2 PFO closure is superior to medical therapy for cryptogenic stroke: a meta-analysis of randomised controlled trials
Ahmad Y, Howard J, Arnold A, Shun-Shin M, Cook C, Malik I, Mayet J, Francis D, Sen S. 2 PFO closure is superior to medical therapy for cryptogenic stroke: a meta-analysis of randomised controlled trials. Heart 2018, 104: a2. DOI: 10.1136/heartjnl-2018-bcs.2.Peer-Reviewed Original ResearchMedical therapyCryptogenic strokeDevice closureAtrial fibrillationRecurrent strokePFO closureNew-onset atrial fibrillationRisk of AFOnset atrial fibrillationPrimary safety endpointPrimary efficacy endpointPrevention of strokeEfficacy endpointFurther strokeSafety endpointTreat basisPatent foramenPatientsTherapyStrokePFOTrialsEndpointPreventionClosure