2023
Delirium in older adults after percutaneous coronary intervention: Prevalence, risks, and clinical phenotypes
Park D, Jamil Y, Hu J, Lowenstern A, Frampton J, Abdullah A, Damluji A, Ahmad Y, Soufer R, Nanna M. Delirium in older adults after percutaneous coronary intervention: Prevalence, risks, and clinical phenotypes. Cardiovascular Revascularization Medicine 2023, 57: 60-67. PMID: 37414611, PMCID: PMC10730763, DOI: 10.1016/j.carrev.2023.06.010.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionHospital mortalityHigher oddsOlder adultsHospital deliriumCoronary interventionAdverse health-related outcomesInpatient percutaneous coronary interventionNon-home dischargePeri-procedural settingAcute kidney injuryImpact of deliriumPost-procedural complicationsNational Inpatient SampleHealth-related outcomesDelirium preventionHospital complicationsMore comorbiditiesGastrointestinal hemorrhageKidney injuryAdverse eventsSecondary outcomesBlood transfusionPrimary outcomeIntracranial hemorrhagePhysiology-guided PCI versus CABG for left main coronary artery disease: insights from the DEFINE-LM registry
Warisawa T, Cook C, Kawase Y, Howard J, Ahmad Y, Seligman H, Rajkumar C, Toya T, Doi S, Nakajima A, Tanigaki T, Omori H, Nakayama M, Vera-Urquiza R, Yuasa S, Sato T, Kikuta Y, Nishina H, Al-Lamee R, Sen S, Lerman A, Akashi Y, Escaned J, Matsuo H, Davies J. Physiology-guided PCI versus CABG for left main coronary artery disease: insights from the DEFINE-LM registry. Cardiovascular Intervention And Therapeutics 2023, 38: 287-298. PMID: 37017899, PMCID: PMC10247826, DOI: 10.1007/s12928-023-00932-z.Peer-Reviewed Original ResearchConceptsUnprotected left main coronary diseasePercutaneous coronary interventionInstantaneous wave-free ratioMain coronary artery diseaseNon-fatal myocardial infarctionCoronary artery bypassCoronary artery diseasePrimary endpointCause deathLesion revascularizationArtery bypassSYNTAX scoreCoronary interventionArtery diseaseClinical outcomesMyocardial infarctionIschemia-driven target lesion revascularizationLeft main coronary artery diseaseArt percutaneous coronary interventionLeft main coronary diseaseLower cardiovascular event ratesMajor adverse cardiovascular eventsLong-term clinical outcomesPropensity scorePhysiology-guided percutaneous coronary interventionTranscatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials
Ahmad Y, Howard J, Arnold A, Madhavan M, Cook C, Alu M, Mack M, Reardon M, Thourani V, Kapadia S, Thyregod H, Sondergaard L, Jørgensen T, Toff W, Van Mieghem N, Makkar R, Forrest J, Leon M. Transcatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials. European Heart Journal 2023, 44: 836-852. PMID: 36660821, DOI: 10.1093/eurheartj/ehac642.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve implantationHigh-risk patientsLow-risk patientsComposite of deathAortic valve replacementValve replacementMAIN OUTCOMENew-onset atrial fibrillationSignificant differencesRandomized clinical trial dataAcute kidney injuryAortic valve implantationMain clinical outcomesRisk of deathClinical trial dataMajor bleedingKidney injurySecondary endpointsVascular complicationsValve implantationClinical outcomesParavalvular leakRandomized trialsAtrial fibrillationPublic Reporting of Stroke After Transcatheter Aortic Valve Replacement A Cautionary Tale ∗
Lansky A, Ahmad Y. Public Reporting of Stroke After Transcatheter Aortic Valve Replacement A Cautionary Tale ∗. JACC Cardiovascular Interventions 2023, 16: 177-178. PMID: 36697153, DOI: 10.1016/j.jcin.2022.11.010.Peer-Reviewed Original Research
2022
Readmission rates and risk factors for readmission after transcatheter aortic valve replacement in patients with end-stage renal disease
Park DY, An S, Hanna JM, Wang SY, Cruz-Solbes AS, Kochar A, Lowenstern AM, Forrest JK, Ahmad Y, Cleman M, Al Damluji A, Nanna MG. Readmission rates and risk factors for readmission after transcatheter aortic valve replacement in patients with end-stage renal disease. PLOS ONE 2022, 17: e0276394. PMID: 36264931, PMCID: PMC9584363, DOI: 10.1371/journal.pone.0276394.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseTranscatheter aortic valve replacementLength of stayAortic valve replacementIndex hospitalizationHospital mortalityReadmission ratesValve replacementRenal diseaseLonger LOSNational Readmission DatabaseRisk of readmissionChronic pulmonary diseaseMultivariable logistic regressionCardiovascular causesCardiovascular readmissionCause readmissionHospital readmissionPulmonary diseaseHospital chargesPoor outcomeRisk factorsHospital costsReadmissionHigher oddsPrediction of Death or HF Hospitalization in Patients With Severe FMR The COAPT Risk Score
Shah N, Madhavan MV, Gray WA, Brener SJ, Ahmad Y, Lindenfeld J, Abraham WT, Grayburn PA, Kar S, Lim DS, Mishell JM, Whisenant BK, Zhang Z, Redfors B, Mack MJ, Stone GW. Prediction of Death or HF Hospitalization in Patients With Severe FMR The COAPT Risk Score. JACC Cardiovascular Interventions 2022, 15: 1893-1905. PMID: 36202557, DOI: 10.1016/j.jcin.2022.08.005.Peer-Reviewed Original ResearchConceptsGuideline-directed medical therapyHeart failure hospitalizationSevere functional mitral regurgitationFunctional mitral regurgitationHeart failureRisk scoreCox proportional hazards modelPredictors of deathProportion of patientsSimple risk scoreKaplan-Meier curvesPrediction of deathPredictive risk scoreQuartiles of riskProportional hazards modelRisk score modelReceiver-operating characteristic plotsHF hospitalizationMitraClip groupMitraClip implantationMitraClip treatmentUseful prognosticationFailure hospitalizationMitraClip therapyEchocardiographic variablesReadmission and In-Hospital Outcomes After Transcatheter Aortic Valve Replacement in Patients With Dementia
Park DY, Sana MK, Shoura S, Hammo H, Hu JR, Forrest JK, Lowenstern A, Cleman M, Ahmad Y, Nanna MG. Readmission and In-Hospital Outcomes After Transcatheter Aortic Valve Replacement in Patients With Dementia. Cardiovascular Revascularization Medicine 2022, 46: 70-77. PMID: 35973922, PMCID: PMC10940024, DOI: 10.1016/j.carrev.2022.08.016.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementAortic stenosisValve replacementSecondary diagnosisHospital adverse outcomesAcute kidney injuryIn-Hospital OutcomesNational Readmission DatabasePresence of dementiaPrevalence of dementiaProportional hazards modelDecade of ageHigher hazardIndex hospitalizationInpatient outcomesKidney injuryDefinitive treatmentPacemaker placementReadmission riskAdverse outcomesReadmissionHigher oddsDecision-making discussionsHigh risk
2021
Patient-Prosthesis Mismatch After SAVR and TAVR The Importance of Comparing Apples With Apples ∗
Chakravarty T, Makar M, Ahmad Y. Patient-Prosthesis Mismatch After SAVR and TAVR The Importance of Comparing Apples With Apples ∗. JACC Cardiovascular Interventions 2021, 14: 1478-1480. PMID: 34238558, DOI: 10.1016/j.jcin.2021.05.011.Peer-Reviewed Original ResearchMeta-Analysis of Usefulness of Cerebral Embolic Protection During Transcatheter Aortic Valve Implantation
Ahmad Y, Howard JP. Meta-Analysis of Usefulness of Cerebral Embolic Protection During Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2021, 146: 69-73. PMID: 33556360, PMCID: PMC8082278, DOI: 10.1016/j.amjcard.2021.01.023.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationCerebral embolic protectionRisk of strokeAortic valve implantationEmbolic protectionValve implantationClinical outcomesNon-disabling strokePrimary end pointNew ischemic lesionsRandomized clinical trialsTotal lesion volumeSignificant differencesFeared complicationIschemic lesionsClinical trialsLesion volumeStroke rateNeuroimaging outcomesMeta-AnalysisSystematic reviewTrial dataStrokeEnd pointSignificant heterogeneity
2020
Drug-Eluting Stents Versus Bypass Surgery for Left Main Disease: An Updated Meta-Analysis of Randomized Controlled Trials With Long-Term Follow-Up
Ahmad Y, Howard JP, Arnold AD, Ali ZA, Francis D, Moses JW, Leon MB, Kirtane AJ, Karmpaliotis D, Stone GW. Drug-Eluting Stents Versus Bypass Surgery for Left Main Disease: An Updated Meta-Analysis of Randomized Controlled Trials With Long-Term Follow-Up. The American Journal Of Cardiology 2020, 132: 168-172. PMID: 32718553, DOI: 10.1016/j.amjcard.2020.06.059.Peer-Reviewed Original ResearchComplete Revascularization by Percutaneous Coronary Intervention for Patients With ST‐Segment–Elevation Myocardial Infarction and Multivessel Coronary Artery Disease: An Updated Meta‐Analysis of Randomized Trials
Ahmad Y, Howard JP, Arnold A, Prasad M, Seligman H, Cook CM, Warisawa T, Shun‐Shun M, Ali Z, Parikh MA, Al‐Lamee R, Sen S, Francis D, Moses JW, Leon MB, Stone GW, Karmpaliotis D. Complete Revascularization by Percutaneous Coronary Intervention for Patients With ST‐Segment–Elevation Myocardial Infarction and Multivessel Coronary Artery Disease: An Updated Meta‐Analysis of Randomized Trials. Journal Of The American Heart Association 2020, 9: e015263. PMID: 32476540, PMCID: PMC7429036, DOI: 10.1161/jaha.119.015263.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionMultivessel coronary artery diseasePercutaneous coronary interventionCulprit-only revascularizationCoronary artery diseaseComplete revascularizationCoronary interventionMyocardial infarctionCardiovascular deathArtery diseaseUnplanned revascularizationMultivessel diseaseCause mortalityEnd pointPrimary efficacy end pointHard clinical outcomesEfficacy end pointSecondary end pointsClinical end pointsElevation myocardial infarctionClinical practice guidelinesTreat basisClinical outcomesRandomized trialsOptimal treatmentSafety of Revascularization Deferral of Left Main Stenosis Based on Instantaneous Wave-Free Ratio Evaluation
Warisawa T, Cook CM, Rajkumar C, Howard JP, Seligman H, Ahmad Y, El Hajj S, Doi S, Nakajima A, Nakayama M, Goto S, Vera-Urquiza R, Sato T, Kikuta Y, Kawase Y, Nishina H, Petraco R, Al-Lamee R, Nijjer S, Sen S, Nakamura S, Lerman A, Matsuo H, Francis DP, Akashi YJ, Escaned J, Davies JE. Safety of Revascularization Deferral of Left Main Stenosis Based on Instantaneous Wave-Free Ratio Evaluation. JACC Cardiovascular Interventions 2020, 13: 1655-1664. PMID: 32417088, DOI: 10.1016/j.jcin.2020.02.035.Peer-Reviewed Original ResearchMeSH KeywordsAgedClinical Decision-MakingCoronary Artery BypassCoronary Artery DiseaseCoronary StenosisEuropeFemaleFractional Flow Reserve, MyocardialHumansJapanMaleMiddle AgedPercutaneous Coronary InterventionPredictive Value of TestsProspective StudiesRegistriesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTime-to-TreatmentTreatment OutcomeUnited StatesConceptsInstantaneous wave-free ratioNonfatal myocardial infarctionPrimary endpointLM stenosisCause deathLesion revascularizationSecondary endpointsCardiac deathMyocardial infarctionIschemia-driven target lesion revascularizationSimilar long-term outcomesStable coronary artery diseaseMain coronary artery stenosisLong-term clinical outcomesSafety of deferralMulticenter observational studyTarget lesion revascularizationLeft main stenosisCoronary artery diseaseLong-term outcomesCoronary artery stenosisDeferred groupLM revascularizationMedian followRevascularization deferralEffects of Percutaneous Coronary Intervention on Death and Myocardial Infarction Stratified by Stable and Unstable Coronary Artery Disease
Chacko L, Howard J, Rajkumar C, Nowbar AN, Kane C, Mahdi D, Foley M, Shun-Shin M, Cole G, Sen S, Al-Lamee R, Francis DP, Ahmad Y. Effects of Percutaneous Coronary Intervention on Death and Myocardial Infarction Stratified by Stable and Unstable Coronary Artery Disease. Circulation Cardiovascular Quality And Outcomes 2020, 13: e006363-e006363. PMID: 32063040, PMCID: PMC7034389, DOI: 10.1161/circoutcomes.119.006363.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAdultAgedAged, 80 and overCause of DeathClinical Decision-MakingCoronary Artery DiseaseFemaleHumansMaleMiddle AgedNon-ST Elevated Myocardial InfarctionPercutaneous Coronary InterventionRandomized Controlled Trials as TopicRisk AssessmentRisk FactorsST Elevation Myocardial InfarctionTime FactorsTreatment OutcomeYoung AdultConceptsST-segment elevation myocardial infarctionStable coronary artery diseaseUnstable coronary artery diseasePercutaneous coronary interventionCoronary artery diseaseSegment elevation acute coronary syndromesAcute coronary syndromeMyocardial infarctionCardiac deathMultivessel diseaseCoronary syndromeCoronary interventionArtery diseaseBenefits of PCITrials of PCITreatment of CADCulprit-only revascularization strategyEarly percutaneous coronary interventionPrimary percutaneous coronary interventionPatients post-myocardial infarctionResidual coronary lesionsPrimary end pointComparative Health EffectivenessPost-myocardial infarctionImmediate revascularization
2013
Is bleeding a necessary evil? The inherent risk of antithrombotic pharmacotherapy used for stroke prevention in atrial fibrillation
Myat A, Ahmad Y, Haldar S, Tantry US, Redwood SR, Gurbel PA, Lip GY. Is bleeding a necessary evil? The inherent risk of antithrombotic pharmacotherapy used for stroke prevention in atrial fibrillation. Expert Review Of Cardiovascular Therapy 2013, 11: 1029-1049. PMID: 23984927, DOI: 10.1586/14779072.2013.815423.Peer-Reviewed Original ResearchConceptsStroke preventionAntithrombotic therapyAntithrombotic agentsNovel oral anticoagulation agentsAtrial fibrillation guidelinesOral anticoagulation agentsDrug-drug interactionsDirect antidoteAF patientsAnticoagulation monitoringAnticoagulation agentsAtrial fibrillationAbsolute riskAntithrombotic pharmacotherapyRelative riskLower riskStrong recommendationsPatientsThromboembolismPreventionRiskTherapyInherent risksAuthors' knowledgeAgentsRecent Developments in Understanding Epidemiology and Risk Determinants of Atrial Fibrillation as a Cause of Stroke
Ahmad Y, Lip GY, Lane DA. Recent Developments in Understanding Epidemiology and Risk Determinants of Atrial Fibrillation as a Cause of Stroke. Canadian Journal Of Cardiology 2013, 29: s4-s13. PMID: 23790597, DOI: 10.1016/j.cjca.2013.03.009.Peer-Reviewed Original ResearchConceptsDevelopment of AFAtrial fibrillationRisk factorsStroke riskAF patientsOccurrence of AFEffective oral anticoagulationAcute cardiac conditionsCause of strokeLow-risk patientsNovel risk factorsNovel therapeutic targetPublic health consequencesFormal anticoagulationOral anticoagulationRisk patientsPatient cohortCardiac conditionsEpidemic proportionsTherapeutic targetClinical practicePatientsAnticoagulationHealth consequencesRisk determinantsPreventing Stroke and Systemic Embolism in Renal Patients with Atrial Fibrillation: Focus on Anticoagulation
Ahmad Y, Lip GY. Preventing Stroke and Systemic Embolism in Renal Patients with Atrial Fibrillation: Focus on Anticoagulation. Contributions To Nephrology 2013, 179: 81-91. PMID: 23652451, DOI: 10.1159/000346726.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnticoagulantsAtrial FibrillationBenzimidazolesBeta-AlanineClinical Trials as TopicComorbidityDabigatranDisease ManagementEmbolismFemaleFibrinolytic AgentsHemorrhageHumansHypertensionIntracranial EmbolismMaleMorpholinesPatient SelectionPyrazolesPyridonesRenal Insufficiency, ChronicRiskRisk FactorsRivaroxabanSeverity of Illness IndexStrokeThiophenesThrombophiliaWarfarinConceptsSevere renal impairmentAtrial fibrillationRisk factorsGeneral populationRenal impairmentRenal diseaseRenal patientsAbsence of AFLarge randomised control trialBenefits of warfarinNew oral anticoagulantsChronic kidney diseaseCohort of patientsRisk of strokeRandomised control trialEctopic vascular calcificationMajority of trialsUnique management challengesAF independentSystemic embolismOral anticoagulantsRenal insufficiencyStroke preventionThromboembolic riskStroke risk
2012
New oral anticoagulants for stroke prevention in atrial fibrillation: impact of gender, heart failure, diabetes mellitus and paroxysmal atrial fibrillation
Ahmad Y, Lip GY, Apostolakis S. New oral anticoagulants for stroke prevention in atrial fibrillation: impact of gender, heart failure, diabetes mellitus and paroxysmal atrial fibrillation. Expert Review Of Cardiovascular Therapy 2012, 10: 1471-1480. PMID: 23253272, DOI: 10.1586/erc.12.148.Peer-Reviewed Original ResearchConceptsNew oral anticoagulantsParoxysmal atrial fibrillationOral anticoagulantsNonparoxysmal atrial fibrillationAtrial fibrillationHeart failureStroke preventionNew anticoagulantsContemporary phase III trialsAdditional prognostic benefitPhase III trialsPresence of diabetesNew drugsImpact of genderIII trialsPrognostic benefitDiabetes mellitusAnticoagulantsPatientsWarfarinEvent ratesCardiovascular medicineFibrillationMellitusDiabetesDabigatran etexilate for the prevention of stroke and systemic embolism in atrial fibrillation: NICE guidance
Ahmad Y, Lip GY. Dabigatran etexilate for the prevention of stroke and systemic embolism in atrial fibrillation: NICE guidance. Heart 2012, 98: 1404. PMID: 22698856, DOI: 10.1136/heartjnl-2012-302101.Peer-Reviewed Original Research