2023
Trends and Inhospital Outcomes of Intravascular Imaging on Single-Vessel Coronary Chronic Total Occlusion Treated With Percutaneous Coronary Intervention
Park D, Hu J, Kanitsoraphan C, Al-Ogaili A, Murthi M, Vardar U, Ahmad Y, Nanna M, Vij A. Trends and Inhospital Outcomes of Intravascular Imaging on Single-Vessel Coronary Chronic Total Occlusion Treated With Percutaneous Coronary Intervention. The American Journal Of Cardiology 2023, 206: 79-85. PMID: 37683583, PMCID: PMC10901566, DOI: 10.1016/j.amjcard.2023.08.051.Peer-Reviewed Original ResearchPercutaneous coronary interventionChronic total occlusionInhospital mortalityIntravascular ultrasoundOptical coherence tomographyInhospital outcomesIntravascular imagingCoronary interventionTotal occlusionCTO-PCISingle-vessel chronic total occlusionSingle-vessel percutaneous coronary interventionCoronary chronic total occlusionsUse of IVUSLarge national analysisUse of OCTIVUS useOCT useCoherence tomographyLogistic regressionPatientsAbsolute numberCochran-ArmitageMortalityLess increase
2022
Catheter ablation improves cardiovascular outcomes in patients with atrial fibrillation and heart failure: a meta-analysis of randomized controlled trials
Simader FA, Howard JP, Ahmad Y, Saleh K, Naraen A, Samways JW, Mohal J, Reddy RK, Kaza N, Keene D, Shun-Shin MJ, Francis DP, Whinnett ZI, Arnold AD. Catheter ablation improves cardiovascular outcomes in patients with atrial fibrillation and heart failure: a meta-analysis of randomized controlled trials. EP Europace 2022, 25: 341-350. PMID: 36305545, PMCID: PMC9934993, DOI: 10.1093/europace/euac173.Peer-Reviewed Original ResearchConceptsHeart failure hospitalizationCatheter ablationHeart failureMedical therapyFailure hospitalizationAtrial fibrillationCardiovascular outcomesPrimary analysisPre-specified primary endpointAtrial fibrillation catheter ablationCause mortalityPrimary endpointSecondary endpointsLower riskPatientsTherapyHospitalizationFibrillationTrialsMortalityLow heterogeneityAblationEndpointOutcomesFailure
2021
Sodium-glucose cotransporter 2 inhibitors in patients with heart failure: a systematic review and meta-analysis of randomized trials
Ahmad Y, Madhavan MV, Stone GW, Francis DP, Makkar R, Bhatt DL, Howard JP. Sodium-glucose cotransporter 2 inhibitors in patients with heart failure: a systematic review and meta-analysis of randomized trials. European Heart Journal - Quality Of Care And Clinical Outcomes 2021, 8: 383-390. PMID: 34617565, PMCID: PMC9170566, DOI: 10.1093/ehjqcco/qcab072.Peer-Reviewed Original ResearchConceptsHeart failure hospitalizationSGLT-2 inhibitorsSodium-glucose cotransporter 2 inhibitorsCotransporter 2 inhibitorsFailure hospitalizationCardiovascular mortalityHeart failureCause mortalityHazard ratioPre-specified primary endpointEjection fraction rangeIndividual clinical endpointsPrimary endpointSecondary endpointsComposite outcomeStandard careRandomized trialsClinical endpointsHospitalizationPatientsSystematic reviewMortalityTrialsEndpointInhibitors
2016
Resolving the paradox of randomised controlled trials and observational studies comparing multi-vessel angioplasty and culprit only angioplasty at the time of STEMI
Ahmad Y, Cook C, Shun-Shin M, Balu A, Keene D, Nijjer S, Petraco R, Baker CS, Malik IS, Bellamy MF, Sethi A, Mikhail GW, Al-Bustami M, Khan M, Kaprielian R, Foale RA, Mayet J, Davies JE, Francis DP, Sen S. Resolving the paradox of randomised controlled trials and observational studies comparing multi-vessel angioplasty and culprit only angioplasty at the time of STEMI. International Journal Of Cardiology 2016, 222: 1-8. PMID: 27448698, DOI: 10.1016/j.ijcard.2016.06.106.Peer-Reviewed Original ResearchConceptsHigh-risk patientsLarge observational studiesObservational studyResidual diseaseMulti-vessel coronary artery diseaseHigh mortalityPrimary percutaneous coronary interventionST-elevation myocardial infarctionPercutaneous coronary interventionCoronary artery diseaseReal-world patientsOptimal treatment strategyAllocation biasCoronary interventionCulprit arteryRisk patientsArtery diseaseMyocardial infarctionSmall RCTsWorld patientsTreatment strategiesPatientsEquivalent mortalitySTEMIMortality35 Thrombus Aspiration does not Reduce Mortality in STEMI Patients: A Meta-Analysis of 20,192 Patients, with Implications for Future Trial Design
Ahmad Y, Sen S, Nijjer S, Keene D, Cook C, Petraco R, Shun-Shin M, Cole G, Al-Lamee R, Malik I, Baker C, Mikhail G, Foale R, Mayet J, Davies J, Francis D. 35 Thrombus Aspiration does not Reduce Mortality in STEMI Patients: A Meta-Analysis of 20,192 Patients, with Implications for Future Trial Design. Heart 2016, 102: a24. DOI: 10.1136/heartjnl-2016-309890.35.Peer-Reviewed Original ResearchThrombus aspirationAvailable RCT dataLong-term followFuture trial designAcute myocardial infarctionMulti-center trialNon-significant reductionSTEMI trialPrimary angioplastySTEMI patientsMyocardial infarctionMortality reductionPatient costsRCT dataTrial designMeta-AnalysisRetrospective consentStrokePatientsMortalityTrialsConfidence intervalsLogical adjunctTotal trialsSignificant increase97 Multi-vessel Angioplasty at the Time of STEMI has Equivalent Mortality to a Culprit Only Strategy: Resolving The Paradox of Randomised Controlled Trials and Observational Studies in Multivessel Disease and STEMI
Ahmad Y, Cook C, Petraco R, Nijjer S, Al-Lamee R, Shun-Shin M, Keene D, Balu A, Malik I, Baker C, Mikhail G, Sethi A, Foale R, Davies J, Mayet J, Francis D, Sen S. 97 Multi-vessel Angioplasty at the Time of STEMI has Equivalent Mortality to a Culprit Only Strategy: Resolving The Paradox of Randomised Controlled Trials and Observational Studies in Multivessel Disease and STEMI. Heart 2016, 102: a68. DOI: 10.1136/heartjnl-2016-309890.97.Peer-Reviewed Original ResearchHigh-risk patientsLarge observational studiesObservational studyResidual diseaseEquivalent mortalityPrimary percutaneous coronary interventionST-elevation myocardial infarctionMulti-vessel diseasePercutaneous coronary interventionRandomised Controlled TrialsAllocation biasMultivessel diseaseCoronary interventionRisk patientsControlled TrialsMyocardial infarctionSmall RCTsPatientsHigh mortalitySTEMIMortalityDiseaseConflicting resultsRCTsPPCI
2015
TCT-262 Thrombus aspiration does not reduce mortality in STEMI patients: a meta-analysis of 20,192 patients, with implications for future trial design
Ahmad Y, Sen S, Keene D, Cook C, Nijjer S, Petraco R, Finegold J, Shun-Shin M, Cole G, Malik I, Baker C, Bellamy M, Kaprielian R, Mikhail G, Davies J, Mayet J, Francis D. TCT-262 Thrombus aspiration does not reduce mortality in STEMI patients: a meta-analysis of 20,192 patients, with implications for future trial design. Journal Of The American College Of Cardiology 2015, 66: b103-b104. DOI: 10.1016/j.jacc.2015.08.945.Peer-Reviewed Original Research