2024
Intravascular imaging-guided coronary drug-eluting stent implantation: an updated network meta-analysis
Stone G, Christiansen E, Ali Z, Andreasen L, Maehara A, Ahmad Y, Landmesser U, Holm N. Intravascular imaging-guided coronary drug-eluting stent implantation: an updated network meta-analysis. The Lancet 2024, 403: 824-837. PMID: 38401549, DOI: 10.1016/s0140-6736(23)02454-6.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionIntravascular imaging guidanceTarget vessel myocardial infarctionIntravascular imaging-guided percutaneous coronary interventionAngiography-guided percutaneous coronary interventionImaging-guided percutaneous coronary interventionOptical coherence tomographyAngiography guidanceTarget lesion revascularisationImage guidanceMeta-analysisTarget lesion failureInternational Prospective Register of Systematic ReviewsSystematic reviewProspective Register of Systematic ReviewsMyocardial infarctionDrug-eluting stentsCardiac deathInternational Prospective RegisterLesion failureStent thrombosisRisk of cardiac deathRisk of target lesion failureStudy-level dataIntravascular ultrasound-guided percutaneous coronary interventionIntravascular Imaging–Guided Versus Angiography‐Guided Percutaneous Coronary Intervention: A Systematic Review and Meta‐Analysis of Randomized Trials
Sreenivasan J, Reddy R, Jamil Y, Malik A, Chamie D, Howard J, Nanna M, Mintz G, Maehara A, Ali Z, Moses J, Chen S, Chieffo A, Colombo A, Leon M, Lansky A, Ahmad Y. Intravascular Imaging–Guided Versus Angiography‐Guided Percutaneous Coronary Intervention: A Systematic Review and Meta‐Analysis of Randomized Trials. Journal Of The American Heart Association 2024, 13: e031111. PMID: 38214263, PMCID: PMC10926835, DOI: 10.1161/jaha.123.031111.Peer-Reviewed Original ResearchConceptsAdverse cardiac eventsPercutaneous coronary interventionAngiography-guided percutaneous coronary interventionTarget vessel revascularizationTarget-lesion revascularizationCardiac eventsCardiac deathImaging-guided percutaneous coronary interventionWeighted mean follow-up durationMeta-analysisPrimary outcomeMean follow-up durationStent thrombosisMeta-analysis of randomized trialsStudy-level meta-analysisComplex lesion subsetsIntravascular imagingAll-cause deathRandom-effects meta-analysisStandard of careIntention-to-treat principleUpdates of clinical guidelinesMixed-effects meta-regressionComplex percutaneous coronary interventionIntravascular imaging-guided percutaneous coronary intervention
2023
The association of timing of coronary artery bypass grafting for non-ST-elevation myocardial infarction and clinical outcomes in the contemporary United States
Park D, Singireddy S, Mangalesh S, Fishman E, Ambrosini A, Jamil Y, Vij A, Sikand N, Ahmad Y, Frampton J, Nanna M. The association of timing of coronary artery bypass grafting for non-ST-elevation myocardial infarction and clinical outcomes in the contemporary United States. Coronary Artery Disease 2023, 35: 261-269. PMID: 38164979, PMCID: PMC11042982, DOI: 10.1097/mca.0000000000001314.Peer-Reviewed Original ResearchLength of stayCoronary artery bypassElevation myocardial infarctionNSTEMI hospitalizationsHospital mortalityArtery bypassCABG surgeryMyocardial infarctionHigher oddsLonger LOSBurden of complicationsHospital-associated costsNon-home dischargeAcute kidney injuryHigh-risk featuresPercutaneous coronary interventionAssociation of timingOutcomes of interestNSTEMI populationGastrointestinal hemorrhageHospital outcomesKidney injuryPerioperative complicationsCoronary interventionBlood transfusionImpact and Implications of Neurocognitive Dysfunction in the Management of Ischemic Heart Failure
Tirziu D, Kołodziejczak M, Grubman D, Carrión C, Driskell L, Ahmad Y, Petrie M, Omerovic E, Redfors B, Fremes S, Browndyke J, Lansky A. Impact and Implications of Neurocognitive Dysfunction in the Management of Ischemic Heart Failure. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101198. DOI: 10.1016/j.jscai.2023.101198.Peer-Reviewed Original ResearchIschemic heart failureHeart failureNeurocognitive dysfunctionCognitive impairmentCoronary Artery Bypass GraftingArtery Bypass GraftingChronic cerebral hypoperfusionCoronary artery bypassPercutaneous coronary interventionPoor cognitive functionArtery bypassBypass GraftingCardiovascular outcomesCerebral hypoperfusionCoronary revascularizationCerebral hypoxiaCoronary interventionNeurologic injuryCardiac outputWorse outcomesBrain damageBrain injuryPatient outcomesInvasive approachPatient managementCurrent Landscape and Future Directions of Coronary Revascularization in Ischemic Systolic Heart Failure: A Review
Chuy K, Velazquez E, Lansky A, Jamil Y, Ahmad Y. Current Landscape and Future Directions of Coronary Revascularization in Ischemic Systolic Heart Failure: A Review. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101197. DOI: 10.1016/j.jscai.2023.101197.Peer-Reviewed Original ResearchIschemic systolic heart failureSystolic heart failurePercutaneous coronary interventionHeart failureMedical therapyCoronary revascularizationBenefits of PCITrials of PCILeft ventricular systolic dysfunctionPrevalence of HFBenefit of CABGContemporary medical therapyIschemic ventricular dysfunctionCoronary artery bypassVentricular systolic dysfunctionCoronary artery diseaseIschemic heart diseaseAcute cardiac careComparative clinical effectivenessUnmet clinical needRecent revascularizationArtery bypassSystolic dysfunctionVentricular dysfunctionCoronary interventionTCT-641 Intravascular Imaging-Guided Versus Angiography-Guided Percutaneous Coronary Intervention: A Meta-Analysis of Randomized Trials
Sreenivasan J, Reddy R, Jamil Y, Malik A, Chamie D, Howard J, Nanna M, Mintz G, Maehara A, Ali Z, Moses J, Chen S, Chieffo A, Colombo A, Leon M, Lansky A, Ahmad Y. TCT-641 Intravascular Imaging-Guided Versus Angiography-Guided Percutaneous Coronary Intervention: A Meta-Analysis of Randomized Trials. Journal Of The American College Of Cardiology 2023, 82: b258. DOI: 10.1016/j.jacc.2023.09.652.Peer-Reviewed Original ResearchPercutaneous coronary interventionCoronary interventionRandomized trialsMeta-AnalysisIntravascular imagingTrialsComplex Percutaneous Coronary Intervention Outcomes in Older Adults
Hanna J, Wang S, Kochar A, Park D, Damluji A, Henry G, Ahmad Y, Curtis J, Nanna M. Complex Percutaneous Coronary Intervention Outcomes in Older Adults. Journal Of The American Heart Association 2023, 12: e029057. PMID: 37776222, PMCID: PMC10727245, DOI: 10.1161/jaha.122.029057.Peer-Reviewed Original ResearchConceptsNoncomplex percutaneous coronary interventionsComplex percutaneous coronary interventionStable ischemic heart diseasePercutaneous coronary interventionIschemic heart diseaseTarget lesion revascularizationEvent-free survivalHeart diseaseOlder adultsCause deathLesion revascularizationClinical characteristicsElective percutaneous coronary interventionPercutaneous coronary intervention outcomesWorse event-free survivalMedical therapy useCox regression modelLarge health systemNoncardiac comorbiditiesRevascularization riskCoronary interventionTherapy useClinical outcomesDisease featuresLower riskTrends and Inhospital Outcomes of Intravascular Imaging on Single-Vessel Coronary Chronic Total Occlusion Treated With Percutaneous Coronary Intervention
Park D, Hu J, Kanitsoraphan C, Al-Ogaili A, Murthi M, Vardar U, Ahmad Y, Nanna M, Vij A. Trends and Inhospital Outcomes of Intravascular Imaging on Single-Vessel Coronary Chronic Total Occlusion Treated With Percutaneous Coronary Intervention. The American Journal Of Cardiology 2023, 206: 79-85. PMID: 37683583, PMCID: PMC10901566, DOI: 10.1016/j.amjcard.2023.08.051.Peer-Reviewed Original ResearchPercutaneous coronary interventionChronic total occlusionInhospital mortalityIntravascular ultrasoundOptical coherence tomographyInhospital outcomesIntravascular imagingCoronary interventionTotal occlusionCTO-PCISingle-vessel chronic total occlusionSingle-vessel percutaneous coronary interventionCoronary chronic total occlusionsUse of IVUSLarge national analysisUse of OCTIVUS useOCT useCoherence tomographyLogistic regressionPatientsAbsolute numberCochran-ArmitageMortalityLess increaseInsight Into the Optimal Timing of Percutaneous Coronary Intervention and Transcatheter Aortic Valve Replacement
Park D, Simonato M, Ahmad Y, Banks A, Lowenstern A, Nanna M. Insight Into the Optimal Timing of Percutaneous Coronary Intervention and Transcatheter Aortic Valve Replacement. Current Problems In Cardiology 2023, 49: 102050. PMID: 37643698, PMCID: PMC10924682, DOI: 10.1016/j.cpcardiol.2023.102050.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementPercutaneous coronary artery interventionAcute kidney injuryAortic valve replacementKidney injuryValve replacementPercutaneous coronary interventionCoronary artery diseaseCoronary artery interventionPaucity of dataHospital mortalityNonhome dischargeCoronary interventionSecondary outcomesSelect patientsArtery diseaseArtery interventionClinical outcomesHigher oddsPCI timingPatientsReadmissionOptimal timingSame daySignificant differencesLong-term Incidence of Myocardial Infarction and Death After CABG and PCI for Isolated Left Anterior Descending Artery Disease: A Meta-analysis of Randomized Controlled Trials
Prasad M, Ahmad Y, Howard J, Ben-Ami J, Madhavan M, Kirtane A, McEntegart M, Flattery E, Stone G, Leon M, Moses J. Long-term Incidence of Myocardial Infarction and Death After CABG and PCI for Isolated Left Anterior Descending Artery Disease: A Meta-analysis of Randomized Controlled Trials. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100636. DOI: 10.1016/j.jscai.2023.100636.Peer-Reviewed Original ResearchPercutaneous coronary interventionLong-term incidenceMyocardial infarctionLAD diseaseArtery diseaseLeft anterior descending (LAD) coronary artery diseaseAnterior descending (LAD) coronary artery diseaseLeft internal mammary artery graftInternal mammary artery graftRisk of MIMammary artery graftsCoronary artery bypassCoronary artery diseaseRandomized Controlled TrialsSignificant differencesArtery bypassArtery graftCause mortalityVessel revascularizationCoronary interventionSecondary outcomesControlled TrialsLeft anteriorPrimary outcomeCABGDelirium in older adults after percutaneous coronary intervention: Prevalence, risks, and clinical phenotypes
Park D, Jamil Y, Hu J, Lowenstern A, Frampton J, Abdullah A, Damluji A, Ahmad Y, Soufer R, Nanna M. Delirium in older adults after percutaneous coronary intervention: Prevalence, risks, and clinical phenotypes. Cardiovascular Revascularization Medicine 2023, 57: 60-67. PMID: 37414611, PMCID: PMC10730763, DOI: 10.1016/j.carrev.2023.06.010.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionHospital mortalityHigher oddsOlder adultsHospital deliriumCoronary interventionAdverse health-related outcomesInpatient percutaneous coronary interventionNon-home dischargePeri-procedural settingAcute kidney injuryImpact of deliriumPost-procedural complicationsNational Inpatient SampleHealth-related outcomesDelirium preventionHospital complicationsMore comorbiditiesGastrointestinal hemorrhageKidney injuryAdverse eventsSecondary outcomesBlood transfusionPrimary outcomeIntracranial hemorrhagePhysiology-guided PCI versus CABG for left main coronary artery disease: insights from the DEFINE-LM registry
Warisawa T, Cook C, Kawase Y, Howard J, Ahmad Y, Seligman H, Rajkumar C, Toya T, Doi S, Nakajima A, Tanigaki T, Omori H, Nakayama M, Vera-Urquiza R, Yuasa S, Sato T, Kikuta Y, Nishina H, Al-Lamee R, Sen S, Lerman A, Akashi Y, Escaned J, Matsuo H, Davies J. Physiology-guided PCI versus CABG for left main coronary artery disease: insights from the DEFINE-LM registry. Cardiovascular Intervention And Therapeutics 2023, 38: 287-298. PMID: 37017899, PMCID: PMC10247826, DOI: 10.1007/s12928-023-00932-z.Peer-Reviewed Original ResearchConceptsUnprotected left main coronary diseasePercutaneous coronary interventionInstantaneous wave-free ratioMain coronary artery diseaseNon-fatal myocardial infarctionCoronary artery bypassCoronary artery diseasePrimary endpointCause deathLesion revascularizationArtery bypassSYNTAX scoreCoronary interventionArtery diseaseClinical outcomesMyocardial infarctionIschemia-driven target lesion revascularizationLeft main coronary artery diseaseArt percutaneous coronary interventionLeft main coronary diseaseLower cardiovascular event ratesMajor adverse cardiovascular eventsLong-term clinical outcomesPropensity scorePhysiology-guided percutaneous coronary intervention
2022
Coronary Intravascular Lithotripsy
Sreenivasan J, Shah A, Riangwiwat T, Rajendran R, Sosa C, Gupta R, Frishman W, Timmermans R, Ahmad H, Aronow W, Ahmad Y. Coronary Intravascular Lithotripsy. Cardiology In Review 2022, 32: 267-272. PMID: 36541962, DOI: 10.1097/crd.0000000000000502.Peer-Reviewed Original ResearchPercutaneous coronary interventionCoronary artery calcificationCoronary intravascular lithotripsyIntravascular lithotripsyArtery calcificationCoronary stenosisLong-term clinical outcome dataSuccessful percutaneous coronary interventionSerious procedural complicationsAdverse cardiac eventsCurrent clinical dataClinical outcome dataCurrent treatment modalitiesAdjunctive therapyCardiac eventsCoronary interventionCoronary calcificationProcedural complicationsProspective studyTreatment modalitiesClinical dataOutcome dataStent deploymentCalcificationSteep learning curveMeta-Analysis of Provisional Versus Systematic Double-Stenting Strategy for Left Main Bifurcation Lesions
Abdelfattah OM, Radwan A, Sayed A, Elbadawi A, Derbas LA, Saleh Y, Ahmad Y, ElJack A, Masoumi A, Karmpaliotis D, Elgendy IY, Alfonso F. Meta-Analysis of Provisional Versus Systematic Double-Stenting Strategy for Left Main Bifurcation Lesions. Cardiovascular Revascularization Medicine 2022, 45: 53-62. PMID: 35934644, DOI: 10.1016/j.carrev.2022.07.017.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsTarget lesion revascularizationPercutaneous coronary interventionBifurcation percutaneous coronary interventionSecond generation drug eluting stentsDrug eluting stentsDouble-stent strategyMyocardial infarctionObservational studyLesion revascularizationCause mortalityCardiovascular mortalityDouble stentingStent thrombosisProvisional stentingLower major adverse cardiovascular eventsInternational Clinical Trials Registry PlatformClinical Trials Registry PlatformMain bifurcation lesionsAdverse cardiovascular eventsCochrane Central RegisterTrials Registry PlatformSignificant lower rateProvisional stenting strategyCardiovascular eventsPCI in Patients With Heart Failure: Current Evidence, Impact of Complete Revascularization, and Contemporary Techniques to Improve Outcomes
Ahmad Y, Petrie M, Jolicoeur E, Madhavan M, Velazquez E, Moses J, Lansky A, Stone G. PCI in Patients With Heart Failure: Current Evidence, Impact of Complete Revascularization, and Contemporary Techniques to Improve Outcomes. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100020. DOI: 10.1016/j.jscai.2022.100020.Peer-Reviewed Original ResearchPercutaneous coronary interventionLeft ventricular systolic dysfunctionCoronary artery diseaseHeart failureComplete revascularizationMedical therapyClinical outcomesClinical trialsCoronary artery bypassVentricular systolic dysfunctionClinical trial evidenceHigh operative riskHigh-risk patientsMajor cardiac surgeryExtent of revascularizationMinority of patientsFuture clinical trialsArtery bypassCause mortalityPeriprocedural complicationsSystolic dysfunctionCoronary interventionOperative riskArtery diseaseCardiac surgery
2021
Long-term follow-up after ultrathin vs. conventional 2nd-generation drug-eluting stents: a systematic review and meta-analysis of randomized controlled trials
Madhavan MV, Howard JP, Naqvi A, Ben-Yehuda O, Redfors B, Prasad M, Shahim B, Leon MB, Bangalore S, Stone GW, Ahmad Y. Long-term follow-up after ultrathin vs. conventional 2nd-generation drug-eluting stents: a systematic review and meta-analysis of randomized controlled trials. European Heart Journal 2021, 42: 2643-2654. PMID: 34002202, PMCID: PMC8282325, DOI: 10.1093/eurheartj/ehab280.Peer-Reviewed Original ResearchConceptsThin-strut drug-eluting stentsUltrathin-strut drug-eluting stentsTarget lesion failureDrug-eluting stentsStent thrombosisMyocardial infarctionCardiac deathCause mortalityCD-TLRRisk of TLFSystematic reviewPre-specified primary endpointRisk of MIRevascularization of patientsWeighted mean followTarget lesion revascularizationPercutaneous coronary interventionStandard of careNew trial dataCause deathLesion revascularizationEligible trialsLesion failureMean followPrimary endpoint
2020
Response by Ahmad et al to Letter Regarding Article “Effects of Percutaneous Coronary Intervention on Death and Myocardial Infarction Stratified by Stable and Unstable Coronary Artery Disease: A Meta-Analysis of Randomized Controlled Trials”
Ahmad Y, Howard JP, Francis DP. Response by Ahmad et al to Letter Regarding Article “Effects of Percutaneous Coronary Intervention on Death and Myocardial Infarction Stratified by Stable and Unstable Coronary Artery Disease: A Meta-Analysis of Randomized Controlled Trials”. Circulation Cardiovascular Quality And Outcomes 2020, 13: e006862. PMID: 32482084, DOI: 10.1161/circoutcomes.120.006862.Peer-Reviewed Original ResearchComplete Revascularization by Percutaneous Coronary Intervention for Patients With ST‐Segment–Elevation Myocardial Infarction and Multivessel Coronary Artery Disease: An Updated Meta‐Analysis of Randomized Trials
Ahmad Y, Howard JP, Arnold A, Prasad M, Seligman H, Cook CM, Warisawa T, Shun‐Shun M, Ali Z, Parikh MA, Al‐Lamee R, Sen S, Francis D, Moses JW, Leon MB, Stone GW, Karmpaliotis D. Complete Revascularization by Percutaneous Coronary Intervention for Patients With ST‐Segment–Elevation Myocardial Infarction and Multivessel Coronary Artery Disease: An Updated Meta‐Analysis of Randomized Trials. Journal Of The American Heart Association 2020, 9: e015263. PMID: 32476540, PMCID: PMC7429036, DOI: 10.1161/jaha.119.015263.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionMultivessel coronary artery diseasePercutaneous coronary interventionCulprit-only revascularizationCoronary artery diseaseComplete revascularizationCoronary interventionMyocardial infarctionCardiovascular deathArtery diseaseUnplanned revascularizationMultivessel diseaseCause mortalityEnd pointPrimary efficacy end pointHard clinical outcomesEfficacy end pointSecondary end pointsClinical end pointsElevation myocardial infarctionClinical practice guidelinesTreat basisClinical outcomesRandomized trialsOptimal treatmentResponse by Ahmad et al to Letter Regarding Article, “Effects of Percutaneous Coronary Intervention on Death and Myocardial Infarction Stratified by Stable and Unstable Coronary Artery Disease: A Meta-Analysis of Randomized Controlled Trials”
Ahmad Y, Howard JP, Francis DP. Response by Ahmad et al to Letter Regarding Article, “Effects of Percutaneous Coronary Intervention on Death and Myocardial Infarction Stratified by Stable and Unstable Coronary Artery Disease: A Meta-Analysis of Randomized Controlled Trials”. Circulation Cardiovascular Quality And Outcomes 2020, 13: e006642. PMID: 32283970, DOI: 10.1161/circoutcomes.120.006642.Peer-Reviewed Original ResearchMortality after drug-eluting stents vs. coronary artery bypass grafting for left main coronary artery disease: a meta-analysis of randomized controlled trials
Ahmad Y, Howard JP, Arnold AD, Cook CM, Prasad M, Ali ZA, Parikh MA, Kosmidou I, Francis DP, Moses JW, Leon MB, Kirtane AJ, Stone GW, Karmpaliotis D. Mortality after drug-eluting stents vs. coronary artery bypass grafting for left main coronary artery disease: a meta-analysis of randomized controlled trials. European Heart Journal 2020, 41: 3228-3235. PMID: 32118272, PMCID: PMC7557472, DOI: 10.1093/eurheartj/ehaa135.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryPercutaneous coronary interventionDrug-eluting stentsMain coronary artery diseaseCoronary artery diseaseMyocardial infarctionCardiac deathUnplanned revascularizationCause mortalityCoronary interventionArtery diseaseLeft main coronary artery diseaseRandomized clinical trial evidenceSimilar long-term mortalityArtery bypass graft surgerySignificant differencesUnplanned revascularization proceduresWeighted mean followBypass graft surgeryCoronary artery bypassPrimary efficacy endpointClinical trial evidenceLong-term mortalityRisk of strokeGold standard therapy