2023
Catheter Ablation for Ventricular Tachycardia After MI: A Reconstructed Individual Patient Data Meta-analysis of Randomised Controlled Trials
Reddy R, Howard J, Ahmad Y, Shun-Shin M, Simader F, Miyazawa A, Saleh K, Naraen A, Samways J, Katritsis G, Mohal J, Kaza N, Porter B, Keene D, Linton N, Francis D, Whinnett Z, Luther V, Kanagaratnam P, Arnold A. Catheter Ablation for Ventricular Tachycardia After MI: A Reconstructed Individual Patient Data Meta-analysis of Randomised Controlled Trials. Arrhythmia & Electrophysiology Review 2023, 12: e26. PMID: 38124803, PMCID: PMC10731517, DOI: 10.15420/aer.2023.07.Peer-Reviewed Original ResearchCatheter ablationMedical therapyIndividual patient dataCause mortalityPrior MIVT recurrenceDefibrillator shocksIndividual Patient Data Meta-AnalysisVentricular tachycardia catheter ablationReconstructed individual patient dataPrespecified primary endpointPrespecified secondary endpointPatient dataPrespecified subgroup analysisProportion of patientsRandomised Controlled TrialsIndividual patient assessmentData Meta-AnalysisCause hospitalisationPrimary endpointSecondary endpointsPrognostic impactControlled TrialsPatient assessmentSubgroup analysisCatheter ablation for ventricular tachycardia after myocardial infarction: meta-analysis of randomised controlled trials
Reddy R, Howard J, Ahmad Y, Shun-Shin M, Simader F, Miyazawa A, Saleh K, Samways J, Keene D, Linton N, Francis D, Whinnett Z, Luther V, Kanagaratnam P, Arnold A. Catheter ablation for ventricular tachycardia after myocardial infarction: meta-analysis of randomised controlled trials. European Heart Journal 2023, 44: ehad655.392. DOI: 10.1093/eurheartj/ehad655.392.Peer-Reviewed Original ResearchIndividual patient dataReconstructed individual patient dataPrior myocardial infarctionCatheter ablationMedical therapyMyocardial infarctionCause mortalityVT recurrenceDefibrillator shocksVentricular tachycardiaPatient dataCox proportional hazards regression modelPost-infarct ventricular tachycardiaPre-specified primary endpointPre-specified secondary endpointsVentricular tachycardia catheter ablationProportional hazards regression modelsResults Eight trialsProportion of patientsKaplan-Meier curvesHazards regression modelsCause hospitalisationPrimary endpointSecondary endpointsPrognostic impactTranscatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials
Ahmad Y, Howard J, Arnold A, Madhavan M, Cook C, Alu M, Mack M, Reardon M, Thourani V, Kapadia S, Thyregod H, Sondergaard L, Jørgensen T, Toff W, Van Mieghem N, Makkar R, Forrest J, Leon M. Transcatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials. European Heart Journal 2023, 44: 836-852. PMID: 36660821, DOI: 10.1093/eurheartj/ehac642.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve implantationHigh-risk patientsLow-risk patientsComposite of deathAortic valve replacementValve replacementMAIN OUTCOMENew-onset atrial fibrillationSignificant differencesRandomized clinical trial dataAcute kidney injuryAortic valve implantationMain clinical outcomesRisk of deathClinical trial dataMajor bleedingKidney injurySecondary endpointsVascular complicationsValve implantationClinical outcomesParavalvular leakRandomized trialsAtrial fibrillation
2022
Catheter ablation improves cardiovascular outcomes in patients with atrial fibrillation and heart failure: a meta-analysis of randomized controlled trials
Simader FA, Howard JP, Ahmad Y, Saleh K, Naraen A, Samways JW, Mohal J, Reddy RK, Kaza N, Keene D, Shun-Shin MJ, Francis DP, Whinnett ZI, Arnold AD. Catheter ablation improves cardiovascular outcomes in patients with atrial fibrillation and heart failure: a meta-analysis of randomized controlled trials. EP Europace 2022, 25: 341-350. PMID: 36305545, PMCID: PMC9934993, DOI: 10.1093/europace/euac173.Peer-Reviewed Original ResearchConceptsHeart failure hospitalizationCatheter ablationHeart failureMedical therapyFailure hospitalizationAtrial fibrillationCardiovascular outcomesPrimary analysisPre-specified primary endpointAtrial fibrillation catheter ablationCause mortalityPrimary endpointSecondary endpointsLower riskPatientsTherapyHospitalizationFibrillationTrialsMortalityLow heterogeneityAblationEndpointOutcomesFailureMechanical thrombectomy with retrievable stents and aspiration catheters for acute ischaemic stroke: a meta-analysis of randomised controlled trials.
Rajkumar CA, Ganesananthan S, Ahmad Y, Seligman H, Thornton GD, Foley M, Nowbar AN, Howard JP, Francis DP, Keeble TR, Grunwald IQ, Al-Lamee RK, Malik I, Shun-Shin MJ. Mechanical thrombectomy with retrievable stents and aspiration catheters for acute ischaemic stroke: a meta-analysis of randomised controlled trials. EuroIntervention 2022, 17: e1425-e1434. PMID: 34503942, PMCID: PMC9896406, DOI: 10.4244/eij-d-21-00343.Peer-Reviewed Original ResearchConceptsSymptomatic intracranial hemorrhageAcute ischemic strokeModified Rankin ScaleIschemic strokeCause mortalityMechanical thrombectomyAspiration catheterIntracranial hemorrhageRetrievable stentsAnterior circulation ischemic strokeLong-term neurological outcomeAcute anterior circulation strokeTrial of thrombectomyAnterior circulation strokeStandard of careIntravenous thrombolysisNeurological outcomeSecondary endpointsPrimary endpointSubsequent disabilityMRS scoreRankin ScaleMedical therapyThrombectomyTreatment strategies
2021
Sodium-glucose cotransporter 2 inhibitors in patients with heart failure: a systematic review and meta-analysis of randomized trials
Ahmad Y, Madhavan MV, Stone GW, Francis DP, Makkar R, Bhatt DL, Howard JP. Sodium-glucose cotransporter 2 inhibitors in patients with heart failure: a systematic review and meta-analysis of randomized trials. European Heart Journal - Quality Of Care And Clinical Outcomes 2021, 8: 383-390. PMID: 34617565, PMCID: PMC9170566, DOI: 10.1093/ehjqcco/qcab072.Peer-Reviewed Original ResearchConceptsHeart failure hospitalizationSGLT-2 inhibitorsSodium-glucose cotransporter 2 inhibitorsCotransporter 2 inhibitorsFailure hospitalizationCardiovascular mortalityHeart failureCause mortalityHazard ratioPre-specified primary endpointEjection fraction rangeIndividual clinical endpointsPrimary endpointSecondary endpointsComposite outcomeStandard careRandomized trialsClinical endpointsHospitalizationPatientsSystematic reviewMortalityTrialsEndpointInhibitorsSingle Versus Dual Antiplatelet Therapy After Transcatheter Aortic Valve Replacement: A Meta-Analysis of Randomized Clinical Trials
Ahmad Y, Howard JP, Madhavan MV, Leon MB, Makkar RR. Single Versus Dual Antiplatelet Therapy After Transcatheter Aortic Valve Replacement: A Meta-Analysis of Randomized Clinical Trials. Cardiovascular Revascularization Medicine 2021, 34: 46-53. PMID: 33514490, PMCID: PMC8814464, DOI: 10.1016/j.carrev.2021.01.016.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementDual antiplatelet therapyAortic valve replacementLife-threatening bleedingRisk of strokeMyocardial infarctionMajor bleedingCardiac deathAntiplatelet therapyValve replacementRandomized clinical trialsSignificant differencesIschemic endpointsPrimary endpointSecondary endpointsTotal patientsClinical trialsBleedingMeta-AnalysisTrialsStrokeEndpointDeathInfarctionPatients
2020
Safety of Revascularization Deferral of Left Main Stenosis Based on Instantaneous Wave-Free Ratio Evaluation
Warisawa T, Cook CM, Rajkumar C, Howard JP, Seligman H, Ahmad Y, El Hajj S, Doi S, Nakajima A, Nakayama M, Goto S, Vera-Urquiza R, Sato T, Kikuta Y, Kawase Y, Nishina H, Petraco R, Al-Lamee R, Nijjer S, Sen S, Nakamura S, Lerman A, Matsuo H, Francis DP, Akashi YJ, Escaned J, Davies JE. Safety of Revascularization Deferral of Left Main Stenosis Based on Instantaneous Wave-Free Ratio Evaluation. JACC Cardiovascular Interventions 2020, 13: 1655-1664. PMID: 32417088, DOI: 10.1016/j.jcin.2020.02.035.Peer-Reviewed Original ResearchMeSH KeywordsAgedClinical Decision-MakingCoronary Artery BypassCoronary Artery DiseaseCoronary StenosisEuropeFemaleFractional Flow Reserve, MyocardialHumansJapanMaleMiddle AgedPercutaneous Coronary InterventionPredictive Value of TestsProspective StudiesRegistriesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTime-to-TreatmentTreatment OutcomeUnited StatesConceptsInstantaneous wave-free ratioNonfatal myocardial infarctionPrimary endpointLM stenosisCause deathLesion revascularizationSecondary endpointsCardiac deathMyocardial infarctionIschemia-driven target lesion revascularizationSimilar long-term outcomesStable coronary artery diseaseMain coronary artery stenosisLong-term clinical outcomesSafety of deferralMulticenter observational studyTarget lesion revascularizationLeft main stenosisCoronary artery diseaseLong-term outcomesCoronary artery stenosisDeferred groupLM revascularizationMedian followRevascularization deferral