2023
TCT-641 Intravascular Imaging-Guided Versus Angiography-Guided Percutaneous Coronary Intervention: A Meta-Analysis of Randomized Trials
Sreenivasan J, Reddy R, Jamil Y, Malik A, Chamie D, Howard J, Nanna M, Mintz G, Maehara A, Ali Z, Moses J, Chen S, Chieffo A, Colombo A, Leon M, Lansky A, Ahmad Y. TCT-641 Intravascular Imaging-Guided Versus Angiography-Guided Percutaneous Coronary Intervention: A Meta-Analysis of Randomized Trials. Journal Of The American College Of Cardiology 2023, 82: b258. DOI: 10.1016/j.jacc.2023.09.652.Peer-Reviewed Original ResearchRevascularisation, periprocedural events and survival - and the survival of the randomised controlled trial.
Lansky A, Ahmad Y. Revascularisation, periprocedural events and survival - and the survival of the randomised controlled trial. EuroIntervention 2023, 18: 1218-1219. PMID: 36939109, PMCID: PMC10018286, DOI: 10.4244/eij-e-23-00004.Peer-Reviewed Original Research
2022
Clinical Research on Transcatheter Aortic Valve Replacement for Bicuspid Aortic Valve Disease: Principles, Challenges, and an Agenda for the Future
Ahmad Y, Madhavan M, Baron S, Forrest J, Borger M, Leipsic J, Cavalcante J, Wang D, McCarthy P, Szerlip M, Kapadia S, Makkar R, Mack M, Leon M, Cohen D. Clinical Research on Transcatheter Aortic Valve Replacement for Bicuspid Aortic Valve Disease: Principles, Challenges, and an Agenda for the Future. Structural Heart 2022, 7: 100102. PMID: 37275317, PMCID: PMC10236801, DOI: 10.1016/j.shj.2022.100102.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementBicuspid aortic valve diseaseSurgical aortic valve replacementAortic valve replacementAortic valve diseaseValve replacementClinical researchValve diseaseValvular heart diseaseDesign of RCTsProcedural therapiesProspective registryHeart diseaseExclusion criteriaRisk scorePatientsRCTsDiseaseCardiovascular communityMultidisciplinary workshopSelection biasTrialsInternational expertsPotential studiesRegistryCatheter ablation improves cardiovascular outcomes in patients with atrial fibrillation and heart failure: a meta-analysis of randomized controlled trials
Simader FA, Howard JP, Ahmad Y, Saleh K, Naraen A, Samways JW, Mohal J, Reddy RK, Kaza N, Keene D, Shun-Shin MJ, Francis DP, Whinnett ZI, Arnold AD. Catheter ablation improves cardiovascular outcomes in patients with atrial fibrillation and heart failure: a meta-analysis of randomized controlled trials. EP Europace 2022, 25: 341-350. PMID: 36305545, PMCID: PMC9934993, DOI: 10.1093/europace/euac173.Peer-Reviewed Original ResearchConceptsHeart failure hospitalizationCatheter ablationHeart failureMedical therapyFailure hospitalizationAtrial fibrillationCardiovascular outcomesPrimary analysisPre-specified primary endpointAtrial fibrillation catheter ablationCause mortalityPrimary endpointSecondary endpointsLower riskPatientsTherapyHospitalizationFibrillationTrialsMortalityLow heterogeneityAblationEndpointOutcomesFailure
2021
TCT-119 Association Among Degree of Coronary Artery Calcification, Clinical Presentation, and Adverse Clinical Outcomes After PCI: A Patient-Level Pooled Analysis of 11 Randomized Trials
Madhavan M, Galougahi K, Redfors B, Ahmad Y, Prasad M, Genereux P, Maehara A, Zhou Z, Ben-Yehuda O, von Birgelen C, Smits P, Mehran R, Ali Z, Serruys P, Kirtane A, Leon M, Stone G. TCT-119 Association Among Degree of Coronary Artery Calcification, Clinical Presentation, and Adverse Clinical Outcomes After PCI: A Patient-Level Pooled Analysis of 11 Randomized Trials. Journal Of The American College Of Cardiology 2021, 78: b50. DOI: 10.1016/j.jacc.2021.09.969.Peer-Reviewed Original ResearchSodium-glucose cotransporter 2 inhibitors in patients with heart failure: a systematic review and meta-analysis of randomized trials
Ahmad Y, Madhavan MV, Stone GW, Francis DP, Makkar R, Bhatt DL, Howard JP. Sodium-glucose cotransporter 2 inhibitors in patients with heart failure: a systematic review and meta-analysis of randomized trials. European Heart Journal - Quality Of Care And Clinical Outcomes 2021, 8: 383-390. PMID: 34617565, PMCID: PMC9170566, DOI: 10.1093/ehjqcco/qcab072.Peer-Reviewed Original ResearchConceptsHeart failure hospitalizationSGLT-2 inhibitorsSodium-glucose cotransporter 2 inhibitorsCotransporter 2 inhibitorsFailure hospitalizationCardiovascular mortalityHeart failureCause mortalityHazard ratioPre-specified primary endpointEjection fraction rangeIndividual clinical endpointsPrimary endpointSecondary endpointsComposite outcomeStandard careRandomized trialsClinical endpointsHospitalizationPatientsSystematic reviewMortalityTrialsEndpointInhibitorsSingle Versus Dual Antiplatelet Therapy After Transcatheter Aortic Valve Replacement: A Meta-Analysis of Randomized Clinical Trials
Ahmad Y, Howard JP, Madhavan MV, Leon MB, Makkar RR. Single Versus Dual Antiplatelet Therapy After Transcatheter Aortic Valve Replacement: A Meta-Analysis of Randomized Clinical Trials. Cardiovascular Revascularization Medicine 2021, 34: 46-53. PMID: 33514490, PMCID: PMC8814464, DOI: 10.1016/j.carrev.2021.01.016.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementDual antiplatelet therapyAortic valve replacementLife-threatening bleedingRisk of strokeMyocardial infarctionMajor bleedingCardiac deathAntiplatelet therapyValve replacementRandomized clinical trialsSignificant differencesIschemic endpointsPrimary endpointSecondary endpointsTotal patientsClinical trialsBleedingMeta-AnalysisTrialsStrokeEndpointDeathInfarctionPatients
2020
Drug-Eluting Stents Versus Bypass Surgery for Left Main Disease: An Updated Meta-Analysis of Randomized Controlled Trials With Long-Term Follow-Up
Ahmad Y, Howard JP, Arnold AD, Ali ZA, Francis D, Moses JW, Leon MB, Kirtane AJ, Karmpaliotis D, Stone GW. Drug-Eluting Stents Versus Bypass Surgery for Left Main Disease: An Updated Meta-Analysis of Randomized Controlled Trials With Long-Term Follow-Up. The American Journal Of Cardiology 2020, 132: 168-172. PMID: 32718553, DOI: 10.1016/j.amjcard.2020.06.059.Peer-Reviewed Original Research
2019
Clinical Events After Deferral of LAD Revascularization Following Physiological Coronary Assessment
Sen S, Ahmad Y, Dehbi HM, Howard JP, Iglesias JF, Al-Lamee R, Petraco R, Nijjer S, Bhindi R, Lehman S, Walters D, Sapontis J, Janssens L, Vrints CJ, Khashaba A, Laine M, Van Belle E, Krackhardt F, Bojara W, Going O, Härle T, Indolfi C, Niccoli G, Ribichini F, Tanaka N, Yokoi H, Takashima H, Kikuta Y, Erglis A, Vinhas H, Silva PC, Baptista SB, Alghamdi A, Hellig F, Koo BK, Nam CW, Shin ES, Doh JH, Brugaletta S, Alegria-Barrero E, Meuwissen M, Piek JJ, van Royen N, Sezer M, Di Mario C, Gerber RT, Malik IS, Sharp ASP, Talwar S, Tang K, Samady H, Altman J, Seto AH, Singh J, Jeremias A, Matsuo H, Kharbanda RK, Patel MR, Serruys P, Escaned J, Davies JE. Clinical Events After Deferral of LAD Revascularization Following Physiological Coronary Assessment. Journal Of The American College Of Cardiology 2019, 73: 444-453. PMID: 30704577, PMCID: PMC6354033, DOI: 10.1016/j.jacc.2018.10.070.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsInstantaneous wave-free ratioFractional flow reserveLAD lesionsMyocardial infarctionUnplanned revascularizationLeft anterior descending (LAD) arteryEvent ratesLower myocardial infarctionAdverse cardiac eventsAnterior descending (LAD) arteryPhysiological assessmentLow event ratesMACE rateCardiac eventsCardiovascular deathClinical eventsFlow reserveHigh riskPatientsLesionsLADRevascularizationTrialsTreatmentRight ventricular pacing for hypertrophic obstructive cardiomyopathy: meta-analysis and meta-regression of clinical trials
Arnold AD, Howard JP, Chiew K, Kerrigan WJ, de Vere F, Johns HT, Churlilov L, Ahmad Y, Keene D, Shun-Shin MJ, Cole GD, Kanagaratnam P, Sohaib SMA, Varnava A, Francis DP, Whinnett ZI. Right ventricular pacing for hypertrophic obstructive cardiomyopathy: meta-analysis and meta-regression of clinical trials. European Heart Journal - Quality Of Care And Clinical Outcomes 2019, 5: 321-333. PMID: 30715300, PMCID: PMC6775860, DOI: 10.1093/ehjqcco/qcz006.Peer-Reviewed Original ResearchConceptsNYHA classObservational studyLeft ventricular outflow tract gradient reductionNew York Heart Association classVentricular outflow tract gradient reductionUnblinded observational studyHypertrophic obstructive cardiomyopathyRight ventricular pacingGenuine treatment effectNon-significant trendObstructive cardiomyopathyAssociation classFunctional outcomeBlinded RCTVentricular pacingClinical trialsEligibility criteriaRCTsGradient reductionGreater reductionTreatment effectsTrialsPatientsCardiomyopathyPacing
2018
P3551Right ventricular pacing for LVOT gradient reduction in hypertrophic obstructive cardiomyopathy: a meta-analysis and meta-regression of clinical trials
Arnold A, Howard J, Ahmad Y, Chiew K, Kerrigan W, De Vere F, Keene D, Shun-Shin M, Cole G, Sohaib A, Varnava A, Francis D, Whinnett Z. P3551Right ventricular pacing for LVOT gradient reduction in hypertrophic obstructive cardiomyopathy: a meta-analysis and meta-regression of clinical trials. European Heart Journal 2018, 39: ehy563.p3551. DOI: 10.1093/eurheartj/ehy563.p3551.Peer-Reviewed Original ResearchP716PFO closure is superior to medical therapy for cryptogenic stroke: a meta-analysis of randomised controlled trials
Ahmad Y, Howard J, Arnold A, Shun-Shin M, Cook C, Petraco R, Sutaria N, Malik I, Mayet J, Francis D, Sen S. P716PFO closure is superior to medical therapy for cryptogenic stroke: a meta-analysis of randomised controlled trials. European Heart Journal 2018, 39: ehy564.p716. DOI: 10.1093/eurheartj/ehy564.p716.Peer-Reviewed Original Research2 PFO closure is superior to medical therapy for cryptogenic stroke: a meta-analysis of randomised controlled trials
Ahmad Y, Howard J, Arnold A, Shun-Shin M, Cook C, Malik I, Mayet J, Francis D, Sen S. 2 PFO closure is superior to medical therapy for cryptogenic stroke: a meta-analysis of randomised controlled trials. Heart 2018, 104: a2. DOI: 10.1136/heartjnl-2018-bcs.2.Peer-Reviewed Original ResearchMedical therapyCryptogenic strokeDevice closureAtrial fibrillationRecurrent strokePFO closureNew-onset atrial fibrillationRisk of AFOnset atrial fibrillationPrimary safety endpointPrimary efficacy endpointPrevention of strokeEfficacy endpointFurther strokeSafety endpointTreat basisPatent foramenPatientsTherapyStrokePFOTrialsEndpointPreventionClosure
2017
TCT-269 PFO Closure is Superior to Medical Therapy for Cryptogenic Stroke: a meta-analysis of randomised controlled trials
Ahmad Y, Shun-Shin M, Howard J, Cook C, Petraco R, Demir O, Mikhail G, Sutaria N, Baker C, Davies J, Mayet J, Francis D, Malik I, Sen S. TCT-269 PFO Closure is Superior to Medical Therapy for Cryptogenic Stroke: a meta-analysis of randomised controlled trials. Journal Of The American College Of Cardiology 2017, 70: b111. DOI: 10.1016/j.jacc.2017.09.346.Peer-Reviewed Original Research
2016
35 Thrombus Aspiration does not Reduce Mortality in STEMI Patients: A Meta-Analysis of 20,192 Patients, with Implications for Future Trial Design
Ahmad Y, Sen S, Nijjer S, Keene D, Cook C, Petraco R, Shun-Shin M, Cole G, Al-Lamee R, Malik I, Baker C, Mikhail G, Foale R, Mayet J, Davies J, Francis D. 35 Thrombus Aspiration does not Reduce Mortality in STEMI Patients: A Meta-Analysis of 20,192 Patients, with Implications for Future Trial Design. Heart 2016, 102: a24. DOI: 10.1136/heartjnl-2016-309890.35.Peer-Reviewed Original ResearchThrombus aspirationAvailable RCT dataLong-term followFuture trial designAcute myocardial infarctionMulti-center trialNon-significant reductionSTEMI trialPrimary angioplastySTEMI patientsMyocardial infarctionMortality reductionPatient costsRCT dataTrial designMeta-AnalysisRetrospective consentStrokePatientsMortalityTrialsConfidence intervalsLogical adjunctTotal trialsSignificant increase
2015
TCT-479 Patients consider PCI and CABG equal: Derivation of a novel patient-centered, quantitative analysis of Major Adverse Cardiac Events (MACE) and its application to trials comparing PCI to CABG
Ahmad Y, Nijjer S, Cook C, Petraco R, Malik I, Baker C, Mikhail G, Kaprielian R, Bellamy M, Davies J, Mayet J, Francis D, Sen S. TCT-479 Patients consider PCI and CABG equal: Derivation of a novel patient-centered, quantitative analysis of Major Adverse Cardiac Events (MACE) and its application to trials comparing PCI to CABG. Journal Of The American College Of Cardiology 2015, 66: b195-b196. DOI: 10.1016/j.jacc.2015.08.495.Peer-Reviewed Original ResearchA new method of applying randomised control study data to the individual patient: A novel quantitative patient-centred approach to interpreting composite end points
Ahmad Y, Nijjer S, Cook CM, El-Harasis M, Graby J, Petraco R, Kotecha T, Baker CS, Malik IS, Bellamy MF, Sethi A, Mikhail GW, Al-Bustami M, Khan M, Kaprielian R, Foale RA, Mayet J, Davies JE, Francis DP, Sen S. A new method of applying randomised control study data to the individual patient: A novel quantitative patient-centred approach to interpreting composite end points. International Journal Of Cardiology 2015, 195: 216-224. PMID: 26048380, DOI: 10.1016/j.ijcard.2015.05.109.Peer-Reviewed Original ResearchConceptsIndividual patientsComposite end pointCoronary artery bypassDrug-eluting stentsPatient-centered approachSignificant differencesPatient preference dataPatient-centered metricsArtery bypassCardiac catheterisationComposite endpointPatient preferencesPatientsTrial dataEnd pointTrial resultsEndpointMACECABGSurgeryTrialsStructured toolDeathStudy dataRevascularisation