2024
Physiological Assessment with iFR prior to FFR Measurement in Left Main Disease
Warisawa T, Cook C, Ahmad Y, Howard J, Seligman H, Rajkumar C, Toya T, Doi S, Nakajima A, Nakayama M, Vera-Urquiza R, Yuasa S, Sato T, Kikuta Y, Kawase Y, Nishina H, Al-Lamee R, Sen S, Lerman A, Matsuo H, Akashi Y, Escaned J, Davies J. Physiological Assessment with iFR prior to FFR Measurement in Left Main Disease. Cardiovascular Intervention And Therapeutics 2024, 39: 241-251. PMID: 38642290, PMCID: PMC11164744, DOI: 10.1007/s12928-024-00989-4.Peer-Reviewed Original ResearchMajor adverse cardiovascular eventsArea under the curveFractional flow reserveLeft main diseaseOptimal cut-off valueInstantaneous wave-free ratioAdverse cardiovascular eventsClinical outcomesCardiovascular eventsRevascularization decision-makingFlow reserveMain diseaseClinical outcomes of patientsPhysiological assessmentPrediction of MACEPrediction of adverse cardiovascular eventsFractional flow reserve measurementsInternational multicenter registryReceiver-operating characteristic analysisOutcomes of patientsLeft main coronary artery diseasePrediction of cardiovascular eventsComposite of deathNon-fatal myocardial infarctionIschemia-driven target lesion revascularization
2023
Revascularization and Mortality at 5 Years After Treatment Guided By Instantaneous Wave‐Free Ratio and Fractional Flow Reserve: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials
Sreenivasan J, Jamil Y, Ahmad Y. Revascularization and Mortality at 5 Years After Treatment Guided By Instantaneous Wave‐Free Ratio and Fractional Flow Reserve: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials. Journal Of The American Heart Association 2023, 12: e032015. PMID: 37982225, PMCID: PMC10727296, DOI: 10.1161/jaha.123.032015.Peer-Reviewed Original Research
2022
Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis.
Kelshiker MA, Seligman H, Howard JP, Rahman H, Foley M, Nowbar AN, Rajkumar CA, Shun-Shin MJ, Ahmad Y, Sen S, Al-Lamee R, Petraco R. Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis. European Heart Journal 2022, 43: 1582-1593. PMID: 36282780, DOI: 10.1093/eurheartj/ehab775.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsAbnormal coronary flow reserveCoronary flow reserveCause mortalityCoronary flowHigh incidenceHazard ratioFlow reserveAdverse cardiovascular eventsCoronary microvascular dysfunctionAcute coronary syndromeRandom-effects modelEstimate of effectCardiovascular eventsCardiovascular outcomesCoronary syndromeMicrovascular dysfunctionHeart failureHeart transplantClinical outcomesPatient groupRisk modificationHigh riskClinical practiceSystematic review
2021
Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis
Kelshiker MA, Seligman H, Howard JP, Rahman H, Foley M, Nowbar AN, Rajkumar CA, Shun-Shin MJ, Ahmad Y, Sen S, Al-Lamee R, Petraco R, Cole G, Hoole S, Paul D, Rigo F, Francis D, Mayet J. Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis. European Heart Journal 2021, 43: 1582-1593. PMID: 34849697, PMCID: PMC9020988, DOI: 10.1093/eurheartj/ehab775.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsAbnormal coronary flow reserveCoronary flow reserveCause mortalityCoronary flowHigh incidenceHazard ratioFlow reserveAdverse cardiovascular eventsCoronary microvascular dysfunctionAcute coronary syndromeRandom-effects modelEstimate of effectCardiovascular eventsCardiovascular outcomesCoronary syndromeMicrovascular dysfunctionHeart failureHeart transplantClinical outcomesPatient groupRisk modificationHigh riskClinical practiceSystematic reviewCorrelation of Intravascular Ultrasound and Instantaneous Wave-Free Ratio in Patients With Intermediate Left Main Coronary Artery Disease
Hajj S, Toya T, Warisawa T, Nan J, Lewis BR, Cook CM, Rajkumar C, Howard JP, Seligman H, Ahmad Y, Doi S, Nakajima A, Nakayama M, Goto S, Vera-Urquiza R, Sato T, Kikuta Y, Kawase Y, Nishina H, Nakamura S, Matsuo H, Escaned J, Akashi YJ, Davies JE, Lerman A. Correlation of Intravascular Ultrasound and Instantaneous Wave-Free Ratio in Patients With Intermediate Left Main Coronary Artery Disease. Circulation Cardiovascular Interventions 2021, 14: e009830. PMID: 34092096, PMCID: PMC8206001, DOI: 10.1161/circinterventions.120.009830.Peer-Reviewed Original ResearchConceptsInstantaneous wave-free ratioMinimum lumen areaUse of iFRBody surface areaLumen areaArtery diseaseIntravascular ultrasoundMain coronary artery diseaseMulticenter retrospective observational studyCurve analysisCircumflex artery diseaseMain coronary diseaseVisual angiographic assessmentIndependent core laboratoryRetrospective observational studyCoronary artery diseaseIntravascular ultrasound evaluationFractional flow reserveCoronary diseaseUltrasound evaluationAngiographic assessmentIntravascular ultrasound dataFlow reserveObservational studyPatientsPerformance of quantitative flow ratio in patients with aortic stenosis undergoing transcatheter aortic valve implantation
Sejr‐Hansen M, Christiansen EH, Ahmad Y, Vendrik J, Westra J, Holm NR, Thim T, Seligman H, Hall K, Sen S, Terkelsen CJ, Eftekhari A. Performance of quantitative flow ratio in patients with aortic stenosis undergoing transcatheter aortic valve implantation. Catheterization And Cardiovascular Interventions 2021, 99: 68-73. PMID: 33533535, DOI: 10.1002/ccd.29518.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationAortic valve stenosisCoronary artery diseaseInstantaneous wave-free ratioFractional flow reserveQuantitative flow ratioAortic valve implantationValve implantationDiagnostic performancePressure wirePresence of ASSevere aortic valve stenosisAortic valve replacementCoronary pressure wireGood diagnostic performanceValve replacementAortic stenosisArtery diseaseValve stenosisCoronary angiogramFlow reservePatientsCAD evaluationDiagnostic accuracyStenosis
2020
Difference in functional assessment of individual stenosis severity in serial coronary lesions between resting and hyperemic pressure-wire pullback: Insights from the GIFT registry
Warisawa T, Howard JP, Kawase Y, Tanigaki T, Omori H, Cook CM, Ahmad Y, Francis DP, Akashi YJ, Matsuo H, Davies JE. Difference in functional assessment of individual stenosis severity in serial coronary lesions between resting and hyperemic pressure-wire pullback: Insights from the GIFT registry. International Journal Of Cardiology 2020, 312: 10-15. PMID: 32376416, DOI: 10.1016/j.ijcard.2020.05.001.Peer-Reviewed Original ResearchConceptsFractional flow reserveInstantaneous wave-free ratioCoronary lesionsPressure-wire pullbackCoronary artery lesionsPhysiological assessmentArtery lesionsConsecutive patientsCoronary stenosisHemodynamic significanceWave-free periodFlow reserveHemodynamic interactionSerial lesionsSerial stenosesFunctional assessmentStenosis severityLesionsStenosisHyperemic conditionsStatistical differenceWhole cardiac cycleReference standardCardiac cyclePredominancePer-Vessel Level Analysis of Fractional Flow Reserve and Instantaneous Wave-Free Ratio Discordance ― Insights From the AJIP Registry ―
Warisawa T, Cook CM, Seligman H, Howard JP, Ahmad Y, Rajkumar C, Doi S, Nakayama M, Tanigaki T, Omori H, Nakajima A, Yamanaka F, Goto S, Yakuta Y, Karube K, Uetani T, Kikuta Y, Shiono Y, Kawase Y, Nishina H, Nakamura S, Escaned J, Akashi YJ, Matsuo H, Davies JE. Per-Vessel Level Analysis of Fractional Flow Reserve and Instantaneous Wave-Free Ratio Discordance ― Insights From the AJIP Registry ―. Circulation Journal 2020, 84: 1034-1038. PMID: 32321880, DOI: 10.1253/circj.cj-19-0785.Peer-Reviewed Original ResearchHow Do Fractional Flow Reserve, Whole-Cycle PdPa, and Instantaneous Wave-Free Ratio Correlate With Exercise Coronary Flow Velocity During Exercise-Induced Angina?
Cook CM, Howard JP, Ahmad Y, Shun-Shin MJ, Sethi A, Clesham GJ, Tang KH, Nijjer SS, Kelly PA, Davies JR, Malik IS, Kaprielian R, Mikhail G, Petraco R, Warisawa T, Al-Janabi F, Karamasis GV, Mohdnazri S, Gamma R, de Waard GA, Al-Lamee R, Keeble TR, Mayet J, Sen S, Francis DP, Davies JE. How Do Fractional Flow Reserve, Whole-Cycle PdPa, and Instantaneous Wave-Free Ratio Correlate With Exercise Coronary Flow Velocity During Exercise-Induced Angina? Circulation Cardiovascular Interventions 2020, 13: e008460. PMID: 32200646, DOI: 10.1161/circinterventions.119.008460.Peer-Reviewed Original Research
2019
Physiological Pattern of Disease Assessed by Pressure-Wire Pullback Has an Influence on Fractional Flow Reserve/Instantaneous Wave-Free Ratio Discordance
Warisawa T, Cook CM, Howard JP, Ahmad Y, Doi S, Nakayama M, Goto S, Yakuta Y, Karube K, Shun-Shin MJ, Petraco R, Sen S, Nijjer S, Lamee R, Ishibashi Y, Matsuda H, Escaned J, di Mario C, Francis DP, Akashi YJ, Davies JE. Physiological Pattern of Disease Assessed by Pressure-Wire Pullback Has an Influence on Fractional Flow Reserve/Instantaneous Wave-Free Ratio Discordance. Circulation Cardiovascular Interventions 2019, 12: e007494-e007494. PMID: 31084237, PMCID: PMC6553990, DOI: 10.1161/circinterventions.118.007494.Peer-Reviewed Original ResearchConceptsInstantaneous wave-free ratioFractional flow reservePressure-wire pullbackCoronary artery diseaseArtery diseaseCoronary lesionsHemodynamic significancePhysiological patternsInternational multicenter registryIntermediate coronary lesionsMedian fractional flow reserveMulticenter registryFlow reserveDiseaseLesionsCut pointsIFR measurementDiscordanceRegistryFactorsFractional flow reserve derived from microcatheters versus standard pressure wires: a stenosis-level meta-analysis
Seligman H, Shun-Shin MJ, Vasireddy A, Cook C, Ahmad YY, Howard J, Sen S, Al-Lamee R, Nijjer S, Chamie D, Davies J, Mayet J, Francis DP, Petraco R. Fractional flow reserve derived from microcatheters versus standard pressure wires: a stenosis-level meta-analysis. Open Heart 2019, 6: e000971. PMID: 30997135, PMCID: PMC6443142, DOI: 10.1136/openhrt-2018-000971.Peer-Reviewed Original ResearchFractional flow reserveFlow reserveClinical Events After Deferral of LAD Revascularization Following Physiological Coronary Assessment
Sen S, Ahmad Y, Dehbi HM, Howard JP, Iglesias JF, Al-Lamee R, Petraco R, Nijjer S, Bhindi R, Lehman S, Walters D, Sapontis J, Janssens L, Vrints CJ, Khashaba A, Laine M, Van Belle E, Krackhardt F, Bojara W, Going O, Härle T, Indolfi C, Niccoli G, Ribichini F, Tanaka N, Yokoi H, Takashima H, Kikuta Y, Erglis A, Vinhas H, Silva PC, Baptista SB, Alghamdi A, Hellig F, Koo BK, Nam CW, Shin ES, Doh JH, Brugaletta S, Alegria-Barrero E, Meuwissen M, Piek JJ, van Royen N, Sezer M, Di Mario C, Gerber RT, Malik IS, Sharp ASP, Talwar S, Tang K, Samady H, Altman J, Seto AH, Singh J, Jeremias A, Matsuo H, Kharbanda RK, Patel MR, Serruys P, Escaned J, Davies JE. Clinical Events After Deferral of LAD Revascularization Following Physiological Coronary Assessment. Journal Of The American College Of Cardiology 2019, 73: 444-453. PMID: 30704577, PMCID: PMC6354033, DOI: 10.1016/j.jacc.2018.10.070.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsInstantaneous wave-free ratioFractional flow reserveLAD lesionsMyocardial infarctionUnplanned revascularizationLeft anterior descending (LAD) arteryEvent ratesLower myocardial infarctionAdverse cardiac eventsAnterior descending (LAD) arteryPhysiological assessmentLow event ratesMACE rateCardiac eventsCardiovascular deathClinical eventsFlow reserveHigh riskPatientsLesionsLADRevascularizationTrialsTreatment
2018
Coronary Hemodynamics in Patients With Severe Aortic Stenosis and Coronary Artery Disease Undergoing Transcatheter Aortic Valve Replacement Implications for Clinical Indices of Coronary Stenosis Severity
Ahmad Y, Götberg M, Cook C, Howard JP, Malik I, Mikhail G, Frame A, Petraco R, Rajkumar C, Demir O, Iglesias JF, Bhindi R, Koul S, Hadjiloizou N, Gerber R, Ramrakha P, Ruparelia N, Sutaria N, Kanaganayagam G, Ariff B, Fertleman M, Anderson J, Chukwuemeka A, Francis D, Mayet J, Serruys P, Davies J, Sen S. Coronary Hemodynamics in Patients With Severe Aortic Stenosis and Coronary Artery Disease Undergoing Transcatheter Aortic Valve Replacement Implications for Clinical Indices of Coronary Stenosis Severity. JACC Cardiovascular Interventions 2018, 11: 2019-2031. PMID: 30154062, PMCID: PMC6197079, DOI: 10.1016/j.jcin.2018.07.019.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic Valve StenosisBlood Flow VelocityCardiac CatheterizationCoronary Artery DiseaseCoronary StenosisFemaleFractional Flow Reserve, MyocardialHemodynamicsHumansHyperemiaLondonMalePredictive Value of TestsReproducibility of ResultsSeverity of Illness IndexSwedenTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsSevere aortic stenosisTranscatheter aortic valve replacementCoronary artery diseaseCoronary stenosis severityAortic stenosisHyperemic coronary flowFractional flow reserveArtery diseaseCoronary flowStenosis severityWave-free periodClinical indicesHyperemic flowFlow reserveInstantaneous wave-free ratio valueIntracoronary pressureConcomitant coronary artery diseaseAortic valve replacementStenotic aortic valvesInstantaneous wave-free ratioPhasic coronary flowValve replacementHyperemic indexAortic valveCoronary pressureFractional Flow Reserve and Instantaneous Wave-Free Ratio as Predictors of the Placebo-Controlled Response to Percutaneous Coronary Intervention in Stable Single-Vessel Coronary Artery Disease: Physiology-Stratified Analysis of ORBITA
Al-Lamee R, Howard JP, Shun-Shin MJ, Thompson D, Dehbi HM, Sen S, Nijjer S, Petraco R, Davies J, Keeble T, Tang K, Malik IS, Cook C, Ahmad Y, Sharp ASP, Gerber R, Baker C, Kaprielian R, Talwar S, Assomull R, Cole G, Keenan NG, Kanaganayagam G, Sehmi J, Wensel R, Harrell FE, Mayet J, Thom SA, Davies JE, Francis DP. Fractional Flow Reserve and Instantaneous Wave-Free Ratio as Predictors of the Placebo-Controlled Response to Percutaneous Coronary Intervention in Stable Single-Vessel Coronary Artery Disease: Physiology-Stratified Analysis of ORBITA. Circulation 2018, 138: circulationaha.118.033801. PMID: 29789302, DOI: 10.1161/circulationaha.118.033801.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-1 Receptor AgonistsAgedAngina, StableCardiac CatheterizationCoronary AngiographyCoronary Artery DiseaseCoronary StenosisDobutamineEchocardiography, StressExercise TestExercise ToleranceFemaleFractional Flow Reserve, MyocardialHealth StatusHumansMaleMiddle AgedPercutaneous Coronary InterventionPredictive Value of TestsProgression-Free SurvivalQuality of LifeRecovery of FunctionSeverity of Illness IndexTime FactorsUnited KingdomConceptsPercutaneous coronary interventionInstantaneous wave-free ratioFractional flow reserveSingle-vessel coronary artery diseaseTreadmill exercise timeCoronary artery diseaseExercise timeEchocardiography scoreStable anginaCoronary interventionArtery diseaseFlow reserveCanadian Cardiovascular Society class IIEffect of PCISevere single-vessel diseaseSingle-vessel coronary diseaseMean fractional flow reserveAngina frequency scorePlacebo-controlled effectsPlacebo-controlled efficacyPlacebo-controlled trialTotal exercise timeSingle-vessel diseaseAngina severityEchocardiographic improvementA case report of the clinical effect of chronic total occlusion recanalization on the instantaneous wave-free ratio in the donor artery
Ahmad Y, Al-Lamee R, Davies J, Sen S. A case report of the clinical effect of chronic total occlusion recanalization on the instantaneous wave-free ratio in the donor artery. European Heart Journal - Case Reports 2018, 2: 1-4. PMID: 31020109, PMCID: PMC6177112, DOI: 10.1093/ehjcr/yty014.Peer-Reviewed Original ResearchInstantaneous wave-free ratioPercutaneous coronary interventionChronic total occlusionDonor arteryChronic total occlusion recanalizationAmount of myocardiumFractional flow reserveCoronary stenosis severityCTO recanalizationCoronary interventionClinical effectsCollateral vesselsTotal occlusionCase reportFlow reserveCoronary physiologyStenosis severitySubtended myocardiumRecanalizationPrevious casesArteryFirst caseMyocardiumStenosis
2017
Diagnostic Accuracy of Computed Tomography–Derived Fractional Flow Reserve : A Systematic Review
Cook CM, Petraco R, Shun-Shin MJ, Ahmad Y, Nijjer S, Al-Lamee R, Kikuta Y, Shiono Y, Mayet J, Francis DP, Sen S, Davies JE. Diagnostic Accuracy of Computed Tomography–Derived Fractional Flow Reserve : A Systematic Review. JAMA Cardiology 2017, 2: 803-810. PMID: 28538960, DOI: 10.1001/jamacardio.2017.1314.Peer-Reviewed Original ResearchConceptsFractional flow reserveFlow reserveDiagnostic accuracyFFR-CTSystematic reviewTomography-derived fractional flow reserveVessel diagnostic accuracyPatient-specific factorsSpectrum of diseasePreferred Reporting ItemsSubsequent patient carePeer-reviewed journalsInvasive angiogramMean ageMyocardial ischemiaNoninvasive testsComputed tomographyReporting ItemsDuplicate studiesPatient careMeta-AnalysisCliniciansSystematic searchInvasive FFRScientific meetingsCRT-100.83 Discordance in Stenosis Classification by Pressure Only Indices of Stenosis Severity is Related to Differences in Coronary Flow Reserve: - The DISCORD Study
Cook C, Jeremias A, Ahmad Y, Shun-Shin M, Petraco R, Nijjer S, de Waard G, Sen S, Van de Hoef T, Echavarria-Pinto M, van Lavieren M, Al-Lamee R, Kikuta Y, Shiono Y, Buch A, Meuwissen M, Danad I, Knaapen P, Maeharah A, Koo B, Mintz G, Piek J, Van Royen N, Davies J. CRT-100.83 Discordance in Stenosis Classification by Pressure Only Indices of Stenosis Severity is Related to Differences in Coronary Flow Reserve: - The DISCORD Study. JACC Cardiovascular Interventions 2017, 10: s27. DOI: 10.1016/j.jcin.2016.12.107.Peer-Reviewed Original Research
2016
TCT-513 Discordance In Stenosis Classification by pressure-Only indices of stenosis severity is Related to Differences in coronary flow reserve: The RESOLVING DISCORD study
Cook C, Jeremias A, Ahmad Y, Shun-Shin M, Nijjer S, de Waard G, Sen S, van de Hoef T, Pinto M, van Lavieren M, Petraco R, Al-Lamee R, Meuwissen M, Danad I, Knaapen P, Maehara A, Koo B, Mintz G, Escaned J, Stone G, Piek J, van Royen N, Davies J. TCT-513 Discordance In Stenosis Classification by pressure-Only indices of stenosis severity is Related to Differences in coronary flow reserve: The RESOLVING DISCORD study. Journal Of The American College Of Cardiology 2016, 68: b206-b207. DOI: 10.1016/j.jacc.2016.09.650.Peer-Reviewed Original Research