2023
Catheter Ablation for Ventricular Tachycardia After MI: A Reconstructed Individual Patient Data Meta-analysis of Randomised Controlled Trials
Reddy R, Howard J, Ahmad Y, Shun-Shin M, Simader F, Miyazawa A, Saleh K, Naraen A, Samways J, Katritsis G, Mohal J, Kaza N, Porter B, Keene D, Linton N, Francis D, Whinnett Z, Luther V, Kanagaratnam P, Arnold A. Catheter Ablation for Ventricular Tachycardia After MI: A Reconstructed Individual Patient Data Meta-analysis of Randomised Controlled Trials. Arrhythmia & Electrophysiology Review 2023, 12: e26. PMID: 38124803, PMCID: PMC10731517, DOI: 10.15420/aer.2023.07.Peer-Reviewed Original ResearchCatheter ablationMedical therapyIndividual patient dataCause mortalityPrior MIVT recurrenceDefibrillator shocksIndividual Patient Data Meta-AnalysisVentricular tachycardia catheter ablationReconstructed individual patient dataPrespecified primary endpointPrespecified secondary endpointPatient dataPrespecified subgroup analysisProportion of patientsRandomised Controlled TrialsIndividual patient assessmentData Meta-AnalysisCause hospitalisationPrimary endpointSecondary endpointsPrognostic impactControlled TrialsPatient assessmentSubgroup analysisCatheter ablation for ventricular tachycardia after myocardial infarction: meta-analysis of randomised controlled trials
Reddy R, Howard J, Ahmad Y, Shun-Shin M, Simader F, Miyazawa A, Saleh K, Samways J, Keene D, Linton N, Francis D, Whinnett Z, Luther V, Kanagaratnam P, Arnold A. Catheter ablation for ventricular tachycardia after myocardial infarction: meta-analysis of randomised controlled trials. European Heart Journal 2023, 44: ehad655.392. DOI: 10.1093/eurheartj/ehad655.392.Peer-Reviewed Original ResearchIndividual patient dataReconstructed individual patient dataPrior myocardial infarctionCatheter ablationMedical therapyMyocardial infarctionCause mortalityVT recurrenceDefibrillator shocksVentricular tachycardiaPatient dataCox proportional hazards regression modelPost-infarct ventricular tachycardiaPre-specified primary endpointPre-specified secondary endpointsVentricular tachycardia catheter ablationProportional hazards regression modelsResults Eight trialsProportion of patientsKaplan-Meier curvesHazards regression modelsCause hospitalisationPrimary endpointSecondary endpointsPrognostic impactLong-term Incidence of Myocardial Infarction and Death After CABG and PCI for Isolated Left Anterior Descending Artery Disease: A Meta-analysis of Randomized Controlled Trials
Prasad M, Ahmad Y, Howard J, Ben-Ami J, Madhavan M, Kirtane A, McEntegart M, Flattery E, Stone G, Leon M, Moses J. Long-term Incidence of Myocardial Infarction and Death After CABG and PCI for Isolated Left Anterior Descending Artery Disease: A Meta-analysis of Randomized Controlled Trials. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100636. DOI: 10.1016/j.jscai.2023.100636.Peer-Reviewed Original ResearchPercutaneous coronary interventionLong-term incidenceMyocardial infarctionLAD diseaseArtery diseaseLeft anterior descending (LAD) coronary artery diseaseAnterior descending (LAD) coronary artery diseaseLeft internal mammary artery graftInternal mammary artery graftRisk of MIMammary artery graftsCoronary artery bypassCoronary artery diseaseRandomized Controlled TrialsSignificant differencesArtery bypassArtery graftCause mortalityVessel revascularizationCoronary interventionSecondary outcomesControlled TrialsLeft anteriorPrimary outcomeCABGCerebral Embolic Protection Devices During Transcatheter Aortic Valve Replacement: A Meta-analysis of Randomized Controlled Trials
Reddy R, Ahmad Y, Arnold A, Howard J. Cerebral Embolic Protection Devices During Transcatheter Aortic Valve Replacement: A Meta-analysis of Randomized Controlled Trials. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101031. PMID: 37780935, PMCID: PMC10533415, DOI: 10.1016/j.jscai.2023.101031.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementEmbolic protection devicesAortic valve replacementCause mortalityEnd pointValve replacementCerebral embolic protection devicesAcute kidney injuryPrimary end pointSafety end pointRandomized Controlled TrialsTotal lesion volumeSignificant differencesKidney injuryVascular complicationsFeared complicationControlled TrialsNew lesionsOngoing RCTsLesion volumeMeta-AnalysisStudy registrationSystematic reviewStrokeMeaningful reduction
2022
Catheter ablation improves cardiovascular outcomes in patients with atrial fibrillation and heart failure: a meta-analysis of randomized controlled trials
Simader FA, Howard JP, Ahmad Y, Saleh K, Naraen A, Samways JW, Mohal J, Reddy RK, Kaza N, Keene D, Shun-Shin MJ, Francis DP, Whinnett ZI, Arnold AD. Catheter ablation improves cardiovascular outcomes in patients with atrial fibrillation and heart failure: a meta-analysis of randomized controlled trials. EP Europace 2022, 25: 341-350. PMID: 36305545, PMCID: PMC9934993, DOI: 10.1093/europace/euac173.Peer-Reviewed Original ResearchConceptsHeart failure hospitalizationCatheter ablationHeart failureMedical therapyFailure hospitalizationAtrial fibrillationCardiovascular outcomesPrimary analysisPre-specified primary endpointAtrial fibrillation catheter ablationCause mortalityPrimary endpointSecondary endpointsLower riskPatientsTherapyHospitalizationFibrillationTrialsMortalityLow heterogeneityAblationEndpointOutcomesFailureLong-Term Outcomes of Randomized Controlled Trials Comparing Percutaneous Left Atrial Appendage Closure to Oral Anticoagulation for Nonvalvular Atrial Fibrillation: A Meta-Analysis
Madhavan M, Howard J, Brener M, Der Nigoghossian C, Chen S, Makkar R, Osmancik P, Reddy V, Holmes D, Stone G, Leon M, Ahmad Y. Long-Term Outcomes of Randomized Controlled Trials Comparing Percutaneous Left Atrial Appendage Closure to Oral Anticoagulation for Nonvalvular Atrial Fibrillation: A Meta-Analysis. Structural Heart 2022, 7: 100096. PMID: 37275318, PMCID: PMC10236864, DOI: 10.1016/j.shj.2022.100096.Peer-Reviewed Original ResearchLeft atrial appendage closurePercutaneous left atrial appendage closureRandomized clinical trialsNonvalvular atrial fibrillationOral anticoagulationAtrial appendage closureAtrial fibrillationNonprocedural bleedingCause mortalityAppendage closureHazard ratioHemorrhagic strokeClinical trialsLong-term oral anticoagulationReduced long-term riskLarge-scale clinical trialsIndividual clinical endpointsPrespecified primary endpointCochrane Central RegisterStandard of careNew trial dataSignificant differencesLong-term riskStroke prophylaxisPrimary endpointMeta-Analysis of Provisional Versus Systematic Double-Stenting Strategy for Left Main Bifurcation Lesions
Abdelfattah OM, Radwan A, Sayed A, Elbadawi A, Derbas LA, Saleh Y, Ahmad Y, ElJack A, Masoumi A, Karmpaliotis D, Elgendy IY, Alfonso F. Meta-Analysis of Provisional Versus Systematic Double-Stenting Strategy for Left Main Bifurcation Lesions. Cardiovascular Revascularization Medicine 2022, 45: 53-62. PMID: 35934644, DOI: 10.1016/j.carrev.2022.07.017.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsTarget lesion revascularizationPercutaneous coronary interventionBifurcation percutaneous coronary interventionSecond generation drug eluting stentsDrug eluting stentsDouble-stent strategyMyocardial infarctionObservational studyLesion revascularizationCause mortalityCardiovascular mortalityDouble stentingStent thrombosisProvisional stentingLower major adverse cardiovascular eventsInternational Clinical Trials Registry PlatformClinical Trials Registry PlatformMain bifurcation lesionsAdverse cardiovascular eventsCochrane Central RegisterTrials Registry PlatformSignificant lower rateProvisional stenting strategyCardiovascular eventsEarly Surgery for Patients With Asymptomatic Severe Aortic Stenosis: A Meta-Analysis of Randomized Controlled Trials
Ahmad Y, Howard J, Seligman H, Arnold A, Madhavan M, Forrest J, Geirsson A, Mack M, Lansky A, Leon M. Early Surgery for Patients With Asymptomatic Severe Aortic Stenosis: A Meta-Analysis of Randomized Controlled Trials. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100383. DOI: 10.1016/j.jscai.2022.100383.Peer-Reviewed Original ResearchSurgical aortic valve replacementAsymptomatic severe aortic stenosisSevere aortic stenosisAortic stenosisHF hospitalizationCause mortalityEjection fractionPrespecified primary end pointSevere asymptomatic aortic stenosisSymptomatic severe aortic stenosisEnd pointAortic valve interventionAsymptomatic aortic stenosisHeart failure hospitalizationPrimary end pointAortic valve replacementClass I recommendationCornerstone of managementInitial conservative managementNormal ejection fractionRandomized Controlled TrialsCurrent treatment standardsIndividual end pointsAsymptomatic patientsEarly surgeryCoronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis.
Kelshiker MA, Seligman H, Howard JP, Rahman H, Foley M, Nowbar AN, Rajkumar CA, Shun-Shin MJ, Ahmad Y, Sen S, Al-Lamee R, Petraco R. Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis. European Heart Journal 2022, 43: 1582-1593. PMID: 36282780, DOI: 10.1093/eurheartj/ehab775.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsAbnormal coronary flow reserveCoronary flow reserveCause mortalityCoronary flowHigh incidenceHazard ratioFlow reserveAdverse cardiovascular eventsCoronary microvascular dysfunctionAcute coronary syndromeRandom-effects modelEstimate of effectCardiovascular eventsCardiovascular outcomesCoronary syndromeMicrovascular dysfunctionHeart failureHeart transplantClinical outcomesPatient groupRisk modificationHigh riskClinical practiceSystematic reviewMechanical thrombectomy with retrievable stents and aspiration catheters for acute ischaemic stroke: a meta-analysis of randomised controlled trials.
Rajkumar CA, Ganesananthan S, Ahmad Y, Seligman H, Thornton GD, Foley M, Nowbar AN, Howard JP, Francis DP, Keeble TR, Grunwald IQ, Al-Lamee RK, Malik I, Shun-Shin MJ. Mechanical thrombectomy with retrievable stents and aspiration catheters for acute ischaemic stroke: a meta-analysis of randomised controlled trials. EuroIntervention 2022, 17: e1425-e1434. PMID: 34503942, PMCID: PMC9896406, DOI: 10.4244/eij-d-21-00343.Peer-Reviewed Original ResearchConceptsSymptomatic intracranial hemorrhageAcute ischemic strokeModified Rankin ScaleIschemic strokeCause mortalityMechanical thrombectomyAspiration catheterIntracranial hemorrhageRetrievable stentsAnterior circulation ischemic strokeLong-term neurological outcomeAcute anterior circulation strokeTrial of thrombectomyAnterior circulation strokeStandard of careIntravenous thrombolysisNeurological outcomeSecondary endpointsPrimary endpointSubsequent disabilityMRS scoreRankin ScaleMedical therapyThrombectomyTreatment strategiesPCI in Patients With Heart Failure: Current Evidence, Impact of Complete Revascularization, and Contemporary Techniques to Improve Outcomes
Ahmad Y, Petrie M, Jolicoeur E, Madhavan M, Velazquez E, Moses J, Lansky A, Stone G. PCI in Patients With Heart Failure: Current Evidence, Impact of Complete Revascularization, and Contemporary Techniques to Improve Outcomes. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100020. DOI: 10.1016/j.jscai.2022.100020.Peer-Reviewed Original ResearchPercutaneous coronary interventionLeft ventricular systolic dysfunctionCoronary artery diseaseHeart failureComplete revascularizationMedical therapyClinical outcomesClinical trialsCoronary artery bypassVentricular systolic dysfunctionClinical trial evidenceHigh operative riskHigh-risk patientsMajor cardiac surgeryExtent of revascularizationMinority of patientsFuture clinical trialsArtery bypassCause mortalityPeriprocedural complicationsSystolic dysfunctionCoronary interventionOperative riskArtery diseaseCardiac surgery
2021
Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis
Kelshiker MA, Seligman H, Howard JP, Rahman H, Foley M, Nowbar AN, Rajkumar CA, Shun-Shin MJ, Ahmad Y, Sen S, Al-Lamee R, Petraco R, Cole G, Hoole S, Paul D, Rigo F, Francis D, Mayet J. Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis. European Heart Journal 2021, 43: 1582-1593. PMID: 34849697, PMCID: PMC9020988, DOI: 10.1093/eurheartj/ehab775.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsAbnormal coronary flow reserveCoronary flow reserveCause mortalityCoronary flowHigh incidenceHazard ratioFlow reserveAdverse cardiovascular eventsCoronary microvascular dysfunctionAcute coronary syndromeRandom-effects modelEstimate of effectCardiovascular eventsCardiovascular outcomesCoronary syndromeMicrovascular dysfunctionHeart failureHeart transplantClinical outcomesPatient groupRisk modificationHigh riskClinical practiceSystematic reviewSodium-glucose cotransporter 2 inhibitors in patients with heart failure: a systematic review and meta-analysis of randomized trials
Ahmad Y, Madhavan MV, Stone GW, Francis DP, Makkar R, Bhatt DL, Howard JP. Sodium-glucose cotransporter 2 inhibitors in patients with heart failure: a systematic review and meta-analysis of randomized trials. European Heart Journal - Quality Of Care And Clinical Outcomes 2021, 8: 383-390. PMID: 34617565, PMCID: PMC9170566, DOI: 10.1093/ehjqcco/qcab072.Peer-Reviewed Original ResearchConceptsHeart failure hospitalizationSGLT-2 inhibitorsSodium-glucose cotransporter 2 inhibitorsCotransporter 2 inhibitorsFailure hospitalizationCardiovascular mortalityHeart failureCause mortalityHazard ratioPre-specified primary endpointEjection fraction rangeIndividual clinical endpointsPrimary endpointSecondary endpointsComposite outcomeStandard careRandomized trialsClinical endpointsHospitalizationPatientsSystematic reviewMortalityTrialsEndpointInhibitorsLong-term follow-up after ultrathin vs. conventional 2nd-generation drug-eluting stents: a systematic review and meta-analysis of randomized controlled trials
Madhavan MV, Howard JP, Naqvi A, Ben-Yehuda O, Redfors B, Prasad M, Shahim B, Leon MB, Bangalore S, Stone GW, Ahmad Y. Long-term follow-up after ultrathin vs. conventional 2nd-generation drug-eluting stents: a systematic review and meta-analysis of randomized controlled trials. European Heart Journal 2021, 42: 2643-2654. PMID: 34002202, PMCID: PMC8282325, DOI: 10.1093/eurheartj/ehab280.Peer-Reviewed Original ResearchConceptsThin-strut drug-eluting stentsUltrathin-strut drug-eluting stentsTarget lesion failureDrug-eluting stentsStent thrombosisMyocardial infarctionCardiac deathCause mortalityCD-TLRRisk of TLFSystematic reviewPre-specified primary endpointRisk of MIRevascularization of patientsWeighted mean followTarget lesion revascularizationPercutaneous coronary interventionStandard of careNew trial dataCause deathLesion revascularizationEligible trialsLesion failureMean followPrimary endpointRandomized Blinded Placebo-Controlled Trials of Renal Sympathetic Denervation for Hypertension: A Meta-Analysis
Ahmad Y, Kane C, Arnold AD, Cook CM, Keene D, Shun-Shin M, Cole G, Al-Lamee R, Francis DP, Howard JP. Randomized Blinded Placebo-Controlled Trials of Renal Sympathetic Denervation for Hypertension: A Meta-Analysis. Cardiovascular Revascularization Medicine 2021, 34: 112-118. PMID: 33551282, PMCID: PMC8813172, DOI: 10.1016/j.carrev.2021.01.031.Peer-Reviewed Original ResearchConceptsRenal denervationRelative risk reductionBlood pressureCatheter-based renal denervationMajor adverse cardiac eventsPlacebo-controlled trial dataAmbulatory diastolic blood pressureAmbulatory systolic blood pressurePlacebo-controlled randomized trialSystolic blood pressure changesOffice diastolic pressureRandomized blinded placeboAdverse cardiac eventsOffice blood pressurePlacebo-controlled trialPrimary efficacy outcomeDiastolic blood pressureRenal sympathetic denervationSystolic blood pressureBlood pressure changesRisk reductionCause mortalityEfficacy outcomesSympathetic denervationAdverse events
2020
Complete Revascularization by Percutaneous Coronary Intervention for Patients With ST‐Segment–Elevation Myocardial Infarction and Multivessel Coronary Artery Disease: An Updated Meta‐Analysis of Randomized Trials
Ahmad Y, Howard JP, Arnold A, Prasad M, Seligman H, Cook CM, Warisawa T, Shun‐Shun M, Ali Z, Parikh MA, Al‐Lamee R, Sen S, Francis D, Moses JW, Leon MB, Stone GW, Karmpaliotis D. Complete Revascularization by Percutaneous Coronary Intervention for Patients With ST‐Segment–Elevation Myocardial Infarction and Multivessel Coronary Artery Disease: An Updated Meta‐Analysis of Randomized Trials. Journal Of The American Heart Association 2020, 9: e015263. PMID: 32476540, PMCID: PMC7429036, DOI: 10.1161/jaha.119.015263.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionMultivessel coronary artery diseasePercutaneous coronary interventionCulprit-only revascularizationCoronary artery diseaseComplete revascularizationCoronary interventionMyocardial infarctionCardiovascular deathArtery diseaseUnplanned revascularizationMultivessel diseaseCause mortalityEnd pointPrimary efficacy end pointHard clinical outcomesEfficacy end pointSecondary end pointsClinical end pointsElevation myocardial infarctionClinical practice guidelinesTreat basisClinical outcomesRandomized trialsOptimal treatmentMortality after drug-eluting stents vs. coronary artery bypass grafting for left main coronary artery disease: a meta-analysis of randomized controlled trials
Ahmad Y, Howard JP, Arnold AD, Cook CM, Prasad M, Ali ZA, Parikh MA, Kosmidou I, Francis DP, Moses JW, Leon MB, Kirtane AJ, Stone GW, Karmpaliotis D. Mortality after drug-eluting stents vs. coronary artery bypass grafting for left main coronary artery disease: a meta-analysis of randomized controlled trials. European Heart Journal 2020, 41: 3228-3235. PMID: 32118272, PMCID: PMC7557472, DOI: 10.1093/eurheartj/ehaa135.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryPercutaneous coronary interventionDrug-eluting stentsMain coronary artery diseaseCoronary artery diseaseMyocardial infarctionCardiac deathUnplanned revascularizationCause mortalityCoronary interventionArtery diseaseLeft main coronary artery diseaseRandomized clinical trial evidenceSimilar long-term mortalityArtery bypass graft surgerySignificant differencesUnplanned revascularization proceduresWeighted mean followBypass graft surgeryCoronary artery bypassPrimary efficacy endpointClinical trial evidenceLong-term mortalityRisk of strokeGold standard therapy