2023
Insight Into the Optimal Timing of Percutaneous Coronary Intervention and Transcatheter Aortic Valve Replacement
Park D, Simonato M, Ahmad Y, Banks A, Lowenstern A, Nanna M. Insight Into the Optimal Timing of Percutaneous Coronary Intervention and Transcatheter Aortic Valve Replacement. Current Problems In Cardiology 2023, 49: 102050. PMID: 37643698, PMCID: PMC10924682, DOI: 10.1016/j.cpcardiol.2023.102050.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementPercutaneous coronary artery interventionAcute kidney injuryAortic valve replacementKidney injuryValve replacementPercutaneous coronary interventionCoronary artery diseaseCoronary artery interventionPaucity of dataHospital mortalityNonhome dischargeCoronary interventionSecondary outcomesSelect patientsArtery diseaseArtery interventionClinical outcomesHigher oddsPCI timingPatientsReadmissionOptimal timingSame daySignificant differencesLong-term Incidence of Myocardial Infarction and Death After CABG and PCI for Isolated Left Anterior Descending Artery Disease: A Meta-analysis of Randomized Controlled Trials
Prasad M, Ahmad Y, Howard J, Ben-Ami J, Madhavan M, Kirtane A, McEntegart M, Flattery E, Stone G, Leon M, Moses J. Long-term Incidence of Myocardial Infarction and Death After CABG and PCI for Isolated Left Anterior Descending Artery Disease: A Meta-analysis of Randomized Controlled Trials. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100636. DOI: 10.1016/j.jscai.2023.100636.Peer-Reviewed Original ResearchPercutaneous coronary interventionLong-term incidenceMyocardial infarctionLAD diseaseArtery diseaseLeft anterior descending (LAD) coronary artery diseaseAnterior descending (LAD) coronary artery diseaseLeft internal mammary artery graftInternal mammary artery graftRisk of MIMammary artery graftsCoronary artery bypassCoronary artery diseaseRandomized Controlled TrialsSignificant differencesArtery bypassArtery graftCause mortalityVessel revascularizationCoronary interventionSecondary outcomesControlled TrialsLeft anteriorPrimary outcomeCABGTranscatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials
Ahmad Y, Howard J, Arnold A, Madhavan M, Cook C, Alu M, Mack M, Reardon M, Thourani V, Kapadia S, Thyregod H, Sondergaard L, Jørgensen T, Toff W, Van Mieghem N, Makkar R, Forrest J, Leon M. Transcatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials. European Heart Journal 2023, 44: 836-852. PMID: 36660821, DOI: 10.1093/eurheartj/ehac642.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve implantationHigh-risk patientsLow-risk patientsComposite of deathAortic valve replacementValve replacementMAIN OUTCOMENew-onset atrial fibrillationSignificant differencesRandomized clinical trial dataAcute kidney injuryAortic valve implantationMain clinical outcomesRisk of deathClinical trial dataMajor bleedingKidney injurySecondary endpointsVascular complicationsValve implantationClinical outcomesParavalvular leakRandomized trialsAtrial fibrillationCerebral Embolic Protection Devices During Transcatheter Aortic Valve Replacement: A Meta-analysis of Randomized Controlled Trials
Reddy R, Ahmad Y, Arnold A, Howard J. Cerebral Embolic Protection Devices During Transcatheter Aortic Valve Replacement: A Meta-analysis of Randomized Controlled Trials. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101031. PMID: 37780935, PMCID: PMC10533415, DOI: 10.1016/j.jscai.2023.101031.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementEmbolic protection devicesAortic valve replacementCause mortalityEnd pointValve replacementCerebral embolic protection devicesAcute kidney injuryPrimary end pointSafety end pointRandomized Controlled TrialsTotal lesion volumeSignificant differencesKidney injuryVascular complicationsFeared complicationControlled TrialsNew lesionsOngoing RCTsLesion volumeMeta-AnalysisStudy registrationSystematic reviewStrokeMeaningful reduction
2022
Long-Term Outcomes of Randomized Controlled Trials Comparing Percutaneous Left Atrial Appendage Closure to Oral Anticoagulation for Nonvalvular Atrial Fibrillation: A Meta-Analysis
Madhavan M, Howard J, Brener M, Der Nigoghossian C, Chen S, Makkar R, Osmancik P, Reddy V, Holmes D, Stone G, Leon M, Ahmad Y. Long-Term Outcomes of Randomized Controlled Trials Comparing Percutaneous Left Atrial Appendage Closure to Oral Anticoagulation for Nonvalvular Atrial Fibrillation: A Meta-Analysis. Structural Heart 2022, 7: 100096. PMID: 37275318, PMCID: PMC10236864, DOI: 10.1016/j.shj.2022.100096.Peer-Reviewed Original ResearchLeft atrial appendage closurePercutaneous left atrial appendage closureRandomized clinical trialsNonvalvular atrial fibrillationOral anticoagulationAtrial appendage closureAtrial fibrillationNonprocedural bleedingCause mortalityAppendage closureHazard ratioHemorrhagic strokeClinical trialsLong-term oral anticoagulationReduced long-term riskLarge-scale clinical trialsIndividual clinical endpointsPrespecified primary endpointCochrane Central RegisterStandard of careNew trial dataSignificant differencesLong-term riskStroke prophylaxisPrimary endpoint
2021
Meta-Analysis of Usefulness of Cerebral Embolic Protection During Transcatheter Aortic Valve Implantation
Ahmad Y, Howard JP. Meta-Analysis of Usefulness of Cerebral Embolic Protection During Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2021, 146: 69-73. PMID: 33556360, PMCID: PMC8082278, DOI: 10.1016/j.amjcard.2021.01.023.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationCerebral embolic protectionRisk of strokeAortic valve implantationEmbolic protectionValve implantationClinical outcomesNon-disabling strokePrimary end pointNew ischemic lesionsRandomized clinical trialsTotal lesion volumeSignificant differencesFeared complicationIschemic lesionsClinical trialsLesion volumeStroke rateNeuroimaging outcomesMeta-AnalysisSystematic reviewTrial dataStrokeEnd pointSignificant heterogeneitySingle Versus Dual Antiplatelet Therapy After Transcatheter Aortic Valve Replacement: A Meta-Analysis of Randomized Clinical Trials
Ahmad Y, Howard JP, Madhavan MV, Leon MB, Makkar RR. Single Versus Dual Antiplatelet Therapy After Transcatheter Aortic Valve Replacement: A Meta-Analysis of Randomized Clinical Trials. Cardiovascular Revascularization Medicine 2021, 34: 46-53. PMID: 33514490, PMCID: PMC8814464, DOI: 10.1016/j.carrev.2021.01.016.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementDual antiplatelet therapyAortic valve replacementLife-threatening bleedingRisk of strokeMyocardial infarctionMajor bleedingCardiac deathAntiplatelet therapyValve replacementRandomized clinical trialsSignificant differencesIschemic endpointsPrimary endpointSecondary endpointsTotal patientsClinical trialsBleedingMeta-AnalysisTrialsStrokeEndpointDeathInfarctionPatients
2020
Mortality after drug-eluting stents vs. coronary artery bypass grafting for left main coronary artery disease: a meta-analysis of randomized controlled trials
Ahmad Y, Howard JP, Arnold AD, Cook CM, Prasad M, Ali ZA, Parikh MA, Kosmidou I, Francis DP, Moses JW, Leon MB, Kirtane AJ, Stone GW, Karmpaliotis D. Mortality after drug-eluting stents vs. coronary artery bypass grafting for left main coronary artery disease: a meta-analysis of randomized controlled trials. European Heart Journal 2020, 41: 3228-3235. PMID: 32118272, PMCID: PMC7557472, DOI: 10.1093/eurheartj/ehaa135.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryPercutaneous coronary interventionDrug-eluting stentsMain coronary artery diseaseCoronary artery diseaseMyocardial infarctionCardiac deathUnplanned revascularizationCause mortalityCoronary interventionArtery diseaseLeft main coronary artery diseaseRandomized clinical trial evidenceSimilar long-term mortalityArtery bypass graft surgerySignificant differencesUnplanned revascularization proceduresWeighted mean followBypass graft surgeryCoronary artery bypassPrimary efficacy endpointClinical trial evidenceLong-term mortalityRisk of strokeGold standard therapy
2015
A new method of applying randomised control study data to the individual patient: A novel quantitative patient-centred approach to interpreting composite end points
Ahmad Y, Nijjer S, Cook CM, El-Harasis M, Graby J, Petraco R, Kotecha T, Baker CS, Malik IS, Bellamy MF, Sethi A, Mikhail GW, Al-Bustami M, Khan M, Kaprielian R, Foale RA, Mayet J, Davies JE, Francis DP, Sen S. A new method of applying randomised control study data to the individual patient: A novel quantitative patient-centred approach to interpreting composite end points. International Journal Of Cardiology 2015, 195: 216-224. PMID: 26048380, DOI: 10.1016/j.ijcard.2015.05.109.Peer-Reviewed Original ResearchConceptsIndividual patientsComposite end pointCoronary artery bypassDrug-eluting stentsPatient-centered approachSignificant differencesPatient preference dataPatient-centered metricsArtery bypassCardiac catheterisationComposite endpointPatient preferencesPatientsTrial dataEnd pointTrial resultsEndpointMACECABGSurgeryTrialsStructured toolDeathStudy dataRevascularisation