2023
Deferred Versus Performed Revascularization for Left Main Coronary Disease With Hemodynamic Significance
Warisawa T, Cook C, Ahmad Y, Howard J, Seligman H, Rajkumar C, Toya T, Doi S, Nakajima A, Nakayama M, Vera-Urquiza R, Yuasa S, Sato T, Kikuta Y, Kawase Y, Nishina H, Al-Lamee R, Sen S, Lerman A, Matsuo H, Akashi Y, Escaned J, Davies J. Deferred Versus Performed Revascularization for Left Main Coronary Disease With Hemodynamic Significance. Circulation Cardiovascular Interventions 2023, 16: e012700. PMID: 37339234, DOI: 10.1161/circinterventions.122.012700.Peer-Reviewed Original ResearchConceptsIschemia-driven target lesion revascularizationTarget lesion revascularizationLeft main stemCoronary artery diseaseStable coronary artery diseaseLong-term clinical outcomesPrimary end pointSecondary end pointsInstantaneous wave-free ratioLesion revascularizationArtery diseaseClinical outcomesMyocardial infarctionEnd pointRevascularization deferralCardiac deathLeft main coronary diseaseMain coronary artery diseaseBaseline clinical characteristicsComposite of deathContemporary clinical outcomesInternational multicenter registryMain coronary diseaseNonfatal myocardial infarctionMedian follow
2020
Safety of Revascularization Deferral of Left Main Stenosis Based on Instantaneous Wave-Free Ratio Evaluation
Warisawa T, Cook CM, Rajkumar C, Howard JP, Seligman H, Ahmad Y, El Hajj S, Doi S, Nakajima A, Nakayama M, Goto S, Vera-Urquiza R, Sato T, Kikuta Y, Kawase Y, Nishina H, Petraco R, Al-Lamee R, Nijjer S, Sen S, Nakamura S, Lerman A, Matsuo H, Francis DP, Akashi YJ, Escaned J, Davies JE. Safety of Revascularization Deferral of Left Main Stenosis Based on Instantaneous Wave-Free Ratio Evaluation. JACC Cardiovascular Interventions 2020, 13: 1655-1664. PMID: 32417088, DOI: 10.1016/j.jcin.2020.02.035.Peer-Reviewed Original ResearchMeSH KeywordsAgedClinical Decision-MakingCoronary Artery BypassCoronary Artery DiseaseCoronary StenosisEuropeFemaleFractional Flow Reserve, MyocardialHumansJapanMaleMiddle AgedPercutaneous Coronary InterventionPredictive Value of TestsProspective StudiesRegistriesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTime-to-TreatmentTreatment OutcomeUnited StatesConceptsInstantaneous wave-free ratioNonfatal myocardial infarctionPrimary endpointLM stenosisCause deathLesion revascularizationSecondary endpointsCardiac deathMyocardial infarctionIschemia-driven target lesion revascularizationSimilar long-term outcomesStable coronary artery diseaseMain coronary artery stenosisLong-term clinical outcomesSafety of deferralMulticenter observational studyTarget lesion revascularizationLeft main stenosisCoronary artery diseaseLong-term outcomesCoronary artery stenosisDeferred groupLM revascularizationMedian followRevascularization deferralEffects of Percutaneous Coronary Intervention on Death and Myocardial Infarction Stratified by Stable and Unstable Coronary Artery Disease
Chacko L, Howard J, Rajkumar C, Nowbar AN, Kane C, Mahdi D, Foley M, Shun-Shin M, Cole G, Sen S, Al-Lamee R, Francis DP, Ahmad Y. Effects of Percutaneous Coronary Intervention on Death and Myocardial Infarction Stratified by Stable and Unstable Coronary Artery Disease. Circulation Cardiovascular Quality And Outcomes 2020, 13: e006363-e006363. PMID: 32063040, PMCID: PMC7034389, DOI: 10.1161/circoutcomes.119.006363.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAdultAgedAged, 80 and overCause of DeathClinical Decision-MakingCoronary Artery DiseaseFemaleHumansMaleMiddle AgedNon-ST Elevated Myocardial InfarctionPercutaneous Coronary InterventionRandomized Controlled Trials as TopicRisk AssessmentRisk FactorsST Elevation Myocardial InfarctionTime FactorsTreatment OutcomeYoung AdultConceptsST-segment elevation myocardial infarctionStable coronary artery diseaseUnstable coronary artery diseasePercutaneous coronary interventionCoronary artery diseaseSegment elevation acute coronary syndromesAcute coronary syndromeMyocardial infarctionCardiac deathMultivessel diseaseCoronary syndromeCoronary interventionArtery diseaseBenefits of PCITrials of PCITreatment of CADCulprit-only revascularization strategyEarly percutaneous coronary interventionPrimary percutaneous coronary interventionPatients post-myocardial infarctionResidual coronary lesionsPrimary end pointComparative Health EffectivenessPost-myocardial infarctionImmediate revascularization
2019
Dobutamine Stress Echocardiography Ischemia as a Predictor of the Placebo-Controlled Efficacy of Percutaneous Coronary Intervention in Stable Coronary Artery Disease: The Stress Echocardiography-Stratified Analysis of ORBITA
Al-Lamee RK, Shun-Shin MJ, Howard JP, Nowbar AN, Rajkumar C, Thompson D, Sen S, Nijjer S, Petraco R, Davies J, Keeble T, Tang K, Malik I, Bual N, Cook C, Ahmad Y, Seligman H, Sharp ASP, Gerber R, Talwar S, Assomull R, Cole G, Keenan NG, Kanaganayagam G, Sehmi J, Wensel R, Harrell FE, Mayet J, Thom S, Davies JE, Francis DP. Dobutamine Stress Echocardiography Ischemia as a Predictor of the Placebo-Controlled Efficacy of Percutaneous Coronary Intervention in Stable Coronary Artery Disease: The Stress Echocardiography-Stratified Analysis of ORBITA. Circulation 2019, 140: 1971-1980. PMID: 31707827, PMCID: PMC6903430, DOI: 10.1161/circulationaha.119.042918.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionDobutamine stress echocardiographyStable coronary artery diseasePlacebo-controlled effectsPlacebo-controlled efficacyCoronary artery diseaseStress echocardiographyEchocardiography scoreCoronary interventionArtery diseaseCanadian Cardiovascular Society angina classEffect of PCIAngina frequency scoreTreadmill exercise timeDegree of ischemiaQuality of lifeAngina classEchocardiography abnormalitiesORBITA trialAngina frequencyPCI armPlacebo armAkinetic segmentsDyskinetic segmentsLife scores
2018
Impact of Percutaneous Revascularization on Exercise Hemodynamics in Patients With Stable Coronary Disease
Cook CM, Ahmad Y, Howard JP, Shun-Shin MJ, Sethi A, Clesham GJ, Tang KH, Nijjer SS, Kelly PA, Davies JR, Malik IS, Kaprielian R, Mikhail G, Petraco R, Al-Janabi F, Karamasis GV, Mohdnazri S, Gamma R, Al-Lamee R, Keeble TR, Mayet J, Sen S, Francis DP, Davies JE. Impact of Percutaneous Revascularization on Exercise Hemodynamics in Patients With Stable Coronary Disease. Journal Of The American College Of Cardiology 2018, 72: 970-983. PMID: 30139442, PMCID: PMC6580361, DOI: 10.1016/j.jacc.2018.06.033.Peer-Reviewed Original ResearchConceptsStable coronary artery diseasePercutaneous coronary interventionSystemic hemodynamicsCoronary circulationImpact of PCIInstantaneous wave-free ratio valuePeak coronary flow velocitySingle-vessel coronary stenosisSingle-vessel stenosisStable coronary diseaseSystolic blood pressureCoronary artery diseaseCoronary flow velocityCoronary perfusion pressureFractional flow reserve (FFR) valuesCoronary flow reserve valuesPressure-flow measurementsPre-PCISupine ergometerPercutaneous revascularizationPost-PCIAngina symptomsCoronary interventionArtery diseaseCardiac catheterization