2023
Transcatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials
Ahmad Y, Howard J, Arnold A, Madhavan M, Cook C, Alu M, Mack M, Reardon M, Thourani V, Kapadia S, Thyregod H, Sondergaard L, Jørgensen T, Toff W, Van Mieghem N, Makkar R, Forrest J, Leon M. Transcatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials. European Heart Journal 2023, 44: 836-852. PMID: 36660821, DOI: 10.1093/eurheartj/ehac642.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve implantationHigh-risk patientsLow-risk patientsComposite of deathAortic valve replacementValve replacementMAIN OUTCOMENew-onset atrial fibrillationSignificant differencesRandomized clinical trial dataAcute kidney injuryAortic valve implantationMain clinical outcomesRisk of deathClinical trial dataMajor bleedingKidney injurySecondary endpointsVascular complicationsValve implantationClinical outcomesParavalvular leakRandomized trialsAtrial fibrillation
2022
PCI in Patients With Heart Failure: Current Evidence, Impact of Complete Revascularization, and Contemporary Techniques to Improve Outcomes
Ahmad Y, Petrie M, Jolicoeur E, Madhavan M, Velazquez E, Moses J, Lansky A, Stone G. PCI in Patients With Heart Failure: Current Evidence, Impact of Complete Revascularization, and Contemporary Techniques to Improve Outcomes. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100020. DOI: 10.1016/j.jscai.2022.100020.Peer-Reviewed Original ResearchPercutaneous coronary interventionLeft ventricular systolic dysfunctionCoronary artery diseaseHeart failureComplete revascularizationMedical therapyClinical outcomesClinical trialsCoronary artery bypassVentricular systolic dysfunctionClinical trial evidenceHigh operative riskHigh-risk patientsMajor cardiac surgeryExtent of revascularizationMinority of patientsFuture clinical trialsArtery bypassCause mortalityPeriprocedural complicationsSystolic dysfunctionCoronary interventionOperative riskArtery diseaseCardiac surgery
2016
Resolving the paradox of randomised controlled trials and observational studies comparing multi-vessel angioplasty and culprit only angioplasty at the time of STEMI
Ahmad Y, Cook C, Shun-Shin M, Balu A, Keene D, Nijjer S, Petraco R, Baker CS, Malik IS, Bellamy MF, Sethi A, Mikhail GW, Al-Bustami M, Khan M, Kaprielian R, Foale RA, Mayet J, Davies JE, Francis DP, Sen S. Resolving the paradox of randomised controlled trials and observational studies comparing multi-vessel angioplasty and culprit only angioplasty at the time of STEMI. International Journal Of Cardiology 2016, 222: 1-8. PMID: 27448698, DOI: 10.1016/j.ijcard.2016.06.106.Peer-Reviewed Original ResearchConceptsHigh-risk patientsLarge observational studiesObservational studyResidual diseaseMulti-vessel coronary artery diseaseHigh mortalityPrimary percutaneous coronary interventionST-elevation myocardial infarctionPercutaneous coronary interventionCoronary artery diseaseReal-world patientsOptimal treatment strategyAllocation biasCoronary interventionCulprit arteryRisk patientsArtery diseaseMyocardial infarctionSmall RCTsWorld patientsTreatment strategiesPatientsEquivalent mortalitySTEMIMortality97 Multi-vessel Angioplasty at the Time of STEMI has Equivalent Mortality to a Culprit Only Strategy: Resolving The Paradox of Randomised Controlled Trials and Observational Studies in Multivessel Disease and STEMI
Ahmad Y, Cook C, Petraco R, Nijjer S, Al-Lamee R, Shun-Shin M, Keene D, Balu A, Malik I, Baker C, Mikhail G, Sethi A, Foale R, Davies J, Mayet J, Francis D, Sen S. 97 Multi-vessel Angioplasty at the Time of STEMI has Equivalent Mortality to a Culprit Only Strategy: Resolving The Paradox of Randomised Controlled Trials and Observational Studies in Multivessel Disease and STEMI. Heart 2016, 102: a68. DOI: 10.1136/heartjnl-2016-309890.97.Peer-Reviewed Original ResearchHigh-risk patientsLarge observational studiesObservational studyResidual diseaseEquivalent mortalityPrimary percutaneous coronary interventionST-elevation myocardial infarctionMulti-vessel diseasePercutaneous coronary interventionRandomised Controlled TrialsAllocation biasMultivessel diseaseCoronary interventionRisk patientsControlled TrialsMyocardial infarctionSmall RCTsPatientsHigh mortalitySTEMIMortalityDiseaseConflicting resultsRCTsPPCI