2022
Long-Term Outcomes of Randomized Controlled Trials Comparing Percutaneous Left Atrial Appendage Closure to Oral Anticoagulation for Nonvalvular Atrial Fibrillation: A Meta-Analysis
Madhavan M, Howard J, Brener M, Der Nigoghossian C, Chen S, Makkar R, Osmancik P, Reddy V, Holmes D, Stone G, Leon M, Ahmad Y. Long-Term Outcomes of Randomized Controlled Trials Comparing Percutaneous Left Atrial Appendage Closure to Oral Anticoagulation for Nonvalvular Atrial Fibrillation: A Meta-Analysis. Structural Heart 2022, 7: 100096. PMID: 37275318, PMCID: PMC10236864, DOI: 10.1016/j.shj.2022.100096.Peer-Reviewed Original ResearchLeft atrial appendage closurePercutaneous left atrial appendage closureRandomized clinical trialsNonvalvular atrial fibrillationOral anticoagulationAtrial appendage closureAtrial fibrillationNonprocedural bleedingCause mortalityAppendage closureHazard ratioHemorrhagic strokeClinical trialsLong-term oral anticoagulationReduced long-term riskLarge-scale clinical trialsIndividual clinical endpointsPrespecified primary endpointCochrane Central RegisterStandard of careNew trial dataSignificant differencesLong-term riskStroke prophylaxisPrimary endpoint
2013
Recent Developments in Understanding Epidemiology and Risk Determinants of Atrial Fibrillation as a Cause of Stroke
Ahmad Y, Lip GY, Lane DA. Recent Developments in Understanding Epidemiology and Risk Determinants of Atrial Fibrillation as a Cause of Stroke. Canadian Journal Of Cardiology 2013, 29: s4-s13. PMID: 23790597, DOI: 10.1016/j.cjca.2013.03.009.Peer-Reviewed Original ResearchConceptsDevelopment of AFAtrial fibrillationRisk factorsStroke riskAF patientsOccurrence of AFEffective oral anticoagulationAcute cardiac conditionsCause of strokeLow-risk patientsNovel risk factorsNovel therapeutic targetPublic health consequencesFormal anticoagulationOral anticoagulationRisk patientsPatient cohortCardiac conditionsEpidemic proportionsTherapeutic targetClinical practicePatientsAnticoagulationHealth consequencesRisk determinants
2012
Stroke Prevention in Atrial Fibrillation: Concepts and Controversies
Ahmad Y, Lip G. Stroke Prevention in Atrial Fibrillation: Concepts and Controversies. Current Cardiology Reviews 2012, 8: 290-301. PMID: 22920480, PMCID: PMC3492813, DOI: 10.2174/157340312803760820.Peer-Reviewed Original ResearchConceptsStroke risk factorsAtrial fibrillationOral anticoagulationStroke preventionRisk factorsPatient riskIndependent stroke risk factorNew oral anticoagulantsCommon cardiac rhythm disorderLow-risk patientsCardiac rhythm disordersAntiplatelet therapyAntithrombotic therapyOral anticoagulantsSevere strokePerioperative managementEffective therapyRhythm disordersEfficacious agentsGeneral populationNew agentsSimple scorePatientsAnticoagulationFibrillationAnticoagulation in Atrial Fibrillation.
Ahmad Y, Lip GY. Anticoagulation in Atrial Fibrillation. Arrhythmia & Electrophysiology Review 2012, 1: 12-16. PMID: 26835023, PMCID: PMC4711491, DOI: 10.15420/aer.2012.1.12.Peer-Reviewed Original ResearchAtrial fibrillationMost thromboembolic complicationsEfficacy of warfarinNew oral anticoagulantsRisk stratification schemesOral anticoagulationAntithrombotic therapyOral anticoagulantsSevere strokeThromboembolic riskThromboembolic complicationsAF patientsAnticoagulant monitoringCommon arrhythmiaNew anticoagulantsWorse outcomesImproved outcomesNew agentsPatientsAF treatmentStratification schemesAnticoagulationDose variabilityAnticoagulantsWarfarin