Of Cardiology 2020, 312: 10-15. PMID: 32376416, DOI: 10.1016/j.ijcard.2020.05.001.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiac CatheterizationConstriction, PathologicCoronary AngiographyCoronary StenosisFemaleFractional Flow Reserve, MyocardialHumansHyperemiaMaleMiddle AgedPredictive Value of TestsRegistriesSeverity of Illness IndexConceptsFractional flow reserveInstantaneous wave-free ratioCoronary lesionsPressure-wire pullbackCoronary artery lesionsPhysiological assessmentArtery lesionsConsecutive patientsCoronary stenosisHemodynamic significanceWave-free periodFlow reserveHemodynamic interactionSerial lesionsSerial stenosesFunctional assessmentStenosis severityLesionsStenosisHyperemic conditionsStatistical differenceWhole cardiac cycleReference standardCardiac cyclePredominancePer-Vessel Level Analysis of Fractional Flow Reserve and Instantaneous Wave-Free Ratio Discordance ― Insights From the AJIP Registry ―
Warisawa T, Cook CM, Seligman H, Howard JP, Ahmad Y, Rajkumar C, Doi S, Nakayama M, Tanigaki T, Omori H, Nakajima A, Yamanaka F, Goto S, Yakuta Y, Karube K, Uetani T, Kikuta Y, Shiono Y, Kawase Y, Nishina H, Nakamura S, Escaned J, Akashi YJ, Matsuo H, Davies JE. Per-Vessel Level Analysis of Fractional Flow Reserve and Instantaneous Wave-Free Ratio Discordance ― Insights From the AJIP Registry ―. Circulation Journal 2020, 84: 1034-1038. PMID: 32321880, DOI: 10.1253/circj.cj-19-0785.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac CatheterizationCoronary Artery DiseaseCoronary VesselsFemaleFractional Flow Reserve, MyocardialHumansMaleMiddle AgedPredictive Value of TestsRegistriesSeverity of Illness IndexHow Do Fractional Flow Reserve, Whole-Cycle PdPa, and Instantaneous Wave-Free Ratio Correlate With Exercise Coronary Flow Velocity During Exercise-Induced Angina?
Cook CM, Howard JP, Ahmad Y, Shun-Shin MJ, Sethi A, Clesham GJ, Tang KH, Nijjer SS, Kelly PA, Davies JR, Malik IS, Kaprielian R, Mikhail G, Petraco R, Warisawa T, Al-Janabi F, Karamasis GV, Mohdnazri S, Gamma R, de Waard GA, Al-Lamee R, Keeble TR, Mayet J, Sen S, Francis DP, Davies JE. How Do Fractional Flow Reserve, Whole-Cycle PdPa, and Instantaneous Wave-Free Ratio Correlate With Exercise Coronary Flow Velocity During Exercise-Induced Angina? Circulation Cardiovascular Interventions 2020, 13: e008460. PMID: 32200646, DOI: 10.1161/circinterventions.119.008460.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngina PectorisBlood Flow VelocityCardiac CatheterizationCoronary Artery DiseaseExercise TestFemaleFractional Flow Reserve, MyocardialHumansMaleMiddle AgedPredictive Value of TestsPrognosisProof of Concept StudyLong‐Term Effects of Transcatheter Aortic Valve Implantation on Coronary Hemodynamics in Patients With Concomitant Coronary Artery Disease and Severe Aortic Stenosis
Vendrik J, Ahmad Y, Eftekhari A, Howard JP, Wijntjens GWM, Stegehuis VE, Cook C, Terkelsen CJ, Christiansen EH, Koch KT, Piek JJ, Sen S, Baan J. Long‐Term Effects of Transcatheter Aortic Valve Implantation on Coronary Hemodynamics in Patients With Concomitant Coronary Artery Disease and Severe Aortic Stenosis. Journal Of The American Heart Association 2020, 9: e015133. PMID: 32102615, PMCID: PMC7335578, DOI: 10.1161/jaha.119.015133.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationSevere aortic stenosisConcomitant coronary artery diseaseAortic stenosisAortic valve implantationCoronary artery diseasePost-TAVICoronary flowArtery diseaseValve implantationCoronary hemodynamicsLarge-scale prospective randomized trialsFractional flow reserve assessmentProspective randomized trialsLow-risk patientsHyperemic coronary flowInstantaneous wave-free ratioFractional flow reserveCoronary stenosis severityYounger patientsCoronary lesionsRandomized trialsDiastolic flowPatient populationWave-free period
2019
Physiological Pattern of Disease Assessed by Pressure-Wire Pullback Has an Influence on Fractional Flow Reserve/Instantaneous Wave-Free Ratio Discordance
Warisawa T, Cook CM, Howard JP, Ahmad Y, Doi S, Nakayama M, Goto S, Yakuta Y, Karube K, Shun-Shin MJ, Petraco R, Sen S, Nijjer S, Lamee R, Ishibashi Y, Matsuda H, Escaned J, di Mario C, Francis DP, Akashi YJ, Davies JE. Physiological Pattern of Disease Assessed by Pressure-Wire Pullback Has an Influence on Fractional Flow Reserve/Instantaneous Wave-Free Ratio Discordance. Circulation Cardiovascular Interventions 2019, 12: e007494-e007494. PMID: 31084237, PMCID: PMC6553990, DOI: 10.1161/circinterventions.118.007494.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiac CatheterizationCoronary Artery DiseaseFemaleFractional Flow Reserve, MyocardialHumansMaleMiddle AgedPredictive Value of TestsPrognosisRegistriesReproducibility of ResultsRetrospective StudiesConceptsInstantaneous wave-free ratioFractional flow reservePressure-wire pullbackCoronary artery diseaseArtery diseaseCoronary lesionsHemodynamic significancePhysiological patternsInternational multicenter registryIntermediate coronary lesionsMedian fractional flow reserveMulticenter registryFlow reserveDiseaseLesionsCut pointsIFR measurementDiscordanceRegistryFactorsClinical Events After Deferral of LAD Revascularization Following Physiological Coronary Assessment
Sen S, Ahmad Y, Dehbi HM, Howard JP, Iglesias JF, Al-Lamee R, Petraco R, Nijjer S, Bhindi R, Lehman S, Walters D, Sapontis J, Janssens L, Vrints CJ, Khashaba A, Laine M, Van Belle E, Krackhardt F, Bojara W, Going O, Härle T, Indolfi C, Niccoli G, Ribichini F, Tanaka N, Yokoi H, Takashima H, Kikuta Y, Erglis A, Vinhas H, Silva PC, Baptista SB, Alghamdi A, Hellig F, Koo BK, Nam CW, Shin ES, Doh JH, Brugaletta S, Alegria-Barrero E, Meuwissen M, Piek JJ, van Royen N, Sezer M, Di Mario C, Gerber RT, Malik IS, Sharp ASP, Talwar S, Tang K, Samady H, Altman J, Seto AH, Singh J, Jeremias A, Matsuo H, Kharbanda RK, Patel MR, Serruys P, Escaned J, Davies JE. Clinical Events After Deferral of LAD Revascularization Following Physiological Coronary Assessment. Journal Of The American College Of Cardiology 2019, 73: 444-453. PMID: 30704577, PMCID: PMC6354033, DOI: 10.1016/j.jacc.2018.10.070.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary AngiographyCoronary StenosisCoronary VesselsFemaleFractional Flow Reserve, MyocardialHumansMaleMiddle AgedMyocardial RevascularizationConceptsMajor adverse cardiac eventsInstantaneous wave-free ratioFractional flow reserveLAD lesionsMyocardial infarctionUnplanned revascularizationLeft anterior descending (LAD) arteryEvent ratesLower myocardial infarctionAdverse cardiac eventsAnterior descending (LAD) arteryPhysiological assessmentLow event ratesMACE rateCardiac eventsCardiovascular deathClinical eventsFlow reserveHigh riskPatientsLesionsLADRevascularizationTrialsTreatment
2018
Coronary Hemodynamics in Patients With Severe Aortic Stenosis and Coronary Artery Disease Undergoing Transcatheter Aortic Valve Replacement Implications for Clinical Indices of Coronary Stenosis Severity
Ahmad Y, Götberg M, Cook C, Howard JP, Malik I, Mikhail G, Frame A, Petraco R, Rajkumar C, Demir O, Iglesias JF, Bhindi R, Koul S, Hadjiloizou N, Gerber R, Ramrakha P, Ruparelia N, Sutaria N, Kanaganayagam G, Ariff B, Fertleman M, Anderson J, Chukwuemeka A, Francis D, Mayet J, Serruys P, Davies J, Sen S. Coronary Hemodynamics in Patients With Severe Aortic Stenosis and Coronary Artery Disease Undergoing Transcatheter Aortic Valve Replacement Implications for Clinical Indices of Coronary Stenosis Severity. JACC Cardiovascular Interventions 2018, 11: 2019-2031. PMID: 30154062, PMCID: PMC6197079, DOI: 10.1016/j.jcin.2018.07.019.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic Valve StenosisBlood Flow VelocityCardiac CatheterizationCoronary Artery DiseaseCoronary StenosisFemaleFractional Flow Reserve, MyocardialHemodynamicsHumansHyperemiaLondonMalePredictive Value of TestsReproducibility of ResultsSeverity of Illness IndexSwedenTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsSevere aortic stenosisTranscatheter aortic valve replacementCoronary artery diseaseCoronary stenosis severityAortic stenosisHyperemic coronary flowFractional flow reserveArtery diseaseCoronary flowStenosis severityWave-free periodClinical indicesHyperemic flowFlow reserveInstantaneous wave-free ratio valueIntracoronary pressureConcomitant coronary artery diseaseAortic valve replacementStenotic aortic valvesInstantaneous wave-free ratioPhasic coronary flowValve replacementHyperemic indexAortic valveCoronary pressureFractional Flow Reserve and Instantaneous Wave-Free Ratio as Predictors of the Placebo-Controlled Response to Percutaneous Coronary Intervention in Stable Single-Vessel Coronary Artery Disease: Physiology-Stratified Analysis of ORBITA
Al-Lamee R, Howard JP, Shun-Shin MJ, Thompson D, Dehbi HM, Sen S, Nijjer S, Petraco R, Davies J, Keeble T, Tang K, Malik IS, Cook C, Ahmad Y, Sharp ASP, Gerber R, Baker C, Kaprielian R, Talwar S, Assomull R, Cole G, Keenan NG, Kanaganayagam G, Sehmi J, Wensel R, Harrell FE, Mayet J, Thom SA, Davies JE, Francis DP. Fractional Flow Reserve and Instantaneous Wave-Free Ratio as Predictors of the Placebo-Controlled Response to Percutaneous Coronary Intervention in Stable Single-Vessel Coronary Artery Disease: Physiology-Stratified Analysis of ORBITA. Circulation 2018, 138: circulationaha.118.033801. PMID: 29789302, DOI: 10.1161/circulationaha.118.033801.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-1 Receptor AgonistsAgedAngina, StableCardiac CatheterizationCoronary AngiographyCoronary Artery DiseaseCoronary StenosisDobutamineEchocardiography, StressExercise TestExercise ToleranceFemaleFractional Flow Reserve, MyocardialHealth StatusHumansMaleMiddle AgedPercutaneous Coronary InterventionPredictive Value of TestsProgression-Free SurvivalQuality of LifeRecovery of FunctionSeverity of Illness IndexTime FactorsUnited KingdomConceptsPercutaneous coronary interventionInstantaneous wave-free ratioFractional flow reserveSingle-vessel coronary artery diseaseTreadmill exercise timeCoronary artery diseaseExercise timeEchocardiography scoreStable anginaCoronary interventionArtery diseaseFlow reserveCanadian Cardiovascular Society class IIEffect of PCISevere single-vessel diseaseSingle-vessel coronary diseaseMean fractional flow reserveAngina frequency scorePlacebo-controlled effectsPlacebo-controlled efficacyPlacebo-controlled trialTotal exercise timeSingle-vessel diseaseAngina severityEchocardiographic improvement
2017
Fractional Flow Reserve/Instantaneous Wave-Free Ratio Discordance in Angiographically Intermediate Coronary Stenoses An Analysis Using Doppler-Derived Coronary Flow Measurements
Cook CM, Jeremias A, Petraco R, Sen S, Nijjer S, Shun-Shin MJ, Ahmad Y, de Waard G, van de Hoef T, Echavarria-Pinto M, van Lavieren M, Lamee R, Kikuta Y, Shiono Y, Buch A, Meuwissen M, Danad I, Knaapen P, Maehara A, Koo BK, Mintz GS, Escaned J, Stone GW, Francis DP, Mayet J, Piek JJ, van Royen N, Davies JE. Fractional Flow Reserve/Instantaneous Wave-Free Ratio Discordance in Angiographically Intermediate Coronary Stenoses An Analysis Using Doppler-Derived Coronary Flow Measurements. JACC Cardiovascular Interventions 2017, 10: 2514-2524. PMID: 29268881, PMCID: PMC5743106, DOI: 10.1016/j.jcin.2017.09.021.Peer-Reviewed Original ResearchAgedBlood Flow VelocityCardiac CatheterizationCoronary AngiographyCoronary StenosisCoronary VesselsDatabases, FactualEchocardiography, DopplerFemaleFractional Flow Reserve, MyocardialHumansHyperemiaMaleMiddle AgedPredictive Value of TestsPrognosisReproducibility of ResultsRetrospective StudiesSeverity of Illness IndexDiagnostic Accuracy of Computed Tomography–Derived Fractional Flow Reserve : A Systematic Review
Cook CM, Petraco R, Shun-Shin MJ, Ahmad Y, Nijjer S, Al-Lamee R, Kikuta Y, Shiono Y, Mayet J, Francis DP, Sen S, Davies JE. Diagnostic Accuracy of Computed Tomography–Derived Fractional Flow Reserve : A Systematic Review. JAMA Cardiology 2017, 2: 803-810. PMID: 28538960, DOI: 10.1001/jamacardio.2017.1314.Peer-Reviewed Original ResearchMeSH KeywordsCoronary StenosisFractional Flow Reserve, MyocardialHumansMyocardial IschemiaSeverity of Illness IndexTomography, X-Ray ComputedConceptsFractional flow reserveFlow reserveDiagnostic accuracyFFR-CTSystematic reviewTomography-derived fractional flow reserveVessel diagnostic accuracyPatient-specific factorsSpectrum of diseasePreferred Reporting ItemsSubsequent patient carePeer-reviewed journalsInvasive angiogramMean ageMyocardial ischemiaNoninvasive testsComputed tomographyReporting ItemsDuplicate studiesPatient careMeta-AnalysisCliniciansSystematic searchInvasive FFRScientific meetings
2016
Quantification of the Effect of Pressure Wire Drift on the Diagnostic Performance of Fractional Flow Reserve, Instantaneous Wave-Free Ratio, and Whole-Cycle Pd/Pa
Cook CM, Ahmad Y, Shun-Shin MJ, Nijjer S, Petraco R, Al-Lamee R, Mayet J, Francis DP, Sen S, Davies JE. Quantification of the Effect of Pressure Wire Drift on the Diagnostic Performance of Fractional Flow Reserve, Instantaneous Wave-Free Ratio, and Whole-Cycle Pd/Pa. Circulation Cardiovascular Interventions 2016, 9: e002988. PMID: 27076571, PMCID: PMC4836560, DOI: 10.1161/circinterventions.115.002988.Peer-Reviewed Original Research