2023
Transcatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials
Ahmad Y, Howard J, Arnold A, Madhavan M, Cook C, Alu M, Mack M, Reardon M, Thourani V, Kapadia S, Thyregod H, Sondergaard L, Jørgensen T, Toff W, Van Mieghem N, Makkar R, Forrest J, Leon M. Transcatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials. European Heart Journal 2023, 44: 836-852. PMID: 36660821, DOI: 10.1093/eurheartj/ehac642.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve implantationHigh-risk patientsLow-risk patientsComposite of deathAortic valve replacementValve replacementMAIN OUTCOMENew-onset atrial fibrillationSignificant differencesRandomized clinical trial dataAcute kidney injuryAortic valve implantationMain clinical outcomesRisk of deathClinical trial dataMajor bleedingKidney injurySecondary endpointsVascular complicationsValve implantationClinical outcomesParavalvular leakRandomized trialsAtrial fibrillation
2018
2 PFO closure is superior to medical therapy for cryptogenic stroke: a meta-analysis of randomised controlled trials
Ahmad Y, Howard J, Arnold A, Shun-Shin M, Cook C, Malik I, Mayet J, Francis D, Sen S. 2 PFO closure is superior to medical therapy for cryptogenic stroke: a meta-analysis of randomised controlled trials. Heart 2018, 104: a2. DOI: 10.1136/heartjnl-2018-bcs.2.Peer-Reviewed Original ResearchMedical therapyCryptogenic strokeDevice closureAtrial fibrillationRecurrent strokePFO closureNew-onset atrial fibrillationRisk of AFOnset atrial fibrillationPrimary safety endpointPrimary efficacy endpointPrevention of strokeEfficacy endpointFurther strokeSafety endpointTreat basisPatent foramenPatientsTherapyStrokePFOTrialsEndpointPreventionClosurePatent foramen ovale closure vs. medical therapy for cryptogenic stroke: a meta-analysis of randomized controlled trials
Ahmad Y, Howard JP, Arnold A, Shin MS, Cook C, Petraco R, Demir O, Williams L, Iglesias JF, Sutaria N, Malik I, Davies J, Mayet J, Francis D, Sen S. Patent foramen ovale closure vs. medical therapy for cryptogenic stroke: a meta-analysis of randomized controlled trials. European Heart Journal 2018, 39: 1638-1649. PMID: 29590333, PMCID: PMC5946888, DOI: 10.1093/eurheartj/ehy121.Peer-Reviewed Original ResearchConceptsMedical therapyCryptogenic strokeDevice closurePFO closureAtrial fibrillationRecurrent strokeLarge shuntPatent foramenNew-onset atrial fibrillationRisk of AFOnset atrial fibrillationPrimary safety endpointPrimary efficacy endpointAtrial septal aneurysmPrevention of strokeSignificant reductionEfficacy endpointFurther strokeSafety endpointTreat basisSeptal aneurysmSmall shuntPatientsTherapyStroke