2023
The Current Landscape of Transcatheter Tricuspid Valve Intervention
Seligman H, Vora A, Haroian N, Puri R, Heng E, Smith R, Latib A, Makkar R, Sorajja P, Leon M, Ahmad Y. The Current Landscape of Transcatheter Tricuspid Valve Intervention. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101201. DOI: 10.1016/j.jscai.2023.101201.Peer-Reviewed Original ResearchTricuspid regurgitationHeart failureTranscatheter tricuspid valve interventionCaval valve implantationRight heart failureWorse tricuspid regurgitationPulmonary artery pressureReduced ejection fractionSevere tricuspid regurgitationAge-adjusted prevalenceMainstay of therapyTricuspid valve interventionMore contemporary dataArtery pressureValve implantationEjection fractionValve interventionAdverse prognosisValve repairTranscatheter interventionsTR severityPrevalence increasesPotential rolePatientsContemporary dataTranscatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials
Ahmad Y, Howard J, Arnold A, Madhavan M, Cook C, Alu M, Mack M, Reardon M, Thourani V, Kapadia S, Thyregod H, Sondergaard L, Jørgensen T, Toff W, Van Mieghem N, Makkar R, Forrest J, Leon M. Transcatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials. European Heart Journal 2023, 44: 836-852. PMID: 36660821, DOI: 10.1093/eurheartj/ehac642.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve implantationHigh-risk patientsLow-risk patientsComposite of deathAortic valve replacementValve replacementMAIN OUTCOMENew-onset atrial fibrillationSignificant differencesRandomized clinical trial dataAcute kidney injuryAortic valve implantationMain clinical outcomesRisk of deathClinical trial dataMajor bleedingKidney injurySecondary endpointsVascular complicationsValve implantationClinical outcomesParavalvular leakRandomized trialsAtrial fibrillation
2022
Hypoattenuated leaflet thickening (HALT) and reduced leaflet motion (RELM) of aortic bioprostheses: An imaging finding or a complication?
Ahmad Y, Makkar R, Sondergaard L. Hypoattenuated leaflet thickening (HALT) and reduced leaflet motion (RELM) of aortic bioprostheses: An imaging finding or a complication? Progress In Cardiovascular Diseases 2022, 72: 78-83. PMID: 35675882, DOI: 10.1016/j.pcad.2022.05.007.Peer-Reviewed Original ResearchConceptsLeaflet thickeningAortic bioprosthesesLeaflet motionSurgical aortic valve replacementSymptomatic severe aortic stenosisTranscatheter aortic valve implantationSubclinical leaflet thrombosisSurgical aortic bioprosthesesSevere aortic stenosisAortic valve replacementAortic valve implantationForm of strokeThrombotic complicationsValve implantationValve replacementAortic stenosisSurgical riskLeaflet thrombosisEffective therapyComputed tomographyValve functionRandomized dataValve durabilityClinical implicationsNatural history
2021
New frontiers for improving outcomes after transcatheter aortic valve implantation: The role of the conduction system and the impact of pacemakers
Ahmad Y, Makkar R. New frontiers for improving outcomes after transcatheter aortic valve implantation: The role of the conduction system and the impact of pacemakers. Heart Rhythm 2021, 18: 2048-2049. PMID: 34419668, DOI: 10.1016/j.hrthm.2021.08.016.Peer-Reviewed Original ResearchMeta-Analysis of Usefulness of Cerebral Embolic Protection During Transcatheter Aortic Valve Implantation
Ahmad Y, Howard JP. Meta-Analysis of Usefulness of Cerebral Embolic Protection During Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2021, 146: 69-73. PMID: 33556360, PMCID: PMC8082278, DOI: 10.1016/j.amjcard.2021.01.023.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationCerebral embolic protectionRisk of strokeAortic valve implantationEmbolic protectionValve implantationClinical outcomesNon-disabling strokePrimary end pointNew ischemic lesionsRandomized clinical trialsTotal lesion volumeSignificant differencesFeared complicationIschemic lesionsClinical trialsLesion volumeStroke rateNeuroimaging outcomesMeta-AnalysisSystematic reviewTrial dataStrokeEnd pointSignificant heterogeneityPerformance of quantitative flow ratio in patients with aortic stenosis undergoing transcatheter aortic valve implantation
Sejr‐Hansen M, Christiansen EH, Ahmad Y, Vendrik J, Westra J, Holm NR, Thim T, Seligman H, Hall K, Sen S, Terkelsen CJ, Eftekhari A. Performance of quantitative flow ratio in patients with aortic stenosis undergoing transcatheter aortic valve implantation. Catheterization And Cardiovascular Interventions 2021, 99: 68-73. PMID: 33533535, DOI: 10.1002/ccd.29518.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationAortic valve stenosisCoronary artery diseaseInstantaneous wave-free ratioFractional flow reserveQuantitative flow ratioAortic valve implantationValve implantationDiagnostic performancePressure wirePresence of ASSevere aortic valve stenosisAortic valve replacementCoronary pressure wireGood diagnostic performanceValve replacementAortic stenosisArtery diseaseValve stenosisCoronary angiogramFlow reservePatientsCAD evaluationDiagnostic accuracyStenosis
2020
Long‐Term Effects of Transcatheter Aortic Valve Implantation on Coronary Hemodynamics in Patients With Concomitant Coronary Artery Disease and Severe Aortic Stenosis
Vendrik J, Ahmad Y, Eftekhari A, Howard JP, Wijntjens GWM, Stegehuis VE, Cook C, Terkelsen CJ, Christiansen EH, Koch KT, Piek JJ, Sen S, Baan J. Long‐Term Effects of Transcatheter Aortic Valve Implantation on Coronary Hemodynamics in Patients With Concomitant Coronary Artery Disease and Severe Aortic Stenosis. Journal Of The American Heart Association 2020, 9: e015133. PMID: 32102615, PMCID: PMC7335578, DOI: 10.1161/jaha.119.015133.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationSevere aortic stenosisConcomitant coronary artery diseaseAortic stenosisAortic valve implantationCoronary artery diseasePost-TAVICoronary flowArtery diseaseValve implantationCoronary hemodynamicsLarge-scale prospective randomized trialsFractional flow reserve assessmentProspective randomized trialsLow-risk patientsHyperemic coronary flowInstantaneous wave-free ratioFractional flow reserveCoronary stenosis severityYounger patientsCoronary lesionsRandomized trialsDiastolic flowPatient populationWave-free period
2019
Determining the Predominant Lesion in Patients With Severe Aortic Stenosis and Coronary Stenoses
Ahmad Y, Vendrik J, Eftekhari A, Howard JP, Cook C, Rajkumar C, Malik I, Mikhail G, Ruparelia N, Hadjiloizou N, Nijjer S, Al-Lamee R, Petraco R, Warisawa T, Wijntjens GWM, Koch KT, van de Hoef T, de Waard G, Echavarria-Pinto M, Frame A, Sutaria N, Kanaganayagam G, Ariff B, Anderson J, Chukwuemeka A, Fertleman M, Koul S, Iglesias JF, Francis D, Mayet J, Serruys P, Davies J, Escaned J, van Royen N, Götberg M, Terkelsen C, Christiansen E, Piek JJ, Baan J, Sen S. Determining the Predominant Lesion in Patients With Severe Aortic Stenosis and Coronary Stenoses. Circulation Cardiovascular Interventions 2019, 12: e008263-e008263. PMID: 31752515, PMCID: PMC6924937, DOI: 10.1161/circinterventions.119.008263.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisBlood Flow VelocityCardiac CatheterizationCoronary Artery DiseaseCoronary CirculationCoronary StenosisCoronary VesselsEuropeFemaleHemodynamicsHumansMaleMicrocirculationPercutaneous Coronary InterventionPredictive Value of TestsRecovery of FunctionSeverity of Illness IndexTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsTranscatheter aortic valve implantationSevere aortic stenosisPercutaneous coronary interventionAortic stenosisCoronary artery diseaseCoronary stenosisIntermediate coronary stenosisCoronary diseaseCoronary interventionArtery diseaseCoronary microcirculationWave-free periodInstantaneous wave-free ratio valueConcomitant coronary artery diseaseConcomitant coronary diseaseAortic valve implantationInstantaneous wave-free ratioPhysiology-guided revascularizationExertional symptomsPost-TAVIHemodynamic improvementHemodynamic benefitsValve implantationCoronary lesionsMicrovascular resistance
2018
Optimal antiplatelet strategy after transcatheter aortic valve implantation: a meta-analysis
Ahmad Y, Demir O, Rajkumar C, Howard JP, Shun-Shin M, Cook C, Petraco R, Jabbour R, Arnold A, Frame A, Sutaria N, Ariff B, Kanaganayagam G, Francis D, Mayet J, Mikhail G, Malik I, Sen S. Optimal antiplatelet strategy after transcatheter aortic valve implantation: a meta-analysis. Open Heart 2018, 5: e000748. PMID: 29387433, PMCID: PMC5786926, DOI: 10.1136/openhrt-2017-000748.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationDual antiplatelet therapyAortic valve implantationAspirin monotherapyAntiplatelet therapyTAVI centresValve implantationBenefits of DAPTSystematic reviewOptimal antiplatelet strategyIncidence of strokeAntiplatelet useDAPT durationAdverse eventsAntiplatelet strategiesMedian durationInternational guidelinesMonotherapySuitable studiesTherapyElectronic surveyMetaregressionStrokeDeathDuration