Prediction of Death or HF Hospitalization in Patients With Severe FMR The COAPT Risk Score
Shah N, Madhavan MV, Gray WA, Brener SJ, Ahmad Y, Lindenfeld J, Abraham WT, Grayburn PA, Kar S, Lim DS, Mishell JM, Whisenant BK, Zhang Z, Redfors B, Mack MJ, Stone GW. Prediction of Death or HF Hospitalization in Patients With Severe FMR The COAPT Risk Score. JACC Cardiovascular Interventions 2022, 15: 1893-1905. PMID: 36202557, DOI: 10.1016/j.jcin.2022.08.005.Peer-Reviewed Original ResearchConceptsGuideline-directed medical therapyHeart failure hospitalizationSevere functional mitral regurgitationFunctional mitral regurgitationHeart failureRisk scoreCox proportional hazards modelPredictors of deathProportion of patientsSimple risk scoreKaplan-Meier curvesPrediction of deathPredictive risk scoreQuartiles of riskProportional hazards modelRisk score modelReceiver-operating characteristic plotsHF hospitalizationMitraClip groupMitraClip implantationMitraClip treatmentUseful prognosticationFailure hospitalizationMitraClip therapyEchocardiographic variablesEarly Surgery for Patients With Asymptomatic Severe Aortic Stenosis: A Meta-Analysis of Randomized Controlled Trials
Ahmad Y, Howard J, Seligman H, Arnold A, Madhavan M, Forrest J, Geirsson A, Mack M, Lansky A, Leon M. Early Surgery for Patients With Asymptomatic Severe Aortic Stenosis: A Meta-Analysis of Randomized Controlled Trials. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100383. DOI: 10.1016/j.jscai.2022.100383.Peer-Reviewed Original ResearchSurgical aortic valve replacementAsymptomatic severe aortic stenosisSevere aortic stenosisAortic stenosisHF hospitalizationCause mortalityEjection fractionPrespecified primary end pointSevere asymptomatic aortic stenosisSymptomatic severe aortic stenosisEnd pointAortic valve interventionAsymptomatic aortic stenosisHeart failure hospitalizationPrimary end pointAortic valve replacementClass I recommendationCornerstone of managementInitial conservative managementNormal ejection fractionRandomized Controlled TrialsCurrent treatment standardsIndividual end pointsAsymptomatic patientsEarly surgery