2018
Impact of Percutaneous Revascularization on Exercise Hemodynamics in Patients With Stable Coronary Disease
Cook CM, Ahmad Y, Howard JP, Shun-Shin MJ, Sethi A, Clesham GJ, Tang KH, Nijjer SS, Kelly PA, Davies JR, Malik IS, Kaprielian R, Mikhail G, Petraco R, Al-Janabi F, Karamasis GV, Mohdnazri S, Gamma R, Al-Lamee R, Keeble TR, Mayet J, Sen S, Francis DP, Davies JE. Impact of Percutaneous Revascularization on Exercise Hemodynamics in Patients With Stable Coronary Disease. Journal Of The American College Of Cardiology 2018, 72: 970-983. PMID: 30139442, PMCID: PMC6580361, DOI: 10.1016/j.jacc.2018.06.033.Peer-Reviewed Original ResearchConceptsStable coronary artery diseasePercutaneous coronary interventionSystemic hemodynamicsCoronary circulationImpact of PCIInstantaneous wave-free ratio valuePeak coronary flow velocitySingle-vessel coronary stenosisSingle-vessel stenosisStable coronary diseaseSystolic blood pressureCoronary artery diseaseCoronary flow velocityCoronary perfusion pressureFractional flow reserve (FFR) valuesCoronary flow reserve valuesPressure-flow measurementsPre-PCISupine ergometerPercutaneous revascularizationPost-PCIAngina symptomsCoronary interventionArtery diseaseCardiac catheterization
2017
Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial
Al-Lamee R, Thompson D, Dehbi HM, Sen S, Tang K, Davies J, Keeble T, Mielewczik M, Kaprielian R, Malik IS, Nijjer SS, Petraco R, Cook C, Ahmad Y, Howard J, Baker C, Sharp A, Gerber R, Talwar S, Assomull R, Mayet J, Wensel R, Collier D, Shun-Shin M, Thom SA, Davies JE, Francis DP, investigators O, Al-Lamee R, Thompson D, Sen S, Tang K, Davies J, Keeble T, Kaprielian R, Malik I, Nijjer S, Petraco R, Cook C, Ahmad Y, Howard J, Shun-Shin M, Sethi A, Baker C, Sharp A, Ramrakha P, Gerber R, Talwar S, Assomull R, Foale R, Mayet J, Wensel R, Thom S, Davies J, Francis D, Khamis R, Hadjiloizou N, Khan M, Kooner J, Bellamy M, Mikhail G, Clifford P, O'Kane P, Levy T, Swallow R. Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial. The Lancet 2017, 391: 31-40. PMID: 29103656, DOI: 10.1016/s0140-6736(17)32714-9.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionPlacebo procedureExercise timeBiomedical Research CentrePlacebo groupPrimary endpointStable anginaCoronary interventionTrials of PCISingle-vessel stenosisMajor bleeding eventsSerious adverse eventsCardiopulmonary exercise testingDobutamine stress echocardiographySevere coronary stenosisInstantaneous wave-free ratioFractional flow reserveBleeding eventsPCI groupIschemic symptomsAdverse eventsExercise testingMedication optimizationAngina reliefRelated complications