2023
Deferred Versus Performed Revascularization for Left Main Coronary Disease With Hemodynamic Significance
Warisawa T, Cook C, Ahmad Y, Howard J, Seligman H, Rajkumar C, Toya T, Doi S, Nakajima A, Nakayama M, Vera-Urquiza R, Yuasa S, Sato T, Kikuta Y, Kawase Y, Nishina H, Al-Lamee R, Sen S, Lerman A, Matsuo H, Akashi Y, Escaned J, Davies J. Deferred Versus Performed Revascularization for Left Main Coronary Disease With Hemodynamic Significance. Circulation Cardiovascular Interventions 2023, 16: e012700. PMID: 37339234, DOI: 10.1161/circinterventions.122.012700.Peer-Reviewed Original ResearchConceptsIschemia-driven target lesion revascularizationTarget lesion revascularizationLeft main stemCoronary artery diseaseStable coronary artery diseaseLong-term clinical outcomesPrimary end pointSecondary end pointsInstantaneous wave-free ratioLesion revascularizationArtery diseaseClinical outcomesMyocardial infarctionEnd pointRevascularization deferralCardiac deathLeft main coronary diseaseMain coronary artery diseaseBaseline clinical characteristicsComposite of deathContemporary clinical outcomesInternational multicenter registryMain coronary diseaseNonfatal myocardial infarctionMedian followCerebral Embolic Protection Devices During Transcatheter Aortic Valve Replacement: A Meta-analysis of Randomized Controlled Trials
Reddy R, Ahmad Y, Arnold A, Howard J. Cerebral Embolic Protection Devices During Transcatheter Aortic Valve Replacement: A Meta-analysis of Randomized Controlled Trials. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101031. PMID: 37780935, PMCID: PMC10533415, DOI: 10.1016/j.jscai.2023.101031.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementEmbolic protection devicesAortic valve replacementCause mortalityEnd pointValve replacementCerebral embolic protection devicesAcute kidney injuryPrimary end pointSafety end pointRandomized Controlled TrialsTotal lesion volumeSignificant differencesKidney injuryVascular complicationsFeared complicationControlled TrialsNew lesionsOngoing RCTsLesion volumeMeta-AnalysisStudy registrationSystematic reviewStrokeMeaningful reduction
2022
Early Surgery for Patients With Asymptomatic Severe Aortic Stenosis: A Meta-Analysis of Randomized Controlled Trials
Ahmad Y, Howard J, Seligman H, Arnold A, Madhavan M, Forrest J, Geirsson A, Mack M, Lansky A, Leon M. Early Surgery for Patients With Asymptomatic Severe Aortic Stenosis: A Meta-Analysis of Randomized Controlled Trials. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100383. DOI: 10.1016/j.jscai.2022.100383.Peer-Reviewed Original ResearchSurgical aortic valve replacementAsymptomatic severe aortic stenosisSevere aortic stenosisAortic stenosisHF hospitalizationCause mortalityEjection fractionPrespecified primary end pointSevere asymptomatic aortic stenosisSymptomatic severe aortic stenosisEnd pointAortic valve interventionAsymptomatic aortic stenosisHeart failure hospitalizationPrimary end pointAortic valve replacementClass I recommendationCornerstone of managementInitial conservative managementNormal ejection fractionRandomized Controlled TrialsCurrent treatment standardsIndividual end pointsAsymptomatic patientsEarly surgery
2021
Meta-Analysis of Usefulness of Cerebral Embolic Protection During Transcatheter Aortic Valve Implantation
Ahmad Y, Howard JP. Meta-Analysis of Usefulness of Cerebral Embolic Protection During Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2021, 146: 69-73. PMID: 33556360, PMCID: PMC8082278, DOI: 10.1016/j.amjcard.2021.01.023.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationCerebral embolic protectionRisk of strokeAortic valve implantationEmbolic protectionValve implantationClinical outcomesNon-disabling strokePrimary end pointNew ischemic lesionsRandomized clinical trialsTotal lesion volumeSignificant differencesFeared complicationIschemic lesionsClinical trialsLesion volumeStroke rateNeuroimaging outcomesMeta-AnalysisSystematic reviewTrial dataStrokeEnd pointSignificant heterogeneity
2020
Effects of Percutaneous Coronary Intervention on Death and Myocardial Infarction Stratified by Stable and Unstable Coronary Artery Disease
Chacko L, Howard J, Rajkumar C, Nowbar AN, Kane C, Mahdi D, Foley M, Shun-Shin M, Cole G, Sen S, Al-Lamee R, Francis DP, Ahmad Y. Effects of Percutaneous Coronary Intervention on Death and Myocardial Infarction Stratified by Stable and Unstable Coronary Artery Disease. Circulation Cardiovascular Quality And Outcomes 2020, 13: e006363-e006363. PMID: 32063040, PMCID: PMC7034389, DOI: 10.1161/circoutcomes.119.006363.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAdultAgedAged, 80 and overCause of DeathClinical Decision-MakingCoronary Artery DiseaseFemaleHumansMaleMiddle AgedNon-ST Elevated Myocardial InfarctionPercutaneous Coronary InterventionRandomized Controlled Trials as TopicRisk AssessmentRisk FactorsST Elevation Myocardial InfarctionTime FactorsTreatment OutcomeYoung AdultConceptsST-segment elevation myocardial infarctionStable coronary artery diseaseUnstable coronary artery diseasePercutaneous coronary interventionCoronary artery diseaseSegment elevation acute coronary syndromesAcute coronary syndromeMyocardial infarctionCardiac deathMultivessel diseaseCoronary syndromeCoronary interventionArtery diseaseBenefits of PCITrials of PCITreatment of CADCulprit-only revascularization strategyEarly percutaneous coronary interventionPrimary percutaneous coronary interventionPatients post-myocardial infarctionResidual coronary lesionsPrimary end pointComparative Health EffectivenessPost-myocardial infarctionImmediate revascularization