Transcatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials
Ahmad Y, Howard J, Arnold A, Madhavan M, Cook C, Alu M, Mack M, Reardon M, Thourani V, Kapadia S, Thyregod H, Sondergaard L, Jørgensen T, Toff W, Van Mieghem N, Makkar R, Forrest J, Leon M. Transcatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials. European Heart Journal 2023, 44: 836-852. PMID: 36660821, DOI: 10.1093/eurheartj/ehac642.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve implantationHigh-risk patientsLow-risk patientsComposite of deathAortic valve replacementValve replacementMAIN OUTCOMENew-onset atrial fibrillationSignificant differencesRandomized clinical trial dataAcute kidney injuryAortic valve implantationMain clinical outcomesRisk of deathClinical trial dataMajor bleedingKidney injurySecondary endpointsVascular complicationsValve implantationClinical outcomesParavalvular leakRandomized trialsAtrial fibrillationCerebral Embolic Protection Devices During Transcatheter Aortic Valve Replacement: A Meta-analysis of Randomized Controlled Trials
Reddy R, Ahmad Y, Arnold A, Howard J. Cerebral Embolic Protection Devices During Transcatheter Aortic Valve Replacement: A Meta-analysis of Randomized Controlled Trials. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101031. PMID: 37780935, PMCID: PMC10533415, DOI: 10.1016/j.jscai.2023.101031.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementEmbolic protection devicesAortic valve replacementCause mortalityEnd pointValve replacementCerebral embolic protection devicesAcute kidney injuryPrimary end pointSafety end pointRandomized Controlled TrialsTotal lesion volumeSignificant differencesKidney injuryVascular complicationsFeared complicationControlled TrialsNew lesionsOngoing RCTsLesion volumeMeta-AnalysisStudy registrationSystematic reviewStrokeMeaningful reduction