2023
Cerebral Embolic Protection in Transcatheter Aortic Valve Replacement
Iskander M, Jamil Y, Forrest J, Madhavan M, Makkar R, Leon M, Lansky A, Ahmad Y. Cerebral Embolic Protection in Transcatheter Aortic Valve Replacement. Structural Heart 2023, 7: 100169. PMID: 37520138, PMCID: PMC10382985, DOI: 10.1016/j.shj.2023.100169.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementCerebral embolic protection devicesCerebral embolic protectionAortic valve replacementEmbolic protection devicesValve replacementEmbolic protectionSymptomatic severe aortic stenosisSevere aortic stenosisLow-risk patientsPredictors of strokeOccurrence of complicationsRisk of strokeRecent trial dataRelevant clinical studiesOverall evidence baseExpansion of TAVRFeared complicationAortic stenosisSurgical riskTreatment optionsWorse outcomesClinical studiesPatientsTrial data
2022
Imaging, Treatment Options, Patient Selection, and Outcome Considerations for Patients With Bicuspid Aortic Valve Disease
Ahmad Y, Agarwal V, Williams M, Wang D, Reardon M, Cavalcante J, Makkar R, Forrest J. Imaging, Treatment Options, Patient Selection, and Outcome Considerations for Patients With Bicuspid Aortic Valve Disease. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100506. DOI: 10.1016/j.jscai.2022.100506.Peer-Reviewed Original ResearchAortic valve replacementTranscatheter aortic valve replacementBicuspid aortic valve diseaseAortic valve diseaseValve replacementValve diseaseBAV diseaseSevere symptomatic aortic stenosisSurgical aortic valve replacementPivotal randomized trialsAortic valve surgerySymptomatic aortic stenosisRandomized clinical trialsValve surgeryHeart teamAortic stenosisSurgical riskPatient selectionRandomized trialsBicuspid valveSurgical approachTreatment optionsClinical trialsPatientsDiseaseReadmission and In-Hospital Outcomes After Transcatheter Aortic Valve Replacement in Patients With Dementia
Park DY, Sana MK, Shoura S, Hammo H, Hu JR, Forrest JK, Lowenstern A, Cleman M, Ahmad Y, Nanna MG. Readmission and In-Hospital Outcomes After Transcatheter Aortic Valve Replacement in Patients With Dementia. Cardiovascular Revascularization Medicine 2022, 46: 70-77. PMID: 35973922, PMCID: PMC10940024, DOI: 10.1016/j.carrev.2022.08.016.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementAortic stenosisValve replacementSecondary diagnosisHospital adverse outcomesAcute kidney injuryIn-Hospital OutcomesNational Readmission DatabasePresence of dementiaPrevalence of dementiaProportional hazards modelDecade of ageHigher hazardIndex hospitalizationInpatient outcomesKidney injuryDefinitive treatmentPacemaker placementReadmission riskAdverse outcomesReadmissionHigher oddsDecision-making discussionsHigh riskEarly Surgery for Patients With Asymptomatic Severe Aortic Stenosis: A Meta-Analysis of Randomized Controlled Trials
Ahmad Y, Howard J, Seligman H, Arnold A, Madhavan M, Forrest J, Geirsson A, Mack M, Lansky A, Leon M. Early Surgery for Patients With Asymptomatic Severe Aortic Stenosis: A Meta-Analysis of Randomized Controlled Trials. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100383. DOI: 10.1016/j.jscai.2022.100383.Peer-Reviewed Original ResearchSurgical aortic valve replacementAsymptomatic severe aortic stenosisSevere aortic stenosisAortic stenosisHF hospitalizationCause mortalityEjection fractionPrespecified primary end pointSevere asymptomatic aortic stenosisSymptomatic severe aortic stenosisEnd pointAortic valve interventionAsymptomatic aortic stenosisHeart failure hospitalizationPrimary end pointAortic valve replacementClass I recommendationCornerstone of managementInitial conservative managementNormal ejection fractionRandomized Controlled TrialsCurrent treatment standardsIndividual end pointsAsymptomatic patientsEarly surgeryHypoattenuated leaflet thickening (HALT) and reduced leaflet motion (RELM) of aortic bioprostheses: An imaging finding or a complication?
Ahmad Y, Makkar R, Sondergaard L. Hypoattenuated leaflet thickening (HALT) and reduced leaflet motion (RELM) of aortic bioprostheses: An imaging finding or a complication? Progress In Cardiovascular Diseases 2022, 72: 78-83. PMID: 35675882, DOI: 10.1016/j.pcad.2022.05.007.Peer-Reviewed Original ResearchConceptsLeaflet thickeningAortic bioprosthesesLeaflet motionSurgical aortic valve replacementSymptomatic severe aortic stenosisTranscatheter aortic valve implantationSubclinical leaflet thrombosisSurgical aortic bioprosthesesSevere aortic stenosisAortic valve replacementAortic valve implantationForm of strokeThrombotic complicationsValve implantationValve replacementAortic stenosisSurgical riskLeaflet thrombosisEffective therapyComputed tomographyValve functionRandomized dataValve durabilityClinical implicationsNatural history
2021
Performance of quantitative flow ratio in patients with aortic stenosis undergoing transcatheter aortic valve implantation
Sejr‐Hansen M, Christiansen EH, Ahmad Y, Vendrik J, Westra J, Holm NR, Thim T, Seligman H, Hall K, Sen S, Terkelsen CJ, Eftekhari A. Performance of quantitative flow ratio in patients with aortic stenosis undergoing transcatheter aortic valve implantation. Catheterization And Cardiovascular Interventions 2021, 99: 68-73. PMID: 33533535, DOI: 10.1002/ccd.29518.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationAortic valve stenosisCoronary artery diseaseInstantaneous wave-free ratioFractional flow reserveQuantitative flow ratioAortic valve implantationValve implantationDiagnostic performancePressure wirePresence of ASSevere aortic valve stenosisAortic valve replacementCoronary pressure wireGood diagnostic performanceValve replacementAortic stenosisArtery diseaseValve stenosisCoronary angiogramFlow reservePatientsCAD evaluationDiagnostic accuracyStenosis
2020
Long‐Term Effects of Transcatheter Aortic Valve Implantation on Coronary Hemodynamics in Patients With Concomitant Coronary Artery Disease and Severe Aortic Stenosis
Vendrik J, Ahmad Y, Eftekhari A, Howard JP, Wijntjens GWM, Stegehuis VE, Cook C, Terkelsen CJ, Christiansen EH, Koch KT, Piek JJ, Sen S, Baan J. Long‐Term Effects of Transcatheter Aortic Valve Implantation on Coronary Hemodynamics in Patients With Concomitant Coronary Artery Disease and Severe Aortic Stenosis. Journal Of The American Heart Association 2020, 9: e015133. PMID: 32102615, PMCID: PMC7335578, DOI: 10.1161/jaha.119.015133.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationSevere aortic stenosisConcomitant coronary artery diseaseAortic stenosisAortic valve implantationCoronary artery diseasePost-TAVICoronary flowArtery diseaseValve implantationCoronary hemodynamicsLarge-scale prospective randomized trialsFractional flow reserve assessmentProspective randomized trialsLow-risk patientsHyperemic coronary flowInstantaneous wave-free ratioFractional flow reserveCoronary stenosis severityYounger patientsCoronary lesionsRandomized trialsDiastolic flowPatient populationWave-free period
2019
Determining the Predominant Lesion in Patients With Severe Aortic Stenosis and Coronary Stenoses
Ahmad Y, Vendrik J, Eftekhari A, Howard JP, Cook C, Rajkumar C, Malik I, Mikhail G, Ruparelia N, Hadjiloizou N, Nijjer S, Al-Lamee R, Petraco R, Warisawa T, Wijntjens GWM, Koch KT, van de Hoef T, de Waard G, Echavarria-Pinto M, Frame A, Sutaria N, Kanaganayagam G, Ariff B, Anderson J, Chukwuemeka A, Fertleman M, Koul S, Iglesias JF, Francis D, Mayet J, Serruys P, Davies J, Escaned J, van Royen N, Götberg M, Terkelsen C, Christiansen E, Piek JJ, Baan J, Sen S. Determining the Predominant Lesion in Patients With Severe Aortic Stenosis and Coronary Stenoses. Circulation Cardiovascular Interventions 2019, 12: e008263-e008263. PMID: 31752515, PMCID: PMC6924937, DOI: 10.1161/circinterventions.119.008263.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisBlood Flow VelocityCardiac CatheterizationCoronary Artery DiseaseCoronary CirculationCoronary StenosisCoronary VesselsEuropeFemaleHemodynamicsHumansMaleMicrocirculationPercutaneous Coronary InterventionPredictive Value of TestsRecovery of FunctionSeverity of Illness IndexTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsTranscatheter aortic valve implantationSevere aortic stenosisPercutaneous coronary interventionAortic stenosisCoronary artery diseaseCoronary stenosisIntermediate coronary stenosisCoronary diseaseCoronary interventionArtery diseaseCoronary microcirculationWave-free periodInstantaneous wave-free ratio valueConcomitant coronary artery diseaseConcomitant coronary diseaseAortic valve implantationInstantaneous wave-free ratioPhysiology-guided revascularizationExertional symptomsPost-TAVIHemodynamic improvementHemodynamic benefitsValve implantationCoronary lesionsMicrovascular resistance
2018
TCT-9 Coronary pressure and flow in patients with severe aortic stenosis and coronary artery disease undergoing TAVI: implications for clinical indices of coronary stenosis severity
Ahmad Y, Gotberg M, Cook C, Howard J, Malik I, Mikhail G, Francis D, Mayet J, Davies J, Sen S. TCT-9 Coronary pressure and flow in patients with severe aortic stenosis and coronary artery disease undergoing TAVI: implications for clinical indices of coronary stenosis severity. Journal Of The American College Of Cardiology 2018, 72: b4. DOI: 10.1016/j.jacc.2018.08.1085.Peer-Reviewed Original ResearchCoronary Hemodynamics in Patients With Severe Aortic Stenosis and Coronary Artery Disease Undergoing Transcatheter Aortic Valve Replacement Implications for Clinical Indices of Coronary Stenosis Severity
Ahmad Y, Götberg M, Cook C, Howard JP, Malik I, Mikhail G, Frame A, Petraco R, Rajkumar C, Demir O, Iglesias JF, Bhindi R, Koul S, Hadjiloizou N, Gerber R, Ramrakha P, Ruparelia N, Sutaria N, Kanaganayagam G, Ariff B, Fertleman M, Anderson J, Chukwuemeka A, Francis D, Mayet J, Serruys P, Davies J, Sen S. Coronary Hemodynamics in Patients With Severe Aortic Stenosis and Coronary Artery Disease Undergoing Transcatheter Aortic Valve Replacement Implications for Clinical Indices of Coronary Stenosis Severity. JACC Cardiovascular Interventions 2018, 11: 2019-2031. PMID: 30154062, PMCID: PMC6197079, DOI: 10.1016/j.jcin.2018.07.019.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic Valve StenosisBlood Flow VelocityCardiac CatheterizationCoronary Artery DiseaseCoronary StenosisFemaleFractional Flow Reserve, MyocardialHemodynamicsHumansHyperemiaLondonMalePredictive Value of TestsReproducibility of ResultsSeverity of Illness IndexSwedenTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsSevere aortic stenosisTranscatheter aortic valve replacementCoronary artery diseaseCoronary stenosis severityAortic stenosisHyperemic coronary flowFractional flow reserveArtery diseaseCoronary flowStenosis severityWave-free periodClinical indicesHyperemic flowFlow reserveInstantaneous wave-free ratio valueIntracoronary pressureConcomitant coronary artery diseaseAortic valve replacementStenotic aortic valvesInstantaneous wave-free ratioPhasic coronary flowValve replacementHyperemic indexAortic valveCoronary pressure229Coronary haemodynamics in patients with severe aortic stenosis and coronary artery disease undergoing TAVI: implications for clinical indices of coronary stenosis severity
Ahmad Y, Gotberg M, Malik I, Mikhail G, Howard J, Demir O, Petraco R, Iglesias J, Francis D, Mayet J, Davies J, Sen S. 229Coronary haemodynamics in patients with severe aortic stenosis and coronary artery disease undergoing TAVI: implications for clinical indices of coronary stenosis severity. European Heart Journal 2018, 39: ehy564.229. DOI: 10.1093/eurheartj/ehy564.229.Peer-Reviewed Original ResearchAssessing coronary disease in patients with severe aortic stenosis: the need for a 'valid' gold standard for validation studies?
Sen S, Ahmad Y, Davies J. Assessing coronary disease in patients with severe aortic stenosis: the need for a 'valid' gold standard for validation studies? EuroIntervention 2018, 13: 1499-1502. PMID: 29345238, DOI: 10.4244/eijv13i13a240.Peer-Reviewed Original Research
2017
Acute myocardial infarction and stroke secondary to valve thrombosis following transcatheter aortic valve replacement—what can happen when antiplatelet agents are stopped
Lam MC, Kanaganayagam G, Ahmad Y, Fertleman M, Ariff B. Acute myocardial infarction and stroke secondary to valve thrombosis following transcatheter aortic valve replacement—what can happen when antiplatelet agents are stopped. Quantitative Imaging In Medicine And Surgery 2017, 7: 605-607. PMID: 29184771, PMCID: PMC5682404, DOI: 10.21037/qims.2017.10.04.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementDual antiplatelet therapyAortic valve replacementValve replacementAortic stenosisSevere aortic stenosisCoronary artery bypassPast medical historyAcute myocardial infarctionAntiplatelet therapyArtery bypassAntiplatelet agentsPost procedureMedical historyMyocardial infarctionMonthsVomitingInfarctionStenosisThrombosisPatientsAdmissionBypassTherapyStrokeAortic Stenosis in Dialysis Patients
Ahmad Y, Bellamy MF, Baker CSR. Aortic Stenosis in Dialysis Patients. Seminars In Dialysis 2017, 30: 224-231. PMID: 28239994, DOI: 10.1111/sdi.12582.Peer-Reviewed Original ResearchConceptsAortic stenosisExercise-induced symptomsSevere aortic stenosisAortic valve stenosisDialysis populationExercise capacityRenal failureValve replacementDialysis patientsValve stenosisCardiac outputConventional surgeryPercutaneous techniquesGeneral populationStenosis severityStenosisPatientsSymptomsObjective assessmentValvePotential pitfallsComorbiditiesEchocardiographySurgeryAccurate interpretation