2023
Aortic Valve Calcium Score Is Associated With Acute Stroke in Transcatheter Aortic Valve Replacement Patients
Foley M, Hall K, Howard J, Ahmad Y, Gandhi M, Mahboobani S, Okafor J, Rahman H, Hadjiloizou N, Ruparelia N, Mikhail G, Malik I, Kanaganayagam G, Sutaria N, Rana B, Ariff B, Barden E, Anderson J, Afoke J, Petraco R, Al-Lamee R, Sen S. Aortic Valve Calcium Score Is Associated With Acute Stroke in Transcatheter Aortic Valve Replacement Patients. Cardiovascular Revascularization Medicine 2023, 53: s108. DOI: 10.1016/j.carrev.2023.05.250.Peer-Reviewed Original ResearchCRT-700.27 Aortic Valve Calcium Score Is Associated With Acute Stroke in Transcatheter Aortic Valve Replacement Patients
Foley M, Hall K, Howard J, Ahmad Y, Gandhi M, Mahboobani S, Okafor J, Rahman H, Hadjiloizou N, Ruparelia N, Mikhail G, Malik I, Kanaganayagam G, Sutaria N, Rana B, Ariff B, Barden E, Anderson J, Afoke J, Petraco R, Al-Lamee R, Sen S. CRT-700.27 Aortic Valve Calcium Score Is Associated With Acute Stroke in Transcatheter Aortic Valve Replacement Patients. JACC Cardiovascular Interventions 2023, 16: s91. DOI: 10.1016/j.jcin.2023.01.288.Peer-Reviewed Original ResearchCerebral Embolic Protection Devices During Transcatheter Aortic Valve Replacement: A Meta-analysis of Randomized Controlled Trials
Reddy R, Ahmad Y, Arnold A, Howard J. Cerebral Embolic Protection Devices During Transcatheter Aortic Valve Replacement: A Meta-analysis of Randomized Controlled Trials. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101031. PMID: 37780935, PMCID: PMC10533415, DOI: 10.1016/j.jscai.2023.101031.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementEmbolic protection devicesAortic valve replacementCause mortalityEnd pointValve replacementCerebral embolic protection devicesAcute kidney injuryPrimary end pointSafety end pointRandomized Controlled TrialsTotal lesion volumeSignificant differencesKidney injuryVascular complicationsFeared complicationControlled TrialsNew lesionsOngoing RCTsLesion volumeMeta-AnalysisStudy registrationSystematic reviewStrokeMeaningful reduction
2021
Meta-Analysis of Usefulness of Cerebral Embolic Protection During Transcatheter Aortic Valve Implantation
Ahmad Y, Howard JP. Meta-Analysis of Usefulness of Cerebral Embolic Protection During Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2021, 146: 69-73. PMID: 33556360, PMCID: PMC8082278, DOI: 10.1016/j.amjcard.2021.01.023.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationCerebral embolic protectionRisk of strokeAortic valve implantationEmbolic protectionValve implantationClinical outcomesNon-disabling strokePrimary end pointNew ischemic lesionsRandomized clinical trialsTotal lesion volumeSignificant differencesFeared complicationIschemic lesionsClinical trialsLesion volumeStroke rateNeuroimaging outcomesMeta-AnalysisSystematic reviewTrial dataStrokeEnd pointSignificant heterogeneitySingle Versus Dual Antiplatelet Therapy After Transcatheter Aortic Valve Replacement: A Meta-Analysis of Randomized Clinical Trials
Ahmad Y, Howard JP, Madhavan MV, Leon MB, Makkar RR. Single Versus Dual Antiplatelet Therapy After Transcatheter Aortic Valve Replacement: A Meta-Analysis of Randomized Clinical Trials. Cardiovascular Revascularization Medicine 2021, 34: 46-53. PMID: 33514490, PMCID: PMC8814464, DOI: 10.1016/j.carrev.2021.01.016.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementDual antiplatelet therapyAortic valve replacementLife-threatening bleedingRisk of strokeMyocardial infarctionMajor bleedingCardiac deathAntiplatelet therapyValve replacementRandomized clinical trialsSignificant differencesIschemic endpointsPrimary endpointSecondary endpointsTotal patientsClinical trialsBleedingMeta-AnalysisTrialsStrokeEndpointDeathInfarctionPatients
2018
Reply to: Assessing the quality of evidence supporting patent foramen ovale closure over medical therapy after cryptogenic stroke
Ahmad Y, Howard J, Arnold A, Shun-Shin M, Cook C, Francis D, Sen S. Reply to: Assessing the quality of evidence supporting patent foramen ovale closure over medical therapy after cryptogenic stroke. European Heart Journal 2018, 39: 3620-3620. PMID: 30137277, DOI: 10.1093/eurheartj/ehy498.Peer-Reviewed Original ResearchP716PFO closure is superior to medical therapy for cryptogenic stroke: a meta-analysis of randomised controlled trials
Ahmad Y, Howard J, Arnold A, Shun-Shin M, Cook C, Petraco R, Sutaria N, Malik I, Mayet J, Francis D, Sen S. P716PFO closure is superior to medical therapy for cryptogenic stroke: a meta-analysis of randomised controlled trials. European Heart Journal 2018, 39: ehy564.p716. DOI: 10.1093/eurheartj/ehy564.p716.Peer-Reviewed Original Research2 PFO closure is superior to medical therapy for cryptogenic stroke: a meta-analysis of randomised controlled trials
Ahmad Y, Howard J, Arnold A, Shun-Shin M, Cook C, Malik I, Mayet J, Francis D, Sen S. 2 PFO closure is superior to medical therapy for cryptogenic stroke: a meta-analysis of randomised controlled trials. Heart 2018, 104: a2. DOI: 10.1136/heartjnl-2018-bcs.2.Peer-Reviewed Original ResearchMedical therapyCryptogenic strokeDevice closureAtrial fibrillationRecurrent strokePFO closureNew-onset atrial fibrillationRisk of AFOnset atrial fibrillationPrimary safety endpointPrimary efficacy endpointPrevention of strokeEfficacy endpointFurther strokeSafety endpointTreat basisPatent foramenPatientsTherapyStrokePFOTrialsEndpointPreventionClosurePatent foramen ovale closure vs. medical therapy for cryptogenic stroke: a meta-analysis of randomized controlled trials
Ahmad Y, Howard JP, Arnold A, Shin MS, Cook C, Petraco R, Demir O, Williams L, Iglesias JF, Sutaria N, Malik I, Davies J, Mayet J, Francis D, Sen S. Patent foramen ovale closure vs. medical therapy for cryptogenic stroke: a meta-analysis of randomized controlled trials. European Heart Journal 2018, 39: 1638-1649. PMID: 29590333, PMCID: PMC5946888, DOI: 10.1093/eurheartj/ehy121.Peer-Reviewed Original ResearchConceptsMedical therapyCryptogenic strokeDevice closurePFO closureAtrial fibrillationRecurrent strokeLarge shuntPatent foramenNew-onset atrial fibrillationRisk of AFOnset atrial fibrillationPrimary safety endpointPrimary efficacy endpointAtrial septal aneurysmPrevention of strokeSignificant reductionEfficacy endpointFurther strokeSafety endpointTreat basisSeptal aneurysmSmall shuntPatientsTherapyStrokeOptimal antiplatelet strategy after transcatheter aortic valve implantation: a meta-analysis
Ahmad Y, Demir O, Rajkumar C, Howard JP, Shun-Shin M, Cook C, Petraco R, Jabbour R, Arnold A, Frame A, Sutaria N, Ariff B, Kanaganayagam G, Francis D, Mayet J, Mikhail G, Malik I, Sen S. Optimal antiplatelet strategy after transcatheter aortic valve implantation: a meta-analysis. Open Heart 2018, 5: e000748. PMID: 29387433, PMCID: PMC5786926, DOI: 10.1136/openhrt-2017-000748.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationDual antiplatelet therapyAortic valve implantationAspirin monotherapyAntiplatelet therapyTAVI centresValve implantationBenefits of DAPTSystematic reviewOptimal antiplatelet strategyIncidence of strokeAntiplatelet useDAPT durationAdverse eventsAntiplatelet strategiesMedian durationInternational guidelinesMonotherapySuitable studiesTherapyElectronic surveyMetaregressionStrokeDeathDuration
2017
TCT-269 PFO Closure is Superior to Medical Therapy for Cryptogenic Stroke: a meta-analysis of randomised controlled trials
Ahmad Y, Shun-Shin M, Howard J, Cook C, Petraco R, Demir O, Mikhail G, Sutaria N, Baker C, Davies J, Mayet J, Francis D, Malik I, Sen S. TCT-269 PFO Closure is Superior to Medical Therapy for Cryptogenic Stroke: a meta-analysis of randomised controlled trials. Journal Of The American College Of Cardiology 2017, 70: b111. DOI: 10.1016/j.jacc.2017.09.346.Peer-Reviewed Original ResearchAcute myocardial infarction and stroke secondary to valve thrombosis following transcatheter aortic valve replacement—what can happen when antiplatelet agents are stopped
Lam MC, Kanaganayagam G, Ahmad Y, Fertleman M, Ariff B. Acute myocardial infarction and stroke secondary to valve thrombosis following transcatheter aortic valve replacement—what can happen when antiplatelet agents are stopped. Quantitative Imaging In Medicine And Surgery 2017, 7: 605-607. PMID: 29184771, PMCID: PMC5682404, DOI: 10.21037/qims.2017.10.04.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementDual antiplatelet therapyAortic valve replacementValve replacementAortic stenosisSevere aortic stenosisCoronary artery bypassPast medical historyAcute myocardial infarctionAntiplatelet therapyArtery bypassAntiplatelet agentsPost procedureMedical historyMyocardial infarctionMonthsVomitingInfarctionStenosisThrombosisPatientsAdmissionBypassTherapyStroke
2016
35 Thrombus Aspiration does not Reduce Mortality in STEMI Patients: A Meta-Analysis of 20,192 Patients, with Implications for Future Trial Design
Ahmad Y, Sen S, Nijjer S, Keene D, Cook C, Petraco R, Shun-Shin M, Cole G, Al-Lamee R, Malik I, Baker C, Mikhail G, Foale R, Mayet J, Davies J, Francis D. 35 Thrombus Aspiration does not Reduce Mortality in STEMI Patients: A Meta-Analysis of 20,192 Patients, with Implications for Future Trial Design. Heart 2016, 102: a24. DOI: 10.1136/heartjnl-2016-309890.35.Peer-Reviewed Original ResearchThrombus aspirationAvailable RCT dataLong-term followFuture trial designAcute myocardial infarctionMulti-center trialNon-significant reductionSTEMI trialPrimary angioplastySTEMI patientsMyocardial infarctionMortality reductionPatient costsRCT dataTrial designMeta-AnalysisRetrospective consentStrokePatientsMortalityTrialsConfidence intervalsLogical adjunctTotal trialsSignificant increase
2012
Dabigatran etexilate for the prevention of stroke and systemic embolism in atrial fibrillation: NICE guidance
Ahmad Y, Lip GY. Dabigatran etexilate for the prevention of stroke and systemic embolism in atrial fibrillation: NICE guidance. Heart 2012, 98: 1404. PMID: 22698856, DOI: 10.1136/heartjnl-2012-302101.Peer-Reviewed Original Research